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ATG6 ATG6 ATG4B ATG4B VTI12 VTI12 VTI11 VTI11 ATG1C ATG1C ATG101 ATG101 ATI1 ATI1 VPS34 VPS34 SYP22 SYP22 ATG3 ATG3 ATG18G ATG18G ATG9 ATG9 ATG8E ATG8E ATG4A ATG4A ATG8F ATG8F ATG18A ATG18A ATG7 ATG7 SYP24 SYP24 BZIP8 BZIP8 PEP4 PEP4 TOR TOR VTI13 VTI13 ATG8G ATG8G VPS15 VPS15
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG6Beclin-1-like protein; Required for normal plant development. Required for pollen germination. Required for autophagic activity. Required to limit the pathogen-associated cell death response. May be involved in vacuolar protein sorting. Binds to microtubules. May facilitate efficient recruitment of other ATG proteins to assemble scaffolds for autophagosome biogenesis. Belongs to the beclin family. (517 aa)
ATG4BCysteine protease ATG4b; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes. (477 aa)
VTI12Vesicle transport v-SNARE 12; May function as a v-SNARE responsible for the docking or fusion of transport vesicles within the trans-Golgi network (TGN). May be also involved in retrograde traffic to the cis-Golgi (By similarity); Belongs to the VTI1 family. (222 aa)
VTI11Vesicle transport v-SNARE 11; May function as a v-SNARE responsible for targeting AtELP- containing vesicles from the trans-Golgi network (TGN) to the prevacuolar compartment (PVC). May be also involved in retrograde traffic to the cis-Golgi (By similarity). Promotes the formation of vacuolar membrane 'bulbs'. Required for amyloplast sedimentation in the endodermis during shoot gravitropism, which are thus acting as statoliths. Expression in the endodermis is essential for the shoot gravitropic response, whereas expression in other tissues may be responsible for the correct stem and le [...] (221 aa)
ATG1CSerine/threonine-protein kinase ATG1c; Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. (733 aa)
ATG101Autophagy-related protein 101; Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Required for selective mitophagy. Belongs to the ATG101 family. (215 aa)
ATI1ATG8-interacting protein 1; Involved in a special stress-induced plastid-to-vacuole protein trafficking pathway. Interacts with ATG8F in plastid bodies to subsequently enable their delivery to the vacuole by an autophagic pathway. Interacts with the plastid proteins APE1 and PSBS/NPQ4 and may recruit them as cargo into plastid bodies that may be recognized by the autophagy machinery for degradation in the vacuole. Involved in the alleviation of damage caused by salt stress during plant development, probably through its involvement in plastid-to-vacuole and ER-to- vacuole trafficking. P [...] (256 aa)
VPS34Phosphatidylinositol 3-kinase VPS34; Belongs to the PI3/PI4-kinase family. (814 aa)
SYP22Syntaxin-22; May provide the t-SNARE function in the vacuolar assembly. Promotes the formation of vacuolar membrane 'bulbs'. Required for inflorescence stem gravitropism; Belongs to the syntaxin family. (268 aa)
ATG3Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. (313 aa)
ATG18GAutophagy-related protein 18g; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy (By similarity); Belongs to the WD repeat SVP1 family. (959 aa)
ATG9Autophagy-related protein 9; Required for autophagy that plays an essential role in plant nutrient recycling. Contributes to efficient autophagic flux, especially in early autophagic process prior to the fusion of the autophagosome with the vacuole. Belongs to the ATG9 family. (866 aa)
ATG8EAutophagy-related protein 8e; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
ATG4ACysteine protease ATG4a; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes; Belongs to the peptidase C54 family. (467 aa)
ATG8FAutophagy-related protein 8f; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
ATG18AAutophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. (425 aa)
ATG7Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. (697 aa)
SYP24Putative syntaxin-24; Vesicle trafficking protein that functions in the secretory pathway; Belongs to the syntaxin family. (416 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
PEP4Elicitor peptide 4; Elicitor of plant defense. (81 aa)
TORSerine/threonine-protein kinase TOR; Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic [...] (2481 aa)
VTI13Vesicle transport v-SNARE 13; May function as a v-SNARE responsible for targeting vesicles involved in the secretory pathway. (221 aa)
ATG8GAutophagy-related protein 8g; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
VPS15Serine/threonine-protein kinase VPS15; Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization. (1494 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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