STRINGSTRING
HMG2 HMG2 F1C9.19 F1C9.19 DXPS1 DXPS1 MVD2 MVD2 ISPG ISPG MVD1 MVD1 ISPE ISPE ISPD ISPD DXS DXS ISPH ISPH ISPF ISPF DXPS3 DXPS3 CDC73 CDC73 DXR DXR
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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HMG23-hydroxy-3-methylglutaryl-coenzyme A reductase 2; Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants. Belongs to the HMG-CoA reductase family. (562 aa)
F1C9.19Transferase. (666 aa)
DXPS11-deoxy-D-xylulose 5-phosphate synthase 1. (677 aa)
MVD2Diphosphomevalonate decarboxylase MVD2, peroxisomal; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5-diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000- fold lower than for MVAPP; Belongs to the diphosphomevalonate decarboxylase family. (419 aa)
ISPG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Is essential for chloroplast development and required for the salicylic acid (SA)-mediated disease resistance to biotrophic pathogens. (741 aa)
MVD1Diphosphomevalonate decarboxylase MVD1, peroxisomal; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5- diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5- phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP. Can complement a yeast mutant defective in MVD activity. (412 aa)
ISPE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Is essential for chloroplast development. (383 aa)
ISPD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis. (302 aa)
DXS1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP). Is a limiting enzyme for plastidic isoprenoid biosynthesis and essential for chloroplast development. Belongs to the transketolase family. DXPS subfamily. (717 aa)
ISPH4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)-butenyl 4- diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is essential for chloroplast development. (466 aa)
ISPF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2- phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. Also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl- D-erythritol 3,4-cyclophosphate and CMP. Is essential for chloroplast development; Belongs to the IspF family. (231 aa)
DXPS31-D-deoxyxylulose 5-phosphate synthase-like protein. (700 aa)
CDC73Protein CDC73 homolog; Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS- box genes of the MAF family. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus. (415 aa)
DXR1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D- erythritol 4-phosphate (MEP). Required for chloroplast development. (477 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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