STRINGSTRING
RPL40A RPL40A RPP1 RPP1 RACK1A RACK1A rps12 rps12 RPS6A RPS6A RPS27A RPS27A PS1-2 PS1-2 RPS11A RPS11A ARP1 ARP1 RPS28C RPS28C RPL24B RPL24B RPS13 RPS13 RPL8A RPL8A RPL5B RPL5B RPL23A RPL23A RPL4D RPL4D RPL18AB RPL18AB RPS6B RPS6B rps14 rps14 RPS27AB RPS27AB RPS27AC RPS27AC RPS27AA RPS27AA rps12-A rps12-A RPS12 RPS12 RPL24 RPL24 RPL10B RPL10B RPL40B RPL40B RPL24A RPL24A RPL5A RPL5A RPS1 RPS1 RPL10A RPL10A RPL10C RPL10C HDA2 HDA2 RACK1B RACK1B RPS13-2 RPS13-2 LIMYB LIMYB NOP2A NOP2A TOR TOR RPL10 RPL10 NIK1 NIK1 RACK1C RACK1C RPP3B RPP3B RPS15AE RPS15AE RPS27B RPS27B PS2-2 PS2-2 METK3 METK3 rps14-2 rps14-2 RPL19A RPL19A RPP3A RPP3A RPL14B RPL14B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL40AUbiquitin-60S ribosomal protein L40-1; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is inv [...] (128 aa)
RPP1Probable disease resistance protein RPP1; TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis (By similarity). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. (1194 aa)
RACK1AReceptor for activated C kinase 1A; Major component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways. Involved in multiple hormone responses and developmental processes. MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway. Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (327 aa)
rps12Ribosomal protein S12; Belongs to the universal ribosomal protein uS12 family. (125 aa)
RPS6A40S ribosomal protein S6-1; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (250 aa)
RPS27A40S ribosomal protein S27-1. (84 aa)
PS1-2Presenilin-like protein At1g08700; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (453 aa)
RPS11A40S ribosomal protein S11-1. (160 aa)
ARP160S ribosomal protein L3-1; Belongs to the universal ribosomal protein uL3 family. (389 aa)
RPS28C40S ribosomal protein S28-2. (64 aa)
RPL24B60S ribosomal protein L24-2; Might have an extraribosomal function in reinitiation of translation of ETTIN and MONOPTEROS genes that are involved in the auxin-mediated gynoecium patterning. Essential in leaf polarity establishment, probably having a role for translation in leaf dorsoventral patterning to specify leaf adaxial identity. (163 aa)
RPS1330S ribosomal protein S13, chloroplastic; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; Belongs to the universal ribosomal protein uS13 family. (169 aa)
RPL8A60S ribosomal protein L8-1. (258 aa)
RPL5B60S ribosomal protein L5-2; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] (301 aa)
RPL23A60S ribosomal protein L23. (140 aa)
RPL4D60S ribosomal protein L4-2. (407 aa)
RPL18AB60S ribosomal protein L18a-2; Belongs to the eukaryotic ribosomal protein eL20 family. (178 aa)
RPS6B40S ribosomal protein S6-2; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. (249 aa)
rps1430S ribosomal protein S14, chloroplastic; Binds 16S rRNA, required for the assembly of 30S particles. Belongs to the universal ribosomal protein uS14 family. (100 aa)
RPS27ABUbiquitin-40S ribosomal protein S27a-2; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (157 aa)
RPS27ACUbiquitin-40S ribosomal protein S27a-3; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (157 aa)
RPS27AAUbiquitin-40S ribosomal protein S27a-1; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (156 aa)
rps12-A30S ribosomal protein S12, chloroplastic; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity). (123 aa)
RPS12Ribosomal protein S12, mitochondrial; Protein S12 is involved in the translation initiation step; Belongs to the universal ribosomal protein uS12 family. (125 aa)
RPL2450S ribosomal protein L24, chloroplastic; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity). Required for optimal plastid performance in terms of photosynthesis and growth. Required for the translation of plastid mRNAs. Plays a critical role in biosynthesis of thylakoid membrane proteins encoded by chloroplast genes. (198 aa)
RPL10B60S ribosomal protein L10-2. (221 aa)
RPL40BUbiquitin-60S ribosomal protein L40-2; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is inv [...] (128 aa)
RPL24A60S ribosomal protein L24-1; Might have an extraribosomal function in reinitiation of translation. (164 aa)
RPL5A60S ribosomal protein L5-1; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] (301 aa)
RPS130S ribosomal protein S1, chloroplastic; Required for optimal plastid performance in terms of photosynthesis and growth. Required for the translation of plastid mRNAs. Involved in cellular heat stress response and required for heat tolerance. Required for transcriptional activation of HSFA2 and its target genes in response to heat stress. Plays a critical role in biosynthesis of thylakoid membrane proteins encoded by chloroplast genes. (416 aa)
RPL10A60S ribosomal protein L10-1; Ribosomal protein involved in translational regulation. Contribute to general translation under UV-B stress. Involved in the NIK1-mediated defense response to geminivirus infection. Acts coordinately with LIMYB as a transcriptional repressor. (220 aa)
RPL10C60S ribosomal protein L10-3. (221 aa)
HDA2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (387 aa)
RACK1BReceptor for activated C kinase 1B; Minor component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways. Involved in multiple hormone responses and developmental processes. MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway. Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (326 aa)
RPS13-2Small ribosomal subunit protein S13, mitochondrial; Located at the top of the head of the small subunit, it contacts several helices of the 18S rRNA. (154 aa)
LIMYBL10-interacting MYB domain-containing protein; Transcriptional repressor that associates with ribosomal protein promoters. (449 aa)
NOP2A25S rRNA (cytosine-C(5))-methyltransferase NOP2A; Involved in ribosomal large subunit assembly, required for normal progression of rRNA processing. S-adenosyl-L-methionine-dependent methyltransferase that probably methylates the C(5) position of cytosine 2268 (m5C2268) in nuclear 25S rRNA. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (By similarity). Seems involved in the regulation of cell proliferation in leaves. (682 aa)
TORSerine/threonine-protein kinase TOR; Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic [...] (2481 aa)
RPL1050S ribosomal protein L10, chloroplastic; This protein binds directly to 23S ribosomal RNA. (220 aa)
NIK1Protein NSP-INTERACTING KINASE 1; Involved in defense response to geminivirus and begomovirus infection via regulation of the nuclear trafficking of RPL10A. Phosphorylates RPL10A in vitro. Activation of NIK1 downregulates cytosolic translation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (638 aa)
RACK1CReceptor for activated C kinase 1C; Minor component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways. Involved in multiple hormone responses and developmental processes. MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway. Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (326 aa)
RPP3B60S acidic ribosomal protein P3-2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (120 aa)
RPS15AE40S ribosomal protein S15a-5; Belongs to the universal ribosomal protein uS8 family. (129 aa)
RPS27B40S ribosomal protein S27-2; May be involved in the elimination of damaged mRNA after UV irradiation. (86 aa)
PS2-2Presenilin-like protein At2g29900; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (397 aa)
METK3S-adenosylmethionine synthase 3; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Involved in the biosynthesis of lignin ; Belongs to the AdoMet synthase family. (390 aa)
rps14-2Mitochondrial ribosomal protein S14. (164 aa)
RPL19A60S ribosomal protein L19-1; Belongs to the eukaryotic ribosomal protein eL19 family. (214 aa)
RPP3A60S acidic ribosomal protein P3-1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (119 aa)
RPL14B60S ribosomal protein L14-2; Belongs to the eukaryotic ribosomal protein eL14 family. (134 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.