STRINGSTRING
NPR2 NPR2 MYC4 MYC4 SBT1.2 SBT1.2 TCP9 TCP9 SQS2 SQS2 TPS10 TPS10 LECRK41 LECRK41 CAM1 CAM1 CAM2 CAM2 CHI-B CHI-B CML10 CML10 PR1-2 PR1-2 BG2 BG2 PAL1 PAL1 TGG1 TGG1 AP2 AP2 CAM7 CAM7 CCA1 CCA1 NPR1 NPR1 CAM6 CAM6 TPS8 TPS8 WAK1 WAK1 MYC2 MYC2 NPR4 NPR4 MYB63 MYB63 TPS21 TPS21 SBTI1.1 SBTI1.1 WRKY38 WRKY38 NPR3 NPR3 SBT4.12 SBT4.12 HPT1 HPT1 WAKL10 WAKL10 WRKY54 WRKY54 WRKY51 WRKY51 GES GES TGG2 TGG2 LUP1 LUP1 BZIP8 BZIP8 CP1 CP1 MYB75 MYB75 PDF1.2A PDF1.2A THAS1 THAS1 CYP705A5 CYP705A5 MYC3 MYC3 TPS2 TPS2 MYB107 MYB107 ERF094 ERF094 CYP82G1 CYP82G1 LECRK92 LECRK92 MYB46 MYB46 WRKY62 WRKY62 MYB41 MYB41 NPR6 NPR6 SBT3.3 SBT3.3 TPS3 TPS3 SUR1 SUR1 WRKY60 WRKY60 MYB49 MYB49 MYB24 MYB24 TIR TIR NPR5 NPR5 LECRKS2 LECRKS2 VSP1 VSP1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NPR2Regulatory protein NPR2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (600 aa)
MYC4Transcription factor MYC4; Transcription factor involved in jasmonic acid (JA) gene regulation. With MYC2 and MYC3, controls additively subsets of JA- dependent responses. Can form complexes with all known glucosinolate- related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. (589 aa)
SBT1.2Subtilisin-like protease SBT1.2; Serine protease involved in the negative regulation of stomatal density and distribution. Not active on EPFL6 (AC Q1PEY6). Positive regulator of water use efficiency (WUE). (775 aa)
TCP9Transcription factor TCP9. (356 aa)
SQS2Inactive squalene synthase 2; Belongs to the phytoene/squalene synthase family. (413 aa)
TPS10Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 10; In the C-terminal section; belongs to the trehalose phosphatase family. (861 aa)
LECRK41L-type lectin-domain containing receptor kinase IV.1; In the N-terminal section; belongs to the leguminous lectin family. (675 aa)
CAM1Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CAM2Calmodulin-2; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CHI-BBasic endochitinase B; Defense against chitin-containing fungal pathogens. Seems particularly implicated in resistance to jasmonate-inducing pathogens such as A.brassicicola. In vitro antifungal activity against T.reesei, but not against A.solani, F.oxysporum, S.sclerotiorum, G.graminis and P.megasperma. (335 aa)
CML10Calmodulin-like protein 10; Potential calcium sensor. (191 aa)
PR1-2Pathogenesis-related protein 1; Partially responsible for acquired pathogen resistance. (161 aa)
BG2Glucan endo-1,3-beta-glucosidase, acidic isoform; Implicated in the defense of plants against pathogens (Probable). Not involved in plasmodesmal callose degradation and in the gating of plasmodesmata during tobamovirus infection. Belongs to the glycosyl hydrolase 17 family. (339 aa)
PAL1Phenylalanine ammonia-lyase 1; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (725 aa)
TGG1Myrosinase 1; Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones. These toxic degradation products can deter insect herbivores. Seems to function in abscisic acid (ABA) and methyl jasmonate (MeJA) signaling in guard cells. Functionally redundant with TGG2. Hydrolyzes sinigrin and, with lower efficiency, p-nitrophenyl beta-D-glucoside. (541 aa)
AP2Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...] (432 aa)
CAM7Calmodulin-7; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro. (149 aa)
CCA1Protein CCA1; Transcription factor involved in the circadian clock and in the phytochrome regulation. Binds to the promoter regions of APRR1/TOC1 and TCP21/CHE to repress their transcription. Binds to the promoter regions of CAB2A and CAB2B to promote their transcription. Represses both LHY and itself. (608 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
CAM6Calmodulin-6; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
TPS8Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 8; In the N-terminal section; belongs to the glycosyltransferase 20 family. (856 aa)
WAK1Wall-associated receptor kinase 1; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. Required during plant's response to pathogen infection and in plant defense against heavy metal toxicity. Phosphorylates the oxygen-evolving enhancer protein 2 (OEE2) in an GRP-3-dependent manner. (735 aa)
MYC2Transcription factor MYC2; Transcriptional activator. Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways. With MYC3 and MYC4, controls additively subsets of JA-dependent responses. In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters. Binds directly to the prom [...] (623 aa)
NPR4Regulatory protein NPR4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. (574 aa)
MYB63Transcription factor MYB63; Transcriptional activator that binds DNA to the AC cis- elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of promoters and specifically activates lignin biosynthetic genes during secondary wall formation mediated by SND1. (294 aa)
TPS21Alpha-humulene/(-)-(E)-beta-caryophyllene synthase; Involved in sesquiterpene (C15) biosynthesis. The major products are beta-caryophyllene and alpha-humulene. Does not convert geranyl diphosphate (GPP) to any monoterpenes. Belongs to the terpene synthase family. Tpsa subfamily. (547 aa)
SBTI1.1Subtilisin-like protease SBT1.1; Serine protease that cleaves the phytosulfokines PSK3, PSK2 and PSK5 in vitro. Phytosulfokines are plant growth factors or peptide hormones that promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation. Belongs to the peptidase S8 family. (774 aa)
WRKY38Probable WRKY transcription factor 38; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). (289 aa)
NPR3Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens. (586 aa)
SBT4.12Subtilisin-like protease SBT4.12. (736 aa)
HPT1Homogentisate phytyltransferase 1, chloroplastic; Involved in the synthesis of tocopherol (vitamin E). Catalyzes the condensation of homogentisate and phytyl diphosphate to form dimethylphytylhydrquinone. Low activity with geranylgeranyl diphosphate as substrate, but no activity with farnesyl diphosphate or solanesyl diphosphate. Tocopherol functions to limit lipid oxidation during seed desiccation, quiescence and germination and early seedling development. Protects thylakoid membrane lipids from photooxidation and is required for low-temperature adaptation. Belongs to the UbiA prenylt [...] (393 aa)
WAKL10Wall-associated receptor kinase-like 10; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. (769 aa)
WRKY54Probable WRKY transcription factor 54; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Together with WRKY70, negative regulator of developmental senescence, probably via the regulation of several senescence-associated markers genes. Positive regulator of EDS1-dependent defense against E.amylovora. In collaboration with WRKY70, prevents stomatal closure and, consequently, osmotic stress tolerance. Together with WRKY46 and WRKY70, promotes brassinosteroid (BR)- regulated plant [...] (346 aa)
WRKY51Probable WRKY transcription factor 51; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Involved in defense responses. May act as positive regulator of salicylic acid (SA)-mediated signaling and negative regulator of jasmonic acid (JA)-mediated signaling ; Belongs to the WRKY group II-c family. (194 aa)
GES(E,E)-geranyllinalool synthase; Involved in the biosynthesis of homoterpenes, attractants of herbivores parasitoids and predators (e.g. predatory mites and parasitoid wasps). Involved in diterpene (C20) biosynthesis. Catalyzes the conversion of geranylgeranyl diphosphate to (E,E)-geranyllinalool, the precursor of the insect-induced volatile C16-homoterpene TMTT. (877 aa)
TGG2Myrosinase 2; May degrade glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones. These toxic degradation products can deter insect herbivores. Seems to function in abscisic acid (ABA) and methyl jasmonate (MeJA) signaling in guard cells. Functionally redundant with TGG1; Belongs to the glycosyl hydrolase 1 family. (547 aa)
LUP1Lupeol synthase 1; Multifunctional enzyme that converts oxidosqualene to lupeol and 3,20-dihydroxylupane. Minor production of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol. (757 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
CP1Calcium-binding protein CP1; Binds calcium in vitro. (160 aa)
MYB75Transcription factor MYB75; Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of. phenylpropanoid-derived compounds such as anthocyanins and proanthocyanidin, probably together with GL3 and BHLH2. Regulates the expression of CHS, DFRA, LDOX, and BAN. (248 aa)
PDF1.2ADefensin-like protein 16; Confers broad-spectrum resistance to pathogens. Has antifungal activity in vitro; Belongs to the DEFL family. (80 aa)
THAS1Thalianol synthase; Converts oxidosqualene to thalianol. Belongs to the terpene cyclase/mutase family. (766 aa)
CYP705A5Cytochrome P450 705A5; Converts thalian-diol to a desaturated thalian-diol. Belongs to the cytochrome P450 family. (511 aa)
MYC3Transcription factor MYC3; Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. (592 aa)
TPS2Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2; In the C-terminal section; belongs to the trehalose phosphatase family. (822 aa)
MYB107Putative MYB family transcription factor. (321 aa)
ERF094Ethylene-responsive transcription factor ERF094; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Acts as an essential integrator of the JA and ethylene signal transduction pathways. Activates the expression of the PDF1.2A gene; Belongs to the AP2/ERF transcription factor family. ERF subfamily. (244 aa)
CYP82G1Dimethylnonatriene synthase; Involved in the biosynthesis of homoterpenes, attractants of herbivores parasitoids and predators (e.g. predatory mites and parasitoid wasps). Catalyzes the conversion of the C20 (E,E)-geranyllinalool to C16-homoterpene 4,8,12-trimethyltrideca- 1,3,7,11-tetraene (TMTT) of the C15 (E)-nerolidol to C11-homoterpene (E)-4,8-dimethyl-1,3,7-nonatriene (DMNT); these volatile compounds are produced upon insect herbivore attack and emitted from flowers and vegetative tissues during herbivore feeding. Required during resistance responses to the fungus Alternaria bras [...] (515 aa)
LECRK92L-type lectin-domain containing receptor kinase IX.2; Promotes hydrogen peroxide H(2)O(2) production and cell death; In the N-terminal section; belongs to the leguminous lectin family. (675 aa)
MYB46Transcription factor MYB46; Transcription activator. Involved in the regulation of secondary wall biosynthesis in fibers and vessels. Transcription activator of the mannan synthase CSLA9 that recognizes and binds to the DNA consensus sequence 5'-[AG][GT]T[AT]GGT[GA]-3' cis- regulatory element of CSLA9 promoter. Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1. Functions redundantly with MYB83 in the transcriptional regulatory cascade leading to secondary wa [...] (280 aa)
WRKY62Probable WRKY transcription factor 62; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group III family. (263 aa)
MYB41Transcription factor MYB41; Transcription factor involved in salt stress response. Confers tolerance to salt stress. Involved in distinct cellular processes in response to osmotic stress, including control of primary metabolism and negative regulation of short-term transcriptional responses to osmotic stress. Can activate the steps necessary for aliphatic suberin synthesis and deposition of cell wall-associated suberin-like lamellae. Involved in the production of aliphatic suberin under abiotic stress conditions. (282 aa)
NPR6Regulatory protein NPR6; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB [...] (467 aa)
SBT3.3Subtilisin-like protease SBT3.3; Serine protease that plays a role in the control of the establishment of immune priming and systemic induced resistance. (777 aa)
TPS3Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 3; In the C-terminal section; belongs to the trehalose phosphatase family. (783 aa)
SUR1S-alkyl-thiohydroximate lyase SUR1; C-S lyase involved in glucosinolate biosynthesis. Converts S- (alkylacetohydroximoyl)-L-cysteine to thiohydroximate. Functions in auxin homeostasis. Probably required for glucosinolate activation in response to pathogens; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (462 aa)
WRKY60Probable WRKY transcription factor 60; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). (271 aa)
MYB49Myb-related transcription factor-like protein. (319 aa)
MYB24Transcription factor MYB24; Transcription factor acting redundantly with MYB21 and MYB57 to control stamen filament elongation in the late developed flowers. Contributes with MYB21 to induction of MYB108 by jasmonate. Repressed at the transcript levels by DELLA proteins. (214 aa)
TIRToll/interleukin-1 receptor-like protein; Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity). (176 aa)
NPR5Regulatory protein NPR5; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB [...] (491 aa)
LECRKS2Receptor like protein kinase S.2. (851 aa)
VSP1Vegetative storage protein 1; May function as somatic storage protein during early seedling development; Belongs to the APS1/VSP family. (270 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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