STRINGSTRING
KEG KEG F20M13.40 F20M13.40 MKK4 MKK4 AHA3 AHA3 UBC10 UBC10 GBF3 GBF3 RD29A RD29A T25N20.10 T25N20.10 CPK4 CPK4 CPK6 CPK6 TGA1 TGA1 SIZ1 SIZ1 CPK32 CPK32 DWA2 DWA2 UPL3 UPL3 CIPK26 CIPK26 THO6 THO6 MUK11.16 MUK11.16 CUL4 CUL4 DPBF2 DPBF2 ACT2 ACT2 TIFY3B TIFY3B DPBF4 DPBF4 BZIP8 BZIP8 BHLH2 BHLH2 HAB1 HAB1 BZIP15 BZIP15 MRH10.19 MRH10.19 DPBF3 DPBF3 FUS3 FUS3 ABF4 ABF4 ABF3 ABF3 ABF2 ABF2 ABF1 ABF1 CPK10 CPK10 ABI5 ABI5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KEGE3 ubiquitin-protein ligase KEG; Mediates E2-dependent protein ubiquitination. Acts as a negative regulator of abscisic acid signaling. Required for ABI5 degradation, by mediating its ubiquitination. Together with EDR1, may regulate endocytic trafficking and/or the formation of signaling complexes on trans-Golgi network (TGN)/ early endosome (EE) vesicles during stress responses. (1625 aa)
F20M13.40Transducin/WD40 repeat-like superfamily protein. (471 aa)
MKK4Mitogen-activated protein kinase kinase 4; Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the [...] (366 aa)
AHA3ATPase 3, plasma membrane-type; The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. (949 aa)
UBC10Ubiquitin-conjugating enzyme E2 10; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
GBF3G-box-binding factor 3; Binds to the G-box motif (5'-CCACGTGG-3') of the rbcS-1A gene promoter. G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control. (382 aa)
RD29ALow-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family. (710 aa)
T25N20.10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein. (205 aa)
CPK4Calcium-dependent protein kinase 4; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions as regulator of the calcium- mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA- responsive transcription factors ABF1 and ABF4 in vitro. Phosphorylates the nuclear zinc finger Di19 in vitro. (501 aa)
CPK6Calcium-dependent protein kinase 6; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. Phosphorylates FD ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (544 aa)
TGA1Transcription factor TGA1; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'- TGACGTGG-3') another cis-acting element found in plant histone promoters; Belongs to the bZIP family. (368 aa)
SIZ1E3 SUMO-protein ligase SIZ1; E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugation and facilitates basal thermotolerance. Involved in freezing [...] (884 aa)
CPK32Calcium-dependent protein kinase 32; May play a role in signal transduction pathways that involve calcium as a second messenger. Involved in maintaining Ca2+ homeostasis in pollen tube tips by regulating CNGC18. Functions as regulator of the calcium-mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA-responsive transcription factor ABF4 in vitro ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (538 aa)
DWA2WD repeat-containing protein DWA2; Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin- protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling. May function as the substrate recognition module within this complex leading to ABI5 degradation. Functionally redundant with DWA1. (350 aa)
UPL3E3 ubiquitin-protein ligase UPL3; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the repression of endoreduplication process and the cell morphogenesis in the trichomes. (1888 aa)
CIPK26CBL-interacting serine/threonine-protein kinase 26; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Involved in the calcium-dependent regulation of reactive oxygen species production by the NADPH oxidase RBOHF. (439 aa)
THO6THO complex subunit 6; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. (367 aa)
MUK11.16BZIP protein. (307 aa)
CUL4Cullin-4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin- protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin- protein ligase complex which mediates ubiquit [...] (792 aa)
DPBF2ABSCISIC ACID-INSENSITIVE 5-like protein 1; Could participate in abscisic acid-regulated gene expression during seed development. (331 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
TIFY3BProtein TIFY 3B; Repressor of jasmonate responses. (187 aa)
DPBF4ABSCISIC ACID-INSENSITIVE 5-like protein 3; Binds to the embryo specification element and the ABA- responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 gene promoter. Could participate in abscisic acid-regulated gene expression during seed development; Belongs to the bZIP family. ABI5 subfamily. (262 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
BHLH2Transcription factor EGL1; Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involve [...] (596 aa)
HAB1Protein phosphatase 2C 16; Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought. Belongs to the PP2C family. (511 aa)
BZIP15ABSCISIC ACID-INSENSITIVE 5-like protein 8; Could participate in abscisic acid-regulated gene expression. Belongs to the bZIP family. ABI5 subfamily. (370 aa)
MRH10.19Basic-leucine zipper (BZIP) transcription factor family protein. (315 aa)
DPBF3ABSCISIC ACID-INSENSITIVE 5-like protein 2; Binds to the embryo specification element and the ABA- responsive element (ABRE) of the Dc3 gene promoter. Could participate in abscisic acid-regulated gene expression during seed development. (297 aa)
FUS3B3 domain-containing transcription factor FUS3; Transcription regulator involved in gene regulation during late embryogenesis. Its expression to the epidermis is sufficient to control foliar organ identity by regulating positively the synthesis abscisic acid (ABA) and negatively gibberellin production. Negatively regulates TTG1 in the embryo. Positively regulates the abundance of the ABI3 protein in the seed. Cooperates with KIN10 to regulate developmental phase transitions and lateral organ development and act both as positive regulators of abscisic acid (ABA) signaling during germination. (313 aa)
ABF4ABSCISIC ACID-INSENSITIVE 5-like protein 7; Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter. (431 aa)
ABF3ABSCISIC ACID-INSENSITIVE 5-like protein 6; Binds to the ABA-responsive element (ABRE). Mediates stress- responsive ABA signaling; Belongs to the bZIP family. ABI5 subfamily. (454 aa)
ABF2ABSCISIC ACID-INSENSITIVE 5-like protein 5; Involved in ABA and stress responses and acts as a positive component of glucose signal transduction. Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter. (416 aa)
ABF1ABSCISIC ACID-INSENSITIVE 5-like protein 4; Binds to the ABA-responsive element (ABRE). Could participate in abscisic acid-regulated gene expression; Belongs to the bZIP family. ABI5 subfamily. (392 aa)
CPK10Calcium-dependent protein kinase 10; May play a role in signal transduction pathways that involve calcium as a second messenger. May be a positive regulator controlling stress signal transduction. (545 aa)
ABI5Protein ABSCISIC ACID-INSENSITIVE 5; Participates in ABA-regulated gene expression during seed development and subsequent vegetative stage by acting as the major mediator of ABA repression of growth. Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 and Em6 genes promoters. Can also trans- activate its own promoter, suggesting that it is autoregulated. Plays a role in sugar-mediated senescence. Belongs to the bZIP family. ABI5 subfamily. (442 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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