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PHL2 PHL2 PHT1-4 PHT1-4 WRKY18 WRKY18 MDH3 MDH3 MYB107 MYB107 MMDH2 MMDH2 Q9LSF2_ARATH Q9LSF2_ARATH ZAT9 ZAT9 PLPZETA2 PLPZETA2 GDPD1 GDPD1 PAP10-2 PAP10-2 MDH MDH PPCK1 PPCK1 CHIP CHIP PMDH2 PMDH2 MMDH1 MMDH1 DSP1 DSP1 PHR1 PHR1 ZAT6 ZAT6 SPX2 SPX2 MYB34 MYB34 PMDH1 PMDH1 NIA1 NIA1 IPS1 IPS1 MDH2 MDH2 MDH1 MDH1 IPS2 IPS2 SPX3 SPX3 MAF5 MAF5 NAC047 NAC047 PHL1 PHL1 PHL4 PHL4 PHF1 PHF1 MDHNP_ARATH MDHNP_ARATH PHL3 PHL3 SPX1 SPX1 ERF1B ERF1B UBC24 UBC24 NAC048 NAC048 PPCK2 PPCK2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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PHL2Protein PHR1-LIKE 2; Transcriptional activator. Acts redundantly with PHR1 as a key component of the central regulatory system controlling transcriptional responses to Pi starvation. Binds in a sequence-specific manner to phosphate starvation-regulated promoters. (295 aa)
PHT1-4Inorganic phosphate transporter 1-4; High-affinity transporter for external inorganic phosphate. Acts as a H(+):phosphate symporter in both low- and high-Pi conditions. Confers sensitivity to arsenate. (534 aa)
WRKY18WRKY transcription factor 18; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Positively modulates defense-related gene expression and disease resistance; Belongs to the WRKY group II-a family. (310 aa)
MDH3Malate dehydrogenase 3, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments; Belongs to the LDH/MDH superfamily. MDH type 2 family. (339 aa)
MYB107Putative MYB family transcription factor. (321 aa)
MMDH2Malate dehydrogenase 2, mitochondrial; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Can convert 2-ketoglutarate to L-2-hydroxyglutarate in vitro. Belongs to the LDH/MDH superfamily. MDH type 1 family. (341 aa)
Q9LSF2_ARATHSulfate/thiosulfate import ATP-binding protein, putative (DUF506). (281 aa)
ZAT9Zinc finger protein ZAT9; Probable transcription factor that may be involved in stress responses. (288 aa)
PLPZETA2Phospholipase D zeta 2; Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Phosphatidylcholine-selective. Regulates vesicle trafficking and auxin responses. Required for the normal cycling of PIN-2 containing vesicles. Contributes to the supply of inorganic phosphorus for cell metabolism and diacylglycerol moieties for galactolipid synthesis in phosphorus- starved roots. Involved in root elongation during phosphate limitation. Belongs to the phospholipase D family. PXPH-PLD subfamily. (1046 aa)
GDPD1Glycerophosphodiester phosphodiesterase GDPD1, chloroplastic; Hydrolyzes glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine in vitro. May be involved in release of inorganic phosphate (Pi) from phospholipids during Pi starvation. Belongs to the glycerophosphoryl diester phosphodiesterase family. (361 aa)
PAP10-2Purple acid phosphatase 10; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. (468 aa)
MDHMalate dehydrogenase, chloroplastic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Plays a key role in the metabolism of dark chloroplasts and non-green plastids. Essential for embryo viability. Plays an essential role in heterotrophic metabolism in embryos, and autotrophic metabolism in photosynthetic tissues as well. (403 aa)
PPCK1Phosphoenolpyruvate carboxylase kinase 1; Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation. (284 aa)
CHIPE3 ubiquitin-protein ligase CHIP; Has E3 ubiquitin-protein ligase activity and may target misfolded substrates towards proteasomal degradation. Regulates the activity of some serine/threonine-protein phosphatases by E3 ubiquitin- protein ligase activity. Required for responses to biotic and abiotic stresses such as auxin, abscisic acid (ABA), low and high temperature and darkness, probably through the activation of serine/threonine- protein phosphatase and the subsequent modification of the plasma membrane composition. Regulates the chloroplastic Clp proteolytic activity in response to [...] (278 aa)
PMDH2Malate dehydrogenase 2, peroxisomal; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Peroxisomal NAD-dependent malate dehydrogenase involved in fatty acid beta-oxidation. Reoxidizes NADH from the beta- oxidation and provides NAD for the conversion of fatty acyl-CoA to acetyl-CoA. Does not participate directly in the glyoxylate cycle. Required for maintenance of photosynthetic rates under photorespiratory conditions, and carbon flow during photorespiration. Supplies NADH reductant [...] (354 aa)
MMDH1Malate dehydrogenase 1, mitochondrial; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Its activity is essential to shuttle reductants out from the mitochondria to support the photorespiratory flux. Can convert 2-oxoglutarate to (S)-2-hydroxyglutarate in vitro. (341 aa)
DSP1Tyrosine-protein phosphatase DSP1; Possesses phosphotyrosine phosphatase activity in vitro. Hydrolyzes para-nitrophenyl phosphate in vitro. Hydrolyzes O-methylfluorescein phosphate in vitro. Hydrolyzes polyphosphate and ATP in vitro. Dephosphorylates the phosphoinositides PI(3,4,5)P3, PI(3,5)P2, but not PI(3)P, PI(3,4)P2 or PI(4,5)P2. Belongs to the protein-tyrosine phosphatase family. (215 aa)
PHR1Protein PHOSPHATE STARVATION RESPONSE 1; Transcription factor involved in phosphate starvation signaling. Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation- responsive genes. SPX1 is a competitive inhibitor of this DNA-binding. PHR1 binding to its targets is low Pi-dependent. Regulates the expression of miR399. Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions. Regulates lipid remodeling and [...] (409 aa)
ZAT6Zinc finger protein ZAT6; Probable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis. Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture. (238 aa)
SPX2SPX domain-containing protein 2; May inhibit PHR1 DNA-binding activity in a Pi-dependent manner. (287 aa)
MYB34Transcription factor MYB34; Transcription factor involved in tryptophan gene activation and in indole-3-acetic acid (IAA) and indolic glucosinolates (IG) biosynthesis. Acts as a direct transcriptional activator of both Trp synthesis genes and Trp secondary metabolism genes. (295 aa)
PMDH1Malate dehydrogenase 1, peroxisomal; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Peroxisomal NAD-dependent malate dehydrogenase involved in fatty acid beta-oxidation. Reoxidizes NADH from the beta- oxidation and provides NAD for the conversion of fatty acyl-CoA to acetyl-CoA. Does not participate directly in the glyoxylate cycle. Required for maintenance of photosynthetic rates under photorespiratory conditions, and carbon flow during photorespiration. Supplies NADH reductant [...] (354 aa)
NIA1Nitrate reductase [NADH] 1; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria. (917 aa)
IPS1Inositol-3-phosphate synthase isozyme 1; Catalyzes the majority of myo-inositol synthesis required for plant growth and development. Acts as a repressor of programmed cell death and protects plant cells against cell death under high light intensity or long days. Controls its own transcription by inhibiting ATXR6 activity. Reduces the deposition of inhibitory histone marks on its own promoter; Belongs to the myo-inositol 1-phosphate synthase family. (511 aa)
MDH2Malate dehydrogenase 2, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)
MDH1Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)
IPS2Inositol-3-phosphate synthase isozyme 2; Involved in myo-inositol synthesis. (510 aa)
SPX3SPX domain-containing protein 3; Plays a positive role in plant adaptation to phosphate starvation and exerts negative feedback regulation of SPX1. (245 aa)
MAF5Protein MADS AFFECTING FLOWERING 5; Transcription factor involved in the negative regulation of flowering time in short days, probably through the photoperiodic and vernalization pathways. Prevents premature flowering, particularly in the cv. Landsberg erecta background. In non-inductive photoperiods (e.g. short days), required for flowering through VIL2-mediated maintenance of the epigenetically repressed state of MAF5 via H3K9me2 and plant homeodomain / polycomb repressive complex 2 (PHD-PRC2)- dependent H3K27me3. (198 aa)
NAC047NAC transcription factor 47; Transcription factor that binds to the promoter of ACO5, an ACC oxidase involved in ethylene biosynthesis. Mediates waterlogging- induced hyponastic leaf movement, and cell expansion in abaxial cells of the basal petiole region, by directly regulating the expression of ACO5. Required for normal seed development and morphology. (359 aa)
PHL1Protein PHR1-LIKE 1; Transcription factor acting as central integrator of phosphate starvation responses. Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis ; Belongs to the MYB-CC family. (413 aa)
PHL4Myb family transcription factor PHL4; Transcription factor involved in male gametophyte development. (397 aa)
PHF1SEC12-like protein 1; Involved in Pi uptake by facilitating the trafficking of PHT1-1/PHT1;1 from the endoplasmic reticulum to the plasma membrane. (398 aa)
MDHNP_ARATHMalate dehydrogenase [NADP], chloroplastic; The chloroplastic, NADP-dependent form is essential for the photosynthesis C4 cycle, which allows plants to circumvent the problem of photorespiration. In C4 plants, NADP-MDH activity acts to convert oxaloacetate to malate in chloroplasts of mesophyll cells for transport to the bundle sheath cells (Probable). Plays an essential role in the regulation of catalase activity and the accumulation of a hydrogen peroxide-dependent signal by transmitting the redox state of the chloroplast to other cell compartments. (443 aa)
PHL3Protein PHR1-LIKE 3; Transcriptional activator. Probable component of the central regulatory system controlling transcriptional responses to Pi starvation. Binds in a sequence- specific manner to phosphate starvation-regulated promoters. Required for female gametophyte development and function. (292 aa)
SPX1SPX domain-containing protein 1; Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner. (256 aa)
ERF1BEthylene-responsive transcription factor 1B; Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression during the plant development, and/or mediated by stress factors and by components of stress signal transduction pathways. Seems to be a key integrator of ethylene and jasmonate signals in the regulation of ethylene/jasmonate-dependent defenses. Can mediate resistance to necrotizing fungi (Botrytis cinerea and Plectosphaerella cucumerina) and to soil borne fungi (Fusarium oxysporum conglutinans and Fus [...] (218 aa)
UBC24Probable ubiquitin-conjugating enzyme E2 24; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability. Negatively regulates the protein abundance of PHF1 and PHT1s under Pi- sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane. (907 aa)
NAC048NAC domain containing protein 48. (342 aa)
PPCK2Phosphoenolpyruvate carboxylase kinase 2; Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (278 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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