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PARP2 PARP2 atp6 atp6 APE1 APE1 nad1 nad1 nad5 nad5 nad2 nad2 cox2 cox2 nad9 nad9 nad6 nad6 nad4 nad4 mttB mttB nad3 nad3 nad7 nad7 nad4L nad4L NTH2 NTH2 RECG RECG IMPA2 IMPA2 IMPA9 IMPA9 rbcL rbcL ND2 ND2 FEN1 FEN1 CDA2 CDA2 CDA1 CDA1 IMPA4 IMPA4 ND5 ND5 CTIMC CTIMC atpA atpA HTR4 HTR4 HTR2 HTR2 ATP9 ATP9 ND6 ND6 COX1 COX1 ND3 ND3 ATP6-2 ATP6-2 ATPA ATPA ND1 ND1 COX2 COX2 ATP6-1 ATP6-1 NAD7 NAD7 ND4 ND4 RAD51 RAD51 ND4L ND4L NBS1 NBS1 MBD4L MBD4L CHR25 CHR25 atp9 atp9 RECA RECA SAL1 SAL1 LIG1 LIG1 WHY3 WHY3 SOG1 SOG1 ZDP ZDP MSH1 MSH1 MOC1 MOC1 OSB3 OSB3 OSB2 OSB2 SUVH4 SUVH4 HTR12 HTR12 RCD1 RCD1 RECA3 RECA3 WHY2 WHY2 CMT2 CMT2 CMT3 CMT3 NAD9 NAD9 IMPA1 IMPA1 IMPA5 IMPA5 IMPA8 IMPA8 PARP3 PARP3 HTR11 HTR11 OGG1 OGG1 KU70 KU70 IMPA6 IMPA6 T6J4.12 T6J4.12 MGH3 MGH3 OSB4 OSB4 UNG UNG SMR5 SMR5 F10A5.19 F10A5.19 SMR7 SMR7 T24H18.80 T24H18.80 MBD4 MBD4 BLH9 BLH9 WHY1 WHY1 IMPA7 IMPA7 CDA5 CDA5 CDA3 CDA3 AGO2 AGO2 TIM TIM RAD50 RAD50 DCL1 DCL1 CDA6 CDA6 CDA7 CDA7 OSB1 OSB1 CDA8 CDA8 DDM1 DDM1 PARP1 PARP1 RECA2 RECA2 CHR8 CHR8
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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gene neighborhood
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PARP2Poly [ADP-ribose] polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). (637 aa)
atp6ATP synthase subunit a. (385 aa)
APE1Acclimation of photosynthesis to environment. (431 aa)
nad1NADH-ubiquinone oxidoreductase chain 1; Belongs to the complex I subunit 1 family. (325 aa)
nad5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (669 aa)
nad2NADH dehydrogenase subunit 2. (488 aa)
cox2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (260 aa)
nad9NADH dehydrogenase subunit 9; Belongs to the complex I 30 kDa subunit family. (190 aa)
nad6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (205 aa)
nad4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (495 aa)
mttBTransport membrane protein. (280 aa)
nad3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (118 aa)
nad7NADH dehydrogenase subunit 7; Belongs to the complex I 49 kDa subunit family. (394 aa)
nad4LNADH dehydrogenase subunit 4L. (100 aa)
NTH2Endonuclease III homolog 2, chloroplastic; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (386 aa)
RECGATP-dependent DNA helicase homolog RECG, chloroplastic; Critical role in recombination and DNA repair. (973 aa)
IMPA2Importin subunit alpha-2; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope (By similarity). Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation. (535 aa)
IMPA9Importin subunit alpha-9; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope (By similarity). Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation. (519 aa)
rbcLRibulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily. (479 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (499 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (383 aa)
CDA2Cytidine deaminase 2; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (337 aa)
CDA1Cytidine deaminase 1; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Functions as a conventional cytidine deaminase. Has no affinity for RNA and is not involved in RNA- editing by C-to-U deamination. (301 aa)
IMPA4Importin subunit alpha-4; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope. Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium and is essential for Agrobacterium-mediated root transformation. (538 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (669 aa)
CTIMCTriosephosphate isomerase, cytosolic; Belongs to the triosephosphate isomerase family. (254 aa)
atpAATP synthase subunit alpha, chloroplastic; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (507 aa)
HTR4Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
HTR2Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
ATP9ATP synthase subunit 9, mitochondrial; This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase. (85 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (205 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (527 aa)
ND3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (119 aa)
ATP6-2ATP synthase subunit a-2; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subu [...] (349 aa)
ATPAATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (507 aa)
ND1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (325 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (260 aa)
ATP6-1ATP synthase subunit a-1; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subu [...] (385 aa)
NAD7NADH dehydrogenase [ubiquinone] iron-sulfur protein 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. (394 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (495 aa)
RAD51DNA repair protein RAD51 homolog 1; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis. (342 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (100 aa)
NBS1Nijmegen breakage syndrome 1 protein; Component of the MRE11-RAD50-NBN complex (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex may be involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, and cell cycle checkpoint control. Functions also in the very early stages of meiosis. (542 aa)
MBD4LMethyl-CpG-binding domain protein 4-like protein; Monofunctional DNA glycosylase targeting U:G and T:G mispairs. Excises uracil derivatives and exhibits a preference for a CpG sequence context, irrespective of the methylation status of the complementary strand. The activity follows a biphasic kinetics, with an initial burst of product accumulation followed by a slower phase. Specifically binds its reaction product. Triggers the base excision repair (BER) pathway. (445 aa)
CHR25Protein CHROMATIN REMODELING 25; Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments. Addition of RAD54 overcomes inhibition of DNA strand exchange by RAD51 bound to substrate dsDNA. Species preference in the RAD51 dissociation and DNA strand exchange assays underlines the importance of specific RAD54-RAD51 interactions. RAD51 is unable to release dsDNA upon ATP hydrolysis, leaving it stuck on the heteroduplex DNA product after DNA strand exchange (By similarity). Involved in DNA repair and mitotic recombina [...] (910 aa)
atp9ATP synthase subunit 9, mitochondrial; Belongs to the ATPase C chain family. (85 aa)
RECADNA repair protein recA homolog 1, chloroplastic; Involved in recombination ability and DNA strand transfer activity. (439 aa)
SAL1SAL1 phosphatase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4- trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is [...] (353 aa)
LIG1DNA ligase 1; Essential protein. DNA ligase that seals nicks in double- stranded DNA during DNA replication, DNA recombination and DNA repair. Involved in repair of both single strand breaks (SSBs) and double strand breaks (DSBs). Required in the endosperm for embryogenesis, probably to repair DNA-breaks generated by DME. (790 aa)
WHY3Single-stranded DNA-binding protein WHY3, chloroplastic; Single-stranded DNA-binding protein that functions in both chloroplasts and nucleus. In chloroplasts, maintains plastid genome stability by preventing break-induced and short homology-dependent illegitimate recombinations. In the nucleus, is recruited to a distal element upstream of the kinesin KP1 to mediate the transcriptional repression of KP1. Can bind double-stranded DNA in vivo. (268 aa)
SOG1SUPPRESSOR OF GAMMA RESPONSE 1; Transcription factor regulating the transcriptional activation response to gamma irradiation. Required for stem-cell death induced by UVB or by gamma irradiation. Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases. Involved in DNA damage response (DDR) system that regulates cell cycle arrest. Functional homolog of animal p53. Regulates SMR5 and SMR7 transcription. Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. (449 aa)
ZDPPolynucleotide 3'-phosphatase ZDP; Nick-sensing 3'-phosphoesterase involved in a base excision repair pathway required for active DNA demethylation. The N-terminal DNA-binding domain binds specifically to gap sites and sharply bends the target DNA. Lacks 5'-kinase activity but is capable of 3'- phosphoglycolate end processing. Inactive on 3'-alpha,beta-unsaturated aldehyde (3'-dRP). Protects partially genes from transcriptional silencing by preventing promoter DNA hypermethylation. (694 aa)
MSH1DNA mismatch repair protein MSH1, mitochondrial; DNA mismatch repair protein specifically involved in maintenance of mitochondrial genome configuration by controlling specific rearranged portion. Functions by suppressing asymmetric recombination at some repeat pairs. (1118 aa)
MOC1Holliday junction resolvase MOC1, chloroplastic; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Mediates chloroplast nucleoid segregation during chloroplast division. (273 aa)
OSB3Protein OSB3, chloroplastic/mitochondrial; Binds single-stranded DNA. (440 aa)
OSB2Protein OSB2, chloroplastic; Binds preferentially single-stranded DNA. Does not bind to RNA. (371 aa)
SUVH4Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements. Belongs to the class V-like SAM-bindi [...] (624 aa)
HTR12Histone H3-like centromeric protein HTR12; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (178 aa)
RCD1Inactive poly [ADP-ribose] polymerase RCD1; Inactive ADP-ribosyltransferase that functions with SRO1 to regulate oxidative stress, hormonal and developmental responses. Required for embryogenesis, vegetative and reproductive development, and abiotic stress responses. May regulate several stress-responsive genes. Seems to play a larger developmental role than SRO1. Does not bind NAD in vitro. (589 aa)
RECA3DNA repair protein recA homolog 2, mitochondrial; Involved in recombination ability and DNA strand transfer activity; Belongs to the RecA family. (389 aa)
WHY2Single-stranded DNA-binding protein WHY2, mitochondrial; Single-stranded DNA-binding protein that associates with mitochondrial DNA and may play a role in the regulation of the gene expression machinery. Seems also to be required to prevent break- induced DNA rearrangements in the mitochondrial genome. Can bind to melt double-stranded DNA in vivo. (238 aa)
CMT2DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. (1295 aa)
CMT3DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (839 aa)
NAD9NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (190 aa)
IMPA1Importin subunit alpha-1; Binds to conventional NLS motifs with high affinity in the absence of an importin beta subunit. Mediates nuclear protein import across the nuclear envelope in vitro in the absence of exogenously added importin beta subunit. Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation. (532 aa)
IMPA5Importin subunit alpha-5; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope. (519 aa)
IMPA8Importin subunit alpha-8; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope. (441 aa)
PARP3Protein ADP-ribosyltransferase PARP3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). (814 aa)
HTR11Histone H3-like 5; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (139 aa)
OGG1DNA-(apurinic or apyrimidinic site) lyase; Involved in repair of DNA damaged by oxidation by incising DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6- diamino-4-hydroxy-5-N-methylformamidopyrimidine (Fapy) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Belongs to the type-1 OGG1 family. (365 aa)
KU70ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double- strand break repair. When associated with KU80, binds to double- stranded telomeric and non-telomeric DNA sequences, but not to single- stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand. Belongs to the ku70 family. (621 aa)
IMPA6Importin subunit alpha-6; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope (By similarity). Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation ; Belongs to the importin alpha family. (538 aa)
T6J4.12Histone H3-like 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
MGH3Histone H3-like 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (137 aa)
OSB4Protein OSB4, chloroplastic; Binds single-stranded DNA. (360 aa)
UNGUracil-DNA glycosylase, mitochondrial; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. More active on U:G, U:T and U:C mispairs than on U:A pairs. Highly specific for uracil and no activity with 5- substituted uracil or cytosine derivatives. Required for initiation of base excision repair (BER) of uracil. (330 aa)
SMR5Cyclin-dependent protein kinase inhibitor SMR5; Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Acts as a potent cell cycle inhibitor, regulating a hydroxyurea-dependent checkpoint in leaves. Essential to activate a high-light-dependent cell cycle checkpoint. (82 aa)
F10A5.19Histone H3-like 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
SMR7Cyclin-dependent protein kinase inhibitor SMR7; Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Acts as a potent cell cycle inhibitor, regulating a hydroxyurea-dependent checkpoint in leaves. (99 aa)
T24H18.80Histone H3-like 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (131 aa)
MBD4Methyl-CpG-binding domain-containing protein 4; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. (186 aa)
BLH9BEL1-like homeodomain protein 9; Transcription factor that is involved in the preservation of the spiral phyllotactic arrangement leading to a regular pattern of organ initiation. Required for maintenance of stem cell fate in the shoot apical meristem, and is essential for specifying floral primordia and establishing early internode patterning events during inflorescence development. Acts as transcription repressor of AG expression in floral and inflorescence meristems. Is also responsive of the nuclear import of SHOOT MERISTEMLESS (STM). In the fruit, plays a central role in patternin [...] (575 aa)
WHY1Single-stranded DNA-binding protein WHY1, chloroplastic; Single-stranded DNA-binding protein that functions in both chloroplasts and nucleus. In chloroplasts, maintains plastid genome stability by preventing break-induced and short homology-dependent illegitimate recombinations. In nucleus, modulates telomere length homeostasis by inhibiting the action of the telomerase at the extreme termini of chromosomes. Is recruited to a distal element upstream of the kinesin KP1 to mediate the transcriptional repression of KP1. Is required for full salicylic acid-dependent plant disease resistanc [...] (263 aa)
IMPA7Importin subunit alpha-7; Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope (By similarity). Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation. (528 aa)
CDA5Cytidine deaminase 5; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (346 aa)
CDA3Cytidine deaminase 3; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (223 aa)
AGO2Protein argonaute 2; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates mainly with siRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Probably involved in antiviral RNA silencing. Associates with siRNA derived from cucumber mosaic virus [...] (1014 aa)
TIMTriosephosphate isomerase, chloroplastic; Belongs to the triosephosphate isomerase family. (315 aa)
RAD50DNA repair protein RAD50; Implicated in double-strand breaks (DSBs) repair by non- homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division. Belongs to the SMC family. RAD50 subfamily. (1316 aa)
DCL1Endoribonuclease Dicer homolog 1; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta- siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of [...] (1909 aa)
CDA6Cytidine deaminase 6; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (293 aa)
CDA7Cytidine deaminase 7; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (307 aa)
OSB1Protein OSB1, mitochondrial; Regulates mitochondrial DNA recombination. Represses homologous recombination, preventing mitochondrial genome instability and unbalanced transmission of alternative mtDNA configurations. Binds preferentially single-stranded DNA. Does not bind to RNA. (261 aa)
CDA8Cytidine deaminase 8; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (293 aa)
DDM1ATP-dependent DNA helicase DDM1; ATP-dependent DNA helicase that plays a role in formation, organization, stability and heritability of heterochromatin and thus regulates several physiological traits. Binds to the nucleosome and promotes chromatin remodeling in an ATP-dependent manner; induces nucleosome repositioning on a short DNA fragment, and, possibly, could be guided to target sites (including silent transposable elements) by small interfering RNAs (siRNAs). Can bind both free and nucleosomal DNA. Required for the heritable maintenance of genome integrity and transcriptional gene [...] (764 aa)
PARP1Poly [ADP-ribose] polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). (983 aa)
RECA2DNA repair protein recA homolog 3, mitochondrial; Involved in recombination ability and DNA strand transfer activity; Belongs to the RecA family. (430 aa)
CHR8Protein CHROMATIN REMODELING 8; Essential factor involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation; Belongs to the SNF2/RAD54 helicase family. (1187 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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