STRINGSTRING
WAK1 WAK1 EFR EFR RLM1A RLM1A MSL8 MSL8 BRI1 BRI1 LRX2 LRX2 CESA1 CESA1 LRX1 LRX1 CAM1 CAM1 CAM2 CAM2 CML10 CML10 KAPP KAPP CAM7 CAM7 CDC5 CDC5 CAM6 CAM6 MPK1 MPK1 ANX2 ANX2 MCA2 MCA2 LRX7 LRX7 MSL2 MSL2 MCA1 MCA1 MSL3 MSL3 DEK1 DEK1 SUB SUB MIK2 MIK2 MSL1 MSL1 AtSLP1 AtSLP1 CESA3 CESA3 MKK1 MKK1 BAK1 BAK1 CESA6 CESA6 TPC1 TPC1 ERD4 ERD4 CP1 CP1 LLG1 LLG1 KIPK1 KIPK1 LRX4 LRX4 THE1 THE1 WAK2 WAK2 RKL1 RKL1 RALF23 RALF23 HERK1 HERK1 FER4 FER4 HERK2 HERK2 KIPK2 KIPK2 GRP3 GRP3 LRX5 LRX5 FLA4 FLA4 ANX1 ANX1 RALF1 RALF1 LRX3 LRX3 OSCA1 OSCA1 LRE LRE FEI1 FEI1 FEI2 FEI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WAK1Wall-associated receptor kinase 1; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. Required during plant's response to pathogen infection and in plant defense against heavy metal toxicity. Phosphorylates the oxygen-evolving enhancer protein 2 (OEE2) in an GRP-3-dependent manner. (735 aa)
EFRLRR receptor-like serine/threonine-protein kinase EFR; Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Reduces transformation by Rhizobium radiobacter probably by inducing plant defense during the interaction. Binding to the effector AvrPto1 from P.syringae blocks the downstream plant immune response while interaction with hopD2 decreases the phosphorylation level of EFR upon elf18 treatment. Specific endoplasmic reticu [...] (1031 aa)
RLM1ADisease resistance protein RML1A; TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Leptosphaeria maculans (blackleg disease). (997 aa)
MSL8Mechanosensitive ion channel protein 8; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Exhibits a 6.3-fold preference for chloride over sodium. Regulates osmotic forces during pollen hydration and germination; Belongs to the MscS (TC 1.A.23) family. (908 aa)
BRI1Protein BRASSINOSTEROID INSENSITIVE 1; Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Pho [...] (1196 aa)
LRX2Leucine-rich repeat extensin-like protein 2; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. Together with LRX2, component of the extracellular mechanism regulating root hair morphogenesis and elongation. (786 aa)
CESA1Cellulose synthase A catalytic subunit 1 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. Required during embryogenesis for cell elongation, orientation of cell expansion and complex cell wall formations, such as interdigitated pattern of epidermal pavement cells, stomatal guard cells and trichomes. Plays a role in lateral roots formation, but seems not necessary for the development of tip-growing cel [...] (1081 aa)
LRX1Leucine-rich repeat extensin-like protein 1; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. Together with LRX2, component of the extracellular mechanism regulating root hair morphogenesis and elongation. (744 aa)
CAM1Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CAM2Calmodulin-2; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CML10Calmodulin-like protein 10; Potential calcium sensor. (191 aa)
KAPPProtein phosphatase 2C 70; Dephosphorylates the Ser/Thr receptor-like kinase RLK5. May function as a signaling component in a pathway involving RLK5. Binds and dephosphorylates CLAVATA1 (CLV1). Functions as a negative regulator of the CLV1 signaling in plant development. Dephosphorylates SERK1 receptor kinase on threonine residues in the A-loop. Dephosphorylation of SERK1 controls SERK1 internalization. Component of a signaling pathway which mediates adaptation to NaCl stress. Is not a component of the SALT OVERLY SENSITIVE (SOS) pathway. (581 aa)
CAM7Calmodulin-7; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro. (149 aa)
CDC5Cell division cycle 5-like protein; Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity. Possesses a sequence specific DNA sequence 'CTCAGCG' binding activity. Involved in mRNA splicing and cell cycle control. May also play a role in the response to DNA damage. Belongs to the CEF1 family. (844 aa)
CAM6Calmodulin-6; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
MPK1Mitogen-activated protein kinase 1. (370 aa)
ANX2Receptor-like protein kinase ANXUR2; Receptor-like protein kinase that controls pollen tube behavior by directing rupture at proper timing to release the sperm cell. (858 aa)
MCA2Protein MID1-COMPLEMENTING ACTIVITY 2; Calcium-permeable stretch-activated channel component. Probably involved in mechanosensing and in mechano-stimulated calcium uptake mechanism. (416 aa)
LRX7Leucine-rich repeat extensin-like protein 7; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. (433 aa)
MSL2Mechanosensitive ion channel protein 2, chloroplastic; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer (By similarity). Controls plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. Acts as a component of the chloroplast division machinery. (673 aa)
MCA1Protein MID1-COMPLEMENTING ACTIVITY 1; Calcium-permeable stretch-activated channel component. Involved in mechano-stimulated calcium uptake mechanism and in mechanosensing in the primary root. (421 aa)
MSL3Mechanosensitive ion channel protein 3, chloroplastic; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Controls plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. Acts as a component of the chloroplast division machinery; Belongs to the MscS (TC 1.A.23) family. (678 aa)
DEK1Calpain-type cysteine protease DEK1; Essential protease involved in epiderm development. Required for aleurone cell development in the endosperm probably by maintaining and restricting the aleurone and embryonic epidermal L1 cell-layer fates as well as meristems organization. Involved in the maintenance of adaxial/abaxial axis information in developing leaves, probably by regulating cell proliferation and expansion. Does not need calcium ions to be active. Required for the formation of giant cells in sepals by determining cell fate and promoting endoreplication. (2151 aa)
SUBProtein STRUBBELIG; Regulates the expression of transcription factors that define the cell fates. Acts in a non-cell-autonomous fashion, functions in a radial inside-out signaling process, and mediates cell morphogenesis and cell fate across clonally distinct cell layers in floral primordia, developing ovules, and root meristems. Seems to be required for the regulation of cell shape and the orientation of the mitotic division plane. Involved in root hair specification, in the formation of the outer integument and the shape of organs such as carpels and petals and is necessary for the s [...] (768 aa)
MIK2MDIS1-interacting receptor like kinase 2; Involved in the pollen tube perception of the female signal. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1045 aa)
MSL1Mechanosensitive ion channel protein 1, mitochondrial; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer; Belongs to the MscS (TC 1.A.23) family. (497 aa)
AtSLP1SPFH/Band 7/PHB domain-containing membrane-associated protein family. (411 aa)
CESA3Cellulose synthase A catalytic subunit 3 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation, especially in roots. Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. (1065 aa)
MKK1Mitogen-activated protein kinase kinase 1; MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Activates by phosphorylation the downstream MPK4. Acts redundantly with MKK2. MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H(2)O(2) production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination. (354 aa)
BAK1BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1; Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors. Involved in brassinosteroid (BR) signal transduction. Phosphorylates BRI1. May be involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1- BAK1 heterodimers. Interaction with MSBP1 stimulates the endocytosis of BAK1 and suppresses brassinosteroid signaling. Acts in pathogen- associ [...] (615 aa)
CESA6Cellulose synthase A catalytic subunit 6 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. The presence of each protein CESA1 and CESA6 is critical for cell expansion. The hypocotyl elongation is based on a CESA6-dependent cell elongation in dark and a CESA6-independent cell elongation in light. The transition between these two mechanisms requires photosynthesis and PHYB, but not CRY1. The CESA6-depend [...] (1084 aa)
TPC1Two pore calcium channel protein 1; Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. (733 aa)
ERD4CSC1-like protein ERD4; Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions. (724 aa)
CP1Calcium-binding protein CP1; Binds calcium in vitro. (160 aa)
LLG1GPI-anchored protein LLG1; Component of the FER-regulated Rho GTPase signaling complex. Acts as a chaperone and coreceptor for FER. Required for localization of FER to the plasma membrane. (168 aa)
KIPK1Serine/threonine-protein kinase KIPK1; Could be involved in the negative regulation of root growth. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (934 aa)
LRX4Leucine-rich repeat extensin-like protein 4; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. (494 aa)
THE1Receptor-like protein kinase THESEUS 1; Receptor-like protein kinase required for cell elongation during vegetative growth, mostly in a brassinosteroid-(BR-) independent manner. Mediates the response of growing plant cells to the perturbation of cellulose synthesis and may act as a cell-wall- integrity sensor. Controls ectopic-lignin accumulation in cellulose- deficient mutant backgrounds. (855 aa)
WAK2Wall-associated receptor kinase 2; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. (732 aa)
RKL1Probable inactive receptor kinase At1g48480; Belongs to the protein kinase superfamily. (655 aa)
RALF23Rapid alkalinization factor 23; Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity). Regulates negatively brassinolide (BL)-mediated signaling pathway (e.g. BL-induced hypocotyl elongation and branching limitation). (138 aa)
HERK1Receptor-like protein kinase HERK 1; Receptor-like protein kinase required for cell elongation during vegetative growth, mostly in a brassinosteroid-(BR-) independent manner. (830 aa)
FER4Ferritin-4, chloroplastic; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity); Belongs to the ferritin family. (259 aa)
HERK2Probable receptor-like protein kinase At1g30570. (849 aa)
KIPK2Serine/threonine-protein kinase KIPK2; Serine/threonine-protein kinase that could be involved in the negative regulation of root growth. (949 aa)
GRP3Glycine-rich protein 3; Regulates the function of the receptor protein kinase WAK1, and namely the phosphorylation of OEE2. (145 aa)
LRX5Leucine-rich repeat extensin-like protein 5; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. (857 aa)
FLA4Fasciclin-like arabinogalactan protein 4; May be a cell surface adhesion protein that is required for normal cell expansion; Belongs to the fasciclin-like AGP family. (420 aa)
ANX1Receptor-like protein kinase ANXUR1; Receptor-like protein kinase that controls pollen tube behavior by directing rupture at proper timing to release the sperm cell. (850 aa)
RALF1Protein RALF-like 1; Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases. Mostly active in roots. Prevents plant growth (e.g. root and leaf length). Suppresses cell elongation of the primary root by activating the cell surface receptor FER and triggering phosphorylation [...] (120 aa)
LRX3Leucine-rich repeat extensin-like protein 3; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization. (760 aa)
OSCA1Protein OSCA1; Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions. Shows the following permeability sequence: K(+) > Ba(2+) = Ca(2+) > Na(+) = Mg(2+) = Cs(+). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions. Belongs to the CSC1 (TC 1.A.17) family. (772 aa)
LREGPI-anchored protein LORELEI; Female gametophyte-specific component of the signaling pathway required for fertilization. Required for reception of the pollen tube by the female gametophyte. Acts specifically at the synergid cell surface for pollen tube reception. Plays a role in double fertilization and early seed development. Component of the FER-regulated Rho GTPase signaling complex. Acts as a chaperone and coreceptor for FER. Required for localization of FER to the plasma membrane. (165 aa)
FEI1LRR receptor-like serine/threonine-protein kinase FEI 1; Involved in the signaling pathway that regulates cell wall function, including cellulose biosynthesis, likely via an 1- aminocyclopropane-1-carboxylic acid (ACC)-mediated signal (a precursor of ethylene). (591 aa)
FEI2LRR receptor-like serine/threonine-protein kinase FEI 2; Involved in the signaling pathway that regulates cell wall function, including cellulose biosynthesis, likely via an 1- aminocyclopropane-1-carboxylic acid (ACC)-mediated signal (a precursor of ethylene); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (589 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.