STRINGSTRING
NERD NERD K18B18.13 K18B18.13 PRK1 PRK1 T26D22.11 T26D22.11 PME1 PME1 F21B7.31 F21B7.31 F11I4.11 F11I4.11 FAF3 FAF3 ACT2 ACT2 F24K9.3 F24K9.3 SSL5 SSL5 HDA6 HDA6 STP11 STP11 PI4KG3 PI4KG3 T3F20.20 T3F20.20 NRPD1 NRPD1 PBL25 PBL25 F25L23.110 F25L23.110 AGO5 AGO5 T13K14.170 T13K14.170
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NERDZinc finger CCCH domain-containing protein 19; Plays a central role in integrating RNA silencing and chromatin signals in 21 nt siRNA-dependent DNA methylation on cytosine pathway leading to transcriptional gene silencing of specific sequences. Involved in a chromatin-based RNA silencing pathway that encompasses both post-transcriptional gene silencing (PTGS) (e.g. RDR1, RDR6 and AGO2) and transcriptional gene silencing (TGS) (e.g. siRNA- dependent DNA methylation and histone H3) components. Mediates siRNA accumulation at specific chromatin loci. Binds H3K4me0 through its PHD to enforc [...] (1773 aa)
K18B18.13Defensin-like protein 200. (129 aa)
PRK1Pollen receptor-like kinase 1; Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth. (662 aa)
T26D22.11Kinase with adenine nucleotide alpha hydrolases-like domain-containing protein. (731 aa)
PME1Pectinesterase 1; Acts in the modification of cell walls via demethylesterification of cell wall pectin (By similarity). Demethylates protein phosphatase 2A (PP2A) that have been reversibly carboxymethylated by LCMT1. Acts as negative regulators of genes involved in salt stress response. In the C-terminal section; belongs to the pectinesterase family. (586 aa)
F21B7.31Cystatin/monellin superfamily protein. (202 aa)
F11I4.11Copia-type reverse transcriptase-like protein. (97 aa)
FAF3Protein FANTASTIC FOUR 3; Able to repress WUS when constitutively overexpressed, but have no effect on CLV3; Belongs to the fantastic four family. (288 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
F24K9.3Cysteine/Histidine-rich C1 domain family protein. (589 aa)
SSL5Protein STRICTOSIDINE SYNTHASE-LIKE 5. (371 aa)
HDA6Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this e [...] (471 aa)
STP11Sugar transport protein 11; Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, galactose, mannose, xylose and 3-O-methylglucose, but not fructose and ribose. (514 aa)
PI4KG3Phosphatidylinositol 4-kinase gamma 3; The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3); Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. (574 aa)
T3F20.20Mto 1 responding down 1. (193 aa)
NRPD1DNA-directed RNA polymerase IV subunit 1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Largest and catalytic component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences. Essential component of a self- reinforcing loop coupling de novo DNA methylation to siRNA production. Required for in [...] (1453 aa)
PBL25Probable serine/threonine-protein kinase PBL25; May be involved in plant defense signaling. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (381 aa)
F25L23.110F-box/LRR-repeat protein At3g59250. (425 aa)
AGO5Protein argonaute 5; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates with siRNAs of various sizes, from 21-24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal cytosine. Probably involved in antiviral RNA silencing. Associates with siRNAs derived from cuc [...] (997 aa)
T13K14.170Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (275 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (26%) [HD]