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MDH1 MDH1 CTIMC CTIMC SUS1 SUS1 DFRA DFRA CYP73A5 CYP73A5 HXK2 HXK2 SUS2 SUS2 HXK1 HXK1 ATHXK4 ATHXK4 PPC3 PPC3 SWEET17 SWEET17 SPS3-2 SPS3-2 SPS1-2 SPS1-2 LDOX LDOX FLS1 FLS1 F28G11.11 F28G11.11 FLS5 FLS5 FLS3 FLS3 PGD3 PGD3 SDH SDH MIO24.3 MIO24.3 PGD2 PGD2 SUS6 SUS6 GAPC2 GAPC2 LKHA4 LKHA4 SPS2-2 SPS2-2 HXK3 HXK3 T21E18.8 T21E18.8 T21E18.7 T21E18.7 HKL1 HKL1 SWEET16 SWEET16 A3G2XYLT A3G2XYLT SUS4 SUS4 SUS3 SUS3 T16L24.30 T16L24.30 F3H F3H PGK3 PGK3 PGMP PGMP CYP75B1 CYP75B1 BAN BAN PGM2 PGM2 PGD1 PGD1 T28P16.12 T28P16.12 TIM TIM ICDH ICDH EMB3004 EMB3004 PAL4 PAL4 HKL3 HKL3 A0A1P8ARU2 A0A1P8ARU2 SPS4 SPS4 F7H19.50 F7H19.50 SUS5 SUS5 FLS6 FLS6 FLS4 FLS4 PGM3 PGM3 ANS ANS F12L6.16 F12L6.16 F24G24.60 F24G24.60 GAPC1 GAPC1 PGIC PGIC PAL1 PAL1 PAL2 PAL2 PAL3 PAL3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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MDH1Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)
CTIMCTriosephosphate isomerase, cytosolic; Belongs to the triosephosphate isomerase family. (254 aa)
SUS1Sucrose synthase 1; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways; Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily. (808 aa)
DFRADihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism. (382 aa)
CYP73A5Trans-cinnamate 4-monooxygenase; Controls carbon flux to pigments essential for pollination or UV protection, to numerous pytoalexins synthesized by plants when challenged by pathogens, and to lignins. (505 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
SUS2Sucrose synthase 2; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and directs carbon towards starch synthesis in developing seeds. (807 aa)
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
PPC3Phosphoenolpyruvate carboxylase 3; Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (968 aa)
SWEET17Bidirectional sugar transporter SWEET17; Acts as a vacuolar hexose transporter. Regulates fructose (Fru) homeostasis in leaves and roots by exporting/importing Fru through the tonoplast regarding metabolic demand. (241 aa)
SPS3-2Probable sucrose-phosphate synthase 3; Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP- glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation. (1062 aa)
SPS1-2Sucrose-phosphate synthase 1; Plays a major role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP- glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation. Required for nectar secretion. (1043 aa)
LDOXLeucoanthocyanidin dioxygenase; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. Possesses low flavonol synthase activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family. (356 aa)
FLS1Flavonol synthase/flavanone 3-hydroxylase; Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol. Belongs to the iron/ascorbate-dependent oxidoreductase family. (336 aa)
F28G11.11Probable fructokinase-6, chloroplastic; May play an important role in maintaining the flux of carbon towards starch formation; Belongs to the carbohydrate kinase PfkB family. (384 aa)
FLS5Probable flavonol synthase 5; Belongs to the iron/ascorbate-dependent oxidoreductase family. (325 aa)
FLS3Flavonol synthase 3; Catalyzes the formation of flavonols from dihydroflavonols. Possesses low activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family. (308 aa)
PGD36-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (487 aa)
SDHSorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), ribitol and xylitol as substrates, leading to the C2- oxidized products D-fructose, D-ribulose and D-xylulose, respectively. To a lesser extent, can also oxidize arabitol, mannitol, lactitol and maltitol in vitro. Is required for sorbitol metabolism. Cannot use NADP(+) as the electron acceptor. (364 aa)
MIO24.3Probable fructokinase-7; May play an important role in maintaining the flux of carbon towards starch formation. (343 aa)
PGD26-phosphogluconate dehydrogenase, decarboxylating 2; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Required for guided growth of the male gametophytes and interaction between the pollen tube and the ovule. (486 aa)
SUS6Sucrose synthase 6; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements. (942 aa)
GAPC2Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. (338 aa)
LKHA4Leucine aminopeptidase; Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro). (616 aa)
SPS2-2Probable sucrose-phosphate synthase 2; Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP- glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation. Required for nectar secretion. (1047 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
T21E18.8Probable fructokinase-2; May play an important role in maintaining the flux of carbon towards starch formation. (329 aa)
T21E18.7Probable fructokinase-3; May play an important role in maintaining the flux of carbon towards starch formation. (345 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
SWEET16Bidirectional sugar transporter SWEET16; Mediates both low-affinity uptake and efflux of sugar across the vacuolar membrane. Regulates sugars homeostasis in leaves and roots by exporting/importing them through the tonoplast regarding metabolic demand. Acts as a vacuolar hexose transporter, such as glucose (Glc), fructose (Fru), and sucrose (Suc). (230 aa)
A3G2XYLTAnthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase; Contributes to the last few anthocyanin biosynthetic steps. Converts cyanidin 3-O-glucoside to cyanidin 3-O-xylosyl(1->2)glucoside. Can use 3-O-glucosylated anthocyanidins/flavonols and uridine diphosphate (UDP)-xylose as substrates. (468 aa)
SUS4Sucrose synthase 4; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways; Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily. (808 aa)
SUS3Sucrose synthase 3; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and direct carbon towards starch synthesis in developing seeds. (809 aa)
T16L24.30Probable fructokinase-4; May play an important role in maintaining the flux of carbon towards starch formation. (326 aa)
F3HNaringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants. (358 aa)
PGK3Phosphoglycerate kinase 3, cytosolic; Belongs to the phosphoglycerate kinase family. (401 aa)
PGMPPhosphoglucomutase, chloroplastic; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (623 aa)
CYP75B1Flavonoid 3'-monooxygenase; Catalyzes the 3'-hydroxylation of the flavonoid B-ring to the 3',4'-hydroxylated state. Convert naringenin to eriodictyol and dihydrokaempferol to dihydroquercetin; Belongs to the cytochrome P450 family. (513 aa)
BANAnthocyanidin reductase; Involved in the biosynthesis of condensed tannins. Converts cyanidin into (-)-epicatechin as the major product. Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. (340 aa)
PGM2Probable phosphoglucomutase, cytoplasmic 2; This enzyme participates in both the breakdown and synthesis of glucose. (585 aa)
PGD16-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (487 aa)
T28P16.12Probable fructokinase-1; May play an important role in maintaining the flux of carbon towards starch formation. (325 aa)
TIMTriosephosphate isomerase, chloroplastic; Belongs to the triosephosphate isomerase family. (315 aa)
ICDHPeroxisomal isocitrate dehydrogenase [NADP]; May be involved in response to oxidative stresses. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (416 aa)
EMB3004Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic; In the C-terminal section; belongs to the shikimate dehydrogenase family. (603 aa)
PAL4Phenylalanine ammonia-lyase 4; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (707 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
SPS4Probable sucrose-phosphate synthase 4; Plays a role in photosynthetic sucrose synthesis by catalyzing the rate-limiting step of sucrose biosynthesis from UDP- glucose and fructose- 6-phosphate. Involved in the regulation of carbon partitioning in the leaves of plants. May regulate the synthesis of sucrose and therefore play a major role as a limiting factor in the export of photoassimilates out of the leaf. Plays a role for sucrose availability that is essential for plant growth and fiber elongation; Belongs to the glycosyltransferase 1 family. (1050 aa)
F7H19.502-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein. (153 aa)
SUS5Sucrose synthase 5; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements. (836 aa)
FLS6Probable flavonol synthase 6. (293 aa)
FLS4Probable flavonol synthase 4. (279 aa)
PGM3Probable phosphoglucomutase, cytoplasmic 1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (583 aa)
ANSProbable 2-oxoglutarate-dependent dioxygenase ANS; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. (353 aa)
F12L6.16At2g39500/F12L6.16. (55 aa)
F24G24.60Probable fructokinase-5; May play an important role in maintaining the flux of carbon towards starch formation. (324 aa)
GAPC1Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] (338 aa)
PGICGlucose-6-phosphate isomerase, cytosolic; Belongs to the GPI family. (560 aa)
PAL1Phenylalanine ammonia-lyase 1; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (725 aa)
PAL2Phenylalanine ammonia-lyase 2; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (717 aa)
PAL3Phenylalanine ammonia-lyase 3; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton. (694 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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