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SCL23 SCL23 TDR TDR LAC17 LAC17 UMAMIT9 UMAMIT9 FTIP1 FTIP1 PER52 PER52 KNAT7 KNAT7 IRX10 IRX10 COBL4 COBL4 ENODL9 ENODL9 IQD10 IQD10 XCP2 XCP2 SMXL6 SMXL6 NAC012 NAC012 SMXL5 SMXL5 SNE SNE MYB46 MYB46 ACL5 ACL5 CYCB3-1 CYCB3-1 WRKY40 WRKY40 CYCB2-4 CYCB2-4 CALS7 CALS7 MAX2 MAX2 NAC037 NAC037 IRX15 IRX15 CSLD5 CSLD5 SEOB SEOB UMAMIT20 UMAMIT20 CESA7 CESA7 NPF3.1 NPF3.1 CLV3 CLV3 IRX9 IRX9 CYCD6-1 CYCD6-1 UMAMIT12 UMAMIT12 CYCB2-3 CYCB2-3 LACS1 LACS1 KCS11 KCS11 CYCB1-4 CYCB1-4 CESA1 CESA1 NAC073 NAC073 XCP1 XCP1 IRX12 IRX12 SMXL7 SMXL7 PIP2-2 PIP2-2 GL2 GL2 AP2 AP2 CAD7 CAD7 NPF6.3 NPF6.3 CDKB1-2 CDKB1-2 CYCB2-1 CYCB2-1 CYCA2-1 CYCA2-1 PIP1.4 PIP1.4 SUC2 SUC2 UMAMIT22 UMAMIT22 WOX4 WOX4 CESA4 CESA4 SWEET17 SWEET17 NAC043 NAC043 IRX14 IRX14 CDKB2-1 CDKB2-1 CESA8 CESA8 KIN7A KIN7A CHER1 CHER1 HHT1 HHT1 AUX1 AUX1 MYB83 MYB83 CYCA1-1 CYCA1-1 CYCA2-4 CYCA2-4 ABR1 ABR1 UMAMIT21 UMAMIT21 WRKY48 WRKY48 GAUT12 GAUT12 IRX14H IRX14H IRX15-L IRX15-L
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SCL23Scarecrow-like protein 23; Probable transcription factor involved in plant development. (405 aa)
TDRLeucine-rich repeat receptor-like protein kinase TDR; Acts with CLE41p and CLE44p peptides as a ligand-receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1041 aa)
LAC17Laccase-17; Lignin degradation and detoxification of lignin-derived products. (577 aa)
UMAMIT9WAT1-related protein At5g07050. (402 aa)
FTIP1FT-interacting protein 1; Involved in the export of FT from the phloem companion cells to the sieve elements through the plasmodesmata. Regulates flowering time under long days. (794 aa)
PER52Peroxidase 52; Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue; Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily. (324 aa)
KNAT7Homeobox protein knotted-1-like 7; May be involved in secondary cell wall biosynthesis. (291 aa)
IRX10Probable beta-1,4-xylosyltransferase IRX10; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the elongation of glucuronoxylan xylosyl backbone, especially in the formation of GlcUA side chain of xylans. (412 aa)
COBL4COBRA-like protein 4; Belongs to the COBRA family. (431 aa)
ENODL9Predicted GPI-anchored protein. (203 aa)
IQD10IQ-domain 10. (259 aa)
XCP2Cysteine protease XCP2; Cysteine protease involved in xylem tracheary element (TE) autolysis during xylogenesis in roots. Participates in micro autolysis within the intact central vacuole before mega autolysis is initiated by tonoplast implosion. Involved in susceptibility to the bacterial plant pathogen Ralstonia solanacearum. (356 aa)
SMXL6Protein SMAX1-LIKE 6; Probable component of a transcriptional corepressor complex involved in branching control. Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation. Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds. (979 aa)
NAC012NAC domain-containing protein 12; Transcriptional activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulate the secondary cell wall lignification of other tissues. Binds to and activates the promoter of MYB46. (358 aa)
SMXL5Protein SMAX1-LIKE 5; May function in a transcriptional corepressor complex. (1028 aa)
SNEF-box protein SNE; Essential component of a SCF-type E3 ligase complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, such complex probably mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway. Can partially complement the absence of GID2/SLY1. (157 aa)
MYB46Transcription factor MYB46; Transcription activator. Involved in the regulation of secondary wall biosynthesis in fibers and vessels. Transcription activator of the mannan synthase CSLA9 that recognizes and binds to the DNA consensus sequence 5'-[AG][GT]T[AT]GGT[GA]-3' cis- regulatory element of CSLA9 promoter. Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1. Functions redundantly with MYB83 in the transcriptional regulatory cascade leading to secondary wa [...] (280 aa)
ACL5Thermospermine synthase ACAULIS5; Required for correct xylem specification through regulation of the lifetime of the xylem elements. Prevents premature death of the xylem vessel elements. (339 aa)
CYCB3-1Putative cyclin-B3-1; Belongs to the cyclin family. Cyclin AB subfamily. (396 aa)
WRKY40Probable WRKY transcription factor 40; Transcription factor (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element (By similarity). (302 aa)
CYCB2-4Cyclin-B2-4. (431 aa)
CALS7Callose synthase 7; Involved in callose synthesis at the forming cell plate during cytokinesis. During plant growth and development, callose is found as a transitory component of the cell plate in dividing cells, is a major component of pollen mother cell walls and pollen tubes, and is found as a structural component of plasmodesmatal canals (By similarity). (1958 aa)
MAX2F-box protein MAX2; Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the senescence. Is necessary for responses to strigolactones and karrikins. Contributes to the selective repression of axillary shoots and moderates the branching by regulating negatively the auxin transport in primary stems, in an AXR1-independent manner. Required for the progression of leaf senescence mediated by methyl jasmonate. Required at each node to suppress axillary bud growth. (693 aa)
NAC037NAC domain-containing protein 37; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls. (365 aa)
IRX15Protein IRREGULAR XYLEM 15; Required for xylan biosynthesis, but not directly involved in catalyzing the addition of sugars to the growing polymer. (322 aa)
CSLD5Cellulose synthase-like protein D5; Involved in stem and root growth. Possesses xylan and homogalacturonan synthase activity. (1181 aa)
SEOBProtein SIEVE ELEMENT OCCLUSION B; Scaffold protein required to form the phloem filament matrix in sieve elements. (740 aa)
UMAMIT20WAT1-related protein At4g08290; Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family. (384 aa)
CESA7Cellulose synthase A catalytic subunit 7 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening. Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. (1026 aa)
NPF3.1Protein NRT1/ PTR FAMILY 3.1; May act as an efflux-type nitrite transporter. Not regulated by the PII protein involved in the regulation of nitrite uptake into higher plant chloroplasts; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (596 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
IRX9Beta-1,4-xylosyltransferase IRX9; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Xylan xylosyltransferase that acts cooperatively with IRX14 to achieve the successive addition of xylosyl residues during xylan backbone elongation. (351 aa)
CYCD6-1Putative cyclin-D6-1; Belongs to the cyclin family. Cyclin D subfamily. (302 aa)
UMAMIT12WAT1-related protein At2g37460. (380 aa)
CYCB2-3Cyclin-B2-3. (429 aa)
LACS1Long chain acyl-CoA synthetase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in both the wax and cutin pathways. Preferentially uses palmitate, palmitoleate, linoleate and eicosenoate. Seems to have a specific activity against very long-chain fatty acid (VLCFA) class with acids longer than 24 carbons (C(24)). (660 aa)
KCS113-ketoacyl-CoA synthase 11; Active on both saturated and mono-unsaturated acyl chains C16 to C20; Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. (509 aa)
CYCB1-4Cyclin-B1-4; Belongs to the cyclin family. Cyclin AB subfamily. (387 aa)
CESA1Cellulose synthase A catalytic subunit 1 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. Required during embryogenesis for cell elongation, orientation of cell expansion and complex cell wall formations, such as interdigitated pattern of epidermal pavement cells, stomatal guard cells and trichomes. Plays a role in lateral roots formation, but seems not necessary for the development of tip-growing cel [...] (1081 aa)
NAC073NAC domain-containing protein 73; Transcriptional activator that plays a regulatory role in the development of secondary cell wall fibers. Involved in the regulation of cellulose and hemicellulose biosynthetic genes as well as of genes involved in lignin polymerization and signaling. Is not a direct target of SND1. (305 aa)
XCP1Cysteine protease XCP1; Cysteine protease involved in xylem tracheary element (TE) autolysis during xylogenesis in roots. Participates in micro autolysis within the intact central vacuole before mega autolysis is initiated by tonoplast implosion. (355 aa)
IRX12Laccase-4; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for secondary xylem cell wall lignification; Belongs to the multicopper oxidase family. (558 aa)
SMXL7Protein SMAX1-LIKE 7; Probable component of a transcriptional corepressor complex involved in branching control. Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation. Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds ; Belongs to the ClpA/ClpB family. (1002 aa)
PIP2-2Aquaporin PIP2-2; Water channel required to facilitate the transport of water across cell membrane. Plays an predominant role in root water uptake process in conditions of reduced transpiration, and in osmotic fluid transport. Its function is impaired by Hg(2+). Inhibited by cytosolic acidosis which occurs during anoxia in roots. Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily. (285 aa)
GL2Homeobox-leucine zipper protein GLABRA 2; Probable transcription factor required for correct morphological development and maturation of trichomes as well as for normal development of seed coat mucilage. Regulates the frequency of trichome initiation and determines trichome spacing. (747 aa)
AP2Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...] (432 aa)
CAD7Cinnamyl alcohol dehydrogenase 7; Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols; Belongs to the zinc-containing alcohol dehydrogenase family. (357 aa)
NPF6.3Protein NRT1/ PTR FAMILY 6.3; Dual affinity nitrate transporter. Involved in proton- dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be i [...] (590 aa)
CDKB1-2Cyclin-dependent kinase B1-2; Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (311 aa)
CYCB2-1Cyclin-B2-1; Belongs to the cyclin family. Cyclin AB subfamily. (429 aa)
CYCA2-1Cyclin-A2-1; May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication; Belongs to the cyclin family. Cyclin AB subfamily. (443 aa)
PIP1.4Probable aquaporin PIP1-4; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily. (287 aa)
SUC2Sucrose transport protein SUC2; Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system). Can also transport other glucosides such as maltose, arbutin (hydroquinone-beta-D- glucoside), salicin (2-(hydroxymethyl)phenyl-beta-D-glucoside), alpha- phenylglucoside, beta-phenylglucoside, alpha-paranitrophenylglucoside, beta-paranitrophenylglucoside, and paranitrophenyl-beta-thioglucoside. May also transport biotin. Required for apoplastic phloem sucrose loading in source tissues (e.g. leaves) in order to transport it to sink tissues (e.g [...] (512 aa)
UMAMIT22WAT1-related protein At1g43650; Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family. (343 aa)
WOX4WUSCHEL-related homeobox 4; Transcription factor which may be involved in developmental processes. (251 aa)
CESA4Cellulose synthase A catalytic subunit 4 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening. (1049 aa)
SWEET17Bidirectional sugar transporter SWEET17; Acts as a vacuolar hexose transporter. Regulates fructose (Fru) homeostasis in leaves and roots by exporting/importing Fru through the tonoplast regarding metabolic demand. (241 aa)
NAC043NAC domain-containing protein 43; Transcription activator of genes involved in biosynthesis of secondary walls. Together with NST2 and NST3, required for the secondary cell wall thickening of sclerenchymatous fibers, secondary xylem (tracheary elements), and of the anther endocethium, which is necessary for anther dehiscence. May also regulate the secondary cell wall lignification of other tissues. (365 aa)
IRX14Beta-1,4-xylosyltransferase IRX14; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Involved in the elongation of glucuronoxylan xylosyl backbone. Xylan xylosyltransferase that acts cooperatively with IRX9 to achieve the successive addition of xylosyl residues during xylan backbone elongation. Required for the proper composition and structural properties of released seed coat mucilage. Required for the production of highly branched xylan polymers in seed coat mucilage. Xylan with xylose side chains seems to be necessary for pecti [...] (525 aa)
CDKB2-1Cyclin-dependent kinase B2-1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (313 aa)
CESA8Cellulose synthase A catalytic subunit 8 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening. (985 aa)
KIN7AKinesin-like protein KIN-7A; Probable plus end-directed motor protein that functions in the NACK-PQR (ANP1-MKK6-MPK4) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion. Regulates the activity and the localization of ANP1, probably by association through the non-catalytic region of the kinase. Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis. Belongs to the TRA [...] (974 aa)
CHER1Choline transporter protein 1; Regulator of vesicle trafficking, including endocytosis. Necessary for secondary plasmodesmata (PD) formation and development via the secretory trafficking regulation of proteins required for PD development, thus influencing intercellular communication. Modulates ion homeostasis, especially in roots, by monitoring the transport and subsequent subcellular localization of some ion transporters. Choline transporter involved in the regulation of choline metabolite homeostasis during root and phloem development. Modulates phloem morphogenesis and conductivity. [...] (700 aa)
HHT1Omega-hydroxypalmitate O-feruloyl transferase; Involved in the synthesis of aromatics of the suberin polymer. Specifically affects the accumulation of the ferulate constituent of suberin in roots and seeds, but has no effect on the content of p-coumarate or sinapate. (457 aa)
AUX1Auxin transporter protein 1; Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. Unloads auxin from the mature phloem to deliver the hormone to the root meristem via the protophloem cell files. Coordinated subcellular localization of AUX1 is regula [...] (485 aa)
MYB83Transcription factor MYB83; Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1 and its close homologs, including NAC043/NST1, NAC066/NST2, NAC101/VND6 and NAC030/VND7. Is required for functional expression of a number of secondary wall-associated transcription factors and secondary wall biosynthetic genes involved in cellulose, xylan and lignin synthesis. Functions redundantly with MYB46 in the transcriptional regulatory cascade leading to secondary wall form [...] (343 aa)
CYCA1-1Cyclin-A1-1; Belongs to the cyclin family. Cyclin AB subfamily. (460 aa)
CYCA2-4Cyclin-A2-4; Belongs to the cyclin family. Cyclin AB subfamily. (461 aa)
ABR1Ethylene-responsive transcription factor ABR1; Negative regulator of the abscisic acid (ABA) signaling pathway involved in seed germination and in responses to stress conditions. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity); Belongs to the AP2/ERF transcription factor family. ERF subfamily. (391 aa)
UMAMIT21WAT1-related protein At5g64700. (359 aa)
WRKY48Probable WRKY transcription factor 48; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). (399 aa)
GAUT12Probable galacturonosyltransferase 12; Involved in pectin assembly and/or distribution, and in the synthesis of secondary wall glucuronoxylan. Probably involved in the synthesis of the glycosyl sequence at the glucuronoxylan reducing end. May be involved in synthesis of a complex glycan primer for xylan synthesis. (535 aa)
IRX14HProbable beta-1,4-xylosyltransferase IRX14H; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the elongation of glucuronoxylan xylosyl backbone. (492 aa)
IRX15-LProtein IRX15-LIKE; Required for xylan biosynthesis, but not directly involved in catalyzing the addition of sugars to the growing polymer. (317 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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