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SLAH3 SLAH3 CBL5 CBL5 ABCG25 ABCG25 CIPK26 CIPK26 AKT6 AKT6 MPK12 MPK12 NPF4.6 NPF4.6 CIPK23 CIPK23 SRK2E SRK2E GORK GORK BAK1 BAK1 SLAH2 SLAH2 ALMT4 ALMT4 ABCB14 ABCB14 WAG1 WAG1 CP1 CP1 RBOHD RBOHD DTX50 DTX50 SLAC1 SLAC1 CIPK5 CIPK5 ALMT9 ALMT9 CBL9 CBL9 MPK9 MPK9 CPK23 CPK23 SKOR SKOR ABCG40 ABCG40 ALMT6 ALMT6 ALMT1 ALMT1 GRH1 GRH1 CPK21 CPK21 SLAH4 SLAH4 GHR1 GHR1 ABI2 ABI2 CIPK11 CIPK11 RBOHF RBOHF ALMT12 ALMT12 CBL1 CBL1 CAM1 CAM1 CAM2 CAM2 NIA1 NIA1 CML10 CML10 BG2 BG2 ABI1 ABI1 CAM7 CAM7 KAT3 KAT3 PHOT2 PHOT2 CAM6 CAM6 PBL27 PBL27 KAT2 KAT2 CPK4 CPK4 CPK5 CPK5 CPK6 CPK6 AKT2 AKT2 AKT1 AKT1 KAT1 KAT1 SRK2D SRK2D CPK3 CPK3 SLAH1 SLAH1
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SLAH3S-type anion channel SLAH3; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity. Functions as an essential negative regulator of inward potassium channels in guard cells. Essential for the efficient stomatal closure and opening in guard cells. (635 aa)
CBL5Calcineurin B-like protein 5; Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a positive regulator of salt or drought responses; Belongs to the calcineurin regulatory subunit family. (203 aa)
ABCG25ABC transporter G family member 25. (662 aa)
CIPK26CBL-interacting serine/threonine-protein kinase 26; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Involved in the calcium-dependent regulation of reactive oxygen species production by the NADPH oxidase RBOHF. (439 aa)
AKT6Potassium channel AKT6; Highly selective inward-rectifying potassium channel that could mediate potassium uptake in the pollen membrane. Plays an important role in pollen tube development. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins. Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily. (888 aa)
MPK12Mitogen-activated protein kinase 12; Negative regulator of the auxin transduction signaling pathway. Involved in stomatal movement regulation by phosphorylating and repressing HT1 and HT1-mediated GHR1 phosphorylation. Required for CO(2)- mediated stomatal movements (e.g. closure). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
NPF4.6Protein NRT1/ PTR FAMILY 4.6; Low-affinity proton-dependent nitrate transporter. Involved in constitutive nitrate uptake. Not involved in histidine or dipeptides transport. Involved in (+)-abscisic acid (ABA) transport, but not in gibberellin, indole-3-acetic acid or jasmonic acid import. Mediates cellular ABA uptake. Nitrate does not compete with abscisic acid as a substrate of NPF4.6 ; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (585 aa)
CIPK23CBL-interacting serine/threonine-protein kinase 23; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it fr [...] (482 aa)
SRK2ESerine/threonine-protein kinase SRK2E; Activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomata closure in response to drought, darkness, high CO(2), plant pathogens, or decreases in atmospheric relative humidity (RH). Involved in the resistance to drought by avoiding water loss. Required for the stomata closure mediated by pathogen-associated molecular pattern (PAMPs) (e.g. flg22 and LPS) of pathogenic bacteria such as P.syringae pv. tomato (Pst) and E.coli O157:H7. As a plant defense process, stomata are closed transiently in order [...] (362 aa)
GORKPotassium channel GORK; Major selective outward-rectifying potassium channel of the guard cell membrane. Involved in regulation of stomatal movements according to the water status. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization. Conductance of the channel is modulated in a potassium-dependent fashion. May interact with the cytoskeleton or with regulatory proteins. (820 aa)
BAK1BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1; Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors. Involved in brassinosteroid (BR) signal transduction. Phosphorylates BRI1. May be involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1- BAK1 heterodimers. Interaction with MSBP1 stimulates the endocytosis of BAK1 and suppresses brassinosteroid signaling. Acts in pathogen- associ [...] (615 aa)
SLAH2S-type anion channel SLAH2; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Belongs to the SLAC1 S-type anion channel family. (519 aa)
ALMT4Aluminum-activated malate transporter 4; Malate transporter; Belongs to the aromatic acid exporter (TC 2.A.85) family. (548 aa)
ABCB14ABC transporter B family member 14. (1247 aa)
WAG1Serine/threonine-protein kinase WAG1; Serine/threonine-protein kinase involved in the regulation of auxin signaling. Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing PIN-mediated polar auxin transport. Phosphorylates conserved serine residues in the PIN auxin efflux carriers. Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis. Acts as suppressors of root waving. (476 aa)
CP1Calcium-binding protein CP1; Binds calcium in vitro. (160 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
DTX50Protein DETOXIFICATION 50; Functions as a multidrug and toxin extrusion transporter in the export of abscisic acid (ABA) in guard cells. Plays a role in ABA- mediated growth inhibition and responses to drought conditions. May act as a negative regulator of hypocotyl cell elongation in the light. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (505 aa)
SLAC1Guard cell S-type anion channel SLAC1; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Cl(-) efflux through SLAC1 causes membrane depolarization, which activates outward- rectifying K1 channels, leading to KCl and water efflux to reduce turgor further and cause stomatal closure, that reduces water loss and promotes leaf turgor. Essential for stomatal closure in response to CO(2), abscisic acid (ABA), ozone O(3), light/dark transitions, humidity change, calcium ions, hydrogen peroxide H(2)O(2), reactive oxygen species (ROS), and nit [...] (556 aa)
CIPK5CBL-interacting serine/threonine-protein kinase 5; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity). (445 aa)
ALMT9Aluminum-activated malate transporter 9; Vacuolar malate channel. Has a higher selectivity for malate than for fumarate. Exhibits also a weak chloride conductance. (598 aa)
CBL9Calcineurin B-like protein 9; Acts as a calcium sensor involved in abscisic acid (ABA) signaling and stress-induced ABA biosynthesis pathways. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. May function as a negative regulator of stress and ABA responses. Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to [...] (213 aa)
MPK9Mitogen-activated protein kinase 9; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (510 aa)
CPK23Calcium-dependent protein kinase 23; May play a role in signal transduction pathways that involve calcium as a second messenger. Could act as a calcium sensor involved in drought- and salt stress-induced calcium signaling cascades. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (520 aa)
SKORPotassium channel SKOR; Highly selective outward-rectifying potassium channel. Involved in potassium release into the xylem sap toward the shoots. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization. The voltage-dependence of the channel is abolished by internal or external acidification. May interact with the cytoskeleton or with regulatory proteins; Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily. (828 aa)
ABCG40ABC transporter G family member 40; May be a general defense protein (By similarity). Functions as a pump to exclude Pb(2+) ions and/or Pb(2+)-containing toxic compounds from the cytoplasm. Contributes to Pb(2+) ions resistance. Confers some resistance to the terpene sclareol. (1423 aa)
ALMT6Aluminum-activated malate transporter 6; Malate transporter; Belongs to the aromatic acid exporter (TC 2.A.85) family. (538 aa)
ALMT1Aluminum-activated malate transporter 1; Malate transporter critical for aluminum tolerance. The STOP1 transcription factor is required for ALMT1 expression. (493 aa)
GRH1GRR1-like protein 1; Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. Involved in embryogenesis regulation by auxin. Confers sensitivity to the virulent bacterial pathogen P.syringae. Mediates glucose repression in yeast. (585 aa)
CPK21Calcium-dependent protein kinase 21; May play a role in signal transduction pathways that involve calcium as a second messenger. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (531 aa)
SLAH4S-type anion channel SLAH4; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. (365 aa)
GHR1LRR receptor-like serine/threonine-protein kinase GHR1; Receptor kinase acting as an early component in abscisic acid (ABA) signaling. Required for darkness, ABA, high CO(2) and hydrogen peroxide (H(2)O(2)) induction of S-type anion currents in guard cells leading to stomatal closure, possibly via the phosphorylation and activation of the anion channel SLAC1 and as a scaffolding component. Seems to act in parallel with SRK2E/OST1 in the ABA signaling pathway which regulates stomatal movement. Binds ATP. Involved in the local and/or systemic stomatal responses (e.g. stomatal closure) to [...] (1053 aa)
ABI2Protein phosphatase 2C 77; Repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H(2)O(2) and oxidative burst in response to ABA and dehydration. Represses GHR1 and, to some extent, SRK2E/OST1, kinases involved in the regulation of SLAC1-dependent stomatal closure. Controls [...] (423 aa)
CIPK11CBL-interacting serine/threonine-protein kinase 11; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Acts as a negative regulator of the plasma membrane proton pump AHA2 by preventing its interaction with 14-3-3 protein. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (435 aa)
RBOHFRespiratory burst oxidase homolog protein F; Calcium-dependent NADPH oxidase that generates superoxide. Generates reactive oxygen species (ROS) during incompatible interactions with pathogens and is important in the regulation of the hypersensitive response (HR). Involved in abscisic acid-induced stomatal closing and in UV-B and abscisic acid ROS-dependent signaling. Belongs to the RBOH (TC 5.B.1.3) family. (944 aa)
ALMT12Aluminum-activated malate transporter 12; Malate-sensitive anion transporter permeable to chloride, nitrate, sulfate and malate. Involved in dark-, CO(2)-, abscisic acid- and water-deficient-induced stomatal closure. Belongs to the R- type anion channels. (560 aa)
CBL1Calcineurin B-like protein 1; Acts as a calcium sensor involved in the signaling pathway during growth and development and in response to abiotic stresses. May function as a positive regulator of salt and drought responses and as a negative regulator of cold response. Contributes to the regulation of early stress-related CBF/DREB transcription factors. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Mediates the activation of AKT1 [...] (213 aa)
CAM1Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CAM2Calmodulin-2; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
NIA1Nitrate reductase [NADH] 1; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria. (917 aa)
CML10Calmodulin-like protein 10; Potential calcium sensor. (191 aa)
BG2Glucan endo-1,3-beta-glucosidase, acidic isoform; Implicated in the defense of plants against pathogens (Probable). Not involved in plasmodesmal callose degradation and in the gating of plasmodesmata during tobamovirus infection. Belongs to the glycosyl hydrolase 17 family. (339 aa)
ABI1Protein phosphatase 2C 56; Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), drought-induced resistance and rhizogenesis, response to glucose, high light stress, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as the actin reorganization in guard cells in response to ABA. Involved in the resistance to the bacterial pathogen Pseudomonas syrin [...] (434 aa)
CAM7Calmodulin-7; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro. (149 aa)
KAT3Potassium channel KAT3; Probable modulatory (alpha) subunit of inward-rectifying potassium channels. Could mediate potassium uptake from the soil solution by plant roots in association with AKT1. (662 aa)
PHOT2Phototropin-2; Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Phosphorylates BLUS1, a kinase involved in stomatal opening. Mediates calcium spiking of extra- and intracellular origins in response to blue light. Involved in hypocotyl phototropism. Contributes to the chloroplast accumulation in low blue light and mediates their translocation (avoidance response) at high fluence. Regulates stomata opening and photomorphogenesis response of leaf tissue. Not involved in hypocotyl elongation inhibition, anthocyanin accumul [...] (915 aa)
CAM6Calmodulin-6; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
PBL27Serine/threonine-protein kinase PBL27; Receptor-like cytoplasmic kinase involved in the transduction of signal between the host cell surface chitin receptor complex CERK1- LYK5 and the intracellular MAPKKK5-dependent mitogen-activated protein kinase (MAPK) cascade that leads to chitin-induced immunity. Phosphorylates and activates MAPKKK5 when phosphorylated by CERK1 after elicitation by chitin. (513 aa)
KAT2Potassium channel KAT2; Highly selective inward-rectifying potassium channel. This voltage-dependent channel could mediate long-term potassium influx into guard cells leading to stomatal opening. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. The channel activity is enhanced upon external acidification. (697 aa)
CPK4Calcium-dependent protein kinase 4; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions as regulator of the calcium- mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA- responsive transcription factors ABF1 and ABF4 in vitro. Phosphorylates the nuclear zinc finger Di19 in vitro. (501 aa)
CPK5Calcium-dependent protein kinase 5; May play a role in signal transduction pathways that involve calcium as a second messenger; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (556 aa)
CPK6Calcium-dependent protein kinase 6; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. Phosphorylates FD ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (544 aa)
AKT2Potassium channel AKT2/3; Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/pr [...] (802 aa)
AKT1Potassium channel AKT1; Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpol [...] (857 aa)
KAT1Potassium channel KAT1; Highly selective inward-rectifying potassium channel. This voltage-gated channel could mediate long-term potassium influx into guard cells leading to stomatal opening. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. The channel activity is enhanced upon external acidification. Also permeable to ammonium ions. Blocked by tetraethylammonium and barium ions. (677 aa)
SRK2DSerine/threonine-protein kinase SRK2D; Together with SRK2I, key component and activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as seed germination, Pro accumulation, root growth inhibition, dormancy and seedling growth, and, to a lesser extent, stomatal closure; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (362 aa)
CPK3Calcium-dependent protein kinase 3; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. (529 aa)
SLAH1S-type anion channel SLAH1; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Belongs to the SLAC1 S-type anion channel family. (385 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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