STRINGSTRING
NTL8 NTL8 ANR1 ANR1 JUB1 JUB1 LBD16 LBD16 NAC017 NAC017 NAC016 NAC016 LRE LRE NAC013 NAC013 NAC098 NAC098 NRT2.1 NRT2.1 NIA2 NIA2 NIA1 NIA1 CCA1 CCA1 ARF7 ARF7 ARF5 ARF5 NPF6.3 NPF6.3 IAA12 IAA12 IAA14 IAA14 NAC002 NAC002 NIR1 NIR1 TGA1 TGA1 NAC078 NAC078 NLP7 NLP7 NPF4.6 NPF4.6 DOF5.4 DOF5.4 NAC072 NAC072 NAC053 NAC053 ACT2 ACT2 NAC019 NAC019 NRT3.1 NRT3.1 NRT2.3 NRT2.3 NAC92 NAC92 LBD37 LBD37 NAC054 NAC054 NAC056 NAC056 NAC055 NAC055 CDC73 CDC73 NRT2.2 NRT2.2 AFB3 AFB3 NPF6.4 NPF6.4 NRT3.2 NRT3.2 NAC062 NAC062 NLP5 NLP5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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NTL8NAC domain-containing protein 40; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt- responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions. (335 aa)
ANR1MADS-box transcription factor ANR1; Probable transcription factor. Required for root plasticity in response to nitrate, NO(3)(-). Promotes lateral root growth in a NRT1.1-dependent manner. (234 aa)
JUB1Transcription factor JUNGBRUNNEN 1; Transcription factor that binds to the 5'- RRYGCCGT-3' consensus core sequence. Central longevity regulator. Negative regulator of leaf senescence. Modulates cellular H(2)O(2) levels and enhances tolerance to various abiotic stresses through the regulation of DREB2A. (275 aa)
LBD16LOB domain-containing protein 16; Transcriptional activator. Involved in lateral root formation. Regulated by the transcriptional activators ARF7 and ARF19. Functions in the initiation and emergence of lateral roots, in conjunction with LBD18, downstream of ARF7 and ARF19. Acts downstream of the auxin influx carriers AUX1 and LAX1 in the regulation of lateral root initiation and development. (245 aa)
NAC017NAC domain-containing protein 17; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator that acts as positive regulator of AOX1A during mitochondrial dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial retrograde signaling. (557 aa)
NAC016NAC domain-containing protein 16; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcriptional activator that promotes leaf senescence by up- regulating senescence-associated genes in response to developmental and stress-induced senescence signals. Functions in salt and oxidative stress-responsive signaling pathways. Binds to the promoter of NAC029/NAP and NAC059/ORS1 genes. (564 aa)
LREGPI-anchored protein LORELEI; Female gametophyte-specific component of the signaling pathway required for fertilization. Required for reception of the pollen tube by the female gametophyte. Acts specifically at the synergid cell surface for pollen tube reception. Plays a role in double fertilization and early seed development. Component of the FER-regulated Rho GTPase signaling complex. Acts as a chaperone and coreceptor for FER. Required for localization of FER to the plasma membrane. (165 aa)
NAC013NAC domain-containing protein 13; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Involved in oxidative stress tolerance by mediating regulation of mitochondrial retrograde signaling during mitochondrial dysfunction. Interacts directly with the mitochondrial dysfunction DNA consensus motif 5'- CTTGNNNNNCA[AC]G-3', a cis-regulatory elements of several mitochondrial retrograde regulation-induced genes, and triggers increased oxidative stress tolerance. (528 aa)
NAC098Protein CUP-SHAPED COTYLEDON 2; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of [...] (375 aa)
NRT2.1High-affinity nitrate transporter 2.1; Involved in nitrate transport, but does not seem to be able to mediate transport by its own. Acts as a dual component transporter with NTR3.1. Acts as a repressor of lateral root initiation under high sucrose/low nitrate conditions. (530 aa)
NIA2Nitrate reductase [NADH] 2; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria. (917 aa)
NIA1Nitrate reductase [NADH] 1; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria. (917 aa)
CCA1Protein CCA1; Transcription factor involved in the circadian clock and in the phytochrome regulation. Binds to the promoter regions of APRR1/TOC1 and TCP21/CHE to repress their transcription. Binds to the promoter regions of CAB2A and CAB2B to promote their transcription. Represses both LHY and itself. (608 aa)
ARF7Auxin response factor 7; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Act as a transcriptional activator of several tropic stimulus-induced (TSI) genes, including SAUR50. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Required for differential growth responses of aerial tissues. Involved in ethylene responses. Regulates lateral root formation through direct regulation of LBD16 and/or LB [...] (1164 aa)
ARF5Auxin response factor 5; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity. (902 aa)
NPF6.3Protein NRT1/ PTR FAMILY 6.3; Dual affinity nitrate transporter. Involved in proton- dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be i [...] (590 aa)
IAA12Auxin-responsive protein IAA12; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin- responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. (239 aa)
IAA14Auxin-responsive protein IAA14; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin- responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. (228 aa)
NAC002NAC domain-containing protein 2. (289 aa)
NIR1Ferredoxin--nitrite reductase, chloroplastic; Catalyzes the six-electron reduction of nitrite to ammonium. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (586 aa)
TGA1Transcription factor TGA1; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'- TGACGTGG-3') another cis-acting element found in plant histone promoters; Belongs to the bZIP family. (368 aa)
NAC078NAC domain-containing protein 78; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcripition activator associated with the induction of genes related to flavonoid biosynthesis and required for the accumulation of anthocyanins in response to high light stress. Plays a role in the regulation of 20S and 26S proteasomes in response to high light stress. (567 aa)
NLP7Protein NLP7; Transcription factor involved in regulation of nitrate assimilation and in transduction of the nitrate signal. (959 aa)
NPF4.6Protein NRT1/ PTR FAMILY 4.6; Low-affinity proton-dependent nitrate transporter. Involved in constitutive nitrate uptake. Not involved in histidine or dipeptides transport. Involved in (+)-abscisic acid (ABA) transport, but not in gibberellin, indole-3-acetic acid or jasmonic acid import. Mediates cellular ABA uptake. Nitrate does not compete with abscisic acid as a substrate of NPF4.6 ; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (585 aa)
DOF5.4Dof zinc finger protein DOF5.4; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence. Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity). (307 aa)
NAC072NAC domain-containing protein 72; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (297 aa)
NAC053NAC domain-containing protein 53; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (Ref.6,. Promotes reactive oxygen species (ROS) production during drought-induced leaf senescence. In response to abscisic acid (ABA)-mediated drought stress signals, binds directly to the promoters of RBOHC and RBOHE genes, encoding ROS biosynthetic enzymes, resulting in ROS accumulation and triggering leaf senescence via programmed cell death (PCD). ROS-induced leaf senescence sustains plant survival under drought conditions. Involved in heat [...] (549 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
NAC019NAC domain-containing protein 19; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
NRT3.1High-affinity nitrate transporter 3.1; Acts as a dual component transporter with NTR2.1. Required for high-affinity nitrate transport. Acts as a repressor of lateral root initiation. May be involved in targeting NRT2 proteins to the plasma membrane. Belongs to the NAR2 family. (210 aa)
NRT2.3High affinity nitrate transporter 2.3; Involved in high-affinity nitrate transport. Acts as a dual component transporter with NTR3.1 (By similarity). (539 aa)
NAC92NAC domain-containing protein 92; Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[ACG][CA]GT[AG](5- 6n)[CT]AC[AG]-3'. Promotes lateral root development. Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with salt- and H(2)O(2)- dependent signaling pathways. Regulates also genes during seed germination. Regulates positively aging-induced cell death. Involved in age-related resistance (ARR) against Pseudomonas syringae pv. t [...] (285 aa)
LBD37LOB domain-containing protein 37. (250 aa)
NAC054Protein CUP-SHAPED COTYLEDON 1; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Seems to act as an inhibitor of cell division. (310 aa)
NAC056NAC transcription factor 56; Transcription factor of the NAC family (Probable). Together with NAC018/NARS2, regulates embryogenesis by regulating the development and degeneration of ovule integuments, a process required for intertissue communication between the embryo and the maternal integument. (364 aa)
NAC055NAC domain-containing protein 55; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
CDC73Protein CDC73 homolog; Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS- box genes of the MAF family. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus. (415 aa)
NRT2.2High-affinity nitrate transporter 2.2; Involved in high-affinity nitrate transport. (522 aa)
AFB3Protein AUXIN SIGNALING F-BOX 3; Confers sensitivity to the virulent bacterial pathogen P.syringae (By similarity). Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin- regulated transcription. Involved in embryogenesis regulation by auxin. (577 aa)
NPF6.4Protein NRT1/ PTR FAMILY 6.4; Low-affinity nitrate transporter; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (590 aa)
NRT3.2High-affinity nitrate transporter 3.2; Acts as a dual component transporter with NTR2.1. Required for high-affinity nitrate transport (By similarity); Belongs to the NAR2 family. (209 aa)
NAC062NAC domain-containing protein 62; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant resistance to pathogen infection, incorporating cold signals into pathogen resistance responses. Plays a regulatory role in abscisic acid (ABA)-mediated drought-resistance response. (469 aa)
NLP5Protein NLP5; Probable transcription factor. (808 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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