STRINGSTRING
TIC214 TIC214 TOC33 TOC33 SRO3 SRO3 AKR4C8 AKR4C8 TOC159 TOC159 PAP1 PAP1 FTSZ2-1 FTSZ2-1 ADH1 ADH1 CPN60 CPN60 CDC48A CDC48A T25N20.10 T25N20.10 TOC34 TOC34 PSBP1 PSBP1 FTSZ1 FTSZ1 SP1 SP1 TIC110 TIC110 ACT2 ACT2 OEP80 OEP80 FTSH11 FTSH11 CRL CRL CLPC1 CLPC1 ARC6 ARC6 TIC40 TIC40 SMR7 SMR7 FTSZ2-2 FTSZ2-2 TOC132 TOC132 TOC75-3 TOC75-3 PDV2 PDV2 TIC236 TIC236
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIC214Protein TIC 214; Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein- conducting channel at the inner envelope. Belongs to the TIC214 family. (1786 aa)
TOC33Translocase of chloroplast 33, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Binds GTP, GDP, XTP, but not ATP. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast, especially during early development stages. (297 aa)
SRO3Probable inactive poly [ADP-ribose] polymerase SRO3; Probable inactive ADP-ribosyltransferase that may be involved in stress and developmental responses. (305 aa)
AKR4C8Aldo-keto reductase family 4 member C8; Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress. (311 aa)
TOC159Translocase of chloroplast 159, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Required for chloroplast biogenesis. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. TOC159 subfamily. (1503 aa)
PAP1Probable plastid-lipid-associated protein 1, chloroplastic; Probably involved in light/cold stress-related jasmonate (JA) biosynthesis. Contributes to the protection of photosystem II (PSII) against light stress; Belongs to the PAP/fibrillin family. (318 aa)
FTSZ2-1Cell division protein FtsZ homolog 2-1, chloroplastic; Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Belongs to the FtsZ family. (478 aa)
ADH1Alcohol dehydrogenase class-P; Alcohol dehydrogenase mostly active on ethanol (EtOH), but exhibits broad substrates selectivity for primary and secondary alcohols (e.g. butanol, propyl alcohol, pentanol, isopentanol, ethylene glycol, isopropanol, methanol and tertiary butyl alcohol). Converts allyl alcohol to highly toxic acryl- aldehyde. Required for survival and acclimation in hypoxic conditions, especially in roots. (379 aa)
CPN60Chaperonin CPN60, mitochondrial; Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. (577 aa)
CDC48ACell division control protein 48 homolog A; Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity). (809 aa)
T25N20.10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein. (205 aa)
TOC34Translocase of chloroplast 34, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast. (313 aa)
PSBP1Oxygen-evolving enhancer protein 2-1, chloroplastic; May be involved in the regulation of photosystem II; Belongs to the psbP family. (263 aa)
FTSZ1Cell division protein FtsZ homolog 1, chloroplastic; Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Involved in blue light-induced chloroplast movements. May regulate thylakoid development. Belongs to the FtsZ family. (433 aa)
SP1E3 ubiquitin-protein ligase SP1; E3 ubiquitin-protein ligase involved in the regulation of protein import in the chloroplast. Associates with TOC complexes and mediates ubiquitination of TOC components, promoting their degradation via the ubiquitin-proteasome system (UPS). Plays a role in the reorganization of the TOC machinery. Involved in a mechanism that regulates plastid biogenesis via UPS. Promotes stress tolerance by depleting the chloroplast protein import apparatus, which limits photosystem assembly and the potential for reactive oxygen species (ROS) formation. May act as negat [...] (343 aa)
TIC110Protein TIC110, chloroplastic; Involved in protein precursor import into chloroplasts. Forms a voltage-dependent cation-selective channel at the inner envelope of chloroplasts, which specifically responds to a transit peptide. Associates with both the precursor and mature forms of the preprotein. (1016 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
OEP80Outer envelope protein 80, chloroplastic; Plays an essential role during early stages of plastid development; Belongs to the OEP80 (TC 1.B.33.2) family. (732 aa)
FTSH11ATP-dependent zinc metalloprotease FTSH 11, chloroplastic/mitochondrial; Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complexes I and Involved in thermotolerance but not in high light stress resistance or in the assembly/stability of the complexes I and V of the mitochondrial oxidative phosphorylation system; In the N-terminal section; belongs to the AAA ATPase family. (806 aa)
CRLChromophore lyase CRL, chloroplastic; Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity). Required for plastid division, and involved in cell differentiation and regulation of the cell division plane. Maintenance of plastid homeostasis controls plant preconditioning to stress and stress acclimation. Belongs to the CpcT/CpeT biliprotein lyase family. (269 aa)
CLPC1Chaperone protein ClpC1, chloroplastic; Molecular chaperone that hydrolyzes ATP and is associated with the chloroplast protein import apparatus. May function as the motor for chloroplast protein translocation, as translocation requires ATP hydrolysis in the stroma. May interact with a ClpP-like protease involved in degradation of denatured proteins in the chloroplast. Involved in the regulation of chlorophyll b biosynthesis through the destabilization of chlorophyllide a oxygenase (CAO) protein in response to the accumulation of chlorophyll b. Involved in leaf iron homeostasis. Belongs [...] (929 aa)
ARC6Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic; Component of the plastid division machinery. Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1. Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring. Required for plastid equatoria [...] (801 aa)
TIC40Protein TIC 40, chloroplastic; Involved in protein precursor import into chloroplasts. Part of the motor complex consisting of a co-chaperone (TIC40) and a chaperone (HSP93) associated with the import channel (TIC110). Causes the release of bound transit peptides from TIC110 and stimulates ATP hydrolysis by HSP93. Involved in reinsertion of proteins from the chloroplast stroma into the inner membrane. (447 aa)
SMR7Cyclin-dependent protein kinase inhibitor SMR7; Probable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Acts as a potent cell cycle inhibitor, regulating a hydroxyurea-dependent checkpoint in leaves. (99 aa)
FTSZ2-2Cell division protein FtsZ homolog 2-2, chloroplastic; Exhibits GTPase activity (By similarity). Component of the plastid division machinery that forms a contractile ring at the division site. (473 aa)
TOC132Translocase of chloroplast 132, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast. (1206 aa)
TOC75-3Protein TOC75-3, chloroplastic; Essential protein. Mediates the insertion of proteins targeted to the outer membrane of chloroplasts (By similarity). Required for the import of protein precursors into chloroplasts. Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane. (818 aa)
PDV2Plastid division protein PDV2; Component of the plastid division machinery. Required to mediate the recruitment of ARC5 at the midplastid constriction site in the cytoplasm. Relays plastid division site position between stroma and outer surface via interactions with the cytoplasmic ARC5 and the inner membrane ARC6 that recruits stromal FtsZ ring. (307 aa)
TIC236Protein TIC236, chloroplastic; Part of the inner chloroplast membrane translocon complex (TIC) which associates with the outer chloroplast membrane translocon complex (TOC) and forms a supercomplex involved in protein precursor import into the chloroplast stroma. Required for the import of HSP93, TIC40 and RBCS protein precursors in the chloroplast stroma. Links the outer and inner membrane translocons of the chloroplast envelope. Belongs to the TamB family. (2166 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.