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RBR1 RBR1 T5I8.13 T5I8.13 BRIZ1 BRIZ1 LIG6 LIG6 NQR NQR ABI2 ABI2 PXG3 PXG3 EIN3 EIN3 PYR1 PYR1 GLCNAC1PUT2 GLCNAC1PUT2 GDU1 GDU1 DREB2A DREB2A HSP18.1 HSP18.1 RD21A RD21A LTI65 LTI65 RD29A RD29A UBC7 UBC7 APX3 APX3 HOS1 HOS1 HSFA3 HSFA3 MPN9.19 MPN9.19 AIP2 AIP2 NAC072 NAC072 AIRP1 AIRP1 RZF1 RZF1 DRIP2 DRIP2 BZIP8 BZIP8 ZEP ZEP T31K7.4 T31K7.4 RBOHD RBOHD KPNB1 KPNB1 ATR ATR DHAR2 DHAR2 RECQL2 RECQL2 SCRM SCRM ATP1 ATP1 RGLG2 RGLG2 AIRP2 AIRP2 SDIR1 SDIR1 NCA1 NCA1 ABF4 ABF4 ABF3 ABF3 DRIP1 DRIP1 EBF1 EBF1 ERF053 ERF053 MDAR3 MDAR3 RGLG1 RGLG1 OSCA1 OSCA1 RHA2A RHA2A RHA2B RHA2B MAPKKK18 MAPKKK18
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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RBR1Retinoblastoma-related protein 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate. Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation. Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate m [...] (1013 aa)
T5I8.13Twinkle homolog protein, chloroplastic/mitochondrial; Has both DNA primase and DNA helicase activities and may be involved in organelle DNA replication. Capable of producing RNA primers of 9 to 18 bases from a single-stranded DNA template. (709 aa)
BRIZ1BRAP2 RING ZnF UBP domain-containing protein 1; RING-type ubiquitin E3 ligase required for seed germination and post-germination growth. (488 aa)
LIG6DNA ligase 6; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (Probable). Required to maintain seed viability (e.g. longevity and storability) and during seed germination, probably by repairing DNA damage accumulated during seed development, storage and/or imbibition. Facilitates seed germination in cold conditions (2 degrees Celsius) and under oxidative stress (e.g. menadione, a genotoxic agent). Involved in repair of X- ray-induced damage ; Belongs to the ATP-dependent DNA ligase family. (1396 aa)
NQRARP protein (REF). (652 aa)
ABI2Protein phosphatase 2C 77; Repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H(2)O(2) and oxidative burst in response to ABA and dehydration. Represses GHR1 and, to some extent, SRK2E/OST1, kinases involved in the regulation of SLAC1-dependent stomatal closure. Controls [...] (423 aa)
PXG3Probable peroxygenase 3; Probable calcium-binding peroxygenase. May be involved in the degradation of storage lipid in oil bodies, in abiotic stress-related signaling pathway and in drought tolerance through stomatal control under water deficit conditions. (236 aa)
EIN3Protein ETHYLENE INSENSITIVE 3; Probable transcription factor acting as a positive regulator in the ethylene response pathway. Is required for ethylene responsiveness in adult plant tissues. Binds a primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter with consequence to activate the transcription of this gene. (628 aa)
PYR1Abscisic acid receptor PYR1; Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA. Can be activated by both (-)-ABA and (+)-ABA. Promotes drought tolerance. (191 aa)
GLCNAC1PUT2UDP-N-acetylglucosamine diphosphorylase 2; Uridylyltransferase involved in the biosynthesis of UDP- glucosamine, an essential precursor for glycoprotein and glycolipid synthesis. Can use UDP-glucosamine, the 4-epimer UDP-galactosamine and UDP-glucose as substrates. Acts redundantly with GLCNAC1PUT1. Required for gametogenesis and embryo development. (502 aa)
GDU1Protein GLUTAMINE DUMPER 1; Probable subunit of an amino acid transporter involved in the regulation of the amino acid metabolism. Stimulates amino acid export by activating nonselective amino acid facilitators. Required the interaction with the RING-type E3 ubiquitin-protein ligase LOG2 to fulfill its function. Plays a role in the Gln export at hydathodes, at xylem parenchyma into xylem sap and from mesophyll into leaf apoplasm. Acts upstream genes involved in the salicylic acid (SA) pathway and in the geminivirus-host interaction. Belongs to the GLUTAMINE DUMPER 1 (TC 9.B.60) family. (158 aa)
DREB2ADehydration-responsive element-binding protein 2A; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription. Belongs to the AP2/ERF transcription factor family. ERF subfamily. (335 aa)
HSP18.118.1 kDa class I heat shock protein. (161 aa)
RD21ACysteine proteinase RD21A; Cysteine protease that plays a role in immunity, senescence, and biotic and abiotic stresses (Probable). Involved in immunity against the necrotrophic fungal pathogen Botrytis cinerea. Involved in elicitor-stimulated programmed cell death (PCD). During infection by the necrotrophic fungal pathogen Botrytis cinerea, functions as PCD-promoting protease that is released from the ER body or vacuole to the cytoplasm. Accumulates in endoplasmic reticulum-derived bodies in epidermal cells and may participate in cell death in stressed or injured cells. Involved in wa [...] (462 aa)
LTI65Low-temperature-induced 65 kDa protein; Belongs to the LTI78/LTI65 family. (619 aa)
RD29ALow-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family. (710 aa)
UBC7Ubiquitin-conjugating enzyme E2 7; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation. (166 aa)
APX3L-ascorbate peroxidase 3; Plays a key role in hydrogen peroxide removal. (287 aa)
HOS1E3 ubiquitin-protein ligase HOS1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1. Acts as a negative regulator of cold signaling pathways. Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable). Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels. (927 aa)
HSFA3Heat stress transcription factor A-3; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress response. Activated by DREB2A under heat stress; Belongs to the HSF family. Class A subfamily. (412 aa)
MPN9.19E3 ubiquitin-protein ligase RING1-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Promotes polyubiquitination of target proteins. (328 aa)
AIP2E3 ubiquitin-protein ligase AIP2; E3 ubiquitin-protein ligase that acts as a negative regulator of abscisic acid (ABA) signaling. Mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ABI3. (310 aa)
NAC072NAC domain-containing protein 72; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (297 aa)
AIRP1E3 ubiquitin-protein ligase AIRP1; Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro. Plays combinatory roles with AIRP2 in the positive regulation of the abscisic acid-mediated drought stress response. (153 aa)
RZF1E3 ubiquitin-protein ligase RZF1; E3 ubiquitin-protein ligase that promotes osmotic stress responses. Regulates negatively drought-mediated control of early seedling development, probably by influencing proline content, water loss, membrane ion leakage and the expression of dehydration stress- related genes (e.g. RAB18, RD29A, RD29B, AOX1A, ERD15, ERD1, COR15A, P5CS1 and P5CR). (320 aa)
DRIP2E3 ubiquitin protein ligase DRIP2; E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress. Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A. Functionally redundant with DRIP1. (420 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
ZEPZeaxanthin epoxidase, chloroplastic; Zeaxanthin epoxidase that plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. Converts zeaxanthin into antheraxanthin and subsequently violaxanthin. Required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression and disease resistance and non-photochemical quencing (NPQ). Through its role in ABA biosynthesis, regulates the expression of stress-responsive genes such as RD29A during osmotic stress and is required for normal [...] (667 aa)
T31K7.4RING-H2 zinc finger protein. (300 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
KPNB1Importin subunit beta-1; Acts as negative effector of drought tolerance. Involved in the regulation of stomatal closure and in the abscisic acid (ABA)- mediated pathway that lead to drought tolerance. Does not directly mediate nuclear import of ABI1 and ABI2 which are key regulators of the ABA signaling pathway. May be involved in nuclear translocation of other type 2C protein phosphatases that mediate ABA signaling. (870 aa)
ATRSerine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...] (2702 aa)
DHAR2Glutathione S-transferase DHAR2; Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses. Plays a role in ozone tolerance; Belongs to the GST superfamily. DHAR family. (213 aa)
RECQL2ATP-dependent DNA helicase Q-like 2; 3'-5' DNA helicase that may play a role in the repair of DNA. Its DNA unwinding activity in vitro is dependent on magnesium, and ATP or dATP. Can use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors. Catalyzes Holliday junction branch migration and replication fork regression. Disrupts D-loop structures ; Belongs to the helicase family. RecQ subfamily. (705 aa)
SCRMTranscription factor ICE1; Transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. Binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA. Functions as a dimer with SPCH during stomatal initiation. (494 aa)
ATP1Probable pterin-4-alpha-carbinolamine dehydratase, chloroplastic; Involved in tetrahydrobiopterin biosynthesis (By similarity). Interacts with and acts downstream of the E3 ubiquitin-protein ligase SDIR1 in abscisic acid (ABA) and salt stress signaling. Regulates the expression of the bZIP transcription factor ABI5, which mediates responses to ABA during seed germination and salt stress. The SDIR1- ATP1/SDIRIP1 complex plays an important role in ABA signaling through the ubiquitination pathway. Acts downstream of AIRP2 in regulation of ABA signaling during drought stress. (220 aa)
RGLG2E3 ubiquitin-protein ligase RGLG2; E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance. Mediates ubiquitination and subsequent proteasomal degradation of ERF053 in response to drought stress. Acts as a negative regulator of drought stress response. (468 aa)
AIRP2E3 ubiquitin-protein ligase AIRP2; Possesses E3 ubiquitin-protein ligase activity in vitro when associated with the E2 enzyme UBC8 in vitro. Plays combinatory roles with AIRP1 in the positive regulation of the abscisic acid-mediated drought stress response. Plays a positive role in abscisic acid- and high salinity-regulated seed germination through the ubiquitin-proteasome- dependent down-regulation of ATP1/SDIRIP1. (242 aa)
SDIR1E3 ubiquitin-protein ligase SDIR1; E3 ubiquitin-protein ligase that acts as a positive regulator of abscisic acid-related stress signal transduction. Interacts with and ubiquitinates ATP1/SDIRIP1 to modulate ATP1/SDIRIP1 stability through the 26S proteasome pathway. Regulates abscisic acid (ABA) and salt stress responses by negatively affecting ATP1/SDIRIP1 stability. The SDIR1-ATP1/SDIRIP1 complex plays an important role in ABA signaling through the ubiquitination pathway. (273 aa)
NCA1Protein NCA1; Has holdase chaperone activity that may fold catalase to a functional structure. Not required for the peroxisome import of catalases. Required for the activity of catalases and acts mainly at the post-transcriptional level. (405 aa)
ABF4ABSCISIC ACID-INSENSITIVE 5-like protein 7; Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter. (431 aa)
ABF3ABSCISIC ACID-INSENSITIVE 5-like protein 6; Binds to the ABA-responsive element (ABRE). Mediates stress- responsive ABA signaling; Belongs to the bZIP family. ABI5 subfamily. (454 aa)
DRIP1E3 ubiquitin protein ligase DRIP1; E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress. Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A. Functionally redundant with DRIP2. (421 aa)
EBF1EIN3-binding F-box protein 1; Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins. Confers insensitivity to ethylene. (628 aa)
ERF053Ethylene-responsive transcription factor ERF053; Transcriptional activator involved in abiotic stress tolerance. Can directly regulate stress-related gene expression by binding to the DNA sequence 5'-[AG]CCGAC-3' (DRE element) of their promoter region. Involved in the regulation of stomatal closure movement under drought stress. Acts as a positive regulator of drought stress response. (336 aa)
MDAR3Monodehydroascorbate reductase 3; Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process. Required for producing sufficient ascorbate to maintain the interaction between Piriformospora indica and Arabidopsis in a mutualistic state. (441 aa)
RGLG1E3 ubiquitin-protein ligase RGLG1; E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance. Together with RGLG5, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA. Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling. Acts as a negative regulator of drought stress response. (489 aa)
OSCA1Protein OSCA1; Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions. Shows the following permeability sequence: K(+) > Ba(2+) = Ca(2+) > Na(+) = Mg(2+) = Cs(+). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions. Belongs to the CSC1 (TC 1.A.17) family. (772 aa)
RHA2AE3 ubiquitin-protein ligase RHA2A; E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development. Acts additively with RHA2B in regulating ABA signaling and drought response. Possesses E3 ubiquitin ligase activity in vitro. (155 aa)
RHA2BE3 ubiquitin-protein ligase RHA2B; E3 ubiquitin-protein ligase involved in the positive regulation of abscisic acid (ABA) signaling and responses to salt and osmotic stresses during seed germination and early seedling development. Acts additively with RHA2A in regulating ABA signaling and drought response. Possesses E3 ubiquitin ligase activity in vitro. (147 aa)
MAPKKK18Mitogen-activated protein kinase kinase kinase 18; Component of the abscisic acid (ABA) signaling pathway that acts as ABA signal transducer in the context of abiotic stresses. Triggers MPK1, MPK2, MPK7 and MPK14 activation in a MKK3-dependent manner and MPK6 activation in a MKK3-independent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module. Positive regulator of ABA responses leading to the induction of gene expression (e.g. RD29B and RAB18) and involved in various responses including stomatal development, stomatal movement, inhibition of germination and root growt [...] (339 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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