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MYB75 MYB75 MYB111 MYB111 OMT1 OMT1 GL3 GL3 MYB114 MYB114 MYB113 MYB113 TT8 TT8 A3G2XYLT A3G2XYLT MYB11 MYB11 F3H F3H CCR1-2 CCR1-2 CCR2-2 CCR2-2 CYP75B1 CYP75B1 PAL4 PAL4 MYB4 MYB4 TTG1 TTG1 MYB90 MYB90 F5F19.5 F5F19.5 F7H19.50 F7H19.50 MYB12 MYB12 ANS ANS CHS CHS PAL1 PAL1 PAL2 PAL2 PAL3 PAL3 DFRA DFRA CYP73A5 CYP73A5 ANL2 ANL2 MYB7 MYB7 CYP84A1 CYP84A1 MYB86 MYB86 LDOX LDOX FLS1 FLS1 MYBL2 MYBL2 BHLH2 BHLH2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene co-occurrence
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MYB75Transcription factor MYB75; Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of. phenylpropanoid-derived compounds such as anthocyanins and proanthocyanidin, probably together with GL3 and BHLH2. Regulates the expression of CHS, DFRA, LDOX, and BAN. (248 aa)
MYB111Transcription factor MYB111; Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis primarily in cotyledons and leaves. Confers tolerance to UV-B. (342 aa)
OMT1Flavone 3'-O-methyltransferase 1; Methylates OH residues of flavonoid compounds. Converts quercetin into isorhamnetin. Dihydroquercetin is not a substrate. Catalyzes the methylation of monolignols, the lignin precursors. Does not contribute to the phenylpropanoid pattern of the pollen tryphine, but is probably confined to isorhamnetin glycoside biosynthesis. Involved in melatonin biosynthesis. Can function as acetylserotonin O- methyltransferase. Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Belongs to the class I- [...] (363 aa)
GL3Transcription factor GLABRA 3; Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication. Regulates also trichome cell wall maturation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell form [...] (637 aa)
MYB114Transcription factor MYB114; Transcription activator, when associated with BHLH002/EGL3/MYC146, BHLH012/MYC1, or BHLH042/TT8. (139 aa)
MYB113Transcription factor MYB113; Transcription activator, when associated with BHLH002/EGL3/MYC146, BHLH012/MYC1, or BHLH042/TT8. (246 aa)
TT8Transcription factor TT8; Transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression. (518 aa)
A3G2XYLTAnthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase; Contributes to the last few anthocyanin biosynthetic steps. Converts cyanidin 3-O-glucoside to cyanidin 3-O-xylosyl(1->2)glucoside. Can use 3-O-glucosylated anthocyanidins/flavonols and uridine diphosphate (UDP)-xylose as substrates. (468 aa)
MYB11Transcription factor MYB11; Modulates overall growth by reducing the proliferation activity of meristematic cells and delaying development. Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Confers tolerance to UV-B. (343 aa)
F3HNaringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants. (358 aa)
CCR1-2Cinnamoyl-CoA reductase 1; Involved in the latter stages of lignin biosynthesis. Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes. (344 aa)
CCR2-2Cinnamoyl-CoA reductase 2; Cinnamoyl-CoA reductase probably involved in the formation of phenolic compounds associated with the hypersensitive response. Seems not to be involved in lignin biosynthesis. Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. (332 aa)
CYP75B1Flavonoid 3'-monooxygenase; Catalyzes the 3'-hydroxylation of the flavonoid B-ring to the 3',4'-hydroxylated state. Convert naringenin to eriodictyol and dihydrokaempferol to dihydroquercetin; Belongs to the cytochrome P450 family. (513 aa)
PAL4Phenylalanine ammonia-lyase 4; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (707 aa)
MYB4Transcription repressor MYB4; Transcription repressor involved in regulation of protection against UV. Mediates transcriptional repression of CYP73A5, the gene encoding trans-cinnamate 4-monooxygenase, thereby regulating the accumulation of the UV-protectant compound sinapoylmalate. (282 aa)
TTG1Protein TRANSPARENT TESTA GLABRA 1; May regulate MYC transcription factors. Involved in epidermal cell fate specification such as trichome and root hair development, seed mucilage production, and anthocyanin biosynthesis by acting at the dihydroflavonol-4-reductase (DFR) step. Together with GL1 and GL3, promotes trichome formation. Activates the transcription of GL2. (341 aa)
MYB90Transcription factor MYB90; Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of phenylpropanoid-derived compounds such as anthocyanins. (249 aa)
F5F19.5O-methyltransferase family protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. (363 aa)
F7H19.502-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein. (153 aa)
MYB12Transcription factor MYB12; Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis mainly in the root. Confers tolerance to UV-B. (371 aa)
ANSProbable 2-oxoglutarate-dependent dioxygenase ANS; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. (353 aa)
CHSChalcone synthase; The primary product of this enzyme is 4,2',4',6'- tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. (395 aa)
PAL1Phenylalanine ammonia-lyase 1; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (725 aa)
PAL2Phenylalanine ammonia-lyase 2; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton; Belongs to the PAL/histidase family. (717 aa)
PAL3Phenylalanine ammonia-lyase 3; This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton. (694 aa)
DFRADihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism. (382 aa)
CYP73A5Trans-cinnamate 4-monooxygenase; Controls carbon flux to pigments essential for pollination or UV protection, to numerous pytoalexins synthesized by plants when challenged by pathogens, and to lignins. (505 aa)
ANL2Homeobox-leucine zipper protein ANTHOCYANINLESS 2; Probable transcription factor involved in the regulation of the tissue-specific accumulation of anthocyanins and in cellular organization of the primary root. (802 aa)
MYB7Transcription factor MYB7; Transcription factor involved in the negative regulation of flavonol biosynthesis. Represses the early phenylpropanoid genes, phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H) and 4- coumarate-CoA ligase (4CL), as well as the flavonoid-specific genes, flavonoid 3'-hydroxylase (F3'H) and dihydroflavonol 4-reductase (DFR). Plays a role in seed germination inhibition. Negatively regulates the expression of the abscisic acid (ABA) signaling transcription factor ABI5 in seeds. (269 aa)
CYP84A1Cytochrome P450 84A1. (520 aa)
MYB86Transcription factor MYB86; Probable transcription factor. (352 aa)
LDOXLeucoanthocyanidin dioxygenase; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. Possesses low flavonol synthase activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family. (356 aa)
FLS1Flavonol synthase/flavanone 3-hydroxylase; Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol. Belongs to the iron/ascorbate-dependent oxidoreductase family. (336 aa)
MYBL2Putative transcription factor; 20982-20139. (195 aa)
BHLH2Transcription factor EGL1; Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involve [...] (596 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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