STRINGSTRING
RPK2 RPK2 CLE26 CLE26 F1I21.19 F1I21.19 LHCB1.1 LHCB1.1 ARF5 ARF5 ABI3 ABI3 IP5P7 IP5P7 ATHB-8 ATHB-8 PIP5K1 PIP5K1 TIR1 TIR1 AGD3 AGD3 CLE45 CLE45 PIP5K2 PIP5K2 CLE17 CLE17 CLE25 CLE25 PIN4 PIN4 PIN7 PIN7 CUL1 CUL1 AUX1 AUX1 PIN5 PIN5 LAX1 LAX1 PIN8 PIN8 IP5P6 IP5P6 PIN3 PIN3 CALS7 CALS7 PIN6 PIN6 CUL2 CUL2 CLV3 CLV3 VIK VIK F23H11.12 F23H11.12 F23H11.11 F23H11.11 BRL2 BRL2 RPK1 RPK1 ARF6 ARF6 DOF2.2 DOF2.2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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RPK2LRR receptor-like serine/threonine-protein kinase RPK2; Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis). (1151 aa)
CLE26CLAVATA3/ESR (CLE)-related protein 26; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (118 aa)
F1I21.19Putative cullin-like protein 1; Belongs to the cullin family. (721 aa)
LHCB1.1Chlorophyll a-b binding protein 2, chloroplastic; The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated; Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family. (267 aa)
ARF5Auxin response factor 5; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity. (902 aa)
ABI3B3 domain-containing transcription factor ABI3; Participates in abscisic acid-regulated gene expression during seed development. Regulates the transcription of SGR1 and SGR2 that are involved in leaf and embryo degreening. (720 aa)
IP5P7Type IV inositol polyphosphate 5-phosphatase 7; Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3. Acts redundantly with CVP2 for maintaining vascular continuity. Regulates phosphoinositide-dependent VAN3 localization. Functions in salt stress response by regulating reactive oxygen species (ROS) production and stress- responsive genes expression. Belongs to the inositol polyphosphate 5-phosphatase family. (594 aa)
ATHB-8Homeobox-leucine zipper protein ATHB-8; Probable transcription factor involved in the regulation of vascular development. May promote differentiation of precambial and cambial cells. (833 aa)
PIP5K1Phosphatidylinositol 4-phosphate 5-kinase 1; Catalyzes the synthesis of phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4-bisphosphate. (752 aa)
TIR1Protein TRANSPORT INHIBITOR RESPONSE 1; Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae. (594 aa)
AGD3ADP-ribosylation factor GTPase-activating protein AGD3; GTPase-activating protein (GAP) for ADP ribosylation factor (ARF). Involved in the spatial control of provascular differentiation. Required for the formation of the normal pattern of continuous secondary veins. Involved in auxin signaling but not in polar auxin transport or in auxin responses. Required for PIN1 internalization in roots. (827 aa)
CLE45CLAVATA3/ESR (CLE)-related protein 45; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Prevents, in a dose-dependent manner, auxin response in the root meristem thus leading in the repression of protophloem differentiation and periclinal sieve element precursor cell division. (124 aa)
PIP5K2Phosphatidylinositol 4-phosphate 5-kinase 2; Possesses phosphatidylinositol kinase activity in vitro. (754 aa)
CLE17CLAVATA3/ESR (CLE)-related protein 17; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (99 aa)
CLE25CLAVATA3/ESR (CLE)-related protein 25; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (81 aa)
PIN4Auxin efflux carrier component 4; Acts as a component of the auxin efflux carrier. Plays a role in generating a sink for auxin into columella cells. Maintains the endogenous auxin gradient, which is essential for correct root patterning. Involved in EXO70A3-regulated gravitropic responses in columella cells and in root system architecture (RSA). (616 aa)
PIN7Auxin efflux carrier component 7; Acts as a component of the auxin efflux carrier. Mediates the initial auxin gradient which contributes to the establishment of the apical-basal axis in early embryogenesis. (619 aa)
CUL1Cullin-1; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(A [...] (738 aa)
AUX1Auxin transporter protein 1; Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. Unloads auxin from the mature phloem to deliver the hormone to the root meristem via the protophloem cell files. Coordinated subcellular localization of AUX1 is regula [...] (485 aa)
PIN5Auxin efflux carrier component 5; Auxin transporter regulating intracellular auxin homeostasis and metabolism. Mediates the auxin transport from the cytosol into the lumen of the endoplasmic reticulum. May also act as an auxin efflux carrier when located to the cell membrane. PIN5 and PIN8 may have an antagonistic/compensatory activity. Involved in unfolded protein response (UPR) activation. Involved in the control of vein patterning. Promotes vein formation. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells. (351 aa)
LAX1Auxin transporter-like protein 1; Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity). (488 aa)
PIN8Auxin efflux carrier component 8; Component of the intracellular auxin-transport pathway in the male gametophyte. Involved in the regulation of auxin homeostasis in pollen. Involved in the efflux of auxin from the endoplasmic reticulum into the cytoplasm. PIN5 and PIN8 may have an antagonistic/compensatory activity. Involved in the control of vein patterning. Redundantly with PIN6, inhibits the vein-formation- promoting functions of PIN5. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells. (367 aa)
IP5P6Type IV inositol polyphosphate 5-phosphatase 6; Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway. Acts redundantly with CVL1 for maintaining vascular continuity. Regulates phosphoinositide-dependent VAN3 localization. Belongs to the inositol polyphosphate 5-phosphatase family. (617 aa)
PIN3Auxin efflux carrier component 3; Acts as a component of the auxin efflux carrier. Seems to be involved in the lateral auxin transport system and mediates tropic growth. Coordinated polar localization of PIN3 is directly regulated by the vesicle trafficking process. (640 aa)
CALS7Callose synthase 7; Involved in callose synthesis at the forming cell plate during cytokinesis. During plant growth and development, callose is found as a transitory component of the cell plate in dividing cells, is a major component of pollen mother cell walls and pollen tubes, and is found as a structural component of plasmodesmatal canals (By similarity). (1958 aa)
PIN6Auxin efflux carrier component 6; Component of the intracellular auxin-transport pathway. Regulates auxin transport and auxin homeostasis. Directly involved in the regulation of nectar production. Involved in unfolded protein response (UPR) activation. Involved in the control of vein patterning. Redundantly with PIN8, inhibits the vein-formation-promoting functions of PIN5. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells. Belongs to the auxin efflux carrier (TC 2.A.69.1) family. (570 aa)
CUL2Cullin-2; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Involved in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). (742 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
VIKVH1-interacting kinase. (438 aa)
F23H11.12Cullin-like protein 3; Belongs to the cullin family. (255 aa)
F23H11.11Putative cullin-like protein 2; Belongs to the cullin family. (374 aa)
BRL2Serine/threonine-protein kinase BRI1-like 2; Receptor with a serine/threonine-protein kinase activity, which may transduce extracellular spatial and temporal signals into downstream cell differentiation responses in provascular and procambial cells. In contrast to BRI1, BRL1 and BRL3, it does not bind brassinolide. (1143 aa)
RPK1Probable LRR receptor-like serine/threonine-protein kinase RPK1; Involved in the main abscisic acid-mediated (ABA) signaling pathway and in early ABA perception. Together with RPK2, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical- basal axis (e.g. differentiation of the basal pole during early embryogenesis). (540 aa)
ARF6Auxin response factor 6; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Regulates both stamen and gynoecium maturation. Promotes jasmonic acid production. Partially redundant with ARF8. (935 aa)
DOF2.2Dof zinc finger protein DOF2.2; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence. (340 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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