STRINGSTRING
NUP96 NUP96 NUP58 NUP58 NUP85 NUP85 HTT5 HTT5 PIF4 PIF4 SEH1 SEH1 HSFB1 HSFB1 NUP160 NUP160 NUP1 NUP1 NUP88 NUP88 HSFA4C HSFA4C CG1 CG1 HSFA1D HSFA1D HSFA9 HSFA9 HSFA1E HSFA1E NSP1 NSP1 MED18 MED18 HSP70-8 HSP70-8 MED14 MED14 REF6 REF6 HSFB2B HSFB2B NUA NUA NUP214 NUP214 NUP133 NUP133 MED16 MED16 SOC1 SOC1 SEC13B SEC13B HSFA2 HSFA2 HSFA1B HSFA1B HSP21 HSP21 HSFA1A HSFA1A CLPB1 CLPB1 IAA17 IAA17 LFY LFY GLE1 GLE1 NUP43 NUP43 HSP22.0 HSP22.0 RAE1 RAE1 HOS1 HOS1 AAAS AAAS NDC1 NDC1 NUP54 NUP54 HSFA3 HSFA3 NUP107 NUP107 NUP62 NUP62
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NUP96Nuclear pore complex protein NUP96; Contributes to the transfer of mature mRNA from the nucleus to the cytosol. Required for both R gene-mediated and basal disease resistance. RNA export seems to play a critical role in stress responses and regulation of plant growth and development. (1046 aa)
NUP58Nuclear pore complex protein NUP58; Involved in nucleocytoplasmic trafficking. May have regulatory roles in the gibberellin pathway, in auxin signaling and in light perception. (513 aa)
NUP85Nuclear pore complex protein NUP85; Functions as component of the nuclear pore complex (NPC). (716 aa)
HTT5Protein HEAT-INDUCED TAS1 TARGET 5; Mediates both basal and acquired thermotolerance. Belongs to the heat induced plant HTT protein family. (178 aa)
PIF4Transcription factor PIF4; Transcription factor acting negatively in the phytochrome B signaling pathway. May regulate the expression of a subset of genes involved in cell expansion by binding to the G-box motif (By similarity). Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box variant 5'-CA[CT]GTG-3' to stimulate specific gene expression to adapt global physiology (e.g. hypocotyl elongation in low blue light). Belongs to the bHLH protein family. (430 aa)
SEH1Protein SEH1; Required for proper export of mRNAs from the nucleus to the cytoplasm; Belongs to the WD repeat SEC13 family. (326 aa)
HSFB1Heat stress transcription factor B-1; Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE); Belongs to the HSF family. Class B subfamily. (284 aa)
NUP160Nuclear pore complex protein NUP160; Contributes to the transfer of mature mRNA from the nucleus to the cytosol. Required for both R gene-mediated and basal disease resistance. RNA export seems to play a critical role in stress responses and regulation of plant growth and development. Required for proper expression of factors associated with auxin signaling. (1495 aa)
NUP1Nuclear pore complex protein NUP1; Nucleoporin required for nuclear mRNA export. Functions as an adapter and/or regulator molecule in the periphery of the nuclear pore complex (NPC). May interact with importin proteins and mediate active nucleocytoplasmic transport through the NPC. Involved in regulation of nuclear morphology. (1309 aa)
NUP88Nuclear pore complex protein NUP88; Involved in the regulation of exportin-mediated nuclear protein export. Required for resistance mediated by multiple R proteins and for the appropriate nuclear accumulation of SNC1 and of the downstream defense signaling components EDS1 and NPR1. Not involved in salt tolerance, ethylene and auxin responses, but required for systemic acquired resistance. (810 aa)
HSFA4CHeat stress transcription factor A-4c; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). May be involved in general response to auxin. (345 aa)
CG1Zinc finger CCCH domain-containing protein 16. (435 aa)
HSFA1DHeat stress transcription factor A-1d; Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). (485 aa)
HSFA9Heat stress transcription factor A-9; Seed-specific transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Seems to be specialized for the developmental expression of heat shock protein (HSP) genes during seed maturation. Activated by ABI3; Belongs to the HSF family. Class A subfamily. (331 aa)
HSFA1EHeat stress transcription factor A-1e; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). (468 aa)
NSP1Nitrile-specifier protein 1; Responsible for constitutive and herbivore-induced simple nitrile formation. Promotes simple nitriles, but not epithionitrile or thiocyanate formation. Converts allylglucosinolate, 4- methylsulfinylbutylglucosinolate, 4-methylthiobutylglucosinolate and benzylglucosinolate to their corresponding simple nitriles in the presence of myrosinase; Belongs to the jacalin lectin family. (470 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general [...] (219 aa)
HSP70-8Heat shock 70 kDa protein 8; In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions. (563 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general [...] (1703 aa)
REF6Lysine-specific demethylase REF6; Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3. Demethylates both tri- (H3K27me3) and di-methylated (H3K27me2) H3K27me. Demethylates also H3K4me3/2 and H3K36me3/2 in an in vitro assay. Involved in the transcriptional regulation of hundreds of genes regulating developmental patterning and responses to various stimuli. Binds DNA via its four zinc fingers in a sequence- specific manner, 5'-CTCTGYTY-3', to promote the demethylation of H3K27me3 and the regulation of organ boundary formation. Involved in the regulation of flowering ti [...] (1360 aa)
HSFB2BHeat stress transcription factor B-2b; Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). (377 aa)
NUANuclear-pore anchor; Component of the nuclear pore complex. Acts as a docking site for activities required for desumoylation and mRNA export. Required for the proper expression or localization of a subset of miRNAs. Plays a role in meristematic cell division by interacting with spindle assembly checkpoint proteins. (2093 aa)
NUP214Nuclear pore complex protein NUP214; Required for normal embryogenesis and seed viability. Involved in the first asymmetrical cell division of the zygote. Regulates the number and planes of cell divisions required for generating the normal embryo proper and suspensor, apical-basal axis, cotyledons and meristem. (1819 aa)
NUP133Nuclear pore complex protein NUP133; Belongs to the nucleoporin Nup133 family. (1285 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general [...] (1278 aa)
SOC1MADS-box protein SOC1; Transcription activator active in flowering time control. May integrate signals from the photoperiod, vernalization and autonomous floral induction pathways. Can modulate class B and C homeotic genes expression. When associated with AGL24, mediates effect of gibberellins on flowering under short-day conditions, and regulates the expression of LEAFY (LFY), which links floral induction and floral development. (214 aa)
SEC13BProtein transport protein SEC13 homolog B; Required for protein transport from the endoplasmic reticulum to the Golgi apparatus. (302 aa)
HSFA2Heat stress transcription factor A-2; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). Belongs to the HSF family. Class A subfamily. (345 aa)
HSFA1BHeat stress transcription factor A-1b; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE); Belongs to the HSF family. Class A subfamily. (481 aa)
HSP21Heat shock protein 21, chloroplastic; Chaperone protein required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription. Belongs to the small heat shock protein (HSP20) family. (227 aa)
HSFA1AHeat stress transcription factor A-1a; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE); Belongs to the HSF family. Class A subfamily. (495 aa)
CLPB1Chaperone protein ClpB1; Molecular chaperone that plays an important role in thermotolerance. Together with HSA32, required for long-term acquired thermotolerance (LAT) in plants and naturally high basal thermotolerance observed in germinating seedlings. Belongs to the ClpA/ClpB family. (911 aa)
IAA17Auxin-responsive protein IAA17; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin- responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. (229 aa)
LFYProtein LEAFY; Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1. Is required subsequently for the transition of an inflorescence meristem into a floral meristem, by an immediate upstream regulation of the ABC classes of floral homeotic genes. Activates directly APETALA1, CAULIFLOWER and AGAMOUS, and indirectly APETALA3 and PISTILLATA with the cooperation of UFO. Belongs to the FLO/LFY family. (420 aa)
GLE1Protein GLE1; Required for seed viability; Belongs to the GLE1 family. (611 aa)
NUP43Nuclear pore complex protein NUP43. (361 aa)
HSP22.022.0 kDa heat shock protein. (195 aa)
RAE1Protein RAE1. (349 aa)
HOS1E3 ubiquitin-protein ligase HOS1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1. Acts as a negative regulator of cold signaling pathways. Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable). Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels. (927 aa)
AAASAladin. (447 aa)
NDC1Alternative NAD(P)H-ubiquinone oxidoreductase C1, chloroplastic/mitochondrial; Bifunctional oxidoreductase ables to act both on prenyl naphthoquinones and on prenyl benzoquinones. May serve a respiratory function. Involved in an electron flow toward the plastoglobule plastoquinone pool. Required for plastochromanol-8 accumulation and for phylloquinone (vitamin K1) production. Probably not directly involved in cyclic or chlororespiratory electron flows under standard growth conditions, but participates in the redox metabolism of plastoquinone-9 and the tocophrol recycling-intermediate a [...] (519 aa)
NUP54Nuclear pore complex protein NUP54. (377 aa)
HSFA3Heat stress transcription factor A-3; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress response. Activated by DREB2A under heat stress; Belongs to the HSF family. Class A subfamily. (412 aa)
NUP107Nuclear pore complex protein NUP107. (1101 aa)
NUP62Nuclear pore complex protein NUP62. (739 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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