STRINGSTRING
GOLS3 GOLS3 CSLB1 CSLB1 CSLB2 CSLB2 HSFA2 HSFA2 DREB2A DREB2A APT1 APT1 ARF7 ARF7 LTI65 LTI65 RD29A RD29A CSLG3 CSLG3 HSFA6A HSFA6A IPS2 IPS2 NAC002 NAC002 COR15A COR15A CSLG1 CSLG1 SPX3 SPX3 PHO1-H10 PHO1-H10 PYL9 PYL9 CSLA1 CSLA1 SDI1 SDI1 SPX1 SPX1 PHO1 PHO1 CSLG2 CSLG2 WSD1 WSD1 NAC081 NAC081 ABA3 ABA3 NAC019 NAC019 SAG113 SAG113 AMI1 AMI1 GAPC2 GAPC2 GOLS2 GOLS2 MYB102 MYB102 NAC055 NAC055 LTP4 LTP4 NCED3 NCED3 AOC2 AOC2 BHLH28 BHLH28 MBF1C MBF1C MYB11 MYB11 MYB41 MYB41 MYB74 MYB74 F6a14.18 F6a14.18 LSU1 LSU1 WER WER ABI5 ABI5 ERF053 ERF053 MYB77 MYB77 MYB49 MYB49 HSFA7A HSFA7A MYB90 MYB90 MAPKKK18 MAPKKK18 NAC072 NAC072 NAC098 NAC098 PXG3 PXG3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GOLS3Galactinol synthase 3; Galactinol synthase involved in the biosynthesis of raffinose family oligosaccharides (RFOs) that function as osmoprotectants. May promote plant stress tolerance (By similarity). (334 aa)
CSLB1Cellulose synthase-like protein B1; Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall. (757 aa)
CSLB2Cellulose synthase-like protein B2; Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall. (757 aa)
HSFA2Heat stress transcription factor A-2; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). Belongs to the HSF family. Class A subfamily. (345 aa)
DREB2ADehydration-responsive element-binding protein 2A; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription. Belongs to the AP2/ERF transcription factor family. ERF subfamily. (335 aa)
APT1Adenine phosphoribosyltransferase 1, chloroplastic; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Contributes primarily to the recycling of adenine into adenylate nucleotides, but is also involved in the inactivation of cytokinins by phosphoribosylation. Catalyzes the conversion of cytokinins from free bases (active form) to the corresponding nucleotides (inactive form). Belongs to the purine/pyrimidine phosphoribosyltransferase family. (243 aa)
ARF7Auxin response factor 7; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Act as a transcriptional activator of several tropic stimulus-induced (TSI) genes, including SAUR50. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Required for differential growth responses of aerial tissues. Involved in ethylene responses. Regulates lateral root formation through direct regulation of LBD16 and/or LB [...] (1164 aa)
LTI65Low-temperature-induced 65 kDa protein; Belongs to the LTI78/LTI65 family. (619 aa)
RD29ALow-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family. (710 aa)
CSLG3Cellulose synthase-like protein G3; Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall; Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like G subfamily. (751 aa)
HSFA6AHeat stress transcription factor A-6a; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). (282 aa)
IPS2Inositol-3-phosphate synthase isozyme 2; Involved in myo-inositol synthesis. (510 aa)
NAC002NAC domain-containing protein 2. (289 aa)
COR15AProtein COLD-REGULATED 15A, chloroplastic; Exhibits cryoprotective activity toward stromal substrates (e.g. LDH and rubisco) in chloroplasts and in protoplasts and confers freezing tolerance to plants in a CBF-dependent manner. Protectant against various stresses (e.g. cold, drought and heat stress) by preventing protein aggregation (e.g. LDH) and attenuating enzyme inactivation. Influences the intrinsic curvature of the inner membrane of the chloroplast envelope, and modulates the freeze-induced lamellar-to-hexagonal II phase transitions that occur in regions where the plasma membrane [...] (139 aa)
CSLG1Cellulose synthase-like protein G1; Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall. (760 aa)
SPX3SPX domain-containing protein 3; Plays a positive role in plant adaptation to phosphate starvation and exerts negative feedback regulation of SPX1. (245 aa)
PHO1-H10Phosphate transporter PHO1 homolog 10; May transport inorganic phosphate (Pi); Belongs to the SYG1 (TC 2.A.94) family. (777 aa)
PYL9Abscisic acid receptor PYL9; Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) in an ABA- independent manner but more efficiently when activated by ABA. Confers enhanced sensitivity to ABA. Can be activated only by (+)-ABA but not by (-)-ABA. (187 aa)
CSLA1Probable glucomannan 4-beta-mannosyltransferase 1; Probable mannan synthase which consists of a 4-beta- mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4- mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. (553 aa)
SDI1Protein SULFUR DEFICIENCY-INDUCED 1; Involved in the utilization of stored sulfate under sulfur- deficient conditions; Belongs to the MS5 protein family. (306 aa)
SPX1SPX domain-containing protein 1; Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner. (256 aa)
PHO1Phosphate transporter PHO1; Inositol polyphosphate sensor that associates with transcription factors to regulate inorganic phosphate (Pi) starvation responses. Probably acts by binding inositol polyphosphate via its SPX domain. Acts as a Pi exporter, mediating efflux of Pi out of cells. Transfers Pi from the epidermal and cortical cells to the root xylem vessels. Involved in the transfer of Pi from roots to shoots. Involved in abscisic acid (ABA) induction of stomatal closure and ABA repression of stomatal opening. Belongs to the SYG1 (TC 2.A.94) family. (782 aa)
CSLG2Cellulose synthase-like protein G2; Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall. (722 aa)
WSD1O-acyltransferase WSD1; Bifunctional wax ester synthase/diacylglycerol acyltransferase. Involved in cuticular wax biosynthesis. In the N-terminal section; belongs to the long-chain O- acyltransferase family. (481 aa)
NAC081Protein ATAF2; Involved in disease resistance response. May function as repressor of pathogenesis-related proteins. May function in the regulation of host basal defense responses against viral infection. Transcriptional activator involved in responses to wounding and infection with tobamovirus (TMV). Binds to the DNA sequences 5'-AAAATATCT-3' and 5'AGATTTTT-3' of CYP734A1/BAS1 and CYP72C1/SOB7 promoters, respectively. Acts as suppressor of the brassinosteroid (BR)-inactivating enzymes CYP734A1/BAS1 and CYP72C1/SOB7, and prevents their expression in almost all tissues. Plays a central r [...] (283 aa)
ABA3Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. Modulates cold stress- and osmotic stress-responsive gene expression by acting as key regulator of abscisic acid (ABA) biosynthesis. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. (819 aa)
NAC019NAC domain-containing protein 19; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
SAG113Probable protein phosphatase 2C 78; Acts as negative regulator of abscisic acid (ABA) signaling for stomatal closure in leaves, and controls water loss during leaf senescence. Activated by the NAC029/NAP transcription factor during ABA signaling in senescing leaves. Functions as negative regulator of osmotic stress and ABA signaling. Acts as negative regulator of response to drought. Belongs to the PP2C family. (413 aa)
AMI1Amidase 1; Amidase involved in auxin biosynthesis. Converts indole-3- acetamide to indole-3-acetate. Converts phenyl-2-acetamide (PAM) to phenyl-2-acetate. Substrate preference is PAM > IAM. Can also use L-asparagine, oleamide and 1-naphtalene-acetamide as substrates, but not indole-3- acetonitrile or indole-3-acetyl-L-aspartic acid. (425 aa)
GAPC2Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. (338 aa)
GOLS2Galactinol synthase 2; Galactinol synthase involved in the biosynthesis of raffinose family oligosaccharides (RFOs) that function as osmoprotectants. Promotes stress tolerance of factors such as drought, chilling, salinity and methylviologen (MV), a superoxide radical generating drug, by mediating an increase in levels of the endogenous osmoprotective compounds, galactinol and raffinose; Belongs to the glycosyltransferase 8 family. Galactosyltransferase subfamily. (335 aa)
MYB102Transcription factor MYB102; Probable transcription factor that may function in osmotic stress and wounding signaling pathways (Probable). Contributes to basal resistance against the herbivore Pieris rapae (white cabbage butterfly) feeding. (350 aa)
NAC055NAC domain-containing protein 55; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
LTP4Non-specific lipid-transfer protein 4; Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity). (112 aa)
NCED39-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic; Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid biosynthesis from carotenoids, in response to water stress. (599 aa)
AOC2Allene oxide cyclase 2, chloroplastic; Involved in the production of 12-oxo-phytodienoic acid (OPDA), a precursor of jasmonic acid; Belongs to the allene oxide cyclase family. (253 aa)
BHLH28Transcription factor bHLH28. (511 aa)
MBF1CMultiprotein-bridging factor 1c; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. Involved in the tolerance to heat and osmotic stress by partially activating the ethylene-response signal transduction pathway. Belongs to the MBF1 family. (148 aa)
MYB11Transcription factor MYB11; Modulates overall growth by reducing the proliferation activity of meristematic cells and delaying development. Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Confers tolerance to UV-B. (343 aa)
MYB41Transcription factor MYB41; Transcription factor involved in salt stress response. Confers tolerance to salt stress. Involved in distinct cellular processes in response to osmotic stress, including control of primary metabolism and negative regulation of short-term transcriptional responses to osmotic stress. Can activate the steps necessary for aliphatic suberin synthesis and deposition of cell wall-associated suberin-like lamellae. Involved in the production of aliphatic suberin under abiotic stress conditions. (282 aa)
MYB74Transcription factor MYB74; Probable transcription factor that may function in salt stress response. (324 aa)
F6a14.18Putative MYB47 transcription factor. (267 aa)
LSU1Protein RESPONSE TO LOW SULFUR 1. (94 aa)
WERTranscription factor WER; Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC. (203 aa)
ABI5Protein ABSCISIC ACID-INSENSITIVE 5; Participates in ABA-regulated gene expression during seed development and subsequent vegetative stage by acting as the major mediator of ABA repression of growth. Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 and Em6 genes promoters. Can also trans- activate its own promoter, suggesting that it is autoregulated. Plays a role in sugar-mediated senescence. Belongs to the bZIP family. ABI5 subfamily. (442 aa)
ERF053Ethylene-responsive transcription factor ERF053; Transcriptional activator involved in abiotic stress tolerance. Can directly regulate stress-related gene expression by binding to the DNA sequence 5'-[AG]CCGAC-3' (DRE element) of their promoter region. Involved in the regulation of stomatal closure movement under drought stress. Acts as a positive regulator of drought stress response. (336 aa)
MYB77Transcription factor MYB77; Transcription factor involved in auxin response. Functions in auxin signal transduction and modulates lateral root growth. Interacts with ARF response factors to promote auxin-responsive gene expression. In response to auxin, binds sequence-specific motifs in the promoter of the auxin-responsive gene IAA19, and activates IAA19 transcription. The IAA19 transcription activation by MYB77 is enhanced by direct interaction between MYB77 and PYL8. (301 aa)
MYB49Myb-related transcription factor-like protein. (319 aa)
HSFA7AHeat stress transcription factor A-7a; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). (272 aa)
MYB90Transcription factor MYB90; Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of phenylpropanoid-derived compounds such as anthocyanins. (249 aa)
MAPKKK18Mitogen-activated protein kinase kinase kinase 18; Component of the abscisic acid (ABA) signaling pathway that acts as ABA signal transducer in the context of abiotic stresses. Triggers MPK1, MPK2, MPK7 and MPK14 activation in a MKK3-dependent manner and MPK6 activation in a MKK3-independent manner. Mediates the ABA-dependent activation of the MKK3-MPK7 module. Positive regulator of ABA responses leading to the induction of gene expression (e.g. RD29B and RAB18) and involved in various responses including stomatal development, stomatal movement, inhibition of germination and root growt [...] (339 aa)
NAC072NAC domain-containing protein 72; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (297 aa)
NAC098Protein CUP-SHAPED COTYLEDON 2; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of [...] (375 aa)
PXG3Probable peroxygenase 3; Probable calcium-binding peroxygenase. May be involved in the degradation of storage lipid in oil bodies, in abiotic stress-related signaling pathway and in drought tolerance through stomatal control under water deficit conditions. (236 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.