STRINGSTRING
SARD1 SARD1 RGI3 RGI3 CBP60C CBP60C F22D22.11 F22D22.11 CBP60G CBP60G K19M22.8 K19M22.8 WRKY22 WRKY22 BIK1 BIK1 F25I18.9 F25I18.9 CRK23 CRK23 CNGC1 CNGC1 CNGC2 CNGC2 LRK10L-1.2 LRK10L-1.2 PSBR PSBR NPR1 NPR1 CBP60D CBP60D MPK3 MPK3 SAG101 SAG101 NIK2 NIK2 MIK2 MIK2 CRCK2 CRCK2 CRPK1 CRPK1 CNGC4 CNGC4 WRKY6 WRKY6 WRKY18 WRKY18 WRKY9 WRKY9 RBOHD RBOHD WRKY8 WRKY8 MOJ9.11 MOJ9.11 LRR1 LRR1 ADR1 ADR1 CRK35 CRK35 RCH2 RCH2 CES101 CES101 WRKY70 WRKY70 ADR1-L2 ADR1-L2 LBD41 LBD41 PAD4 PAD4 WRKY45 WRKY45 ICS1 ICS1 RBOHB RBOHB CSLC8 CSLC8 WRKY46 WRKY46 CHIP CHIP LEA2 LEA2 WRKY7 WRKY7 EDS1 EDS1 WRKY29 WRKY29 WRKY11 WRKY11 WRKY13 WRKY13 WRKY42 WRKY42
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
RGI3LRR receptor-like serine/threonine-protein kinase; Acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT). Links RGF1 signal with its downstream components. (1091 aa)
CBP60CCalmodulin-binding protein 60 C; Transcription activator that binds DNA in a sequence-specific manner, likely 5'-GAAATTTTGG-3', to promote the expression of target genes. (622 aa)
F22D22.11Transmembrane receptor. (353 aa)
CBP60GCalmodulin-binding protein 60 G; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P. syringae pv. tomato DC3000, and microbe- associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in b [...] (563 aa)
K19M22.8LRR protein. (1089 aa)
WRKY22WRKY transcription factor 22; Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element. Activates WRKY 29, SIRK and its own promoters; Belongs to the WRKY group II-e family. (298 aa)
BIK1Serine/threonine-protein kinase BIK1; Plays a central role in immune responses. Required to activate the resistance responses to necrotrophic pathogens. Phosphorylates FLS2 and BAK1. Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2. Acts additively with PBL1 in PTI defenses. Acts as positive regulator of the PAMP flg22-induced increase of cytosolic calcium. Binds directly and phosphorylates the NADPH oxidase RBOHD at specific sites in a calcium-independent manner to enhance reactive oxygen species (ROS) [...] (395 aa)
F25I18.9Probable leucine-rich repeat receptor-like protein kinase At2g33170. (1124 aa)
CRK23Putative cysteine-rich receptor-like protein kinase 23; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily. (830 aa)
CNGC1Cyclic nucleotide-gated ion channel 1; Acts as cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K(+), Na(+) and Pb(2+). (716 aa)
CNGC2Cyclic nucleotide-gated ion channel 2; Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium, cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis, re- establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs. (726 aa)
LRK10L-1.2LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.2; Probable receptor-like serine/threonine-protein kinase involved in abscisic acid (ABA) signaling. Acts as a positive regulator of abiotic stress response. (651 aa)
PSBRPhotosystem II 10 kDa polypeptide, chloroplastic; Associated with the oxygen-evolving complex of photosystem II. (140 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
CBP60DCalmodulin-binding protein 60 D; Transcription activator that binds DNA in a sequence-specific manner, likely 5'-GAAATTTTGG-3', to promote the expression of target genes; Belongs to the plant ACBP60 protein family. (601 aa)
MPK3Mitogen-activated protein kinase 3; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Mediates the phosphorylation of VIP1 and subsequent stress genes transcription in response to Agrobacterium. MKK9-M [...] (370 aa)
SAG101Senescence-associated carboxylesterase 101; Acyl hydrolase that triggers the leaf senescence onset. Can use triolein as substrate to produce oleic acids. (537 aa)
NIK2Protein NSP-INTERACTING KINASE 2; Involved in defense response to geminivirus infection (By similarity). Phosphorylates RPL10A in vitro; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (635 aa)
MIK2MDIS1-interacting receptor like kinase 2; Involved in the pollen tube perception of the female signal. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1045 aa)
CRCK2Calmodulin-binding receptor-like cytoplasmic kinase 2; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (411 aa)
CRPK1Cold-responsive protein kinase 1; Negative regulator of freezing tolerance that phosphorylates 14-3-3 proteins (e.g. GRF6) thus triggering their translocation from the cytosol to the nucleus in response to cold stress. (390 aa)
CNGC4Cyclic nucleotide-gated ion channel 4; Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and sodium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Might constitute a common downstream component of the signaling pathways leading to hypersensitive response (HR). (694 aa)
WRKY6WRKY transcription factor 6; Transcription factor involved in the control of processes related to senescence and pathogen defense. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes. Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression ; Belongs to the WRKY group II-b family. (553 aa)
WRKY18WRKY transcription factor 18; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Positively modulates defense-related gene expression and disease resistance; Belongs to the WRKY group II-a family. (310 aa)
WRKY9Probable WRKY transcription factor 9; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). (374 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
WRKY8WRKY transcription factor 8; Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring stress-responsive cis-acting element. Functions as positive regulator of salt stress response. Binds the W box of LTI78/RD29A stress-response gene and directly regulates its transcription under salt stress. Functions antagonistically with VQ9 to regulate sodium and potassium homeostasis under salt stress by regulating the expression of downstream SOS (SALT OVERLY SENSITIVE) stress-responsive genes. The DNA-binding activity of WRKY8 is decreased by VQ9. Func [...] (326 aa)
MOJ9.11Probably inactive leucine-rich repeat receptor-like protein kinase At5g06940; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (872 aa)
LRR1Leucine-rich repeat protein 1; Involved in plant defense response. (218 aa)
ADR1Disease resistance protein ADR1; Disease resistance (R) protein that mediates resistance against Hyaloperonospora parasitica in a salicylic acid-dependent manner. Also mediates resistance against Erysiphe cichoracearum is both salicylic acid-dependent and partially NPR1-dependent. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. (787 aa)
CRK35Putative cysteine-rich receptor-like protein kinase 35. (669 aa)
RCH2Receptor-like protein kinase 2; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1141 aa)
CES101G-type lectin S-receptor-like serine/threonine-protein kinase CES101; Promotes the expression of genes involved in photosynthesis at least in dedifferentiated calli. (850 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
ADR1-L2Probable disease resistance protein At5g04720; Probable disease resistance protein; Belongs to the disease resistance NB-LRR family. (811 aa)
LBD41LOB domain-containing protein 41. (263 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
WRKY45Probable WRKY transcription factor 45; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. (147 aa)
ICS1Isochorismate synthase 1, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity. (569 aa)
RBOHBRespiratory burst oxidase homolog protein B; Calcium-dependent NADPH oxidase that generates superoxide; Belongs to the RBOH (TC 5.B.1.3) family. (843 aa)
CSLC8Probable xyloglucan glycosyltransferase 8; Probable beta-1,4-glucan synthase rather involved in the synthesis of the xyloglucan backbone than cellulose. Seems to work simultaneously with xyloglucan 6-xylosyltransferase. Xyloglucan is a noncellulosic polysaccharides of plant cell wall and consists of a glucan backbone substituted by xylose, galactose and fucose (By similarity); Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like C subfamily. (690 aa)
WRKY46Probable WRKY transcription factor 46; Transcription factor involved in the regulation of osmotic stress responses and stomatal movement. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Positive regulator of EDS1-dependent defense against E.amylovora. Together with WRKY70 and WRKY53, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2. Together with WRKY54 and WRKY70, prom [...] (295 aa)
CHIPE3 ubiquitin-protein ligase CHIP; Has E3 ubiquitin-protein ligase activity and may target misfolded substrates towards proteasomal degradation. Regulates the activity of some serine/threonine-protein phosphatases by E3 ubiquitin- protein ligase activity. Required for responses to biotic and abiotic stresses such as auxin, abscisic acid (ABA), low and high temperature and darkness, probably through the activation of serine/threonine- protein phosphatase and the subsequent modification of the plasma membrane composition. Regulates the chloroplastic Clp proteolytic activity in response to [...] (278 aa)
LEA2Late embryogenis abundant protein 2; Belongs to the LEA type 3 family. (91 aa)
WRKY7Probable WRKY transcription factor 7; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-d family. (353 aa)
EDS1Protein EDS1; Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation. Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling. Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid. Nuclear localization is essential for bas [...] (623 aa)
WRKY29Probable WRKY transcription factor 29; Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element. Activates WRKY 22, SIRK and its own promoters; Belongs to the WRKY group II-e family. (304 aa)
WRKY11Probable WRKY transcription factor 11; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Regulates rhizobacterium B.cereus AR156-induced systemic resistance (ISR) to P.syringae pv. tomato DC3000, probably by activating the jasmonic acid (JA)- signaling pathway ; Belongs to the WRKY group II-d family. (325 aa)
WRKY13Probable WRKY transcription factor 13; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (304 aa)
WRKY42WRKY transcription factor 42; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression. (528 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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