STRINGSTRING
DOG1 DOG1 B3H7M7_ARATH B3H7M7_ARATH TGA10 TGA10 AS1 AS1 CCH CCH CAM1 CAM1 CAM2 CAM2 CML10 CML10 PR1-2 PR1-2 TGA2 TGA2 CAM7 CAM7 NPR1 NPR1 CAM6 CAM6 ASK7 ASK7 TGA6 TGA6 TGA4 TGA4 TGA5 TGA5 PR1 PR1 TGA3 TGA3 TGA1 TGA1 NPR4 NPR4 CDKE-1 CDKE-1 MUK11.16 MUK11.16 NPR3 NPR3 WRKY50 WRKY50 TGA9 TGA9 TGA7 TGA7 ATX1 ATX1 GRXC7 GRXC7 SARD1 SARD1 BZIP8 BZIP8 CP1 CP1 HOS15 HOS15 WRKY70 WRKY70 PAN PAN PRB1 PRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DOG1Protein DELAY OF GERMINATION 1; Required for the induction of seed dormancy. The level of DOG1 protein in freshly harvested seeds determines the level of seed dormancy. Determines the temperature window for germination by regulating the expression of micropylar endosperm-weakening genes through temperature control of the gibberellins metabolism. Regulates seed dormancy and flowering time through an influence on levels of microRNAs miR156 and miR172. Regulator of seed maturation interfering with abscisic acid signaling components and activating ABI5. In cv. Cvi-1, enhances glucose induc [...] (291 aa)
B3H7M7_ARATHCorepressor. (170 aa)
TGA10Transcription factor TGA10; Together with TGA9, basic leucine-zipper transcription factor required for anther development, probably via the activation of SPL expression in anthers and via the regulation of genes with functions in early and middle tapetal development. Required for signaling responses to pathogen-associated molecular patterns (PAMPs) such as flg22 that involves chloroplastic reactive oxygen species (ROS) production and subsequent expression of H(2)O(2)-responsive genes ; Belongs to the bZIP family. (460 aa)
AS1Transcription factor AS1; Transcription factor required for normal cell differentiation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 2 (LBD6/AS2) to repress the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3/ETT, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis. Binds directly to KNAT1, KNAT2, and KNATM chromatin, regulating leaf development. [...] (367 aa)
CCHCopper transport protein CCH; Involved in copper homeostasis. Can complement the yeast mutants atx1 and sod1. (121 aa)
CAM1Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CAM2Calmodulin-2; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CML10Calmodulin-like protein 10; Potential calcium sensor. (191 aa)
PR1-2Pathogenesis-related protein 1; Partially responsible for acquired pathogen resistance. (161 aa)
TGA2Transcription factor TGA2; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as- 1 element of PR-1 promoter is salicylic acid-inducible and mediated by NPR1. Could also bind to the C-boxes (5'-ATGACGTCAT-3') with high affinity. (330 aa)
CAM7Calmodulin-7; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro. (149 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
CAM6Calmodulin-6; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
ASK7Shaggy-related protein kinase eta; Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5. Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in v [...] (380 aa)
TGA6Transcription factor TGA6; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'- TGACGTGG-3') another cis-acting element found in plant histone promoters (By similarity). (330 aa)
TGA4Transcription factor TGA4; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'- TGACGTGG-3') another cis-acting element found in plant histone promoters. (364 aa)
TGA5Transcription factor TGA5; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'- TGACGTGG-3') another cis-acting element found in plant histone promoters. (330 aa)
PR1Putative pathogenesis-related protein 1, 18.9K; Belongs to the CRISP family. (166 aa)
TGA3Transcription factor TGA3; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as- 1 element of PR-1 promoter is salicylic acid-inducible and mediated by NPR1. Could also bind to the Hex-motif (5'-TGACGTGG-3') another cis- acting element fo [...] (384 aa)
TGA1Transcription factor TGA1; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1. Could also bind to the Hex-motif (5'- TGACGTGG-3') another cis-acting element found in plant histone promoters; Belongs to the bZIP family. (368 aa)
NPR4Regulatory protein NPR4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. (574 aa)
CDKE-1Cyclin-dependent kinase E-1; Involved in cell differentiation. Required for the specification of stamen and carpel identities and for the proper termination of stem cells in the floral meristem. (470 aa)
MUK11.16BZIP protein. (307 aa)
NPR3Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens. (586 aa)
WRKY50Probable WRKY transcription factor 50; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (173 aa)
TGA9Transcription factor TGA9; Together with TGA10, basic leucine-zipper transcription factor required for anther development, probably via the activation of SPL expression in anthers and via the regulation of genes with functions in early and middle tapetal development. Required for signaling responses to pathogen-associated molecular patterns (PAMPs) such as flg22 that involves chloroplastic reactive oxygen species (ROS) production and subsequent expression of H(2)O(2)- responsive genes. (481 aa)
TGA7Transcription factor TGA7; Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. May be involved in the induction of the systemic acquired resistance (SAR) via its interaction with NPR1 (By similarity); Belongs to the bZIP family. (368 aa)
ATX1Copper transport protein ATX1; Plays an important role in copper homeostasis by conferring tolerance to excess of copper and subclinical copper deficiency during vegetative stage. Can complement the yeast mutants atx1 and sod1. (76 aa)
GRXC7Glutaredoxin-C7; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). Involved in flower development as a regulator of petal primorida initiation and further petal morphogenesis. May mediate post-translational modifications of target proteins required for normal petal organ initiation and morphogenesis. ROXY1/TGA protein interactions can occur in vivo and support their biological relevance in petal development. May be involved in the regulation of the floral regulato [...] (136 aa)
SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
CP1Calcium-binding protein CP1; Binds calcium in vitro. (160 aa)
HOS15WD40 repeat-containing protein HOS15; Acts as repressor of cold stress-regulated gene expression. Interacts specifically with and promotes deacetylation of histone H4. Plays a role in gene regulation for plant acclimation and tolerance to cold stress. (613 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
PANTranscription factor PERIANTHIA; Transcriptional activator involved in the determination of floral organ number. Acts to determine floral organ patterning by establishing floral organ primordia in specific numbers and positions. Plays a role in regulating stem cell fate by directly controlling AG expression. Binds to the 5'-AAGAAT-3' cis-acting element found in AG promoter. Might represent a target for a post-translational modification by GRXC7/ROXY1; Belongs to the bZIP family. (452 aa)
PRB1Pathogenesis-related protein 1; Probably involved in the defense reaction of plants against pathogens. (161 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.