STRINGSTRING
GALS1 GALS1 GALT2 GALT2 CMT1 CMT1 GDCST GDCST GALS3 GALS3 MTP11 MTP11 TUBB6 TUBB6 PPH1 PPH1 ECA1 ECA1 GAUT13 GAUT13 IRT1 IRT1 CAX2 CAX2 IPUT1 IPUT1 GAUT14 GAUT14 GAUT5 GAUT5 HPAT1 HPAT1 T30G6.16 T30G6.16 PAM71 PAM71 ACT2 ACT2 NRAMP2 NRAMP2 NRAMP4 NRAMP4 GAUT1 GAUT1 WAK2 WAK2 GALS2 GALS2 XXT1 XXT1 MGP4 MGP4 NRAMP1 NRAMP1 NRAMP3 NRAMP3 ECA3 ECA3 GAUT7 GAUT7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GALS1Galactan beta-1,4-galactosyltransferase GALS1; Involved in the biosynthesis of beta-1,4-galactan. Can transfer galactose residues from UDP-galactose to beta-1,4- galactopentaose in vitro. Forms specifically beta-1,4-galactosyl linkages and can add successive beta-1,4-galactosyl residues to the acceptor. Beta-1,4-galactans are abundant polysaccharides in plant cell walls and are found as side-chain of rhamnogalacturonan I, which is a major component of pectin. (496 aa)
GALT2Hydroxyproline O-galactosyltransferase GALT2; Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth. (684 aa)
CMT1Putative DNA (cytosine-5)-methyltransferase CMT1; May be involved in the CpXpG methylation and in gene silencing; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (791 aa)
GDCSTAminomethyltransferase, mitochondrial; The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (408 aa)
GALS3Galactan beta-1,4-galactosyltransferase GALS3; Involved in the biosynthesis of beta-1,4-galactan. Beta-1,4- galactans are abundant polysaccharides in plant cell walls and are found as side-chain of rhamnogalacturonan I, which is a major component of pectin; Belongs to the glycosyltransferase 92 family. (504 aa)
MTP11Metal tolerance protein 11; Cation/proton antiporter involved in endogenous manganese tolerance probably through vesicular trafficking and exocytosis. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (394 aa)
TUBB6Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (449 aa)
PPH1Protein phosphatase 2C 57. (388 aa)
ECA1Calcium-transporting ATPase 1, endoplasmic reticulum-type; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the endoplasmic reticulum lumen. Also regulates manganese ion homeostasis by pumping it into endomembrane compartments. Can also transport zinc. (1061 aa)
GAUT13Probable galacturonosyltransferase 13; May be involved in pectin and/or xylans biosynthesis in cell walls. (533 aa)
IRT1Fe(2+) transport protein 1; High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions; Belongs to the ZIP transporter (TC 2.A.5) family. (347 aa)
CAX2Vacuolar cation/proton exchanger 2; Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily. (441 aa)
IPUT1Inositol phosphorylceramide glucuronosyltransferase 1; Mediates the transfer of glucuronic acid (GlcA) from UDP-GlcA to glycosyl inositol phosphorylceramides (GIPCs). The formation of GIPCs sphingolipids seems essential for pollen function. (537 aa)
GAUT14Probable galacturonosyltransferase 14; May be involved in pectin and/or xylans biosynthesis in cell walls. (532 aa)
GAUT5Probable galacturonosyltransferase 5; May be involved in pectin and/or xylans biosynthesis in cell walls. (610 aa)
HPAT1Hydroxyproline O-arabinosyltransferase 1; Glycosyltransferase involved in the O-arabinosylation of several proteins including extensins and small signaling peptides. Catalyzes the transfer of the initial L-arabinose to the hydroxyl group of Hyp residues. Contributes redundantly with HPAT2 and HPAT3 to arabinosylation of EXT3. (366 aa)
T30G6.16GDT1-like protein 3. (293 aa)
PAM71Protein PAM71, chloroplastic; Mn(2+)/H(+) exchanger, which transport Mn(2+)from the chloroplast stroma into the acidic thylakoid lumen. Might be a chloroplast-localized Ca(2+)/H(+) antiporter. Regulates Ca(2+), Mn(2+) and pH homeostasis. Required for chloroplast development ; Belongs to the GDT1 family. (370 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
NRAMP2Metal transporter Nramp2; Seems to be involved in iron uptake; Belongs to the NRAMP (TC 2.A.55) family. (530 aa)
NRAMP4Metal transporter Nramp4; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP3 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP3, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts. (512 aa)
GAUT1Polygalacturonate 4-alpha-galacturonosyltransferase; Involved in pectin biosynthesis. Catalyzes the transfer of galacturonic acid from uridine 5'-diphosphogalacturonic acid onto the pectic polysaccharide homogalacturonan. (673 aa)
WAK2Wall-associated receptor kinase 2; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. (732 aa)
GALS2Galactan beta-1,4-galactosyltransferase GALS2; Involved in the biosynthesis of beta-1,4-galactan. Beta-1,4- galactans are abundant polysaccharides in plant cell walls and are found as side-chain of rhamnogalacturonan I, which is a major component of pectin; Belongs to the glycosyltransferase 92 family. (519 aa)
XXT1Xyloglucan 6-xylosyltransferase 1; Xylosyltransferase specific to UDP-D-xylose that accepts both cellopentaose and cellohexaose as substrates, with a better use of cellohexaose, to produce xyloglucan. Adds preferentially the first xylosyl residue to the fourth glucosyl residue from the reducing end of both acceptors. Transfer one xylose mainly to the second glucose residue from the non-reducing end. The acceptor should have a minimum of four glucose residues. (460 aa)
MGP4UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase MGP4; Catalyzes the transfer of D-xylose from UDP-alpha-D-xylose onto L-fucose. Probably involved in the biosynthesis of rhamnogalacturonan II (RG-II) through xylosylation of the internal fucose moiety of the A-chain of RG-II, a structurally complex pectic polysaccharide of the primary cell wall. RG-II is essential for the cell wall integrity of rapidly growing tissues such as roots and pollen tube growth and elongation. (360 aa)
NRAMP1Metal transporter Nramp1; High affinity manganese (Mn) transporter involved in Mn acquisition from the soil. Required for Mn uptake into the root in conditions of low Mn availability. Can transport iron (Fe), cadmium (Cd) and cobalt (Co). (532 aa)
NRAMP3Metal transporter Nramp3; Vacuolar metal transporter involved in intracellular metal homeostasis. Can transport iron (Fe), manganese (Mn) and cadmium (Cd). Regulates metal accumulation under Fe starvation. Acts redundantly with NRAMP4 to mobilize vacuolar Fe and provide sufficient Fe during seed germination. In association with NRAMP4, required for optimal growth and photosynthesis under Mn deficiency. Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts. Involved in basal resistance to the bacterial pathogen E.chrysanthemi. (509 aa)
ECA3Calcium-transporting ATPase 3, endoplasmic reticulum-type; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to an endomembrane compartment. Involved in calcium-enhanced root growth, in tolerance to toxic levels of manganese and in secretory processes. Has a crucial role in manganese nutrition, but is not involved in transporting copper, iron or zinc; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. (998 aa)
GAUT7Probable galacturonosyltransferase 7; May be involved in pectin biosynthesis; Belongs to the glycosyltransferase 8 family. (619 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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