STRINGSTRING
PIN6 PIN6 PMK PMK BAS BAS PILS1 PILS1 ISPG ISPG ISPE ISPE CAS1 CAS1 HMGS HMGS ISPD ISPD FPS1 FPS1 LAS1 LAS1 DXS DXS PRL1 PRL1 FPS2 FPS2 LUP2 LUP2 AAT1 AAT1 PIN7 PIN7 ISPH ISPH PILS2 PILS2 ISPF ISPF PIN5 PIN5 AACT1 AACT1 PIN8 PIN8 PIN2 PIN2 PILS6 PILS6 PIN3 PIN3 PILS5 PILS5 DXR DXR
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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PIN6Auxin efflux carrier component 6; Component of the intracellular auxin-transport pathway. Regulates auxin transport and auxin homeostasis. Directly involved in the regulation of nectar production. Involved in unfolded protein response (UPR) activation. Involved in the control of vein patterning. Redundantly with PIN8, inhibits the vein-formation-promoting functions of PIN5. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells. Belongs to the auxin efflux carrier (TC 2.A.69.1) family. (570 aa)
PMKPhosphomevalonate kinase, peroxisomal. (505 aa)
BASBeta-amyrin synthase; Converts oxidosqualene to beta-amyrin. Belongs to the terpene cyclase/mutase family. (759 aa)
PILS1Protein PIN-LIKES 1; Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. (472 aa)
ISPG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Is essential for chloroplast development and required for the salicylic acid (SA)-mediated disease resistance to biotrophic pathogens. (741 aa)
ISPE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Is essential for chloroplast development. (383 aa)
CAS1Cycloartenol synthase; Converts oxidosqualene to cycloartenol and 1% parkeol. Involved in plastid biogenesis. Essential for the male gametophyte function; Belongs to the terpene cyclase/mutase family. (759 aa)
HMGSHydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (461 aa)
ISPD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis. (302 aa)
FPS1Farnesyl pyrophosphate synthase 1, mitochondrial; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. (384 aa)
LAS1Lanosterol synthase; Converts oxidosqualene to lanosterol. Belongs to the terpene cyclase/mutase family. (756 aa)
DXS1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP). Is a limiting enzyme for plastidic isoprenoid biosynthesis and essential for chloroplast development. Belongs to the transketolase family. DXPS subfamily. (717 aa)
PRL1Protein pleiotropic regulatory locus 1; Pleiotropic regulator of glucose, stress and hormone responses. Also regulates cytochrome P450 CYP90A1/CPD. Coordinates the expression of hormone- and stress-related genes and genes related to cell wall modification and growth, leading to altered sugar-dependent growth and developmental responses. Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity. By suppressing the expression of several (1)O(2)-responsive genes, PRL1 seems to play a major role [...] (486 aa)
FPS2Farnesyl pyrophosphate synthase 2; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (342 aa)
LUP2Amyrin synthase LUP2; Multifunctional enzyme that converts oxidosqualene to nine different triterpenes, mainly lupeol, beta-amyrin and alpha-amyrin in a 15:50:30 ratio; Belongs to the terpene cyclase/mutase family. (763 aa)
AAT1Acetyl-CoA acetyltransferase, cytosolic 1. (403 aa)
PIN7Auxin efflux carrier component 7; Acts as a component of the auxin efflux carrier. Mediates the initial auxin gradient which contributes to the establishment of the apical-basal axis in early embryogenesis. (619 aa)
ISPH4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)-butenyl 4- diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is essential for chloroplast development. (466 aa)
PILS2Protein PIN-LIKES 2; Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. (457 aa)
ISPF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2- phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. Also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl- D-erythritol 3,4-cyclophosphate and CMP. Is essential for chloroplast development; Belongs to the IspF family. (231 aa)
PIN5Auxin efflux carrier component 5; Auxin transporter regulating intracellular auxin homeostasis and metabolism. Mediates the auxin transport from the cytosol into the lumen of the endoplasmic reticulum. May also act as an auxin efflux carrier when located to the cell membrane. PIN5 and PIN8 may have an antagonistic/compensatory activity. Involved in unfolded protein response (UPR) activation. Involved in the control of vein patterning. Promotes vein formation. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells. (351 aa)
AACT1Probable acetyl-CoA acetyltransferase, cytosolic 2; Belongs to the thiolase-like superfamily. Thiolase family. (415 aa)
PIN8Auxin efflux carrier component 8; Component of the intracellular auxin-transport pathway in the male gametophyte. Involved in the regulation of auxin homeostasis in pollen. Involved in the efflux of auxin from the endoplasmic reticulum into the cytoplasm. PIN5 and PIN8 may have an antagonistic/compensatory activity. Involved in the control of vein patterning. Redundantly with PIN6, inhibits the vein-formation- promoting functions of PIN5. PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells. (367 aa)
PIN2Auxin efflux carrier component 2; Acts as a component of the auxin efflux carrier. Seems to be involved in the root-specific auxin transport, and mediates the root gravitropism. Its particular localization suggest a role in the translocation of auxin towards the elongation zone. (647 aa)
PILS6Protein PIN-LIKES 6; Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling; Belongs to the auxin efflux carrier (TC 2.A.69.2) family. (431 aa)
PIN3Auxin efflux carrier component 3; Acts as a component of the auxin efflux carrier. Seems to be involved in the lateral auxin transport system and mediates tropic growth. Coordinated polar localization of PIN3 is directly regulated by the vesicle trafficking process. (640 aa)
PILS5Protein PIN-LIKES 5; Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling. (396 aa)
DXR1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D- erythritol 4-phosphate (MEP). Required for chloroplast development. (477 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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