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LAC5 LAC5 IRX12 IRX12 LAC2 LAC2 MIOX2 MIOX2 DFRA DFRA KAT3 KAT3 NPF6.3 NPF6.3 LAC16 LAC16 KAT2 KAT2 AKT2 AKT2 XTH30 XTH30 AKT1 AKT1 KAT1 KAT1 LAC3 LAC3 LAC10 LAC10 GXM1 GXM1 TT10 TT10 GUX2 GUX2 AKT6 AKT6 COBL7 COBL7 MIOX4 MIOX4 MIOX1 MIOX1 T10F18.130 T10F18.130 SQD2 SQD2 LAC11 LAC11 MSL1 MSL1 ASD2 ASD2 GUX3 GUX3 GORK GORK HHT1 HHT1 FLS1 FLS1 SLAH2 SLAH2 F26A9.8 F26A9.8 IRX15-L IRX15-L COBL9 COBL9 LAC17 LAC17 MIOX5 MIOX5 LAC12 LAC12 LAC14 LAC14 GUX4 GUX4 IRX10 IRX10 LAC9 LAC9 LAC8 LAC8 CAX6 CAX6 sks13 sks13 sks11 sks11 LAC1 LAC1 GXM3 GXM3 GUX1 GUX1 PME31 PME31 LAC13 LAC13 EXPB3 EXPB3 SKOR SKOR F3H F3H AKT5 AKT5 CYP75B1 CYP75B1 BAN BAN ASD1 ASD1 EXPB1 EXPB1 LAC7 LAC7 FUT1 FUT1 T28P6.3 T28P6.3 GXM2 GXM2 ABCG36 ABCG36 LAC6 LAC6 IRX9 IRX9 CSLA7 CSLA7 IRX7 IRX7 Sks12 Sks12 F4HTT8_ARATH F4HTT8_ARATH GUX5 GUX5 F4K6Z5_ARATH F4K6Z5_ARATH AXY4 AXY4 CESA1 CESA1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LAC5Laccase-5; Lignin degradation and detoxification of lignin-derived products. (580 aa)
IRX12Laccase-4; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for secondary xylem cell wall lignification; Belongs to the multicopper oxidase family. (558 aa)
LAC2Laccase-2; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for root elongation in dehydration conditions; Belongs to the multicopper oxidase family. (573 aa)
MIOX2Inositol oxygenase 2; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis; Belongs to the myo-inositol oxygenase family. (317 aa)
DFRADihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism. (382 aa)
KAT3Potassium channel KAT3; Probable modulatory (alpha) subunit of inward-rectifying potassium channels. Could mediate potassium uptake from the soil solution by plant roots in association with AKT1. (662 aa)
NPF6.3Protein NRT1/ PTR FAMILY 6.3; Dual affinity nitrate transporter. Involved in proton- dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be i [...] (590 aa)
LAC16Laccase-16; Lignin degradation and detoxification of lignin-derived products. (566 aa)
KAT2Potassium channel KAT2; Highly selective inward-rectifying potassium channel. This voltage-dependent channel could mediate long-term potassium influx into guard cells leading to stomatal opening. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. The channel activity is enhanced upon external acidification. (697 aa)
AKT2Potassium channel AKT2/3; Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/pr [...] (802 aa)
XTH30Probable xyloglucan endotransglucosylase/hydrolase protein 30; Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues (By similarity); Belongs to the glycosyl hydrolase 16 family. XTH group 3 subfamily. (343 aa)
AKT1Potassium channel AKT1; Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpol [...] (857 aa)
KAT1Potassium channel KAT1; Highly selective inward-rectifying potassium channel. This voltage-gated channel could mediate long-term potassium influx into guard cells leading to stomatal opening. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. The channel activity is enhanced upon external acidification. Also permeable to ammonium ions. Blocked by tetraethylammonium and barium ions. (677 aa)
LAC3Laccase-3; Lignin degradation and detoxification of lignin-derived products. (570 aa)
LAC10Laccase-10; Lignin degradation and detoxification of lignin-derived products. (558 aa)
GXM1Glucuronoxylan 4-O-methyltransferase 1; Methyltransferase catalyzing 4-O-methylation of glucuronic acid side chains on xylan; Belongs to the methyltransferase superfamily. (282 aa)
TT10Laccase-15; Lignin degradation and detoxification of lignin-derived products (By similarity). Involved in lignin synthesis in seed coats, in seed coat permeability, in seed germination, and in root elongation. Required for the seed coat (testa) brown pigmentation by mediating the polymerization of proanthocyanidin (tannin) from its monomer precursor epicatechin. Slightly promotes seed dormancy. Belongs to the multicopper oxidase family. (565 aa)
GUX2UDP-glucuronate:xylan alpha-glucuronosyltransferase 2; Glycosyltransferase required for the addition of both glucuronic acid and 4-O-methylglucuronic acid branches to xylan in stem cell walls. In association with GUX1, is responsible for almost all of the substitutions of the xylan backbone in stem glucuronoxylan. (596 aa)
AKT6Potassium channel AKT6; Highly selective inward-rectifying potassium channel that could mediate potassium uptake in the pollen membrane. Plays an important role in pollen tube development. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins. Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily. (888 aa)
COBL7COBRA-like protein 7; Belongs to the COBRA family. (661 aa)
MIOX4Inositol oxygenase 4; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis. (317 aa)
MIOX1Inositol oxygenase 1; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis. (311 aa)
T10F18.130Ascorbate oxidase-like protein; Belongs to the multicopper oxidase family. (573 aa)
SQD2Sulfoquinovosyl transferase SQD2; Catalyzes the transfer of the sulfoquinovose moiety from UDP- sulfoquinovose to diacylglycerol during sulfolipid biosynthesis. Sulfolipid contributes to maintaining a negatively charged lipid-water interface, a requirement for proper function of photosynthetic membranes. Sulfolipid may also function as a substitute of anionic phospholipids under phosphate-limited growth conditions. (510 aa)
LAC11Laccase-11; Lignin degradation and detoxification of lignin-derived products. (557 aa)
MSL1Mechanosensitive ion channel protein 1, mitochondrial; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer; Belongs to the MscS (TC 1.A.23) family. (497 aa)
ASD2Alpha-L-arabinofuranosidase 2; May be involved in the coordinated dissolution of the cell wall matrix during abscission and in the secondary cell wall formation in xylem vessels; Belongs to the glycosyl hydrolase 51 family. (674 aa)
GUX3Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 3; May be involved in the substitutions of the xylan backbone in stem glucuronoxylan. (618 aa)
GORKPotassium channel GORK; Major selective outward-rectifying potassium channel of the guard cell membrane. Involved in regulation of stomatal movements according to the water status. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization. Conductance of the channel is modulated in a potassium-dependent fashion. May interact with the cytoskeleton or with regulatory proteins. (820 aa)
HHT1Omega-hydroxypalmitate O-feruloyl transferase; Involved in the synthesis of aromatics of the suberin polymer. Specifically affects the accumulation of the ferulate constituent of suberin in roots and seeds, but has no effect on the content of p-coumarate or sinapate. (457 aa)
FLS1Flavonol synthase/flavanone 3-hydroxylase; Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol. Belongs to the iron/ascorbate-dependent oxidoreductase family. (336 aa)
SLAH2S-type anion channel SLAH2; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Belongs to the SLAC1 S-type anion channel family. (519 aa)
F26A9.8Glucuronoxylan 4-O-methyltransferase-like protein (DUF579). (295 aa)
IRX15-LProtein IRX15-LIKE; Required for xylan biosynthesis, but not directly involved in catalyzing the addition of sugars to the growing polymer. (317 aa)
COBL9COBRA-like protein 9; Belongs to the COBRA family. (663 aa)
LAC17Laccase-17; Lignin degradation and detoxification of lignin-derived products. (577 aa)
MIOX5Inositol oxygenase 5; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis; Belongs to the myo-inositol oxygenase family. (314 aa)
LAC12Laccase-12; Lignin degradation and detoxification of lignin-derived products. (565 aa)
LAC14Laccase-14; Lignin degradation and detoxification of lignin-derived products. (569 aa)
GUX4Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 4; May be involved in the substitutions of the xylan backbone in stem glucuronoxylan. (557 aa)
IRX10Probable beta-1,4-xylosyltransferase IRX10; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the elongation of glucuronoxylan xylosyl backbone, especially in the formation of GlcUA side chain of xylans. (412 aa)
LAC9Laccase-9; Lignin degradation and detoxification of lignin-derived products. (586 aa)
LAC8Laccase-8; Lignin degradation and detoxification of lignin-derived products (By similarity). Involved in the flowering time inhibition. (584 aa)
CAX6Putative vacuolar cation/proton exchanger 6; Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) and other metal ions into vacuoles using the proton gradient formed by H(+)-ATPase and H(+)-pyrophosphatase (By similarity); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily. (448 aa)
sks13BNH protein pectinesterase-like protein pollen-secific protein-like. (551 aa)
sks11L-ascorbate oxidase pectinesterase-like protein pollen-specific protein-like. (554 aa)
LAC1Laccase-1; Lignin degradation and detoxification of lignin-derived products. (581 aa)
GXM3Glucuronoxylan 4-O-methyltransferase 3; Methyltransferase catalyzing 4-O-methylation of glucuronic acid side chains on xylan; Belongs to the methyltransferase superfamily. (297 aa)
GUX1UDP-glucuronate:xylan alpha-glucuronosyltransferase 1; Glycosyltransferase required for the addition of both glucuronic acid and 4-O-methylglucuronic acid branches to xylan in stem cell walls. In association with GUX2, is responsible for almost all of the substitutions of the xylan backbone in stem glucuronoxylan. (659 aa)
PME31Pectinesterase 31; Acts in the modification of cell walls via demethylesterification of cell wall pectin (By similarity). Acts in a blockwise manner, resulting in a cell wall rigidification. Belongs to the pectinesterase family. (317 aa)
LAC13Laccase-13; Lignin degradation and detoxification of lignin-derived products. (569 aa)
EXPB3Expansin-B3; May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity). (264 aa)
SKORPotassium channel SKOR; Highly selective outward-rectifying potassium channel. Involved in potassium release into the xylem sap toward the shoots. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by depolarization. The voltage-dependence of the channel is abolished by internal or external acidification. May interact with the cytoskeleton or with regulatory proteins; Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily. (828 aa)
F3HNaringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants. (358 aa)
AKT5Probable potassium channel AKT5; Probable potassium channel. May interact with the cytoskeleton or with regulatory proteins (By similarity). Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily. (880 aa)
CYP75B1Flavonoid 3'-monooxygenase; Catalyzes the 3'-hydroxylation of the flavonoid B-ring to the 3',4'-hydroxylated state. Convert naringenin to eriodictyol and dihydrokaempferol to dihydroquercetin; Belongs to the cytochrome P450 family. (513 aa)
BANAnthocyanidin reductase; Involved in the biosynthesis of condensed tannins. Converts cyanidin into (-)-epicatechin as the major product. Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily. (340 aa)
ASD1Alpha-L-arabinofuranosidase 1; May be involved in the coordinated dissolution of the cell wall matrix during abscission and in the secondary cell wall formation in xylem vessels. Prefers arabinoxylan, but may also use pectic arabinans as substrates. (678 aa)
EXPB1Expansin-B1; May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity). Belongs to the expansin family. Expansin B subfamily. (271 aa)
LAC7Laccase-7; Lignin degradation and detoxification of lignin-derived products. (567 aa)
FUT1Galactoside 2-alpha-L-fucosyltransferase; Involved in cell wall biosynthesis. Is both necessary and sufficient for the addition of the terminal fucosyl residue on xyloglucan side chains, but is not involved in the fucosylation of other cell wall components. Associates with other xyloglucan- synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi. (558 aa)
T28P6.3GDSL esterase/lipase. (424 aa)
GXM2Glucuronoxylan 4-O-methyltransferase 2; Methyltransferase catalyzing 4-O-methylation of glucuronic acid side chains on xylan; Belongs to the methyltransferase superfamily. (290 aa)
ABCG36ABC transporter G family member 36; Key factor that controls the extent of cell death in the defense response. Necessary for both callose deposition and glucosinolate activation in response to pathogens. Required for limiting invasion by nonadapted powdery mildews. Confers resistance to cadmium (Cd) and lead (Pb), probably as an efflux pump of Cd2+ or Cd conjugates, and possibly, of chemicals that mediate pathogen resistance. (1469 aa)
LAC6Laccase-6; Lignin degradation and detoxification of lignin-derived products; Belongs to the multicopper oxidase family. (569 aa)
IRX9Beta-1,4-xylosyltransferase IRX9; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Xylan xylosyltransferase that acts cooperatively with IRX14 to achieve the successive addition of xylosyl residues during xylan backbone elongation. (351 aa)
CSLA7Glucomannan 4-beta-mannosyltransferase 7; Probable mannan synthase which consists of a 4-beta- mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4- mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Required for synthesis of a cell wall polysaccharide essential for pollen tube growth, for cell wall structure, or for signaling during plant embryo development. (556 aa)
IRX7Probable glucuronoxylan glucuronosyltransferase IRX7; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the synthesis of the glycosyl sequence at the glucuronoxylan reducing end. Belongs to the glycosyltransferase 47 family. (448 aa)
Sks12At1g55570/T5A14_1. (555 aa)
F4HTT8_ARATHGalacturonosyltransferase. (99 aa)
GUX5Putative UDP-glucuronate:xylan alpha-glucuronosyltransferase 5; May be involved in the substitutions of the xylan backbone in stem glucuronoxylan. (566 aa)
F4K6Z5_ARATHPlant L-ascorbate oxidase; Belongs to the multicopper oxidase family. (588 aa)
AXY4Protein ALTERED XYLOGLUCAN 4; Involved in xyloglucan specific O-acetylation in roots and rosette leaves. May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). (416 aa)
CESA1Cellulose synthase A catalytic subunit 1 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. Required during embryogenesis for cell elongation, orientation of cell expansion and complex cell wall formations, such as interdigitated pattern of epidermal pavement cells, stomatal guard cells and trichomes. Plays a role in lateral roots formation, but seems not necessary for the development of tip-growing cel [...] (1081 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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