(16 nodes) (2022) A Mutation in the MYBL2-1 Gene Is Associated with Purple Pigmentation in Brassica oleracea. network (Arabidopsis thaliana)

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	DFRA	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism. (382 aa)
	FLS5	Probable flavonol synthase 5; Belongs to the iron/ascorbate-dependent oxidoreductase family. (325 aa)
	FLS3	Flavonol synthase 3; Catalyzes the formation of flavonols from dihydroflavonols. Possesses low activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family. (308 aa)
	TT8	Transcription factor TT8; Transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression. (518 aa)
	F3H	Naringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants. (358 aa)
	MYB57	Transcription factor MYB57; Transcription factor acting redundantly with MYB21 and MYB24 to control stamen filament elongation in the late developed flowers. Repressed at the transcript levels by DELLA proteins. (206 aa)
	TTG1	Protein TRANSPARENT TESTA GLABRA 1; May regulate MYC transcription factors. Involved in epidermal cell fate specification such as trichome and root hair development, seed mucilage production, and anthocyanin biosynthesis by acting at the dihydroflavonol-4-reductase (DFR) step. Together with GL1 and GL3, promotes trichome formation. Activates the transcription of GL2. (341 aa)
	FLS6	Probable flavonol synthase 6. (293 aa)
	FLS4	Probable flavonol synthase 4. (279 aa)
	F6H11.100	Transcription factor-like protein. (374 aa)
	ACT7	Actin-7; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation. (377 aa)
	Atmyb2	MYB transcription factor (Atmyb2). (273 aa)
	MYB1	Transcription factor MYB1. (393 aa)
	LDOX	Leucoanthocyanidin dioxygenase; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. Possesses low flavonol synthase activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family. (356 aa)
	FLS1	Flavonol synthase/flavanone 3-hydroxylase; Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol. Belongs to the iron/ascorbate-dependent oxidoreductase family. (336 aa)
	MYBL2	Putative transcription factor; 20982-20139. (195 aa)

Your Current Organism:

Arabidopsis thaliana

NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atmyb2	DFRA	Q39028	P51102	MYB transcription factor (Atmyb2).	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	0.700
Atmyb2	F3H	Q39028	Q9S818	MYB transcription factor (Atmyb2).	Naringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.	0.400
Atmyb2	TT8	Q39028	Q9FT81	MYB transcription factor (Atmyb2).	Transcription factor TT8; Transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression.	0.630
Atmyb2	TTG1	Q39028	Q9XGN1	MYB transcription factor (Atmyb2).	Protein TRANSPARENT TESTA GLABRA 1; May regulate MYC transcription factors. Involved in epidermal cell fate specification such as trichome and root hair development, seed mucilage production, and anthocyanin biosynthesis by acting at the dihydroflavonol-4-reductase (DFR) step. Together with GL1 and GL3, promotes trichome formation. Activates the transcription of GL2.	0.649
DFRA	Atmyb2	P51102	Q39028	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	MYB transcription factor (Atmyb2).	0.700
DFRA	F3H	P51102	Q9S818	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Naringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.	0.998
DFRA	F6H11.100	P51102	O49538	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Transcription factor-like protein.	0.431
DFRA	FLS1	P51102	Q96330	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Flavonol synthase/flavanone 3-hydroxylase; Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol. Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.998
DFRA	FLS3	P51102	Q9FFQ5	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Flavonol synthase 3; Catalyzes the formation of flavonols from dihydroflavonols. Possesses low activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.993
DFRA	FLS4	P51102	F4KAS1	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Probable flavonol synthase 4.	0.993
DFRA	FLS5	P51102	Q9FFQ4	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Probable flavonol synthase 5; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.994
DFRA	FLS6	P51102	F4K7D5	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Probable flavonol synthase 6.	0.993
DFRA	LDOX	P51102	Q96323	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Leucoanthocyanidin dioxygenase; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. Possesses low flavonol synthase activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.999
DFRA	MYB1	P51102	Q42575	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Transcription factor MYB1.	0.792
DFRA	MYBL2	P51102	Q9C9A5	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Putative transcription factor; 20982-20139.	0.854
DFRA	TT8	P51102	Q9FT81	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Transcription factor TT8; Transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression.	0.959
DFRA	TTG1	P51102	Q9XGN1	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	Protein TRANSPARENT TESTA GLABRA 1; May regulate MYC transcription factors. Involved in epidermal cell fate specification such as trichome and root hair development, seed mucilage production, and anthocyanin biosynthesis by acting at the dihydroflavonol-4-reductase (DFR) step. Together with GL1 and GL3, promotes trichome formation. Activates the transcription of GL2.	0.906
F3H	Atmyb2	Q9S818	Q39028	Naringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.	MYB transcription factor (Atmyb2).	0.400
F3H	DFRA	Q9S818	P51102	Naringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.	Dihydroflavonol 4-reductase; Bifunctional enzyme involved in flavonoid metabolism.	0.998
F3H	F6H11.100	Q9S818	O49538	Naringenin,2-oxoglutarate 3-dioxygenase; Catalyzes the 3-beta-hydroxylation of 2S-flavanones to 2R,3R- dihydroflavonols which are intermediates in the biosynthesis of flavonols, anthocyanidins, catechins and proanthocyanidins in plants.	Transcription factor-like protein.	0.591