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APX3 APX3 GPX2 GPX2 GPX3 GPX3 GLX2-2 GLX2-2 GPX6 GPX6 GLX1 GLX1 EMB2360 EMB2360 GPX1 GPX1 LON1 LON1 APX1 APX1 PP2AA3 PP2AA3 APXT APXT T6D22.20 T6D22.20 GPX4 GPX4 GPX8 GPX8 GLX2-4 GLX2-4 DJ1C DJ1C DLD DLD DJ1A DJ1A GPX5 GPX5 DJ1F DJ1F DJ1D DJ1D DJ1B DJ1B GLX2-5 GLX2-5 GPX7 GPX7 DJ1E DJ1E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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APX3L-ascorbate peroxidase 3; Plays a key role in hydrogen peroxide removal. (287 aa)
GPX2Probable glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses; Belongs to the glutathione peroxidase family. (169 aa)
GPX3Probable glutathione peroxidase 3, mitochondrial; May constitute a glutathione peroxidase-like protective system against oxidative stresses. Involved positively in abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Oxidizes and represses target proteins (e.g. the phosphatase activity of ABI1 and ABI2) when oxidized by H(2)O(2), probably after ABA signaling. Modulates the calcium channel activity in guard cells in response to ABA or H(2)O(2). Confers tolerance to drought stress, by [...] (206 aa)
GLX2-2Hydroxyacylglutathione hydrolase cytoplasmic; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (258 aa)
GPX6Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (232 aa)
GLX1Lactoylglutathione lyase GLX1; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (283 aa)
EMB2360Glutathione reductase, chloroplastic; Maintains high levels of reduced glutathione in the chloroplast. (565 aa)
GPX1Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (236 aa)
LON1Lon protease homolog 1, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (940 aa)
APX1L-ascorbate peroxidase 1, cytosolic; Plays a key role in hydrogen peroxide removal. Constitutes a central component of the reactive oxygen gene network. (250 aa)
PP2AA3Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform; The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Involved during developmental process such as seedling and floral developments. Seems to act as a negative regulator of PP2A catalytic activity. (587 aa)
APXTL-ascorbate peroxidase T, chloroplastic; Plays a key role in hydrogen peroxide removal; Belongs to the peroxidase family. Ascorbate peroxidase subfamily. (426 aa)
T6D22.20Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (185 aa)
GPX4Probable glutathione peroxidase 4; May constitute a glutathione peroxidase-like protective system against oxidative stresses; Belongs to the glutathione peroxidase family. (170 aa)
GPX8Probable glutathione peroxidase 8; May constitute a glutathione peroxidase-like protective system against oxidative stresses; Belongs to the glutathione peroxidase family. (167 aa)
GLX2-4Probable hydroxyacylglutathione hydrolase 2, chloroplastic; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (331 aa)
DJ1CProtein DJ-1 homolog C; Plays an essential role in chloroplast development and is required for chloroplast integrity and viability. Belongs to the peptidase C56 family. (472 aa)
DLDD-lactate dehydrogenase [cytochrome], mitochondrial; Catalyzes the stereospecific oxidation of D-lactate to pyruvate. Involved in the detoxification of methylglyoxal and D- lactate, but probably not involved in the metabolization of glycolate. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (567 aa)
DJ1AProtein DJ-1 homolog A; Involved in oxidative stress response. Confers protection against diverse stresses by binding both CSD1 and GPX2 and mediating the cytosolic activation of the Cu-Zn-dependent superoxide dismutase activity of CSD1; Belongs to the peptidase C56 family. (392 aa)
GPX5Probable glutathione peroxidase 5; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (173 aa)
DJ1FDJ-1 protein homolog F; May be involved in oxidative stress response; Belongs to the peptidase C56 family. (399 aa)
DJ1DProtein DJ-1 homolog D; Possesses glyoxalase I activity. Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S- lactoylglutathione. May be involved in oxidative stress response. (388 aa)
DJ1BProtein DJ-1 homolog B; May be involved in oxidative stress response. (438 aa)
GLX2-5Hydroxyacylglutathione hydrolase 2, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (324 aa)
GPX7Putative glutathione peroxidase 7, chloroplastic; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (233 aa)
DJ1EDJ-1 protein homolog E; May be involved in oxidative stress response; Belongs to the peptidase C56 family. (398 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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