STRINGSTRING
CLE26 CLE26 CLE2 CLE2 SPL3 SPL3 CLE8 CLE8 CLE22 CLE22 CLE1 CLE1 CLE14 CLE14 CLE3 CLE3 CLE20 CLE20 CLE45 CLE45 CLE42 CLE42 WOX8 WOX8 CLE46 CLE46 CLE25 CLE25 CLE19 CLE19 RFS2 RFS2 CLE9 CLE9 CLE27 CLE27 CLE40 CLE40 ABCF4 ABCF4 CLV3 CLV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLE26CLAVATA3/ESR (CLE)-related protein 26; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (118 aa)
CLE2CLAVATA3/ESR (CLE)-related protein 2; Extracellular signal peptide that regulates cell fate. May act with CLV1 as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions. (75 aa)
SPL3Squamosa promoter-binding-like protein 3; Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3' of AP1 promoter. Binds specifically to the 5'-GTAC-3' core sequence. Promotes both vegetative phase change and flowering. Regulates phase-specific patterns of leaf epidermal differentiation and flowering time, but does not seem to affect leaf shape. (131 aa)
CLE8CLAVATA3/ESR (CLE)-related protein 8; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Positively regulates the expression of the transcription factor WOX8 and thus, regulates early embryo development. (86 aa)
CLE22CLAVATA3/ESR (CLE)-related protein 22; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (103 aa)
CLE1CLAVATA3/ESR (CLE)-related protein 1; Extracellular signal peptide that regulates cell fate. Belongs to the CLV3/ESR signal peptide family. (74 aa)
CLE14CLAVATA3/ESR (CLE)-related protein 14; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Acts as an elicitor of the root meristem differentiation through the CLV2/CRN complex signaling pathway. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. (80 aa)
CLE3CLAVATA3/ESR (CLE)-related protein 3; Extracellular signal peptide that regulates cell fate. Belongs to the CLV3/ESR signal peptide family. (83 aa)
CLE20CLAVATA3/ESR (CLE)-related protein 20; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem ; Belongs to the CLV3/ESR signal peptide family. (83 aa)
CLE45CLAVATA3/ESR (CLE)-related protein 45; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Prevents, in a dose-dependent manner, auxin response in the root meristem thus leading in the repression of protophloem differentiation and periclinal sieve element precursor cell division. (124 aa)
CLE42CLAVATA3/ESR (CLE)-related protein 42; Extracellular signal peptide that regulates cell fate. Represses tracheary element differentiation but promotes the formation of procambial cells; Belongs to the CLV3/ESR signal peptide family. (88 aa)
WOX8WUSCHEL-related homeobox 8; Probable transcription factor, which may be involved in embryonic patterning. May be required for basal embryo development after fertilization. Acts partially redundantly with STIP in promoting embryonic cell division and proliferation. Promotes cotyledon boundary formation by maintaining the symmetry in CUC genes expression domains ; Belongs to the WUS homeobox family. (325 aa)
CLE46CLAVATA3/ESR (CLE)-related protein 46; Extracellular signal peptide that regulates cell fate. (76 aa)
CLE25CLAVATA3/ESR (CLE)-related protein 25; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (81 aa)
CLE19CLAVATA3/ESR (CLE)-related protein 19; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (74 aa)
RFS2Probable galactinol--sucrose galactosyltransferase 2; Transglycosidase operating by a ping-pong reaction mechanism. Involved in the synthesis of raffinose, a major soluble carbohydrate in seeds, roots and tubers (By similarity); Belongs to the glycosyl hydrolases 36 family. (773 aa)
CLE9CLAVATA3/ESR (CLE)-related protein 9; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (120 aa)
CLE27CLAVATA3/ESR (CLE)-related protein 27; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (91 aa)
CLE40CLAVATA3/ESR (CLE)-related protein 40; Extracellular signal peptide secreted by differentiated root cells that regulates root cell fate. Acts with ACR4 as a ligand- receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Promotes cell differentiation in the distal root meristem in a dose-dependent manner, especially the transition from columella stem cells (CSC) daughters into columella cells (CCs). Induces ACR4 expression in root quiescent center (QC). Involved in WUX5 QC-specific expression pattern [...] (80 aa)
ABCF4ABC transporter F family member 4; Belongs to the ABC transporter superfamily. ABCF family. EF3 (TC 3.A.1.121) subfamily. (723 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.