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PCNA2 PCNA2 ADF4 ADF4 UEV1D UEV1D PRXIIC PRXIIC METK3 METK3 CSY3 CSY3 PCNA PCNA CSY5 CSY5 CSY1 CSY1 CSY2 CSY2 GLN1-3 GLN1-3 METK4 METK4 FQR1 FQR1 LOX3 LOX3 HSP70-4 HSP70-4 CBSX3 CBSX3 DHAR1 DHAR1 LOX4 LOX4 GLN1-4 GLN1-4 UGD4 UGD4 LOX6 LOX6 CBSX2 CBSX2 GLN1-2 GLN1-2 GLN1-5 GLN1-5 CBSX1 CBSX1 PAF2 PAF2 HSP70-3 HSP70-3 SAM2 SAM2 CSY4 CSY4 HSP70-1 HSP70-1 HSP70-2 HSP70-2 SAM1 SAM1 PAF1 PAF1 LOX2 LOX2 UBC13 UBC13 GSTF6 GSTF6 GLN2 GLN2 GLN1-1 GLN1-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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co-expression
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PCNA2Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). May be involved in UV resistance. Belongs to the PCNA family. (264 aa)
ADF4Actin-depolymerizing factor 4; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers. Contributes to the stochastic dynamic turnover of actin filaments. Binds monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin. Involved in resistance triggered by the effector AvrPphB of Pseudomonas syringae pv tomato (Pst). May modulate the AvrPphB-RPS5-mediated defense signal transduction pathway. During AvrPphB-triggered resistance signaling pathway, involved in the control of MPK3 an [...] (139 aa)
UEV1DUbiquitin-conjugating enzyme E2 variant 1D; Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. Involved in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage; Belongs to the ubiquitin-conjugating enzyme family. (146 aa)
PRXIICPeroxiredoxin-2C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. Prx5 subfamily. (162 aa)
METK3S-adenosylmethionine synthase 3; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. Involved in the biosynthesis of lignin ; Belongs to the AdoMet synthase family. (390 aa)
CSY3Citrate synthase 3, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (509 aa)
PCNAProliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
CSY5Citrate synthase 5, mitochondrial; Belongs to the citrate synthase family. (464 aa)
CSY1Citrate synthase 1, peroxisomal; Belongs to the citrate synthase family. (480 aa)
CSY2Citrate synthase 2, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (514 aa)
GLN1-3Glutamine synthetase cytosolic isozyme 1-3; Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (354 aa)
METK4S-adenosylmethionine synthase 4; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (393 aa)
FQR1NAD(P)H dehydrogenase (quinone) FQR1; Catalyzes the transfer of electrons from NADH and NADPH to several quinones in vitro. May act as detoxification enzyme, and protect against auxin-induced oxidative stress. (204 aa)
LOX3Lipoxygenase 3, chloroplastic; 13S-lipoxygenase that can use linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity). (919 aa)
HSP70-4Heat shock 70 kDa protein 4; In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). ATP-dependent molecular chaperone that assists folding of unfolded or misfolded proteins under stress conditions. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the E3 ubiquitin-protein ligase CHIP. Recognizes specific sequence motifs in tr [...] (650 aa)
CBSX3CBS domain-containing protein CBSX3, mitochondrial. (206 aa)
DHAR1Glutathione S-transferase DHAR1, mitochondrial; Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses, subsequently to biotic or abiotic inducers. As a peripheral membrane protein, could also function as voltage-gated ion channel. Belongs to the GST superfamily. DHAR family. (213 aa)
LOX4Lipoxygenase 4, chloroplastic; Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity). 13S-lipoxygenase that can use linolenic acid as substrates. (926 aa)
GLN1-4Glutamine synthetase cytosolic isozyme 1-4; High-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
UGD4UDP-glucose 6-dehydrogenase 4; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (480 aa)
LOX6Lipoxygenase 6, chloroplastic; Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity). 13S-lipoxygenase that can use linolenic acid as substrates. (917 aa)
CBSX2CBS domain-containing protein CBSX2, chloroplastic. (238 aa)
GLN1-2Glutamine synthetase cytosolic isozyme 1-2; Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
GLN1-5Glutamine synthetase cytosolic isozyme 1-5; Belongs to the glutamine synthetase family. (353 aa)
CBSX1CBS domain-containing protein CBSX1, chloroplastic. (236 aa)
PAF2Proteasome subunit alpha type-1-B; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. May play a role in thiol biosynthesis and arsenic tolerance in association with PAF1/ARS5. (277 aa)
HSP70-3Heat shock 70 kDa protein 3; In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions. (649 aa)
SAM2S-adenosylmethionine synthase 2; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (393 aa)
CSY4Citrate synthase 4, mitochondrial; Belongs to the citrate synthase family. (474 aa)
HSP70-1Heat shock 70 kDa protein 1; In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Probably involved in defense response. Chaperone involved in protein targeting to chloroplasts. May cooperate with SGT1 and HSP90 in R gene-mediated resistance towards the oomycete Hyaloperonospora parasitica (downy mildew). Plays a role with WPP-domain proteins in facilitating WIT1 nuclear [...] (651 aa)
HSP70-2Heat shock 70 kDa protein 2; In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions. Belongs to the heat shock protein 70 (TC 1.A.33) family. DnaK subfamily. (653 aa)
SAM1S-adenosylmethionine synthase 1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family. (393 aa)
PAF1Proteasome subunit alpha type-1-A; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Negatively regulates thiol biosynthesis and arsenic tolerance. (278 aa)
LOX2Lipoxygenase 2, chloroplastic; 13S-lipoxygenase that can use linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Required for the wound-induced synthesis of jasmonic acid (JA) in leaves. (896 aa)
UBC13Ubiquitin-conjugating enzyme E2 13; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
GSTF6Glutathione S-transferase F6; Involved in camalexin biosynthesis by probably catalyzing the conjugation of GSH with indole-3-acetonitrile (IAN). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides. (208 aa)
GLN2Glutamine synthetase, chloroplastic/mitochondrial; The light-modulated chloroplast/mitochondrial enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration. Belongs to the glutamine synthetase family. (430 aa)
GLN1-1Glutamine synthetase cytosolic isozyme 1-1; High-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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