node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKBH10B | ALKBH2 | Q9ZT92 | Q9SIE0 | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | 0.810 |
ALKBH10B | CPSF30 | Q9ZT92 | A9LNK9 | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | 0.835 |
ALKBH10B | FIP37 | Q9ZT92 | Q9ZSZ8 | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] | 0.942 |
ALKBH10B | HAKAI | Q9ZT92 | Q9LFC0 | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | E3 ubiquitin-protein ligase HAKAI homolog; Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. | 0.928 |
ALKBH2 | ALKBH10B | Q9SIE0 | Q9ZT92 | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | 0.810 |
ALKBH2 | ALKBH9B | Q9SIE0 | Q9SL49 | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. | 0.807 |
ALKBH2 | CPSF30 | Q9SIE0 | A9LNK9 | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | 0.657 |
ALKBH2 | FIP37 | Q9SIE0 | Q9ZSZ8 | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] | 0.784 |
ALKBH2 | HAKAI | Q9SIE0 | Q9LFC0 | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | E3 ubiquitin-protein ligase HAKAI homolog; Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. | 0.695 |
ALKBH9B | ALKBH2 | Q9SL49 | Q9SIE0 | RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | 0.807 |
ALKBH9B | CPSF30 | Q9SL49 | A9LNK9 | RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | 0.849 |
ALKBH9B | FIP37 | Q9SL49 | Q9ZSZ8 | RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. | FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] | 0.941 |
ALKBH9B | HAKAI | Q9SL49 | Q9LFC0 | RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. | E3 ubiquitin-protein ligase HAKAI homolog; Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. | 0.928 |
CPSF30 | ALKBH10B | A9LNK9 | Q9ZT92 | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | 0.835 |
CPSF30 | ALKBH2 | A9LNK9 | Q9SIE0 | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | 0.657 |
CPSF30 | ALKBH9B | A9LNK9 | Q9SL49 | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | RNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. | 0.849 |
CPSF30 | FIP37 | A9LNK9 | Q9ZSZ8 | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] | 0.969 |
CPSF30 | HAKAI | A9LNK9 | Q9LFC0 | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] | E3 ubiquitin-protein ligase HAKAI homolog; Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. | 0.815 |
FIP37 | ALKBH10B | Q9ZSZ8 | Q9ZT92 | FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] | RNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. | 0.942 |
FIP37 | ALKBH2 | Q9ZSZ8 | Q9SIE0 | FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). | 0.784 |