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nad9 nad9 nad7 nad7 ABI4 ABI4 B3H674_ARATH B3H674_ARATH POLIA POLIA NAC013 NAC013 NDA2 NDA2 RDR5 RDR5 RDR4 RDR4 RDR3 RDR3 RDR2 RDR2 RPS10 RPS10 ndhH ndhH psbA psbA ATP6-2 ATP6-2 COX2 COX2 ATP6-1 ATP6-1 M490_ARATH M490_ARATH M500_ARATH M500_ARATH NAD7 NAD7 Q0WVW4_ARATH Q0WVW4_ARATH KIN10 KIN10 Atmyb2 Atmyb2 AOX1A AOX1A MSH1 MSH1 POLIB POLIB CDKE-1 CDKE-1 RCD1 RCD1 NDB2 NDB2 NAD9 NAD9 ACT2 ACT2 WRKY63 WRKY63 PCMP-E69 PCMP-E69 CI51 CI51 CRS1 CRS1 RPOT2 RPOT2 RDR1 RDR1 SF1 SF1 MTERF18 MTERF18 T20K12.260 T20K12.260 ABF4 ABF4 WRKY40 WRKY40 RDR6 RDR6 NAC017 NAC017 OTP51 OTP51 F3G5.2 F3G5.2 WTF9 WTF9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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nad9NADH dehydrogenase subunit 9; Belongs to the complex I 30 kDa subunit family. (190 aa)
nad7NADH dehydrogenase subunit 7; Belongs to the complex I 49 kDa subunit family. (394 aa)
ABI4Ethylene-responsive transcription factor ABI4; Transcription regulator that probably binds to the GCC-box pathogenesis-related promoter element. Binds also to the S-box (5'- CACTTCCA-3') photosynthesis-associated nuclear genes-related (PhANGs- related) promoter element, and thus acts as a transcription inhibitor. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. May have a function in the deetiolation process. Confers sensitivity to abscisic acid (ABA), and regulates the ABA signaling pathway during seed germinatio [...] (328 aa)
B3H674_ARATHAlternative NAD(P)H dehydrogenase. (87 aa)
POLIADNA polymerase I A, chloroplastic/mitochondrial; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria. May be required for DNA repair in both organelles; Belongs to the DNA polymerase type-A family. (1050 aa)
NAC013NAC domain-containing protein 13; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Involved in oxidative stress tolerance by mediating regulation of mitochondrial retrograde signaling during mitochondrial dysfunction. Interacts directly with the mitochondrial dysfunction DNA consensus motif 5'- CTTGNNNNNCA[AC]G-3', a cis-regulatory elements of several mitochondrial retrograde regulation-induced genes, and triggers increased oxidative stress tolerance. (528 aa)
NDA2Internal alternative NAD(P)H-ubiquinone oxidoreductase A2, mitochondrial; Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane. (508 aa)
RDR5Probable RNA-dependent RNA polymerase 5; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family. (977 aa)
RDR4Probable RNA-dependent RNA polymerase 4; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family. (927 aa)
RDR3Probable RNA-dependent RNA polymerase 3; Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs); Belongs to the RdRP family. (992 aa)
RDR2RNA-dependent RNA polymerase 2; RNA-dependent direct polymerase involved in the production of small interfering RNAs (siRNAs). Required for the biogenesis of endogenous siRNAs of 24 nucleotide which derive from heterochromatin and DNA repeats such as transposons or endogenous gene tandem repeats, such as repeats present in FWA gene. Involved in transcriptional gene silencing (TGS). Component of the RNA-directed DNA methylation (RdDM) silencing pathway that utilizes siRNAs to guide DNA methyltransferases to asymmetric cytosines. Involved in control of flowering time through RdDM of FWA [...] (1133 aa)
RPS1040S ribosomal protein S10, mitochondrial. (241 aa)
ndhHNAD(P)H-quinone oxidoreductase subunit H, chloroplastic; NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Belongs to the complex I 49 kDa subunit family. (393 aa)
psbAPhotosystem II protein D1; Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. (353 aa)
ATP6-2ATP synthase subunit a-2; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subu [...] (349 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (260 aa)
ATP6-1ATP synthase subunit a-1; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subu [...] (385 aa)
M490_ARATHUncharacterized mitochondrial protein AtMg00490. (107 aa)
M500_ARATHUncharacterized mitochondrial protein AtMg00500. (141 aa)
NAD7NADH dehydrogenase [ubiquinone] iron-sulfur protein 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. (394 aa)
Q0WVW4_ARATHRNA-binding KH domain-containing protein. (607 aa)
KIN10SNF1-related protein kinase catalytic subunit alpha KIN10; Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, a central regulator of cellular energy homeostasis, which, in response to seemingly unrelated darkness, sugar and stress conditions, activates energy-producing pathways and inhibits energy-consuming processes. May play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA c [...] (512 aa)
Atmyb2MYB transcription factor (Atmyb2). (273 aa)
AOX1AUbiquinol oxidase 1a, mitochondrial; Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. Increases respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures. (354 aa)
MSH1DNA mismatch repair protein MSH1, mitochondrial; DNA mismatch repair protein specifically involved in maintenance of mitochondrial genome configuration by controlling specific rearranged portion. Functions by suppressing asymmetric recombination at some repeat pairs. (1118 aa)
POLIBDNA polymerase I B, chloroplastic/mitochondrial; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria. (1034 aa)
CDKE-1Cyclin-dependent kinase E-1; Involved in cell differentiation. Required for the specification of stamen and carpel identities and for the proper termination of stem cells in the floral meristem. (470 aa)
RCD1Inactive poly [ADP-ribose] polymerase RCD1; Inactive ADP-ribosyltransferase that functions with SRO1 to regulate oxidative stress, hormonal and developmental responses. Required for embryogenesis, vegetative and reproductive development, and abiotic stress responses. May regulate several stress-responsive genes. Seems to play a larger developmental role than SRO1. Does not bind NAD in vitro. (589 aa)
NDB2External alternative NAD(P)H-ubiquinone oxidoreductase B2, mitochondrial; Alternative NADH-ubiquinone oxidoreductase which catalyzes the oxidation of mitochondrial NADH does not translocate protons across the inner mitochondrial membrane (By similarity). Calcium-dependent NAD(P)H dehydrogenase; more efficient on NADH. Binds calcium ions. (582 aa)
NAD9NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (190 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
WRKY63Probable WRKY transcription factor 63; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group III family. (241 aa)
PCMP-E69Pentatricopeptide repeat-containing protein At1g74600, chloroplastic. (895 aa)
CI51NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (486 aa)
CRS1Chloroplastic group IIA intron splicing facilitator CRS1, chloroplastic; Required for the splicing of group IIA introns in chloroplasts, by regulating the intron folding. Forms splicing particles with RNA. May also be involved in chloroplast protein translation. (720 aa)
RPOT2DNA-directed RNA polymerase 2, chloroplastic/mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1011 aa)
RDR1RNA-dependent RNA polymerase 1; RNA-dependent direct polymerase involved in antiviral silencing. Required for the production of some small RNAs (mainly 21 and some 22 nucleotides) derived from the crucifer-infecting tobamovirus (TMV-cg). Required for turnip mosaic virus (TuMV) silencing and accumulation of viral siRNAs. Involved in cucumber mosaic virus (CMV) silencing. Required for the biogenesis of viral secondary siRNAs, process that follows the production of primary siRNAs derived from viral RNA replication. Specifically targets the positive-strand of the 3 RNA genomes of CMV and p [...] (1107 aa)
SF1Splicing factor-like protein 1; Necessary for the splicing of pre-mRNA. Required during development and for abscisic acid (ABA) responses. Belongs to the BBP/SF1 family. (804 aa)
MTERF18Transcription termination factor MTEF18, mitochondrial; Transcription termination factor involved in the regulation of mitochondrial-encoded gene expression. Essential for normal plant growth and development. (558 aa)
T20K12.260Pentatricopeptide repeat-containing protein At3g61360; Belongs to the PPR family. P subfamily. (498 aa)
ABF4ABSCISIC ACID-INSENSITIVE 5-like protein 7; Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter. (431 aa)
WRKY40Probable WRKY transcription factor 40; Transcription factor (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element (By similarity). (302 aa)
RDR6RNA-dependent RNA polymerase 6; RNA-dependent RNA polymerase involved in post-transcriptional gene silencing (PTGS). Possesses ssRNA and ssDNA-dependent polymerase activity, but does not have priming activity. Possesses in vitro 3' nucleotidyltransferase activity in the presence of UTP as single nucleotide. Required for the production of 21 nucleotide trans-acting small interfering RNAs (ta-siRNAs) derived from TAS1, TAS2 and TAS3 endogenous transcripts. Acts in the RDR6/SGS3/DCL4/AGO7 ta-siRNA pathway involved in leaf developmental timing. Required for the production of natural siRNAs [...] (1196 aa)
NAC017NAC domain-containing protein 17; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator that acts as positive regulator of AOX1A during mitochondrial dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial retrograde signaling. (557 aa)
OTP51Pentatricopeptide repeat-containing protein At2g15820, chloroplastic; Promotes the splicing of group II introns in chloroplasts. Required for the splicing of intron 2 of plastid ycf3 transcripts, a factor required for the assembly of photosystem I (PSI). Involved in the splicing of several other group-IIa introns. May be involved in the splicing of precursor forms of trnL, trnG, trnI, and trnA. Required for the assembly of PSI and PSII. (849 aa)
F3G5.2Pentatricopeptide repeat-containing protein At2g37230; Belongs to the PPR family. P subfamily. (757 aa)
WTF9Protein WHAT'S THIS FACTOR 9, mitochondrial; RNA-binding protein involved in group II intron splicing. Binds specific group II introns and promotes their splicing (e.g. rpl2 and ccmFC). (387 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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