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COI1 COI1 GPX2 GPX2 PXG3 PXG3 GPX3 GPX3 ADC2 ADC2 RBOHF RBOHF GPX6 GPX6 VSP1 VSP1 STR1 STR1 RBOHE RBOHE MSD1 MSD1 VSP2 VSP2 LOX2 LOX2 GSTF6 GSTF6 CLPD CLPD GPX1 GPX1 LTI65 LTI65 APX1 APX1 RD29A RD29A RD22 RD22 ACS5 ACS5 MYC2 MYC2 CAT3 CAT3 ACS4 ACS4 GPX4 GPX4 GPX8 GPX8 DHAR3 DHAR3 NAC072 NAC072 MDAR2 MDAR2 PIN7 PIN7 NPF2.10 NPF2.10 ABA2 ABA2 NAC019 NAC019 PDF1.2A PDF1.2A RBOHD RBOHD EDR1 EDR1 DHAR2 DHAR2 DHAR1 DHAR1 NAC055 NAC055 ABCB19 ABCB19 F18O14.31 F18O14.31 PIN2 PIN2 GPX5 GPX5 ACS9 ACS9 PIN3 PIN3 ACS11 ACS11 JAR1 JAR1 ACS7 ACS7 GPX7 GPX7 ACS8 ACS8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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COI1Coronatine-insensitive protein 1; Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles [...] (592 aa)
GPX2Probable glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses; Belongs to the glutathione peroxidase family. (169 aa)
PXG3Probable peroxygenase 3; Probable calcium-binding peroxygenase. May be involved in the degradation of storage lipid in oil bodies, in abiotic stress-related signaling pathway and in drought tolerance through stomatal control under water deficit conditions. (236 aa)
GPX3Probable glutathione peroxidase 3, mitochondrial; May constitute a glutathione peroxidase-like protective system against oxidative stresses. Involved positively in abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Oxidizes and represses target proteins (e.g. the phosphatase activity of ABI1 and ABI2) when oxidized by H(2)O(2), probably after ABA signaling. Modulates the calcium channel activity in guard cells in response to ABA or H(2)O(2). Confers tolerance to drought stress, by [...] (206 aa)
ADC2Arginine decarboxylase 2; Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine. Is a major contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis. Accumulation of putrescine plays a positive role in salt stress tolerance. Accumulation of putrescine plays a positive role in freezing tolerance. Production of PA is essential for normal seed development. Controls PA homeostasis which is crucial for normal plant growth and development. Belongs to the Orn/Lys/Arg decarboxylase [...] (711 aa)
RBOHFRespiratory burst oxidase homolog protein F; Calcium-dependent NADPH oxidase that generates superoxide. Generates reactive oxygen species (ROS) during incompatible interactions with pathogens and is important in the regulation of the hypersensitive response (HR). Involved in abscisic acid-induced stomatal closing and in UV-B and abscisic acid ROS-dependent signaling. Belongs to the RBOH (TC 5.B.1.3) family. (944 aa)
GPX6Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (232 aa)
VSP1Vegetative storage protein 1; May function as somatic storage protein during early seedling development; Belongs to the APS1/VSP family. (270 aa)
STR1Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial; Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is 3- mercaptopyruvate > thiosulfate. Involved in embryo and seed development. (379 aa)
RBOHERespiratory burst oxidase homolog protein E; Calcium-dependent NADPH oxidase that generates superoxide. (952 aa)
MSD1Superoxide dismutase [Mn] 1, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (231 aa)
VSP2Vegetative storage protein 2; May function as somatic storage protein during early seedling development; Belongs to the APS1/VSP family. (265 aa)
LOX2Lipoxygenase 2, chloroplastic; 13S-lipoxygenase that can use linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Required for the wound-induced synthesis of jasmonic acid (JA) in leaves. (896 aa)
GSTF6Glutathione S-transferase F6; Involved in camalexin biosynthesis by probably catalyzing the conjugation of GSH with indole-3-acetonitrile (IAN). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides. (208 aa)
CLPDChaperone protein ClpD, chloroplastic; Molecular chaperone that interact with a ClpP-like protease involved in degradation of denatured proteins in the chloroplast. The ATPase activity of CLPD is stimulated by CLPT1. Has no ADPase activity. Interacts with transit peptides with a positional preference. Localization of the signal sequence at the N-terminal end of a protein seems mandatory for interaction to take place ; Belongs to the ClpA/ClpB family. ClpD subfamily. (945 aa)
GPX1Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (236 aa)
LTI65Low-temperature-induced 65 kDa protein; Belongs to the LTI78/LTI65 family. (619 aa)
APX1L-ascorbate peroxidase 1, cytosolic; Plays a key role in hydrogen peroxide removal. Constitutes a central component of the reactive oxygen gene network. (250 aa)
RD29ALow-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family. (710 aa)
RD22BURP domain protein RD22; Acts to suppress chlorophyll degradation under moisture stress. (392 aa)
ACS51-aminocyclopropane-1-carboxylate synthase 5; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene. (470 aa)
MYC2Transcription factor MYC2; Transcriptional activator. Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways. With MYC3 and MYC4, controls additively subsets of JA-dependent responses. In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters. Binds directly to the prom [...] (623 aa)
CAT3Catalase-3; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (492 aa)
ACS41-aminocyclopropane-1-carboxylate synthase 4; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene. (474 aa)
GPX4Probable glutathione peroxidase 4; May constitute a glutathione peroxidase-like protective system against oxidative stresses; Belongs to the glutathione peroxidase family. (170 aa)
GPX8Probable glutathione peroxidase 8; May constitute a glutathione peroxidase-like protective system against oxidative stresses; Belongs to the glutathione peroxidase family. (167 aa)
DHAR3Glutathione S-transferase DHAR3, chloroplastic; Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses (By similarity). (258 aa)
NAC072NAC domain-containing protein 72; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (297 aa)
MDAR2Monodehydroascorbate reductase 2; Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process. (435 aa)
PIN7Auxin efflux carrier component 7; Acts as a component of the auxin efflux carrier. Mediates the initial auxin gradient which contributes to the establishment of the apical-basal axis in early embryogenesis. (619 aa)
NPF2.10Protein NRT1/ PTR FAMILY 2.10; High-affinity, proton-dependent glucosinolate-specific transporter. Involved in the distribution of glucosinolates within the leaf, including import into the glucosinolate-rich S-cells located adjacent to the phloem. Involved in bidirectional long-distance transport of aliphatic but not indole glucosinolates. May be involved in removal of glucosinolates from the xylem in roots. Belongs to the PTR2/POT transporter (TC 2.A.17) family. (636 aa)
ABA2Xanthoxin dehydrogenase; Involved in the biosynthesis of abscisic acid. (285 aa)
NAC019NAC domain-containing protein 19; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
PDF1.2ADefensin-like protein 16; Confers broad-spectrum resistance to pathogens. Has antifungal activity in vitro; Belongs to the DEFL family. (80 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
EDR1Serine/threonine-protein kinase EDR1; MAPKKK serine/threonine-protein kinase involved in the regulation of a MAP kinase cascade (probably including MPK3 and MPK6) that negatively regulates salicylic acid- (SA-) dependent defense responses, abscisic acid (ABA) signaling, and ethylene-induced senescence. Modulates also stress response (e.g. drought) signaling and cell death, in an ORE9-dependent manner. Functions at a point of cross talk between ethylene, ABA and SA signaling that impinges on senescence and cell death. On the other hand, it confers sensitivity to various pathogens such a [...] (933 aa)
DHAR2Glutathione S-transferase DHAR2; Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses. Plays a role in ozone tolerance; Belongs to the GST superfamily. DHAR family. (213 aa)
DHAR1Glutathione S-transferase DHAR1, mitochondrial; Displays a dual function. As a soluble protein, exhibits glutathione-dependent thiol transferase and dehydroascorbate (DHA) reductase activities. Key component of the ascorbate recycling system. Involved in the redox homeostasis, especially in scavenging of ROS under oxidative stresses, subsequently to biotic or abiotic inducers. As a peripheral membrane protein, could also function as voltage-gated ion channel. Belongs to the GST superfamily. DHAR family. (213 aa)
NAC055NAC domain-containing protein 55; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
ABCB19ABC transporter B family member 19; Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues, and from root tips to root elongating zone). Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation. (1252 aa)
F18O14.31Glutathione S-transferase family protein. (153 aa)
PIN2Auxin efflux carrier component 2; Acts as a component of the auxin efflux carrier. Seems to be involved in the root-specific auxin transport, and mediates the root gravitropism. Its particular localization suggest a role in the translocation of auxin towards the elongation zone. (647 aa)
GPX5Probable glutathione peroxidase 5; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (173 aa)
ACS91-aminocyclopropane-1-carboxylate synthase 9; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (470 aa)
PIN3Auxin efflux carrier component 3; Acts as a component of the auxin efflux carrier. Seems to be involved in the lateral auxin transport system and mediates tropic growth. Coordinated polar localization of PIN3 is directly regulated by the vesicle trafficking process. (640 aa)
ACS111-aminocyclopropane-1-carboxylate synthase 11; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (460 aa)
JAR1Jasmonoyl--L-amino acid synthetase JAR1; Catalyzes the synthesis of jasmonates-amino acid conjugates by adenylation; can use Ile and, in vitro at least, Val, Leu and Phe as conjugating amino acids on jasmonic acid (JA) and 9,10-dihydro-JA substrates, and to a lower extent, on 3-oxo-2-(2Z-pentenyl)- cyclopentane-1-butyric acid (OPC-4) and 12-hydroxy-JA (12-OH-JA). Can synthesize adenosine 5-tetraphosphate in vitro. Required for the JA- mediated signaling pathway that regulates many developmental and defense mechanisms, including growth root inhibition, vegetative storage proteins (VSPs) [...] (575 aa)
ACS71-aminocyclopropane-1-carboxylate synthase 7; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene. (447 aa)
GPX7Putative glutathione peroxidase 7, chloroplastic; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (233 aa)
ACS81-aminocyclopropane-1-carboxylate synthase 8; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene. (469 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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