STRINGSTRING
CLE45 CLE45 CLE41 CLE41 CLE25 CLE25 CLE16 CLE16 SYP132 SYP132 CLE44 CLE44 BET12 BET12 SMC2-1 SMC2-1 RABF1 RABF1 SBT4.13 SBT4.13 TDR TDR MEMB12 MEMB12 PXL1 PXL1 CLE9 CLE9 CLE27 CLE27 SBT1.4 SBT1.4 CLE40 CLE40 RPK2 RPK2 RABF2B RABF2B CLV1 CLV1 CLV3 CLV3 PRB1 PRB1 PR-1-LIKE PR-1-LIKE RLP23 RLP23 CLE2 CLE2 SBT1.7 SBT1.7 CLV2 CLV2 T16L1.220 T16L1.220 PR1-2 PR1-2 SBT6.1 SBT6.1 WAK1 WAK1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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CLE45CLAVATA3/ESR (CLE)-related protein 45; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Prevents, in a dose-dependent manner, auxin response in the root meristem thus leading in the repression of protophloem differentiation and periclinal sieve element precursor cell division. (124 aa)
CLE41CLAVATA3/ESR (CLE)-related protein 41; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins in an auxin-dependent manner. (99 aa)
CLE25CLAVATA3/ESR (CLE)-related protein 25; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (81 aa)
CLE16CLAVATA3/ESR (CLE)-related protein 16; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (103 aa)
SYP132Syntaxin-132; Vesicle trafficking protein that functions in the secretory pathway; Belongs to the syntaxin family. (304 aa)
CLE44CLAVATA3/ESR (CLE)-related protein 44; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins. (112 aa)
BET12Bet1-like SNARE 1-2; Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE associated with ER-derived vesicles (By similarity); Belongs to the BET1 family. (130 aa)
SMC2-1Structural maintenance of chromosomes protein 2-1; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis. (1175 aa)
RABF1Ras-related protein RABF1; Endosomal protein probably involved in endocytosis. Probably not involved in vacuolar trafficking. (202 aa)
SBT4.13Subtilisin-like protease SBT4.13; Belongs to the peptidase S8 family. (732 aa)
TDRLeucine-rich repeat receptor-like protein kinase TDR; Acts with CLE41p and CLE44p peptides as a ligand-receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1041 aa)
MEMB12Membrin-12; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network; Belongs to the GOSR2 family. (219 aa)
PXL1Leucine-rich repeat receptor-like protein kinase PXL1; Involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Phosphorylates HIRD11 and LHCA1 in vitro. (1029 aa)
CLE9CLAVATA3/ESR (CLE)-related protein 9; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (120 aa)
CLE27CLAVATA3/ESR (CLE)-related protein 27; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (91 aa)
SBT1.4Subtilisin-like protease SBT1.4. (777 aa)
CLE40CLAVATA3/ESR (CLE)-related protein 40; Extracellular signal peptide secreted by differentiated root cells that regulates root cell fate. Acts with ACR4 as a ligand- receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Promotes cell differentiation in the distal root meristem in a dose-dependent manner, especially the transition from columella stem cells (CSC) daughters into columella cells (CCs). Induces ACR4 expression in root quiescent center (QC). Involved in WUX5 QC-specific expression pattern [...] (80 aa)
RPK2LRR receptor-like serine/threonine-protein kinase RPK2; Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis). (1151 aa)
RABF2BRas-related protein RABF2b; Endosomal protein that may be involved in endocytosis. Involved in the trafficking of proteins from prevacuolar compartments (PVCs) to vacuoles. May activate the MON1-CCZ1 complex which acts as guanine nucleotide exchange factors (GEF) for Rab7 protein family, and serves as a link between Rab5 and Rab7 families in PVCs, and mediates PVC maturation. Involved in vacuolar transport of storage proteins with EREX as effector. Regulates membrane trafficking to protein storage vacuoles (PSVs). Belongs to the small GTPase superfamily. Rab family. (200 aa)
CLV1Receptor protein kinase CLAVATA1; Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (980 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
PRB1Pathogenesis-related protein 1; Probably involved in the defense reaction of plants against pathogens. (161 aa)
PR-1-LIKEPathogenesis-related protein-1-like protein; Belongs to the CRISP family. (176 aa)
RLP23Receptor like protein 23; Involved in the perception of necrosis and ethylene-inducing peptide 1-like proteins (NLPs), that act as extracellular signals mediating immune activation. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. (890 aa)
CLE2CLAVATA3/ESR (CLE)-related protein 2; Extracellular signal peptide that regulates cell fate. May act with CLV1 as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions. (75 aa)
SBT1.7Subtilisin-like protease SBT1.7; Serine protease. Has a substrate preference for the hydrophobic residues Phe and Ala and the basic residue Asp in the P1 position, and for Asp, Leu or Ala in the P1' position. Essential for mucilage release from seed coats. Triggers the accumulation and/or activation of cell wall modifying enzymes necessary either for the loosening of the outer primary cell wall, or to facilitate swelling of the mucilage. (757 aa)
CLV2Receptor-like protein CLAVATA2; Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful [...] (720 aa)
T16L1.220Pathogenesis-related protein-like; Belongs to the CRISP family. (172 aa)
PR1-2Pathogenesis-related protein 1; Partially responsible for acquired pathogen resistance. (161 aa)
SBT6.1Subtilisin-like protease SBT6.1; Serine protease that catalyzes the first step (site-1 cleavage) in the proteolytic activation of various factors, prior to site-2 cleavage. Part of a regulated intramembrane proteolysis (RIP) cascade. Cleaves BZIP17 and BZIP28 after the Arg-Arg-Ile-Leu (RRIL) motif. May cleave BZIP49 after the RRIL motif. Targets the membrane- associated BZIP17 factor, which functions as a stress sensor and transducer in a signaling pathway that resembles an ER stress response. Following salt stress, BZIP17 is cleaved by SBT6.1 (S1P) and S2P at the C-terminus and the N- [...] (1038 aa)
WAK1Wall-associated receptor kinase 1; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. Required during plant's response to pathogen infection and in plant defense against heavy metal toxicity. Phosphorylates the oxygen-evolving enhancer protein 2 (OEE2) in an GRP-3-dependent manner. (735 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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