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ALKBH8 ALKBH8 CPSF30 CPSF30 PAPS2 PAPS2 TCTP1 TCTP1 PAPS3 PAPS3 SCAR2 SCAR2 ARPC2A ARPC2A PAPS4 PAPS4 PAPS1 PAPS1 ALKBH2 ALKBH2 ALKBH9B ALKBH9B FIP37 FIP37 ALKBH10B ALKBH10B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ALKBH8Alkylated DNA repair protein ALKBH8 homolog; Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine. Belongs to the alkB family. (346 aa)
CPSF3030-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] (631 aa)
PAPS2Nuclear poly(A) polymerase 2; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). Mediates the polyadenylation of RNAs that are associated with polynucleotide phosphorylase (e.g. PNP1). (800 aa)
TCTP1Translationally-controlled tumor protein 1; General regulator required for the development of the entire plant. Regulates the duration of cell cycle. Probable activator of Rab GTPases and upstream regulator of the cell growth- regulating TOR (target of rapamycin) network. Might also control spatial growth in pollen tubes or root hairs via the TORC2 signaling branch. Involved in the regulation of abscisic acid- and calcium-mediated stomatal closure, but not in light or H(+)-pumping induced stomatal opening. May regulate microtubules depolymerization. Binds calcium and has a cytoprotecti [...] (168 aa)
PAPS3Nuclear poly(A) polymerase 3; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). (507 aa)
SCAR2Protein SCAR2; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion. Belongs to the SCAR/WAVE family. (1399 aa)
ARPC2AActin-related protein 2/3 complex subunit 2A; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development; Belongs to the ARPC2 family. (318 aa)
PAPS4Nuclear poly(A) polymerase 4; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). (741 aa)
PAPS1Nuclear poly(A) polymerase 1; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). (713 aa)
ALKBH2DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA containing 1- methyladenine and 1-ethenoadenine by oxidative demethylation. Accepts double-stranded and single-stranded substrates, with a preference for dsDNA over ssDNA. Confers resistance to methylating agents such as methylmethanesulphonate (MMS). (314 aa)
ALKBH9BRNA demethylase ALKBH9B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Modulates viral infection of the alfalfa mosaic virus (AMV) and the m6A abundance in its genomic RNAs. (507 aa)
FIP37FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] (330 aa)
ALKBH10BRNA demethylase ALKBH10B; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ALKBH10B-mediated mRNA m6A demethylation stabilizes the mRNA of the key flowering time regulators FT, SPL3 and SPL9, which are involved in the control of floral transition. (569 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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