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HXK1 HXK1 ATHXK4 ATHXK4 PGLCT PGLCT PU1 PU1 ISA2 ISA2 BAM6 BAM6 DPE2 DPE2 IREG3 IREG3 PTST-2 PTST-2 DSP4-2 DSP4-2 HXK3 HXK3 MEX1 MEX1 HKL1 HKL1 DPE1 DPE1 MFP1 MFP1 ISA3 ISA3 GBSS1 GBSS1 PGMP PGMP PHS2 PHS2 PGM2 PGM2 ATG8D ATG8D LSF2 LSF2 HKL3 HKL3 BAM5 BAM5 A0A1P8ARU2 A0A1P8ARU2 SBE3 SBE3 LSF1 LSF1 PGM3 PGM3 HXK2 HXK2 SSL12 SSL12 SS4 SS4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
PGLCTPlastidic glucose transporter 4; May be involved in the efflux of glucose towards the cytosol. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (546 aa)
PU1Pullulanase 1, chloroplastic; Involved in starch degradation and also probably in the trimming of pre-amylopectin chains during starch synthesis. (965 aa)
ISA2Isoamylase 2, chloroplastic; Involved in the trimming of pre-amylopectin chains. Accelerates the crystallization of nascent amylopectin molecules during starch synthesis. ISA1 and ISA2 work exclusively together as a multimeric holoenzyme. ISA1-ISA2 removes preferentially branches that are very close to other branches. (882 aa)
BAM6Beta-amylase 6; Belongs to the glycosyl hydrolase 14 family. (577 aa)
DPE24-alpha-glucanotransferase DPE2; Cytosolic alpha-glucanotransferase essential for the cytosolic metabolism of maltose, an intermediate on the pathway by which starch is converted to sucrose in leaves at night. Metabolizes maltose exported from the chloroplast and is specific for beta-maltose. May play a role in freezing tolerance. Temperature drop induces inactivation of DPE2 that leads to rapid accumulation of maltose, a solute that protects cells from freezing damage. Belongs to the disproportionating enzyme family. (955 aa)
IREG3Solute carrier family 40 member 3, chloroplastic; Probable plastid transporter that may play a role in iron chelation, storage or sequestration under limiting iron conditions. In presence of exogenous antibiotics, may allow opportunistic entry of multiple aminoglycoside antibiotics into the chloroplast. (598 aa)
PTST-2Protein PTST, chloroplastic; Involved in targeting GBSS1 to the starch granule. Was originally thought to be a carbohydrate-binding scaffold protein, but it has been shown that it is mainly found as a soluble protein and that interaction with GBSS1 is a pre-requisite for subsequent starch granule binding. Dissociation from starch as a function of pH, Mg(2+) concentration or redox state is not observed. Interacts primarily with amylopectin and is required for amylose synthesis. (277 aa)
DSP4-2Phosphoglucan phosphatase DSP4, chloroplastic; Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation. Acts as major regulator of the initial steps of starch degradation at the granule surface. Functions during the day by dephosphorylating the night-accumulated phospho- oligosaccharides. Can release phosphate from both the C6 and the C3 positions, but dephosphorylates preferentially the C6 position. (379 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
MEX1Maltose excess protein 1, chloroplastic; Probable maltose transporter. Essential for the conversion of starch to sucrose in leaves at night, probably via the export of maltose from the chloroplast. Required for root cap cells formation. (415 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
DPE14-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic; Chloroplastic alpha-glucanotransferase involved in maltotriose metabolism. Probably uses maltotriose as substrate to transfer a maltosyl unit from one molecule to another, resulting in glucose and maltopentaose. The latter can then be further metabolized to maltose and maltotriose by beta-amylase. Required for normal starch degradation in leaves; Belongs to the disproportionating enzyme family. (576 aa)
MFP1MAR-binding filament-like protein 1; Binds DNA. Interacts with chromatin via matrix attachment regions (MARs). Likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (By similarity). (726 aa)
ISA3Isoamylase 3, chloroplastic; Involved in starch catabolism. ISA3 removes different branches than ISA1-ISA2, namely short chains that prevent amylopectin crystallization. May be the debranching enzyme required to assist beta- amylases for starch degradation in leaves at night. Belongs to the glycosyl hydrolase 13 family. (764 aa)
GBSS1Granule-bound starch synthase 1, chloroplastic/amyloplastic; Required for the synthesis of amylose. Destroyed as it is released from the starch granules during the night. The circadian expression is controlled by CCA1 and LHY transcription factors. (610 aa)
PGMPPhosphoglucomutase, chloroplastic; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (623 aa)
PHS2Alpha-glucan phosphorylase 2, cytosolic; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (841 aa)
PGM2Probable phosphoglucomutase, cytoplasmic 2; This enzyme participates in both the breakdown and synthesis of glucose. (585 aa)
ATG8DAutophagy-related protein 8d; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (120 aa)
LSF2Phosphoglucan phosphatase LSF2, chloroplastic; Starch-associated phosphoglucan phosphatase that selectively dephosphorylates the glucan C3 position. Probably participates in the regulation of starch degradation. (282 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
BAM5Beta-amylase 5; Beta-amylase activity. Major cytosolic beta-amylase isoform in rosette leaves and inflorescences stems. (498 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
SBE31,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic; Catalyzes the formation of the alpha-1,6-glucosidic linkages in starch by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Essential during embryogenesis; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (899 aa)
LSF1Phosphoglucan phosphatase LSF1, chloroplastic; Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation. Participates in the regulation of the initial steps of starch degradation at the granule surface. May release a different set of phosphate groups from those removed by DSP4. (591 aa)
PGM3Probable phosphoglucomutase, cytoplasmic 1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (583 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
SSL12Protein STRICTOSIDINE SYNTHASE-LIKE 12; Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis. (335 aa)
SS4Probable starch synthase 4, chloroplastic/amyloplastic; Probably involved in the priming of starch granule formation. May play a regulatory role in the control of starch accumulation in plastids. Is necessary and sufficient to establish the correct number of starch granules observed in chloroplasts. Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily. (1040 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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