STRINGSTRING
PKP3 PKP3 HKL3 HKL3 LSF2 LSF2 T11I18.16 T11I18.16 TIM TIM F1O11.21 F1O11.21 APL4 APL4 T28P16.12 T28P16.12 PGM2 PGM2 PGMP PGMP GAPCP1 GAPCP1 GBSS1 GBSS1 T16L24.30 T16L24.30 PKP4 PKP4 APL2 APL2 APL3 APL3 HXK2 HXK2 SUS2 SUS2 SUC2 SUC2 HXK1 HXK1 ATHXK4 ATHXK4 GAPCP2 GAPCP2 PS2 PS2 BAM6 BAM6 AMY2 AMY2 DPE2 DPE2 AMY1 AMY1 ADG2 ADG2 APS1 APS1 SUS1 SUS1 CTIMC CTIMC PGIC PGIC GAPC1 GAPC1 BAM5 BAM5 F24G24.60 F24G24.60 M3E9.180 M3E9.180 PGM3 PGM3 SUS5 SUS5 A0A1P8ARU2 A0A1P8ARU2 AMY3 AMY3 PTST-2 PTST-2 Q94KE3_ARATH Q94KE3_ARATH F28G11.11 F28G11.11 T12P18.13 T12P18.13 DSP4-2 DSP4-2 MBK5.16 MBK5.16 BAM8 BAM8 MIO24.3 MIO24.3 PKP2 PKP2 MCD7.8 MCD7.8 SS1 SS1 MAH20.13 MAH20.13 SUS6 SUS6 GAPC2 GAPC2 HXK3 HXK3 PKP1 PKP1 T21E18.8 T21E18.8 T21E18.7 T21E18.7 HKL1 HKL1 Q9LU95_ARATH Q9LU95_ARATH DPE1 DPE1 MFP1 MFP1 SUS4 SUS4 T22P22.110 T22P22.110 F1I16_220 F1I16_220 F1I16_60 F1I16_60 SUS3 SUS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PKP3Plastidial pyruvate kinase 3, chloroplastic; Required for plastidial pyruvate kinase activity. (571 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
LSF2Phosphoglucan phosphatase LSF2, chloroplastic; Starch-associated phosphoglucan phosphatase that selectively dephosphorylates the glucan C3 position. Probably participates in the regulation of starch degradation. (282 aa)
T11I18.16Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
TIMTriosephosphate isomerase, chloroplastic; Belongs to the triosephosphate isomerase family. (315 aa)
F1O11.21Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
APL4Probable glucose-1-phosphate adenylyltransferase large subunit, chloroplastic; This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP (By similarity); Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (523 aa)
T28P16.12Probable fructokinase-1; May play an important role in maintaining the flux of carbon towards starch formation. (325 aa)
PGM2Probable phosphoglucomutase, cytoplasmic 2; This enzyme participates in both the breakdown and synthesis of glucose. (585 aa)
PGMPPhosphoglucomutase, chloroplastic; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (623 aa)
GAPCP1Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic; Involved in plastidial glycolytic pathway and plays a specific role in glycolytic energy production in non-green plastids and chloroplasts. Essential for breakdown of starch to form sucrose for export to non-photosynthetic tissues, and to generate primary metabolites for anabolic pathways such as fatty acid and amino acid synthesis. Plays an important role in plant development by providing substrates for the phosphorylated pathway of serine biosynthesis in roots. Plays a crucial role in pollen development. Functionally red [...] (422 aa)
GBSS1Granule-bound starch synthase 1, chloroplastic/amyloplastic; Required for the synthesis of amylose. Destroyed as it is released from the starch granules during the night. The circadian expression is controlled by CCA1 and LHY transcription factors. (610 aa)
T16L24.30Probable fructokinase-4; May play an important role in maintaining the flux of carbon towards starch formation. (326 aa)
PKP4Plastidial pyruvate kinase 4, chloroplastic. (710 aa)
APL2Glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic; This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP. (518 aa)
APL3Glucose-1-phosphate adenylyltransferase large subunit 3, chloroplastic; This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP. (521 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
SUS2Sucrose synthase 2; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and directs carbon towards starch synthesis in developing seeds. (807 aa)
SUC2Sucrose transport protein SUC2; Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system). Can also transport other glucosides such as maltose, arbutin (hydroquinone-beta-D- glucoside), salicin (2-(hydroxymethyl)phenyl-beta-D-glucoside), alpha- phenylglucoside, beta-phenylglucoside, alpha-paranitrophenylglucoside, beta-paranitrophenylglucoside, and paranitrophenyl-beta-thioglucoside. May also transport biotin. Required for apoplastic phloem sucrose loading in source tissues (e.g. leaves) in order to transport it to sink tissues (e.g [...] (512 aa)
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
GAPCP2Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic; Involved in plastidial glycolytic pathway and plays a specific role in glycolytic energy production in non-green plastids and chloroplasts. Essential for breakdown of starch to form sucrose for export to non-photosynthetic tissues, and to generate primary metabolites for anabolic pathways such as fatty acid and amino acid synthesis. Plays an important role in plant development by providing substrates for the phosphorylated pathway of serine biosynthesis in roots. Plays a crucial role in pollen development. Functionally red [...] (420 aa)
PS2Inorganic pyrophosphatase 1; Catalyzes the specific cleavage of pyrophosphate. Belongs to the HAD-like hydrolase superfamily. (295 aa)
BAM6Beta-amylase 6; Belongs to the glycosyl hydrolase 14 family. (577 aa)
AMY2Probable alpha-amylase 2; Probable alpha-amylase that does not seem to be required for breakdown of transitory starch in leaves. (413 aa)
DPE24-alpha-glucanotransferase DPE2; Cytosolic alpha-glucanotransferase essential for the cytosolic metabolism of maltose, an intermediate on the pathway by which starch is converted to sucrose in leaves at night. Metabolizes maltose exported from the chloroplast and is specific for beta-maltose. May play a role in freezing tolerance. Temperature drop induces inactivation of DPE2 that leads to rapid accumulation of maltose, a solute that protects cells from freezing damage. Belongs to the disproportionating enzyme family. (955 aa)
AMY1Alpha-amylase 1; Possesses alpha-amylase activity in vitro, but seems not required for breakdown of transitory starch in leaves. (423 aa)
ADG2Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic; This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP. (522 aa)
APS1Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic; This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP. (520 aa)
SUS1Sucrose synthase 1; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways; Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily. (808 aa)
CTIMCTriosephosphate isomerase, cytosolic; Belongs to the triosephosphate isomerase family. (254 aa)
PGICGlucose-6-phosphate isomerase, cytosolic; Belongs to the GPI family. (560 aa)
GAPC1Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] (338 aa)
BAM5Beta-amylase 5; Beta-amylase activity. Major cytosolic beta-amylase isoform in rosette leaves and inflorescences stems. (498 aa)
F24G24.60Probable fructokinase-5; May play an important role in maintaining the flux of carbon towards starch formation. (324 aa)
M3E9.180Probable pyruvate kinase, cytosolic isozyme; Key regulatory enzyme of the glycolytic pathway that catalyzes the final step of glycolysis, converting ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate by essentially irreversible transphosphorylation. (497 aa)
PGM3Probable phosphoglucomutase, cytoplasmic 1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (583 aa)
SUS5Sucrose synthase 5; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements. (836 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
AMY3Alpha-amylase 3, chloroplastic; Possesses endoamylolytic activity in vitro, but seems not required for breakdown of transitory starch in leaves. May be involved in the determination of the final structure of glucans by shortening long linear phospho-oligosaccharides in the chloroplast stroma. Can act on both soluble and insoluble glucan substrates to release small linear and branched malto-oligosaccharides. Works synergistically with beta-amylase toward efficient starch degradation. Has activity against p-nitrophenyl maltoheptaoside (BPNP-G7), amylopectin and beta-limit dextrin. Involv [...] (887 aa)
PTST-2Protein PTST, chloroplastic; Involved in targeting GBSS1 to the starch granule. Was originally thought to be a carbohydrate-binding scaffold protein, but it has been shown that it is mainly found as a soluble protein and that interaction with GBSS1 is a pre-requisite for subsequent starch granule binding. Dissociation from starch as a function of pH, Mg(2+) concentration or redox state is not observed. Interacts primarily with amylopectin and is required for amylose synthesis. (277 aa)
Q94KE3_ARATHPyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
F28G11.11Probable fructokinase-6, chloroplastic; May play an important role in maintaining the flux of carbon towards starch formation; Belongs to the carbohydrate kinase PfkB family. (384 aa)
T12P18.13BTB/POZ domain-containing protein At1g63850; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (548 aa)
DSP4-2Phosphoglucan phosphatase DSP4, chloroplastic; Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation. Acts as major regulator of the initial steps of starch degradation at the granule surface. Functions during the day by dephosphorylating the night-accumulated phospho- oligosaccharides. Can release phosphate from both the C6 and the C3 positions, but dephosphorylates preferentially the C6 position. (379 aa)
MBK5.16Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
BAM8Beta-amylase 8; Belongs to the glycosyl hydrolase 14 family. (689 aa)
MIO24.3Probable fructokinase-7; May play an important role in maintaining the flux of carbon towards starch formation. (343 aa)
PKP2Plastidial pyruvate kinase 2; Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination. (579 aa)
MCD7.8Pyruvate kinase; Belongs to the pyruvate kinase family. (498 aa)
SS1Starch synthase 1, chloroplastic/amyloplastic; Involved in the synthesis of short glycan chains within amylopectin in leaves. Is required to generate chains up to about a degree of polymerization of 10 (DP10). (652 aa)
MAH20.13Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
SUS6Sucrose synthase 6; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements. (942 aa)
GAPC2Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. (338 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
PKP1Plastidial pyruvate kinase 1, chloroplastic; Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination. (596 aa)
T21E18.8Probable fructokinase-2; May play an important role in maintaining the flux of carbon towards starch formation. (329 aa)
T21E18.7Probable fructokinase-3; May play an important role in maintaining the flux of carbon towards starch formation. (345 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
Q9LU95_ARATHPyruvate kinase; Belongs to the pyruvate kinase family. (497 aa)
DPE14-alpha-glucanotransferase DPE1, chloroplastic/amyloplastic; Chloroplastic alpha-glucanotransferase involved in maltotriose metabolism. Probably uses maltotriose as substrate to transfer a maltosyl unit from one molecule to another, resulting in glucose and maltopentaose. The latter can then be further metabolized to maltose and maltotriose by beta-amylase. Required for normal starch degradation in leaves; Belongs to the disproportionating enzyme family. (576 aa)
MFP1MAR-binding filament-like protein 1; Binds DNA. Interacts with chromatin via matrix attachment regions (MARs). Likely to participate in nuclear architecture by connecting chromatin with the nuclear matrix and potentially with the nuclear envelope (By similarity). (726 aa)
SUS4Sucrose synthase 4; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways; Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily. (808 aa)
T22P22.110Glycosyl hydrolases family 31 protein; Belongs to the glycosyl hydrolase 31 family. (902 aa)
F1I16_220Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa)
F1I16_60Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
SUS3Sucrose synthase 3; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and direct carbon towards starch synthesis in developing seeds. (809 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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