STRINGSTRING
TRM19 TRM19 F15H11.19 F15H11.19 MYB12 MYB12 PXG3 PXG3 WRKY23 WRKY23 IAA18 IAA18 GATA2 GATA2 GSTF9 GSTF9 DREB2A DREB2A DREB2B DREB2B GAPC1 GAPC1 RAB18 RAB18 COR47 COR47 CAD9 CAD9 AP2 AP2 IAA2 IAA2 GATA12 GATA12 RS40 RS40 RS41 RS41 DREB1B DREB1B LTI65 LTI65 RD29A RD29A RD22 RD22 IAA13 IAA13 NAC102 NAC102 MYB86 MYB86 ZIFL1 ZIFL1 TEM1 TEM1 BZIP8 BZIP8 NAC032 NAC032 LNK4 LNK4 BZIP9 BZIP9 NAC083 NAC083 MYB108 MYB108 RZ1A RZ1A MYB21 MYB21 NHX7 NHX7 BHLH125 BHLH125 MYB3 MYB3 SR45 SR45 ABH1 ABH1 SUR1 SUR1 FMOGS-OX1 FMOGS-OX1 COL9 COL9 WRKY29 WRKY29 MYB4 MYB4 CBP20 CBP20 ANN4 ANN4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
TRM19Afadin. (955 aa)
F15H11.19Chaperone DnaJ-domain superfamily protein. (165 aa)
MYB12Transcription factor MYB12; Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis mainly in the root. Confers tolerance to UV-B. (371 aa)
PXG3Probable peroxygenase 3; Probable calcium-binding peroxygenase. May be involved in the degradation of storage lipid in oil bodies, in abiotic stress-related signaling pathway and in drought tolerance through stomatal control under water deficit conditions. (236 aa)
WRKY23WRKY transcription factor 23; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (337 aa)
IAA18Auxin-responsive protein IAA18; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin- responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. (267 aa)
GATA2GATA transcription factor 2; Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes. (264 aa)
GSTF9Glutathione S-transferase F9; In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide and linoleic acid-13-hydroperoxide. May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides. (215 aa)
DREB2ADehydration-responsive element-binding protein 2A; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription. Belongs to the AP2/ERF transcription factor family. ERF subfamily. (335 aa)
DREB2BDehydration-responsive element-binding protein 2B; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription. Belongs to the AP2/ERF transcription factor family. ERF subfamily. (330 aa)
GAPC1Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] (338 aa)
RAB18Dehydrin Rab18; Belongs to the plant dehydrin family. (186 aa)
COR47Dehydrin COR47. (265 aa)
CAD9Probable cinnamyl alcohol dehydrogenase 9; Involved in lignin biosynthesis. May catalyze the final step specific for the production of lignin monomers, like coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol. (360 aa)
AP2Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...] (432 aa)
IAA2Auxin-responsive protein IAA2; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin- responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. (174 aa)
GATA12GATA transcription factor 12; Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes (By similarity). Transcription activator involved in xylem formation. Functions upstream of NAC030/VND7, a master switch of xylem vessel differentiation ; Belongs to the type IV zinc-finger family. Class A subfamily. (331 aa)
RS40Serine/arginine-rich splicing factor RS40; Required for constitutive and alternative pre-mRNA splicing (Probable). Involved in primary miRNA processing and pri-miRNA biogenesis. Binds both intronless and intron-containing pri-miRNAs. (350 aa)
RS41Serine/arginine-rich splicing factor RS41; Required for constitutive and alternative pre-mRNA splicing (Probable). Involved in primary miRNA processing and pri-miRNA biogenesis. Binds both intronless and intron-containing pri-miRNAs. (356 aa)
DREB1BDehydration-responsive element-binding protein 1B; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation; Belongs to the AP2/ERF transcription factor family. ERF subfamily. (213 aa)
LTI65Low-temperature-induced 65 kDa protein; Belongs to the LTI78/LTI65 family. (619 aa)
RD29ALow-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family. (710 aa)
RD22BURP domain protein RD22; Acts to suppress chlorophyll degradation under moisture stress. (392 aa)
IAA13Auxin-responsive protein IAA13; Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin- responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. (247 aa)
NAC102NAC domain-containing protein 102; May be involved in regulation of seed germination under flooding. (312 aa)
MYB86Transcription factor MYB86; Probable transcription factor. (352 aa)
ZIFL1Protein ZINC INDUCED FACILITATOR-LIKE 1; Major facilitator superfamily (MFS) transporter probably involved in 2,4-dichlorophenoxyacetic acid (2,4-D) export. K(+) may be the physiological substrate of the transporter. [Isoform 3]: Mediates drought stress tolerance by regulating stomatal closure. (478 aa)
TEM1AP2/ERF and B3 domain-containing transcription repressor TEM1; Transcriptional repressor of flowering time on long day plants. Acts directly on FT expression by binding 5'-CAACA-3' and 5'- CACCTG-3 sequences. Functionally redundant with TEM2. Belongs to the AP2/ERF transcription factor family. RAV subfamily. (361 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
NAC032NAC transcription factor 32; Transcriptional activator that positively regulates age- dependent senescence, dark-induced leaf senescence and stress-induced senescence. Regulates leaf senescence through the modulation of the expression of senescence-associated genes SGR1/NYE1, SAG113 and SAUR36/SAG201, which are involved in chlorophyll degradation, and abscisic acid (ABA) and auxin promotion of senescence, respectively. Promotes reactive oxygen species (ROS) production during age-dependent and stress-induced senescence. Regulates positively auxin-mediated responses in roots. Stress-resp [...] (253 aa)
LNK4Protein LNK4; Probable transcriptional coactivator. (274 aa)
BZIP9Basic leucine zipper 9; Transcription factor; Belongs to the bZIP family. (277 aa)
NAC083NAC domain-containing protein 83; Transcriptional repressor that negatively regulates the expression of genes involved in xylem vessel formation. Represses the transcriptional activation activity of NAC030/VND7, which regulates protoxylem vessel differentiation by promoting immature xylem vessel- specific genes expression. Transcriptional activator that regulates the COLD-REGULATED (COR15A and COR15B) and RESPONSIVE TO DEHYDRATION (LTI78/RD29A and LTI65/RD29B) genes by binding directly to their promoters. Mediates signaling crosstalk between salt stress response and leaf aging process. [...] (252 aa)
MYB108Transcription factor MYB108; Transcription factor contributing to the regulation of stamen maturation and male fertility in response to jasmonate signaling. Required for correct timing of anther dehiscence. Acts as a negative regulator of abscisic acid-induced cell death. Not involved in the regulation of BOI. Regulated by MYB21 and at a lower level by MYB24. Negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin- protein ligase complex-dependent manner. (323 aa)
RZ1AGlycine-rich RNA-binding protein RZ1A; Binds RNA and DNA sequences with a preference to single- stranded nucleic acids. Displays strong affinity to poly(G) and poly(U) sequences. May be involved in tolerance to cold stress. (245 aa)
MYB21Transcription factor MYB21; Transcription factor involved in photomorphogenesis in the light. May act downstream of the light receptor network and directly affects transcription of light-induced genes. In darkness, its probable degradation prevent the activation of light-induced genes. Required to activate expression of PAL. Acts redundantly with MYB24 and MYB57 to control stamen filament elongation in the late developed flowers. Contributes with MYB24 to induction of MYB108 by jasmonate. Repressed at the transcript levels by DELLA proteins. (226 aa)
NHX7Sodium/hydrogen exchanger 7; Acts in electroneutral exchange of protons for cations such as Na(+) or Li(+) across plasma membrane. Involved in Na(+) and K(+) homeostasis. Required for cytoplasmic Na(+) and Li(+) detoxification by secreting them from the cytoplasm to the extracellular space. Regulates Na(+) content of the xylem sap. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (1146 aa)
BHLH125Transcription factor bHLH125. (259 aa)
MYB3Transcription factor MYB3. (257 aa)
SR45Serine/arginine-rich splicing factor SR45; Involved in 5' and 3' splicing site selection of introns, and may bridge the 5' and 3' components of the spliceosome. Isoform 1 is required during flower petal development and isoform 2 is involved in root growth. Regulates negatively glucose and abscisic acid (ABA) signaling during early seedling development. Involved in the RNA- directed DNA methylation pathway. Modulates KIN10 stability in response to sugars, probably through the splicing regulation of 5PTASE13, a protein implicated in the proteasomal degradation of KIN10. Belongs to the sp [...] (414 aa)
ABH1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary miRNA processing. In the CBC complex, ABH1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of CBP20 and lock the CBC into a high affinity cap-binding state [...] (848 aa)
SUR1S-alkyl-thiohydroximate lyase SUR1; C-S lyase involved in glucosinolate biosynthesis. Converts S- (alkylacetohydroximoyl)-L-cysteine to thiohydroximate. Functions in auxin homeostasis. Probably required for glucosinolate activation in response to pathogens; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (462 aa)
FMOGS-OX1Flavin-containing monooxygenase FMO GS-OX1; Catalyzes the conversion of methylthioalkyl glucosinolates into methylsulfinylalkyl glucosinolates. Able to S-oxygenate both desulfo- and intact 4-methylthiobutyl glucosinolates, but no activity with methionine, dihomomethionine or 5-methylthiopentaldoxime. (459 aa)
COL9Zinc finger protein CONSTANS-LIKE 9; Belongs to the CONSTANS family. (372 aa)
WRKY29Probable WRKY transcription factor 29; Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element. Activates WRKY 22, SIRK and its own promoters; Belongs to the WRKY group II-e family. (304 aa)
MYB4Transcription repressor MYB4; Transcription repressor involved in regulation of protection against UV. Mediates transcriptional repression of CYP73A5, the gene encoding trans-cinnamate 4-monooxygenase, thereby regulating the accumulation of the UV-protectant compound sinapoylmalate. (282 aa)
CBP20Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs). The CBC complex is involved in miRNA- mediated RNA interference and is required for primary miRNA processing. In the CBC complex, CBP20 recognizes and binds capped RNAs (m7GpppG- capped RNA) but requires ABH1/CBP80 to stabilize the movement of its N- terminal loop and lock the CBC into a high affinity cap-binding state wi [...] (257 aa)
ANN4Annexin D4; May be involved in osmotic stress and abscisic acid signaling in a calcium-dependent manner. (319 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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