(14 nodes) (2020) Biosystems Design to Accelerate C3-to-CAM Progression. network (Arabidopsis thaliana)

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	RD29A	Low-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family. (710 aa)
	PPC2	Phosphoenolpyruvate carboxylase 2; Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (963 aa)
	TDT	Tonoplast dicarboxylate transporter; Putative carrier protein indirectly involved in the uptake of malate and fumarate to the vacuole, probably by regulating the energization across the tonoplast. Uptake of malate to vacuoles is inhibited by citrate and by the uncoupler carbonyl-cyanide m- chlorophenylhydrazone, but seems to be not affected by sodium. Critical for pH homeostasis; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. (540 aa)
	BZIP8	Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
	NADP-ME2	NADP-dependent malic enzyme 2. (588 aa)
	PPCK1	Phosphoenolpyruvate carboxylase kinase 1; Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation. (284 aa)
	PCKA	Phosphoenolpyruvate carboxykinase (ATP). (671 aa)
	NAD-ME2	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period. (607 aa)
	PPDK	Pyruvate, phosphate dikinase 1, chloroplastic; Formation of phosphoenolpyruvate. May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves. (963 aa)
	NADP-ME1	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family. (581 aa)
	TOPP1	Serine/threonine-protein phosphatase PP1 isozyme 1; Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro. Acts as negative regulator of abscisic acid (ABA) signaling. In vitro, can dephosphorylate and inhibit the kinase activity of SRK2E/SNRK2.6, an activator of ABA signaling. (318 aa)
	AP2	Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...] (432 aa)
	PHOT2	Phototropin-2; Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Phosphorylates BLUS1, a kinase involved in stomatal opening. Mediates calcium spiking of extra- and intracellular origins in response to blue light. Involved in hypocotyl phototropism. Contributes to the chloroplast accumulation in low blue light and mediates their translocation (avoidance response) at high fluence. Regulates stomata opening and photomorphogenesis response of leaf tissue. Not involved in hypocotyl elongation inhibition, anthocyanin accumul [...] (915 aa)
	MDH1	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)

Your Current Organism:

Arabidopsis thaliana

NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2	BZIP8	P47927	Q9CA46	Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...]	Basic leucine zipper 8; Belongs to the bZIP family.	0.960
AP2	RD29A	P47927	Q06738	Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...]	Low-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family.	0.785
BZIP8	AP2	Q9CA46	P47927	Basic leucine zipper 8; Belongs to the bZIP family.	Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...]	0.960
BZIP8	RD29A	Q9CA46	Q06738	Basic leucine zipper 8; Belongs to the bZIP family.	Low-temperature-induced 78 kDa protein; Involved in responses to abiotic stresses. Regulates probably root elongation in cold conditions ; Belongs to the LTI78/LTI65 family.	0.794
MDH1	NAD-ME2	P93819	Q8L7K9	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	0.985
MDH1	NADP-ME1	P93819	O82191	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family.	0.910
MDH1	NADP-ME2	P93819	Q9LYG3	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	NADP-dependent malic enzyme 2.	0.906
MDH1	PCKA	P93819	Q9T074	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	Phosphoenolpyruvate carboxykinase (ATP).	0.960
MDH1	PPC2	P93819	Q5GM68	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	Phosphoenolpyruvate carboxylase 2; Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	0.928
MDH1	PPDK	P93819	O23404	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	Pyruvate, phosphate dikinase 1, chloroplastic; Formation of phosphoenolpyruvate. May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves.	0.567
NAD-ME2	MDH1	Q8L7K9	P93819	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	0.985
NAD-ME2	NADP-ME1	Q8L7K9	O82191	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family.	0.913
NAD-ME2	NADP-ME2	Q8L7K9	Q9LYG3	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	NADP-dependent malic enzyme 2.	0.916
NAD-ME2	PCKA	Q8L7K9	Q9T074	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	Phosphoenolpyruvate carboxykinase (ATP).	0.682
NAD-ME2	PPC2	Q8L7K9	Q5GM68	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	Phosphoenolpyruvate carboxylase 2; Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	0.807
NAD-ME2	PPDK	Q8L7K9	O23404	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	Pyruvate, phosphate dikinase 1, chloroplastic; Formation of phosphoenolpyruvate. May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves.	0.984
NADP-ME1	MDH1	O82191	P93819	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family.	Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments.	0.910
NADP-ME1	NAD-ME2	O82191	Q8L7K9	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family.	NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.	0.913
NADP-ME1	PPC2	O82191	Q5GM68	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family.	Phosphoenolpyruvate carboxylase 2; Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	0.679
NADP-ME1	PPCK1	O82191	Q9SPK4	NADP-dependent malic enzyme 1; Belongs to the malic enzymes family.	Phosphoenolpyruvate carboxylase kinase 1; Calcium-independent kinase involved in light-dependent phosphoenolpyruvate carboxylase phosphorylation.	0.600