STRINGSTRING
IAR4 IAR4 F4IWV2_ARATH F4IWV2_ARATH IDH3 IDH3 F11A3.3 F11A3.3 SDH1-1 SDH1-1 CSY4 CSY4 E1_ALPHA E1_ALPHA F8L15_30 F8L15_30 IDH2 IDH2 FUM1 FUM1 PDH2 PDH2 ACO1 ACO1 MKD15.11 MKD15.11 SDH2-2 SDH2-2 SDH2-1 SDH2-1 IDH1 IDH1 IDH6 IDH6 IDH5 IDH5 ACO2-2 ACO2-2 SDH2-3 SDH2-3 MPA24.10 MPA24.10 MMDH2 MMDH2 CSY5 CSY5 ACO3 ACO3 NAD-ME1 NAD-ME1 CICDH CICDH MMDH1 MMDH1 SDH1-2 SDH1-2 NAD-ME2 NAD-ME2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IAR4Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (393 aa)
F4IWV2_ARATH2-oxoglutarate dehydrogenase, E1 component. (1017 aa)
IDH3Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa)
F11A3.3Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (421 aa)
SDH1-1Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (634 aa)
CSY4Citrate synthase 4, mitochondrial; Belongs to the citrate synthase family. (474 aa)
E1_ALPHAPyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (389 aa)
F8L15_30Succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (347 aa)
IDH2Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (367 aa)
FUM1Fumarate hydratase 1, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (By similarity). (492 aa)
PDH2Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (363 aa)
ACO1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. May have a role in respiration. Belongs to the aconitase/IPM isomerase family. (898 aa)
MKD15.11Succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (341 aa)
SDH2-2Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
SDH2-1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (279 aa)
IDH1Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (367 aa)
IDH6Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (374 aa)
IDH5Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (374 aa)
ACO2-2Aconitate hydratase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. Involved in acetate assimilation. (995 aa)
SDH2-3Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (309 aa)
MPA24.10Putative 2-oxoglutarate dehydrogenase E1 component. (1025 aa)
MMDH2Malate dehydrogenase 2, mitochondrial; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Can convert 2-ketoglutarate to L-2-hydroxyglutarate in vitro. Belongs to the LDH/MDH superfamily. MDH type 1 family. (341 aa)
CSY5Citrate synthase 5, mitochondrial; Belongs to the citrate synthase family. (464 aa)
ACO3Aconitate hydratase 3, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. Modulates cytosolic citrate metabolism during lipid mobilization. Required during seedling growth. Belongs to the aconitase/IPM isomerase family. (990 aa)
NAD-ME1NAD-dependent malic enzyme 1, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period. (623 aa)
CICDHCytosolic isocitrate dehydrogenase [NADP]; May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. May be involved in the production of NADPH to promote redox signaling or homeostasis in response to oxidative stress. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (410 aa)
MMDH1Malate dehydrogenase 1, mitochondrial; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Its activity is essential to shuttle reductants out from the mitochondria to support the photorespiratory flux. Can convert 2-oxoglutarate to (S)-2-hydroxyglutarate in vitro. (341 aa)
SDH1-2Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (632 aa)
NAD-ME2NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period. (607 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.