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PCK2 PCK2 LPD1 LPD1 F4IWV2_ARATH F4IWV2_ARATH LPD2 LPD2 ACLA-2 ACLA-2 PDH-E1_ALPHA PDH-E1_ALPHA E1-BETA-2 E1-BETA-2 ACLA-3 ACLA-3 IDH3 IDH3 PMDH1 PMDH1 F11A3.3 F11A3.3 SDH1-1 SDH1-1 SDH3-1 SDH3-1 CSY4 CSY4 E1_ALPHA E1_ALPHA MDH2 MDH2 F8L15_30 F8L15_30 IDH2 IDH2 FUM1 FUM1 MDH1 MDH1 LTA3 LTA3 PDH2 PDH2 ACO1 ACO1 F20D21.4 F20D21.4 F10M23.250 F10M23.250 IAR4 IAR4 MKD15.11 MKD15.11 SDH2-2 SDH2-2 SDH2-1 SDH2-1 IDH1 IDH1 IDH6 IDH6 T15N1.80 T15N1.80 MDC16.5 MDC16.5 IDH5 IDH5 ACO2-2 ACO2-2 ACLB-1 ACLB-1 PDH-E1_BETA PDH-E1_BETA EMB3003 EMB3003 ACLB-2 ACLB-2 FUM2 FUM2 SDH2-3 SDH2-3 MDH3 MDH3 MPA24.10 MPA24.10 MCO15.2 MCO15.2 MMDH2 MMDH2 IDH4 IDH4 CSY2 CSY2 CSY1 CSY1 CSY5 CSY5 LPD2-2 LPD2-2 LPD1-2 LPD1-2 ACLA-1 ACLA-1 ACO3 ACO3 CSY3 CSY3 ICDH ICDH MDH MDH LTA2 LTA2 CICDH CICDH PCKA PCKA PMDH2 PMDH2 MMDH1 MMDH1 SDH1-2 SDH1-2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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PCK2Phosphoenolpyruvate carboxykinase 2. (701 aa)
LPD1Dihydrolipoyl dehydrogenase 1, chloroplastic; Lipoamide dehydrogenase is a component of the plastidial pyruvate dehydrogenase complex (PDC). (623 aa)
F4IWV2_ARATH2-oxoglutarate dehydrogenase, E1 component. (1017 aa)
LPD2Dihydrolipoyl dehydrogenase 2, chloroplastic; Lipoamide dehydrogenase is a component of the plastidial pyruvate dehydrogenase complex (PDC); Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (567 aa)
ACLA-2ATP-citrate synthase alpha chain protein 2; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known anima [...] (423 aa)
PDH-E1_ALPHAPyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (428 aa)
E1-BETA-2Pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (406 aa)
ACLA-3ATP-citrate synthase alpha chain protein 3; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known anima [...] (424 aa)
IDH3Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa)
PMDH1Malate dehydrogenase 1, peroxisomal; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Peroxisomal NAD-dependent malate dehydrogenase involved in fatty acid beta-oxidation. Reoxidizes NADH from the beta- oxidation and provides NAD for the conversion of fatty acyl-CoA to acetyl-CoA. Does not participate directly in the glyoxylate cycle. Required for maintenance of photosynthetic rates under photorespiratory conditions, and carbon flow during photorespiration. Supplies NADH reductant [...] (354 aa)
F11A3.3Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (421 aa)
SDH1-1Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (634 aa)
SDH3-1Succinate dehydrogenase subunit 3-1, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (213 aa)
CSY4Citrate synthase 4, mitochondrial; Belongs to the citrate synthase family. (474 aa)
E1_ALPHAPyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (389 aa)
MDH2Malate dehydrogenase 2, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)
F8L15_30Succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (347 aa)
IDH2Isocitrate dehydrogenase [NAD] regulatory subunit 2, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (367 aa)
FUM1Fumarate hydratase 1, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (By similarity). (492 aa)
MDH1Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)
LTA3Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (637 aa)
PDH2Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (363 aa)
ACO1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. May have a role in respiration. Belongs to the aconitase/IPM isomerase family. (898 aa)
F20D21.4Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (539 aa)
F10M23.2502-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (464 aa)
IAR4Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (393 aa)
MKD15.11Succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (341 aa)
SDH2-2Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
SDH2-1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (279 aa)
IDH1Isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (367 aa)
IDH6Isocitrate dehydrogenase [NAD] catalytic subunit 6, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (374 aa)
T15N1.80Isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial; May be involved in response to oxidative stresses. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (485 aa)
MDC16.5Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (539 aa)
IDH5Isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (374 aa)
ACO2-2Aconitate hydratase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. Involved in acetate assimilation. (995 aa)
ACLB-1ATP-citrate synthase beta chain protein 1; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known animal [...] (608 aa)
PDH-E1_BETAPyruvate dehydrogenase E1 component subunit beta-2, chloroplastic; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (406 aa)
EMB3003Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (465 aa)
ACLB-2ATP-citrate synthase beta chain protein 2; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. n contrast to all known animal [...] (608 aa)
FUM2Fumarate hydratase 2; Cytosolic fumarate hydratase that catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Catalyzes the dehydration of L-malate to fumarate in the cytosol: required for the massive fumarate accumulation during the day in plants grown under high nitrogen. Also required for acclimation of photosynthesis to cold: acts by mediating accumulation of fumarate at low temperature, leading to reduce accumulation of phosphorylated sugars. (499 aa)
SDH2-3Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (309 aa)
MDH3Malate dehydrogenase 3, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments; Belongs to the LDH/MDH superfamily. MDH type 2 family. (339 aa)
MPA24.10Putative 2-oxoglutarate dehydrogenase E1 component. (1025 aa)
MCO15.22-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (464 aa)
MMDH2Malate dehydrogenase 2, mitochondrial; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Can convert 2-ketoglutarate to L-2-hydroxyglutarate in vitro. Belongs to the LDH/MDH superfamily. MDH type 1 family. (341 aa)
IDH4Putative isocitrate dehydrogenase [NAD] subunit-like 4; Performs an essential role in the oxidative function of the citric acid cycle. (294 aa)
CSY2Citrate synthase 2, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (514 aa)
CSY1Citrate synthase 1, peroxisomal; Belongs to the citrate synthase family. (480 aa)
CSY5Citrate synthase 5, mitochondrial; Belongs to the citrate synthase family. (464 aa)
LPD2-2Dihydrolipoyl dehydrogenase 2, mitochondrial; Lipoamide dehydrogenase is a component of the glycine decarboxylase (GDC) or glycine cleavage system as well as of the alpha- ketoacid dehydrogenase complexes. LPD1 is probably the protein most often associated with the glycine decarboxylase complex while LPD2 is probably incorporated into alpha-ketoacid dehydrogenase complexes. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (507 aa)
LPD1-2Dihydrolipoyl dehydrogenase 1, mitochondrial; Lipoamide dehydrogenase is a component of the glycine decarboxylase (GDC) or glycine cleavage system as well as of the alpha- ketoacid dehydrogenase complexes. LPD1 is probably the protein most often associated with the glycine decarboxylase complex while LPD2 is probably incorporated into alpha-ketoacid dehydrogenase complexes. (507 aa)
ACLA-1ATP-citrate synthase alpha chain protein 1; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, used for the elongation of fatty acids and biosynthesis of isoprenoids, flavonoids and malonated derivatives. May supply substrate to the cytosolic acetyl-CoA carboxylase, which generates the malonyl-CoA used for the synthesis of a multitude of compounds, including very long chain fatty acids and flavonoids. Required for normal growth and development and elongation of C18 fatty acids to C20 to C24 fatty acids in seeds. In contrast to all known anima [...] (423 aa)
ACO3Aconitate hydratase 3, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. Modulates cytosolic citrate metabolism during lipid mobilization. Required during seedling growth. Belongs to the aconitase/IPM isomerase family. (990 aa)
CSY3Citrate synthase 3, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (509 aa)
ICDHPeroxisomal isocitrate dehydrogenase [NADP]; May be involved in response to oxidative stresses. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (416 aa)
MDHMalate dehydrogenase, chloroplastic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Plays a key role in the metabolism of dark chloroplasts and non-green plastids. Essential for embryo viability. Plays an essential role in heterotrophic metabolism in embryos, and autotrophic metabolism in photosynthetic tissues as well. (403 aa)
LTA2Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (480 aa)
CICDHCytosolic isocitrate dehydrogenase [NADP]; May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. May be involved in the production of NADPH to promote redox signaling or homeostasis in response to oxidative stress. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (410 aa)
PCKAPhosphoenolpyruvate carboxykinase (ATP). (671 aa)
PMDH2Malate dehydrogenase 2, peroxisomal; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Peroxisomal NAD-dependent malate dehydrogenase involved in fatty acid beta-oxidation. Reoxidizes NADH from the beta- oxidation and provides NAD for the conversion of fatty acyl-CoA to acetyl-CoA. Does not participate directly in the glyoxylate cycle. Required for maintenance of photosynthetic rates under photorespiratory conditions, and carbon flow during photorespiration. Supplies NADH reductant [...] (354 aa)
MMDH1Malate dehydrogenase 1, mitochondrial; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. Its activity is essential to shuttle reductants out from the mitochondria to support the photorespiratory flux. Can convert 2-oxoglutarate to (S)-2-hydroxyglutarate in vitro. (341 aa)
SDH1-2Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (632 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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