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MRG7.17 MRG7.17 ACC2 ACC2 CAC2 CAC2 FAB2 FAB2 LACS1 LACS1 F21J9.2 F21J9.2 KAS_III KAS_III KAS1 KAS1 accD accD ACC1 ACC1 BCCP1 BCCP1 FATA FATA S-ACP-DES6 S-ACP-DES6 AAE13 AAE13 KAS KAS T6D9.100 T6D9.100 LACS7 LACS7 LACS6 LACS6 EMB3147 EMB3147 AAE15 AAE15 LACS3 LACS3 KAS2 KAS2 LACS9 LACS9 CAC3 CAC3 S-ACP-DES1 S-ACP-DES1 S-ACP-DES3 S-ACP-DES3 AAE16 AAE16 BCCP2 BCCP2 T31P16.150 T31P16.150 S-ACP-DES5 S-ACP-DES5 S-ACP-DES4 S-ACP-DES4 S-ACP-DES2 S-ACP-DES2 T26C19.11 T26C19.11 LACS8 LACS8 FATB FATB MOD1 MOD1 ChlADR2 ChlADR2 T11I18.9 T11I18.9 FATA2 FATA2 F17N18.70 F17N18.70 LACS5 LACS5 LACS4 LACS4 LACS2 LACS2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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MRG7.17NAD(P)-binding Rossmann-fold superfamily protein. (277 aa)
ACC2Acetyl-CoA carboxylase 2; Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. (2355 aa)
CAC2Biotin carboxylase, chloroplastic; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (537 aa)
FAB2Stearoyl-[acyl-carrier-protein] 9-desaturase 7, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Required for the activation of certain jasmonic acid (JA)-mediated responses and the repression of the salicylic acid (SA) signaling pathway. Belongs to the fatty acid desaturase type 2 family. (401 aa)
LACS1Long chain acyl-CoA synthetase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in both the wax and cutin pathways. Preferentially uses palmitate, palmitoleate, linoleate and eicosenoate. Seems to have a specific activity against very long-chain fatty acid (VLCFA) class with acids longer than 24 carbons (C(24)). (660 aa)
F21J9.23-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
KAS_III3-oxoacyl-[acyl-carrier-protein] synthase III, chloroplastic; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. KAS III catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities (By similarity); Belongs to the thiolase-like superfamily. FabH family. (404 aa)
KAS13-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity). (473 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (488 aa)
ACC1Acetyl-CoA carboxylase 1; Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. Required for very long chain fatty acids elongation. Necessary for embryo and plant development. Plays a central function in embryo morphogenesis, especially in apical meristem development. Involved in cell proliferation and tissue patterning. May act as a repressor of cytokinin response. (2254 aa)
BCCP1Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (280 aa)
FATAOleoyl-acyl carrier protein thioesterase 1, chloroplastic; Plays an essential role in chain termination during de novo fatty acid synthesis. Possesses high thioesterase activity for oleoyl- ACP versus other acyl-ACPs. Substrate preference is 18:1 > 18:0 > 16:1. (362 aa)
S-ACP-DES6Stearoyl-[acyl-carrier-protein] 9-desaturase 6, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Belongs to the fatty acid desaturase type 2 family. (391 aa)
AAE13Malonate--CoA ligase; Malonate--CoA ligase that catalyzes the formation of malonyl- CoA directly from malonate and CoA. May be required for the detoxification of malonate; Belongs to the ATP-dependent AMP-binding enzyme family. (608 aa)
KAS3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; Catalyzes all the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Able to elongate saturated acyl chains from 4 to at least 16 carbons. Uses malonyl-CoA but not acetyl-CoA as primer substrate. When expressed in a heterologous system, reveals a bimodal distribution of products, with peaks at C8 and C14-C16. The major product of the reaction (octanoyl-ACP) is required for the lipoylation of essential mitochondrial proteins. (461 aa)
T6D9.100Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. (375 aa)
LACS7Long chain acyl-CoA synthetase 7, peroxisomal; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Displays redundant function with LACS7 into the seed development process (By similarity). (700 aa)
LACS6Long chain acyl-CoA synthetase 6, peroxisomal; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Might play a regulatory role both in fatty acid import into glyoxysomes and in fatty acid beta-oxidation. Displays redundant function with LACS7 into the seed development process. (701 aa)
EMB3147Putative malonyl-CoA:Acyl carrier protein transacylase. (393 aa)
AAE15Long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic; Probably involved in the activation of fatty acids to acyl- carrier-protein prior to fatty acid elongation in plastids. Acts on medium- to long-chain fatty acids. (727 aa)
LACS3Long chain acyl-CoA synthetase 3; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (665 aa)
KAS23-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic; Essential protein that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-16 and C-16 to unsaturated C-18 fatty acids. Confers resistance to low temperatures by maintaining chloroplast membranes integrity. Involved in the regulation of fatty acids ratios during seed metabolism. Required for embryo development, especially at the transition from the globular to the heart stage. (541 aa)
LACS9Long chain acyl-CoA synthetase 9, chloroplastic; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate. (691 aa)
CAC3Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity). Belongs to the AccA family. (769 aa)
S-ACP-DES1Stearoyl-[acyl-carrier-protein] 9-desaturase 1, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. (394 aa)
S-ACP-DES3Stearoyl-[acyl-carrier-protein] 9-desaturase 3, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Also able to convert palmitoyl-ACP to palmitoleoyl-ACP at the C9 position. Exhibits delta-9 palmitoyl-[acyl-carrier-protein] desaturase (PAD) activity. Involved in omega-7 monounsaturated fatty acid biosynthesis, especially in the endosperm oil. (401 aa)
AAE16Probable acyl-activating enzyme 16, chloroplastic; May be involved in the activation of fatty acids to acyl- carrier-protein; Belongs to the ATP-dependent AMP-binding enzyme family. (722 aa)
BCCP2Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (255 aa)
T31P16.150(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase-like protein. (219 aa)
S-ACP-DES5Stearoyl-[acyl-carrier-protein] 9-desaturase 5, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Belongs to the fatty acid desaturase type 2 family. (396 aa)
S-ACP-DES4Stearoyl-[acyl-carrier-protein] 9-desaturase 4, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Belongs to the fatty acid desaturase type 2 family. (403 aa)
S-ACP-DES2Stearoyl-[acyl-carrier-protein] 9-desaturase 2, chloroplastic; Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain (By similarity). Exhibits delta-9 palmitoyl-[acyl-carrier-protein] desaturase (PAD) activity. Involved in omega-7 monounsaturated fatty acid biosynthesis, especially in the endosperm oil. (411 aa)
T26C19.11Putative beta-hydroxyacyl-ACP dehydratase. (220 aa)
LACS8Long chain acyl-CoA synthetase 8; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (720 aa)
FATBPalmitoyl-acyl carrier protein thioesterase, chloroplastic; Plays an essential role in chain termination during de novo fatty acid synthesis. Possesses high thioesterase activity for palmitoyl-ACP versus other acyl-ACPs. Substrate preference is 16:0 > 18:1 > 18:0 > 16:1. Plays an essential role in the supply of saturated fatty acids necessary for plant growth and seed development. Contributes to 16:0 production particularly in flowers. May be involved in the synthesis of long chain fatty acid. (412 aa)
MOD1Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic; Catalyzes the NAD-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Catalyzes the last reduction step in the de novo synthesis cycle of fatty acids. Involved in the elongation cycle of fatty acids which are used in lipid metabolism. Required for normal plant growth. (390 aa)
ChlADR2NADPH-dependent aldehyde reductase 2, chloroplastic; Aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons. No activity on alpha,beta-unsaturated ketones. Can use propionaldehyde, butyraldehyde, methylglyoxal, (e)-2-pentenal, (E)-2- hexenal, (Z)-3-hexenal and (E)-2-nonenal as substrates, but not propenal (acrolein), crotonaldehyde, 2-butanone, 3-buten-2-one or 1- penten-3-one ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (272 aa)
T11I18.9NADPH-dependent aldehyde reductase-like protein, chloroplastic; Aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)
FATA2Oleoyl-acyl carrier protein thioesterase 2, chloroplastic; Plays an essential role in chain termination during de novo fatty acid synthesis. Possesses high thioesterase activity for oleoyl- ACP versus other acyl-ACPs. (367 aa)
F17N18.70NAD(P)-binding Rossmann-fold superfamily protein. (263 aa)
LACS5Long chain acyl-CoA synthetase 5; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (666 aa)
LACS4Long chain acyl-CoA synthetase 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (666 aa)
LACS2Long chain acyl-CoA synthetase 2; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in the cutin pathway. Preferentially uses palmitate, palmitoleate, oleate and linoleate. Required for repression of lateral root formation through its role in cutin biosynthesis and subsequent aerial tissues permeability. Belongs to the ATP-dependent AMP-binding enzyme family. (665 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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