STRINGSTRING
ALAAT1 ALAAT1 F19C24.7 F19C24.7 ASP5 ASP5 ASP1 ASP1 ASP3 ASP3 ASP2 ASP2 ASP4 ASP4 PYRB PYRB ASN1 ASN1 ASPGA1 ASPGA1 GDH2-2 GDH2-2 GAD2 GAD2 GAD1 GAD1 CARB CARB GLN2 GLN2 GDH1-2 GDH1-2 GLN1-1 GLN1-1 AGT1 AGT1 F15C21.8 F15C21.8 ASPGB1 ASPGB1 GLN1-5 GLN1-5 GLN1-2 GLN1-2 NLP3 NLP3 F28J12.100 F28J12.100 ALDH12A1 ALDH12A1 AGT2 AGT2 AGT3 AGT3 AO AO POP2 POP2 PURA PURA GLN1-4 GLN1-4 ALAAT2 ALAAT2 T30N20.190 T30N20.190 ASN3 ASN3 GFAT GFAT GGAT1 GGAT1 GAD5 GAD5 GLT1 GLT1 ASN2 ASN2 GLN1-3 GLN1-3 CARA CARA GSH3 GSH3 GGAT2 GGAT2 ALDH5F1 ALDH5F1 ASE1 ASE1 PYD4 PYD4 ASE2 ASE2 F6I7.40 F6I7.40 ASE3 ASE3 GAD4 GAD4 GAD3 GAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALAAT1Alanine aminotransferase 1, mitochondrial; Major alanine aminotransferase in roots. (543 aa)
F19C24.7Amino acid dehydrogenase family protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (637 aa)
ASP5Aspartate aminotransferase, chloroplastic; Amino acid aminotransferase important for the metabolism of amino acids and Krebs-cycle related organic acids. No activity with D- Asp or D-Ala as amino donors. In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
ASP1Aspartate aminotransferase, mitochondrial; Amino acid aminotransferase important for the metabolism of amino acids and Krebs-cycle related organic acids. No activity with D- Asp or D-Ala as amino donors. In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism. (430 aa)
ASP3Aspartate aminotransferase 3, chloroplastic; Amino acid aminotransferase important for the metabolism of amino acids and Krebs-cycle related organic acids. No activity with D- Asp or D-Ala as amino donors. In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
ASP2Aspartate aminotransferase, cytoplasmic isozyme 1; Important for the metabolism of amino acids and Krebs-cycle related organic acids. Involved in plant nitrogen metabolism of Asp and Asp-derived amino acids and in the synthesis of Asp/Asn for seed storage. May be involved in the assessment of the pyridoxal phosphate levels in the cell. (405 aa)
ASP4Aspartate aminotransferase, cytoplasmic isozyme 2; Important for the metabolism of amino acids and Krebs-cycle related organic acids. In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism. (403 aa)
PYRBAspartate carbamoyltransferase, chloroplastic. (390 aa)
ASN1Asparagine synthetase [glutamine-hydrolyzing] 1; Essential for nitrogen assimilation, distribution and remobilization within the plant via the phloem. (584 aa)
ASPGA1Isoaspartyl peptidase/L-asparaginase 1 subunit alpha; Acts in asparagine catabolism but also in the final steps of protein and degradation via hydrolysis of a range of isoaspartyl dipeptides. The affinity for Asn and at least 4 isoaspartyl dipeptides (L-beta-Asp-Ala, L-beta-Asp-Gly, L-beta-Asp-Leu, L-beta-Asp-Phe) is quite low, KM being greater than 4.0 mM. The enzyme is inactive on alpha-aspartyl dipeptides. (315 aa)
GDH2-2Glutamate dehydrogenase 2; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (411 aa)
GAD2Glutamate decarboxylase 2; Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis. (494 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis. Belongs to the group II decarboxylase family. (502 aa)
CARBCarbamoyl-phosphate synthase large chain, chloroplastic; Involved in arginine biosynthesis. Required for mesophyll development; Belongs to the CarB family. (1187 aa)
GLN2Glutamine synthetase, chloroplastic/mitochondrial; The light-modulated chloroplast/mitochondrial enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration. Belongs to the glutamine synthetase family. (430 aa)
GDH1-2Glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (411 aa)
GLN1-1Glutamine synthetase cytosolic isozyme 1-1; High-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
AGT1Serine--glyoxylate aminotransferase; Photorespiratory enzyme that catalyzes transamination reactions with multiple substrates, including asparagine. Function exclusively as a catabolic enzyme in Asn metabolism. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (401 aa)
F15C21.8Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (527 aa)
ASPGB1Isoaspartyl peptidase/L-asparaginase 2 subunit alpha; Acts in asparagine catabolism and also in the final steps of protein degradation via hydrolysis of a range of isoaspartyl dipeptides; Belongs to the Ntn-hydrolase family. (325 aa)
GLN1-5Glutamine synthetase cytosolic isozyme 1-5; Belongs to the glutamine synthetase family. (353 aa)
GLN1-2Glutamine synthetase cytosolic isozyme 1-2; Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
NLP3Omega-amidase, chloroplastic; Omega-amidase involved in the metabolism of asparagine. Probably also closely coupled with glutamine transamination in the methionine salvage cycle. Can use alpha-ketosuccinamate and alpha- hydroxysuccinamate as substrates, producing respectively oxaloacetate and malate, or alpha-ketoglutaramate, producing alpha-ketoglutarate. (369 aa)
F28J12.100Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (536 aa)
ALDH12A1Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial; Plays a role in the inhibition of programmed cell death by converting the toxic proline catabolism intermediate (s)-1-pyrroline-5- carboxylate (P5C) to glutamate; Belongs to the aldehyde dehydrogenase family. (556 aa)
AGT2Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa)
AGT3Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial. (477 aa)
AOL-aspartate oxidase, chloroplastic; Catalyzes the oxidation of L-aspartate to iminoaspartate. Can complement nadB-deficient E.coli mutant. Plays a role in stomatal immunity; Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily. (651 aa)
POP2Gamma-aminobutyrate transaminase POP2, mitochondrial; Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor, but not 2- oxoglutarate. The pyruvate-dependent activity is reversible while the glyoxylate-dependent activity is irreversible. Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors. Modulates steady- state [...] (504 aa)
PURAAdenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (490 aa)
GLN1-4Glutamine synthetase cytosolic isozyme 1-4; High-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
ALAAT2Alanine aminotransferase 2, mitochondrial; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. (540 aa)
T30N20.190Argininosuccinate lyase, chloroplastic. (517 aa)
ASN3Asparagine synthetase [glutamine-hydrolyzing] 3; Essential for nitrogen assimilation, distribution and remobilization within the plant via the phloem. (578 aa)
GFATPutative glucosamine-fructose-6-phosphate aminotransferase. (677 aa)
GGAT1Glutamate--glyoxylate aminotransferase 1; Catalyzes the glutamate:glyoxylate (GGT or GGAT), alanine:glyoxylate (AGT), alanine:2-oxoglutarate (AKT) and glutamate:pyruvate (GPT) aminotransferase reactions in peroxisomes. Required for abscisic acid (ABA)- and stress-mediated responses in an H(2)O(2)-dependent manner. Functions as a photorespiratory aminotransferase that modulates amino acid content during photorespiration (GGAT activity); promotes serine, glycine and citrulline metabolism in response to light. (481 aa)
GAD5Glutamate decarboxylase 5; Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity). (494 aa)
GLT1Glutamate synthase 1 [NADH], chloroplastic; Involved in glutamate biosynthesis. Required for non- photorespiratory ammonium assimilation. Probably involved in primary ammonium assimilation in roots. (2208 aa)
ASN2Asparagine synthetase [glutamine-hydrolyzing] 2; Essential for nitrogen assimilation, distribution and remobilization within the plant via the phloem. (578 aa)
GLN1-3Glutamine synthetase cytosolic isozyme 1-3; Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (354 aa)
CARACarbamoyl-phosphate synthase small chain, chloroplastic; Involved in arginine biosynthesis. Required for mesophyll development; Belongs to the CarA family. (430 aa)
GSH3Probable glutamate dehydrogenase 3; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (411 aa)
GGAT2Glutamate--glyoxylate aminotransferase 2; Catalyzes the Glu:glyoxylate aminotransferase (GGT), Ala:glyoxylate aminotransferase (AGT), Ala:2-oxoglutarate aminotransferase (AKT) and Glu:pyruvate aminotransferase (GPT) reactions in peroxisomes; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. (481 aa)
ALDH5F1Succinate-semialdehyde dehydrogenase, mitochondrial; Oxidizes specifically succinate semialdehyde. Involved in plant response to environmental stress by preventing the accumulation of reactive oxygen species, probably by regulating proline, gamma- hydroxybutyrate (GHB) and gamma-aminobutyrate (GABA) levels. Required for the maintenance of the shoot apical meristem (SAM) structure and subsequent adaxial-abaxial axis-dependent development of cotyledons and leaves. (528 aa)
ASE1Amidophosphoribosyltransferase 1, chloroplastic; Catalyzes the first committed step of 'de novo' purine biosynthesis from glutamine. Involved in plastid biogenesis and cell division. (566 aa)
PYD4Alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (481 aa)
ASE2Amidophosphoribosyltransferase 2, chloroplastic; Catalyzes the first committed step of 'de novo purine biosynthesis from glutamine. Required for chloroplast biogenesis and cell division. Confers sensitivity to the phenyltriazole acetic acid compound [5-(4-chlorophenyl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-acetic acid (DAS734), a bleaching herbicide; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (561 aa)
F6I7.40Argininosuccinate synthase, chloroplastic. (494 aa)
ASE3Amidophosphoribosyltransferase 3, chloroplastic; Catalyzes the first committed step of 'de novo' purine biosynthesis from glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (532 aa)
GAD4Glutamate decarboxylase 4; Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity); Belongs to the group II decarboxylase family. (493 aa)
GAD3Glutamate decarboxylase 3; Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity). (500 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.