STRINGSTRING
T1N15.4 T1N15.4 LPLAT1 LPLAT1 UGP3 UGP3 DGK6 DGK6 DGK7 DGK7 GPP1 GPP1 T19D16.3 T19D16.3 SQD1 SQD1 GPAT6 GPAT6 MGD1 MGD1 MGD2 MGD2 LPP4 LPP4 DGK4 DGK4 DGK1 DGK1 ATS1 ATS1 GPAT8 GPAT8 ALDH3H1 ALDH3H1 ALDH3F1 ALDH3F1 AKR4C10 AKR4C10 GPAT9 GPAT9 LPAT1 LPAT1 LPAT4 LPAT4 LPP3 LPP3 LPAT2 LPAT2 AGAL2 AGAL2 SQD2 SQD2 ALDH2B7 ALDH2B7 AGAL3 AGAL3 F15H18.13 F15H18.13 DGK3 DGK3 GPP2 GPP2 ALDH3I1 ALDH3I1 DGD2 DGD2 SFR2 SFR2 GLYK GLYK T9L24.33 T9L24.33 DGAT2 DGAT2 DGK5 DGK5 DGAT3 DGAT3 LPLAT2 LPLAT2 GPAT5 GPAT5 DGK2 DGK2 PAH2 PAH2 PDAT1 PDAT1 AGAL1 AGAL1 PDAT2 PDAT2 GPAT2 GPAT2 LPAT5 LPAT5 GPAT7 GPAT7 GPAT4 GPAT4 SDP1 SDP1 SDP1L SDP1L GLPK GLPK DGD1 DGD1 PAH1 PAH1 GPAT1 GPAT1 MGD3 MGD3 DGAT1 DGAT1 NPC3 NPC3 ALDH2B4 ALDH2B4 LPAT3 LPAT3 ALDH7B4 ALDH7B4 GPAT3 GPAT3 LPP2 LPP2 LPP1 LPP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
T1N15.4Dihydroxyacetone kinase. (593 aa)
LPLAT1Lysophospholipid acyltransferase 1; Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn- glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn- glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl- sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphati [...] (462 aa)
UGP3UTP--glucose-1-phosphate uridylyltransferase 3, chloroplastic; Involved in the biosynthesis of sulfolipids in the chloroplast. Catalyzes the first committed step in sulfolipid biosynthesis. Converts glucose 1-phosphate to UDP-glucose, the precursor of the polar head of sulfolipid. In addition to glucose 1- phosphate, can use galactose 1-phosphate, but with much lower activity. No uridyltransferase activity with other hexose monophosphates. Specific for UTP and cannot use ATP, CTP, and GTP. (883 aa)
DGK6Diacylglycerol kinase 6; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress. (466 aa)
DGK7Diacylglycerol kinase 7; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress xhibits high specificity for 1,2-dioleoyl-sn-glycerol (1,2- DOG), 1-palmitoyl, 2-oleoyl-sn-glycerol (1,2 POG), 1-stearoyl, 2- linoleoyl-sn-glycerol (1,2-SLG) and 1-oleoyl, 2-palmitoyl-sn-glycerol (1,2-OPG). (492 aa)
GPP1(DL)-glycerol-3-phosphatase 1, mitochondrial; Acts as a glycerol-3-phosphatase with higher stereospecificity for L-glycerol-3-phosphate than DL-glycerol-3- phosphate. Can also dephosphorylate in vitro 5-amino- 6-(5-phospho-D-ribitylamino)uracil, also known as ARPP. (298 aa)
T19D16.3Alpha/beta-Hydrolases superfamily protein. (324 aa)
SQD1UDP-sulfoquinovose synthase, chloroplastic; Involved in the biosynthesis of sulfolipids found in thylakoid membranes. Converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (477 aa)
GPAT6Glycerol-3-phosphate 2-O-acyltransferase 6; Esterifies acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate, a step in cutin biosynthesis. Belongs to the GPAT/DAPAT family. (501 aa)
MGD1Monogalactosyldiacylglycerol synthase 1, chloroplastic; Involved in the synthesis of the major structural component of photosynthetic membranes. Required for proper thylakoid membrane biogenesis. Does not discriminate between prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2-diacylglycerol species, but operates with some preference for the prokaryotic one. Belongs to the glycosyltransferase 28 family. (533 aa)
MGD2Monogalactosyldiacylglycerol synthase 2, chloroplastic; Involved in the synthesis of the major structural component of photosynthetic membranes and in the chloroplast envelope biogenesis. Can use both prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2- diacylglycerol species, but operates with some preference for the eukaryotic one; Belongs to the glycosyltransferase 28 family. (468 aa)
LPP4Probable lipid phosphate phosphatase 4. (308 aa)
DGK4Diacylglycerol kinase 4; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity). (487 aa)
DGK1Diacylglycerol kinase 1; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity). (728 aa)
ATS1Glycerol-3-phosphate acyltransferase, chloroplastic; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate. The enzyme from chilling-resistant plants discriminates against non-fluid palmitic acid and selects oleic acid whereas the enzyme from sensitive plants accepts both fatty acids. This is an oleate-selective acyltransferase. (459 aa)
GPAT8Probable glycerol-3-phosphate acyltransferase 8; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (500 aa)
ALDH3H1Aldehyde dehydrogenase family 3 member H1; Involved in oxidative stress tolerance by detoxifying reactive aldehydes derived from lipid peroxidation. Medium- to long- chain saturated aldehydes are preferred substrates, while the short- chain aldehyde propanal is a weak substrate. Is strictely NAD(+) specific. (484 aa)
ALDH3F1Aldehyde dehydrogenase family 3 member F1; Belongs to the aldehyde dehydrogenase family. (484 aa)
AKR4C10Aldo-keto reductase family 4 member C10; Oxidoreductase that may act on a broad range of substrates such as ketosteroids, aldehydes, ketones and sugars. (314 aa)
GPAT9Glycerol-3-phosphate acyltransferase 9; Essential protein. Required for male and female gametophytes development. Exhibits sn-1 acyltransferase activity with high specificity for acyl-coenzyme A, thus triggering storage lipid biosynthesis and playing an important role in the Kennedy pathway of glycerolipid biosynthesis. Catalyzes triacylglycerol (TAG) accumulation involved in membrane lipid and oil biosynthesis, especially in seeds. Contributes also to the biosynthesis of both polar lipids and TAG in developing leaves, as well as lipid droplet production in developing pollen grains. Se [...] (376 aa)
LPAT11-acyl-sn-glycerol-3-phosphate acyltransferase LPAT1, chloroplastic; Plastidial enzyme of the prokaryotic glycerol-3-phosphate pathway that converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at position sn-2. Utilizes palmitoyl-ACP (16:0-ACP) to produce phosphatidic acid containing a saturated group at position sn-2, which is characteristic of lipids synthesized by the prokaryotic pathway. In vitro, can use 16:0-CoA as acyl donor. Essential for embryo development during the transition from the globular to the heart stage when chloroplasts begin [...] (356 aa)
LPAT4Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 4; May convert lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position (By similarity). Has no activity when expressed in bacteria or yeast; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (378 aa)
LPP3Putative lipid phosphate phosphatase 3, chloroplastic; Belongs to the PA-phosphatase related phosphoesterase family. (364 aa)
LPAT21-acyl-sn-glycerol-3-phosphate acyltransferase 2; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C- 18-CoA substrates compared to C-16-CoA substrates. Required for female but not male gametophyte development. (389 aa)
AGAL2Alpha-galactosidase 2; May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion. (396 aa)
SQD2Sulfoquinovosyl transferase SQD2; Catalyzes the transfer of the sulfoquinovose moiety from UDP- sulfoquinovose to diacylglycerol during sulfolipid biosynthesis. Sulfolipid contributes to maintaining a negatively charged lipid-water interface, a requirement for proper function of photosynthetic membranes. Sulfolipid may also function as a substitute of anionic phospholipids under phosphate-limited growth conditions. (510 aa)
ALDH2B7Aldehyde dehydrogenase family 2 member B7, mitochondrial; Possesses activity on acetaldehyde and glycolaldehyde in vitro; Belongs to the aldehyde dehydrogenase family. (534 aa)
AGAL3Alpha-galactosidase 3; May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion. Belongs to the glycosyl hydrolase 27 family. (437 aa)
F15H18.13Alpha/beta-Hydrolases superfamily protein. (382 aa)
DGK3Diacylglycerol kinase 3; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity). (488 aa)
GPP2(DL)-glycerol-3-phosphatase 2; Acts as a glycerol-3-phosphatase with higher stereospecificity for L-glycerol-3-phosphate than DL-glycerol-3- phosphate; Belongs to the HAD-like hydrolase superfamily. DOG/GPP family. (240 aa)
ALDH3I1Aldehyde dehydrogenase family 3 member I1, chloroplastic; Involved in oxidative stress tolerance by detoxifying reactive aldehydes derived from lipid peroxidation. Medium- to long- chain saturated aldehydes are preferred substrates, while the short- chain aldehyde propanal is a weak substrate. Can use both NAD(+) and NADP(+), but the coenzyme preference is substrate dependent. (550 aa)
DGD2Digalactosyldiacylglycerol synthase 2, chloroplastic; Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha- glycosidic linkages. During phosphate shortage, involved in the biosynthesis of digalactosyldiacylglycerol (DGDG) which rescues the limitation of phospholipids (Probable); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (473 aa)
SFR2Galactolipid galactosyltransferase SFR2, chloroplastic; Glycosyl hydrolase family protein acting primarily as a highly specific galactosyltransferase. Synthesizes digalactosyldiacylglycerol from monogalactosyldiacylglycerol in the absence of UDP-galactose in vitro. Hydrolyzes o- and p-nitrophenyl beta-D-glucoside in vitro. Plays a role in freezing tolerance. May play a role in chloroplast protection. (622 aa)
GLYKD-glycerate 3-kinase, chloroplastic; Catalyzes the concluding reaction of the photorespiratory C2 cycle, an indispensable ancillary metabolic pathway to the photosynthetic C3 cycle that enables land plants to grow in an oxygen- containing atmosphere; Belongs to the GLYK kinase family. (456 aa)
T9L24.33Alpha/beta-Hydrolases superfamily protein. (463 aa)
DGAT2Diacylglycerol O-acyltransferase 2; Involved in triacylglycerol (TAG) synthesis. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Can use oleoyl-CoA, linoleoyl-CoA and linolenoyl-CoA as substrates. Has substrate preference for linolenoyl-CoA or oleoyl-CoA compared to linoleoyl-CoA. (314 aa)
DGK5Diacylglycerol kinase 5; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress (By similarity); Belongs to the eukaryotic diacylglycerol kinase family. (509 aa)
DGAT3Diacylglycerol O-acyltransferase 3; Involved in triacylglycerol (TAG) biosynthesis. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. May preferentially use linolenoyl-CoA as substrate and to a lesser extent linoleoyl-CoA. May contribute to the active recycling of linoleate and linolenate into TAG when seed oil breakdown is blocked. (360 aa)
LPLAT2Lysophospholipid acyltransferase 2; Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn- glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn- glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl- sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphati [...] (465 aa)
GPAT5Glycerol-3-phosphate acyltransferase 5; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (502 aa)
DGK2Diacylglycerol kinase 2; Phosphorylates the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA), another important signaling molecule. PA is required for plant development and responses to abiotic stress and pathogen attack. May be involved in the accumulation of PA during cold stress. Exhibits high specificity for 1-stearoyl-2- arachidonoyl- sn-glycerol (1,2-SAG), 1,2-dioleoyl-sn-glycerol (1,2- DOG), 1-palmitoyl, 2-oleoyl-sn-glycerol (1,2 POG), 1-stearoyl, 2- linoleoyl-sn-glycerol (1,2-SLG) and 1-oleoyl, 2-palmitoyl-sn-glycerol (1,2-OPG), but has almost no activit [...] (712 aa)
PAH2Phosphatidate phosphatase PAH2; Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH1 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation. (930 aa)
PDAT1Phospholipid:diacylglycerol acyltransferase 1; Triacylglycerol formation by an acyl-CoA independent pathway. The enzyme preferentially transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1- lysophospholipid. Involved in epoxy and hydroxy fatty acid accumulation in seeds. Has complementary functions with DAG1 that are essential for triacylglycerol synthesis and normal development of both seeds and pollen. (671 aa)
AGAL1Alpha-galactosidase 1; May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion. Belongs to the glycosyl hydrolase 27 family. (410 aa)
PDAT2Putative phospholipid:diacylglycerol acyltransferase 2; Belongs to the AB hydrolase superfamily. Lipase family. (665 aa)
GPAT2Probable glycerol-3-phosphate acyltransferase 2; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Belongs to the GPAT/DAPAT family. (530 aa)
LPAT5Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase 5; May convert lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position (By similarity). Has no activity when expressed in bacteria or yeast. (375 aa)
GPAT7Glycerol-3-phosphate acyltransferase 7; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (500 aa)
GPAT4Glycerol-3-phosphate 2-O-acyltransferase 4; Esterifies acyl-group from acyl-ACP to the sn-2 position of glycerol-3-phosphate, a step in cutin biosynthesis. Belongs to the GPAT/DAPAT family. (503 aa)
SDP1Triacylglycerol lipase SDP1; Involved in the release of fatty acids from the oil body in germinating seedlings. Could hydrolyze triacylglycerols and diacylglycerols but not monoacylglycerols, phospholipids, galactolipids or cholesterol esters. (825 aa)
SDP1LTriacylglycerol lipase SDP1L; May be involved in the release of fatty acids from the oil body in germinating seedlings. Can hydrolyze triacylglycerols in vitro. (801 aa)
GLPKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Required for resistance to nonhost Pseudomonas bacteria and to the pathogenic fungus B.cinerea. (522 aa)
DGD1Digalactosyldiacylglycerol synthase 1, chloroplastic; Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha- glycosidic linkages. Responsible for the final assembly of galactolipids in photosynthetic membranes. Digalactosyldiacylglycerol (DGDG) provides stability to the photosystem I (PSI) complex, especially to the PsaA, PsaB, PsaC, PsaL and PsaH subunits. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (808 aa)
PAH1Phosphatidate phosphatase PAH1; Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH2 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation; Belongs to the lipin family. (904 aa)
GPAT1Glycerol-3-phosphate acyltransferase 1; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Involved in pollen development, by being required for tapetum differentiation and male fertility. In addition to the sporophytic effect, it also exerts a gametophytic effect on pollen performance. Belongs to the GPAT/DAPAT family. (585 aa)
MGD3Monogalactosyldiacylglycerol synthase 3, chloroplastic; Involved in the synthesis of the major structural component of photosynthetic membranes and in the chloroplast envelope biogenesis. Can use both prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2- diacylglycerol species, but operates with some preference for the eukaryotic one. (465 aa)
DGAT1Diacylglycerol O-acyltransferase 1; Major contributor to triacylglycerol (TAG) synthesis and oil accumulation in seeds. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Can use palmitoyl-CoA and oleoyl-CoA as substrates. Can use oleoyl-CoA and linoleoyl-CoA as substrates. Has substrate preference for oleoyl-CoA compared to linoleoyl-CoA. Has complementary functions with PDAT1 that are essential for triacylglycerol synthesis and normal development of both seeds and pollen. (520 aa)
NPC3Non-specific phospholipase C3; Possesses specific phosphatase activity toward lysophosphatidic acid (LPA) in vitro. Does not show phospholipase C activity. May play a role in signal transduction and storage lipid synthesis. May be involved in brassinolide-mediated signaling in root development. (523 aa)
ALDH2B4Aldehyde dehydrogenase family 2 member B4, mitochondrial; Possesses activity on acetaldehyde and glycolaldehyde in vitro; Belongs to the aldehyde dehydrogenase family. (538 aa)
LPAT31-acyl-sn-glycerol-3-phosphate acyltransferase 3; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. Has preference for C- 18-CoA substrates compared to C-16-CoA substrates; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (376 aa)
ALDH7B4Aldehyde dehydrogenase family 7 member B4. (508 aa)
GPAT3Probable glycerol-3-phosphate acyltransferase 3; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Belongs to the GPAT/DAPAT family. (520 aa)
LPP2Lipid phosphate phosphatase 2; May play a general 'housekeeping role' in lipid metabolism. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities with no preference for either substrate. May play a role downstream of the ABA signaling pathway during seed germination and in stomatal movement in leaves. Belongs to the PA-phosphatase related phosphoesterase family. (290 aa)
LPP1Lipid phosphate phosphatase 1; Plays a general role in cellular responses to stress, may be by attenuating the signal produced by phospholipases. Exhibits both diacylglycerol pyrophosphate (DGPP) phosphatase and phosphatidate (PA) phosphatase activities. Substrate preference is diacylglycerol pyrophosphate > phosphatidate; Belongs to the PA-phosphatase related phosphoesterase family. (327 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (22%) [HD]