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| | MTM1 | Phosphatidylinositol-3-phosphatase myotubularin-1; Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Required for recovery after water deprivation, via the accumulation of PtdIns5P upon dehydration; high PtdIns5P levels mediate ATX1 cytoplasmic localization, thus down-regulating the expression of ATX1- dependent gen [...] (840 aa) |
| | MTM2 | Phosphatidylinositol-3-phosphatase myotubularin-2; Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (833 aa) |
| | PIP5K3 | Phosphatidylinositol 4-phosphate 5-kinase 3. (705 aa) |
| | SAL2 | SAL2 phosphatase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity). Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation. Is also able to hydrolyze inositol 1,4-bisphosphate. (347 aa) |
| | ITPK4 | Inositol 1,3,4-trisphosphate 5/6-kinase 4; Kinase that can phosphorylate the inositol polyphosphate Ins(1,3,4)P3 to form InsP4. Also phosphorylates a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4. Does not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity, but possesses inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity. Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity). (488 aa) |
| | NPC2 | Non-specific phospholipase C2. (514 aa) |
| | ITPK2 | Inositol-tetrakisphosphate 1-kinase 2; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 to form InsP5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 or a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4. Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity). Plays a role in [...] (391 aa) |
| | MIOX2 | Inositol oxygenase 2; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis; Belongs to the myo-inositol oxygenase family. (317 aa) |
| | VPS34 | Phosphatidylinositol 3-kinase VPS34; Belongs to the PI3/PI4-kinase family. (814 aa) |
| | IPS1 | Inositol-3-phosphate synthase isozyme 1; Catalyzes the majority of myo-inositol synthesis required for plant growth and development. Acts as a repressor of programmed cell death and protects plant cells against cell death under high light intensity or long days. Controls its own transcription by inhibiting ATXR6 activity. Reduces the deposition of inhibitory histone marks on its own promoter; Belongs to the myo-inositol 1-phosphate synthase family. (511 aa) |
| | CTIMC | Triosephosphate isomerase, cytosolic; Belongs to the triosephosphate isomerase family. (254 aa) |
| | ALDH6B2 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. (607 aa) |
| | PI4KB2 | Phosphatidylinositol 4-kinase beta 2; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5- trisphosphate (By similarity). Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB1, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB1 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. (1116 aa) |
| | FAB1A | 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters. (1757 aa) |
| | F2E2.17 | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (441 aa) |
| | IPS2 | Inositol-3-phosphate synthase isozyme 2; Involved in myo-inositol synthesis. (510 aa) |
| | PLC1 | Phosphoinositide phospholipase C 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for secondary responses to abscisic acid signals. (561 aa) |
| | PLC2 | Phosphoinositide phospholipase C 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. At physiological calcium concentration, the preferred substrate is phosphatidylinositol 4,5-bisphosphate versus phosphatidylinositol. (581 aa) |
| | SAL1 | SAL1 phosphatase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4- trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is [...] (353 aa) |
| | PLC3 | Phosphoinositide phospholipase C 3; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (564 aa) |
| | PIP5K1 | Phosphatidylinositol 4-phosphate 5-kinase 1; Catalyzes the synthesis of phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4-bisphosphate. (752 aa) |
| | HISN7 | Bifunctional phosphatase IMPL2, chloroplastic; Phosphatase required for histidine production. Acts also on L-galactose 1-phosphate (L-Gal 1-P), D-myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D-Ins 1-P). Belongs to the inositol monophosphatase superfamily. (346 aa) |
| | SAC6 | Phosphoinositide phosphatase SAC6; Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Involved in priming for different defense responses. (593 aa) |
| | SAC4 | Phosphoinositide phosphatase SAC4; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). (831 aa) |
| | SAC3 | Phosphoinositide phosphatase SAC3; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). (818 aa) |
| | SAC1 | Phosphoinositide phosphatase SAC1; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for normal cell morphogenesis, cell wall synthesis, and actin organization. (912 aa) |
| | IP5P1 | Type I inositol polyphosphate 5-phosphatase 1; Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but not toward Ins(1,4)P2, Ins(1)P. Seems to be involved in the abscisic acid (ABA) signaling pathway. Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3 ; Belongs to the inositol polyphosphate 5-phosphatase family. (590 aa) |
| | SAL4 | Probable SAL4 phosphatase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Is also able to hydrolyze inositol 1,4- bisphosphate. (345 aa) |
| | PIS2 | Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). (225 aa) |
| | PLC6 | Phosphoinositide phospholipase C 6; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (613 aa) |
| | SAL3 | Probable SAL3 phosphatase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Is also able to hydrolyze inositol 1,4- bisphosphate; Belongs to the inositol monophosphatase superfamily. (357 aa) |
| | PTEN2B | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B; Protein tyrosine phosphatase that exhibits also a weak lipid phosphatase activity towards PtdIns(3)P. (632 aa) |
| | MIOX4 | Inositol oxygenase 4; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis. (317 aa) |
| | NPC6 | Non-specific phospholipase C6. (520 aa) |
| | PIP5K2 | Phosphatidylinositol 4-phosphate 5-kinase 2; Possesses phosphatidylinositol kinase activity in vitro. (754 aa) |
| | MIOX1 | Inositol oxygenase 1; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis. (311 aa) |
| | NPC1 | Non-specific phospholipase C1. (533 aa) |
| | PIP5K9 | Phosphatidylinositol 4-phosphate 5-kinase 9; Plays a role in sugar-mediated root development. Interaction with CINV1 induces repression of CINV1 activity and negative regulation of sugar-mediated root cell elongation. (815 aa) |
| | PIS1 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (227 aa) |
| | SAC5 | Phosphoinositide phosphatase SAC5; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). (785 aa) |
| | PIP5K8 | Phosphatidylinositol 4-phosphate 5-kinase 8. (769 aa) |
| | T4M14.4 | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (486 aa) |
| | IPK1 | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5. (451 aa) |
| | Mik | Inositol 3-kinase; Kinase that phosphorylates myo-inositol to produce multiple myo-inositol monophosphates. Participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds. (353 aa) |
| | F21M12.26 | Histidine acid phosphatase family protein; Belongs to the histidine acid phosphatase family. (487 aa) |
| | PLC4 | Phosphoinositide phospholipase C 4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (597 aa) |
| | PLC5 | Phosphoinositide phospholipase C 5; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (578 aa) |
| | SAC2 | Phosphoinositide phosphatase SAC2; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). (808 aa) |
| | IMPL1 | Phosphatase IMPL1, chloroplastic; Phosphatase acting preferentially on D-myoinositol 1- phosphate (D-Ins 1-P). (371 aa) |
| | SAC8 | Phosphoinositide phosphatase SAC8; Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. (588 aa) |
| | SAC7 | Phosphoinositide phosphatase SAC7; Phosphoinositide phosphatase that preferentially hydrolyzes PtdIns(4)P. Regulates the accumulation of PtdIns(4)P on membrane compartments at the tips of growing root hairs leading to proper root hair development. (597 aa) |
| | PI4KA2 | Phosphatidylinositol 4-kinase alpha 2; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. (525 aa) |
| | MIOX5 | Inositol oxygenase 5; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis; Belongs to the myo-inositol oxygenase family. (314 aa) |
| | IPK2b | Inositol polyphosphate multikinase beta; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6- trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5,6 [...] (300 aa) |
| | PTEN1 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1; Protein tyrosine phosphatase that exhibits also lipid phosphatase activity. Can use phosphatidylinositol substrates such as PtdIns(3,4,5)P(3) as substrate. Pollen-specific phosphatase required for pollen development; Belongs to the PTEN phosphatase protein family. (412 aa) |
| | PI4KB1 | Phosphatidylinositol 4-kinase beta 1; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5- trisphosphate. Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB2, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB2 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. (1121 aa) |
| | IP5P2 | Type I inositol polyphosphate 5-phosphatase 2; Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4. Seems to be involved in the abscisic acid (ABA) signaling pathway. Could also be able to hydrolyze PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Belongs to the inositol polyphosphate 5-phosphatase family. (646 aa) |
| | PIP5K10 | Phosphatidylinositol 4-phosphate 5-kinase 10. (427 aa) |
| | PTEN2A | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A; Binds phosphatidic acid. Protein tyrosine phosphatase that exhibits also lipid phosphatase activity. Hydrolyzed poorly p- nitrophenyl phosphate (p-NPP). Can use PtdIns isomers as substrates. Removes efficiently phosphate from the D3 position of the inositol ring, less from the D4 position and not at all from the D5 position on monophosphorylated PtdIns isomers (PIPs). The presence of a phosphate group in the D5 position on PIP(2) isomers reduces lipid phosphatase activity. Mostly active on P [...] (611 aa) |
| | FAB1B | 1-phosphatidylinositol-3-phosphate 5-kinase FAB1B; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters. (1791 aa) |
| | IPS3 | Probable inositol 3-phosphate synthase isozyme 3; Involved in myo-inositol synthesis. Belongs to the myo-inositol 1-phosphate synthase family. (510 aa) |
| | IPK2a | Inositol polyphosphate multikinase alpha; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6- trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5, [...] (286 aa) |
| | PLC7 | Phosphoinositide phospholipase C 7; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (584 aa) |
| | PIP5K11 | Putative phosphatidylinositol 4-phosphate 5-kinase 11. (401 aa) |
| | PIP5K4 | Phosphatidylinositol 4-phosphate 5-kinase 4. (779 aa) |
| | VTC4 | Inositol-phosphate phosphatase; Phosphatase acting on L-galactose 1-phosphate (L-Gal 1-P), D- myoinositol 3-phosphate (D-Ins 3-P) and D-myoinositol 1-phosphate (D- Ins 1-P). Can also use beta-glycerophosphate (glycerol 2-P) and, to a lesser extent, D-galactose 1-phosphate (D-Gal 1-P), alpha-D-glucose 1- phosphate (a-D-Glc 1-P), D-manitol 1-phosphate and adenosine 2'- monophosphate as substrates. No activity with D-fructose 1-phosphate (D-Fru 1-P), fructose 1,6-bisphosphate (Fru 1,6-bisP), D-glucose 6- phosphate (D-Glc 6-P), D-alpha-glycerophosphate (glycerol 3-P), D- sorbitol 6-phospha [...] (271 aa) |
| | NPC5 | Non-specific phospholipase C5; Non-specific phospholipase C (PLC) which assumes minor PLC activity during inorganic phosphate starvation. Can hydrolyze both phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Required for normal accumulation of digalactosyldiacylglycerol (DGDG) during phosphate limitation and may contribute to the conversion of phospholipids to diacylglycerol, the substrate for galactolipid synthesis. (521 aa) |
| | ITPK1 | Inositol-tetrakisphosphate 1-kinase 1; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway ; Belongs to the ITPK1 family. (319 aa) |
| | PIP5K6 | Phosphatidylinositol 4-phosphate 5-kinase 6. (715 aa) |
| | TIM | Triosephosphate isomerase, chloroplastic; Belongs to the triosephosphate isomerase family. (315 aa) |
| | PIP5K5 | Phosphatidylinositol 4-phosphate 5-kinase 5. (772 aa) |
| | NPC4 | Non-specific phospholipase C4; Non-specific phospholipase C (PLC) which assumes major PLC activity during inorganic phosphate starvation. Substrate preference is phosphatidylcholine (PC), but can also hydrolyze phosphatidylethanolamine (PE) with lower efficiency. Has no activity toward phosphatidic acid (PA). Plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. May be required for lipid- derived signaling molecules that positively modulate abscisic acid (ABA) response and promote plant t [...] (538 aa) |
| | FAB1C | Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). (1648 aa) |
| | ITPK3 | Inositol-tetrakisphosphate 1-kinase 3; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 to form InsP5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 or a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4. Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity). (353 aa) |
| | PIP5K7 | Phosphatidylinositol 4-phosphate 5-kinase 7. (754 aa) |
| | PI4KA1 | Phosphatidylinositol 4-kinase alpha 1; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. Can bind to phosphatidylinositol 4-monophosphate (PI-4-P or PtdIns4P), phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2 or PtdIns4,5P2), and phosphatidic acid (PtdOH), but not to 3- phosphoinositides. May function upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. (2028 aa) |
| | FAB1D | Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). (1456 aa) |
