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DXPS1 DXPS1 F26B6.5 F26B6.5 MVD2 MVD2 ISPG ISPG GGPPS2 GGPPS2 GGPP6 GGPP6 MVD1 MVD1 DPS DPS ISPE ISPE HMG1 HMG1 GGPPS1 GGPPS1 HMG2 HMG2 MK MK HMGS HMGS FLCY FLCY ISPD ISPD FPS1 FPS1 ICMEL2 ICMEL2 DXS DXS FTB FTB IPP1 IPP1 GGR GGR IPP2 IPP2 FPS2 FPS2 CPT4 CPT4 MZN1.24 MZN1.24 SPS3 SPS3 FOLK FOLK SPS2 SPS2 FACE2 FACE2 CPT6 CPT6 IPK IPK CPT9 CPT9 CPT8 CPT8 CPT5 CPT5 FACE1 FACE1 CPT1 CPT1 AAT1 AAT1 SPS1 SPS1 ICMEL1 ICMEL1 ICMTB ICMTB ICME ICME ISPH ISPH PMK PMK CHLP CHLP ISPF ISPF AACT1 AACT1 ICMTA ICMTA DXPS3 DXPS3 F1M23.7 F1M23.7 MUO10.10 MUO10.10 MAL21.19 MAL21.19 MOA2.15 MOA2.15 GGPP3 GGPP3 GGPPS9 GGPPS9 FTA FTA GGPP4 GGPP4 FLDH FLDH DXR DXR F24H14.3 F24H14.3
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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DXPS11-deoxy-D-xylulose 5-phosphate synthase 1. (677 aa)
F26B6.5Alkyl transferase; Belongs to the UPP synthase family. (287 aa)
MVD2Diphosphomevalonate decarboxylase MVD2, peroxisomal; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5-diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000- fold lower than for MVAPP; Belongs to the diphosphomevalonate decarboxylase family. (419 aa)
ISPG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Is essential for chloroplast development and required for the salicylic acid (SA)-mediated disease resistance to biotrophic pathogens. (741 aa)
GGPPS2Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 2; Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit. In vitro, the large subunit catalyzes mainly the trans- addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive. Upon association of the two subunits, the product profile is not changed. (376 aa)
GGPP6Geranylgeranyl pyrophosphate synthase 6, mitochondrial; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (336 aa)
MVD1Diphosphomevalonate decarboxylase MVD1, peroxisomal; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Is specific for (R)-5- diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5- phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP. Can complement a yeast mutant defective in MVD activity. (412 aa)
DPSDehydrodolichyl diphosphate synthase 1; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. (303 aa)
ISPE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Is essential for chloroplast development. (383 aa)
HMG13-hydroxy-3-methylglutaryl-coenzyme A reductase 1; Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants. (592 aa)
GGPPS1Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic; Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit. In vitro, the large subunit catalyzes mainly the trans- addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive. Upon association of the two subunits, the product profile changes and the production of gerany-diphosphate is strongly increased. (371 aa)
HMG23-hydroxy-3-methylglutaryl-coenzyme A reductase 2; Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants. Belongs to the HMG-CoA reductase family. (562 aa)
MKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (378 aa)
HMGSHydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (461 aa)
FLCYFarnesylcysteine lyase; Involved in the degradation of prenylcysteine. Cleaves specifically the thioether bond of S-farnesyl-L-cysteine and has no activity with S-geranylgeranyl-L-cysteine. Recognizes also N-acetyl- farnesylcysteine and may have a role in deprenylation of farnesylated proteins; Belongs to the prenylcysteine oxidase family. (500 aa)
ISPD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis. (302 aa)
FPS1Farnesyl pyrophosphate synthase 1, mitochondrial; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. (384 aa)
ICMEL2Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2; Catalyzes the demethylation of isoprenylcysteine methylesters. May act as a negative regulator of ABA signaling. Belongs to the AB hydrolase superfamily. Isoprenylcysteine methylesterase family. (422 aa)
DXS1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP). Is a limiting enzyme for plastidic isoprenoid biosynthesis and essential for chloroplast development. Belongs to the transketolase family. DXPS subfamily. (717 aa)
FTBProtein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X (CaaX). The beta subunit is responsible for peptide- binding. (482 aa)
IPP1Isopentenyl-diphosphate Delta-isomerase I, chloroplastic; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (291 aa)
GGRHeterodimeric geranylgeranyl pyrophosphate synthase small subunit, chloroplastic; Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase small subunit. The small subunit alone is inactive in vitro while the large subunit GGPPS1 catalyzes mainly the production of geranygeranyl- diphosphate in vitro. Upon association of the two subunits, the product profile changes and the production of gerany-diphosphate is strongly increased. (326 aa)
IPP2Isopentenyl-diphosphate Delta-isomerase II, chloroplastic; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (284 aa)
FPS2Farnesyl pyrophosphate synthase 2; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (342 aa)
CPT4Dehydrodolichyl diphosphate synthase 2; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. (310 aa)
MZN1.24Dehydrodolichyl diphosphate synthase 5; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein; Belongs to the UPP synthase family. (302 aa)
SPS3Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial; May be involved in the supply of solanesyl diphosphate for ubiquinone-9 (UQ-9) biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate. (422 aa)
FOLKFarnesol kinase, chloroplastic; Kinase involved in negative regulation of abscisic acid (ABA) signaling. Substrate preferrence is farnesol > geraniol > geranylgeraniol, but has no activity with farnesyl phosphate. Can use CTP > ATP > GTP = UTP as phosphoryl donor. (307 aa)
SPS2Solanesyl diphosphate synthase 2, chloroplastic; Involved in providing solanesyl diphosphate for plastoquinone-9 (PQ-9) formation in plastids (Probable). Catalyzes the elongation of the prenyl side chain of PQ-9 in plastids. Contributes to the biosynthesis of plastochromanol-8 (PC-8) in plastids. Does not contribute to the synthesis of tocopherol or ubiquinone. PQ-9 and PC-8 are lipophylic antioxidant that act as protectant against photooxidative stress under high light stress conditions. Prefers geranylgeranyl diphosphate to farnesyl diphosphate as substrate. No activity with geranyl [...] (417 aa)
FACE2CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. The substrate specificity is only partially overlapping with that of FACE1. Belongs to the peptidase U48 family. (311 aa)
CPT6Dehydrodolichyl diphosphate synthase 4; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein; Belongs to the UPP synthase family. (289 aa)
IPKIsopentenyl phosphate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the universal five-carbon isoprenoid building block of all natural isoprenoids. Acts in parallel with the mevalonate (MVA) pathway and plays an important role in regulating the formation of both MVA and methylerythritol phosphate (MEP) pathway- derived terpenoid compounds by controlling the ratio of isopentenyl phosphate (IP) and dimethylallyl phosphate (DMAP) to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Controls the levels of IP and DMAP that are competitive inhibitors of [...] (332 aa)
CPT9Dehydrodolichyl diphosphate synthase 8; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. (272 aa)
CPT8Dehydrodolichyl diphosphate synthase 7; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein; Belongs to the UPP synthase family. (271 aa)
CPT5Dehydrodolichyl diphosphate synthase 3; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. (302 aa)
FACE1CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins. The substrate specificity is only partially overlapping with that of FACE2. (424 aa)
CPT1Dehydrodolichyl diphosphate synthase 6; Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein. (295 aa)
AAT1Acetyl-CoA acetyltransferase, cytosolic 1. (403 aa)
SPS1Solanesyl diphosphate synthase 1, chloroplastic; Involved in providing solanesyl diphosphate for plastoquinone-9 (PQ-9) formation in plastids. Catalyzes the elongation of the prenyl side chain of PQ-9 in plastids. Contributes to the biosynthesis of plastochromanol-8 (PC-8) in plastids. Does not contribute to the synthesis of tocopherol or ubiquinone. PQ-9 and PC-8 are lipophylic antioxidant that act as protectant against photooxidative stress under high light stress conditions. Prefers geranylgeranyl diphosphate to farnesyl diphosphate as substrate. No activity with geranyl diphosphate [...] (406 aa)
ICMEL1Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1; Catalyzes the demethylation of isoprenylcysteine methylesters. May be involved in the regulation of ABA signaling (By similarity); Belongs to the AB hydrolase superfamily. Isoprenylcysteine methylesterase family. (476 aa)
ICMTBProtein-S-isoprenylcysteine O-methyltransferase B; Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues, resulting in the modulation of the function of prenylated proteins. Involved in negative regulation of abscisic acid signaling. Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (197 aa)
ICMEIsoprenylcysteine alpha-carbonyl methylesterase ICME; Catalyzes the demethylation of isoprenylcysteine methylesters. In vitro, is specific for N-acetyl-S-farnesyl-L-cysteine methyl ester (AFCme) and has low activity toward N-acetyl-S-geranyl-L- cysteine methyl ester (AGCme). Acts as a positive regulator of ABA signaling. May be involved in the demethylation and inactivation of isoprenylated negative regulators of abscisic acid (ABA) signaling. Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins. (427 aa)
ISPH4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)-butenyl 4- diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is essential for chloroplast development. (466 aa)
PMKPhosphomevalonate kinase, peroxisomal. (505 aa)
CHLPGeranylgeranyl diphosphate reductase, chloroplastic; Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis; Belongs to the geranylgeranyl reductase family. ChlP subfamily. (467 aa)
ISPF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2- phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. Also converts 4-diphosphocytidyl-2C-methyl-D-erythritol into 2C-methyl- D-erythritol 3,4-cyclophosphate and CMP. Is essential for chloroplast development; Belongs to the IspF family. (231 aa)
AACT1Probable acetyl-CoA acetyltransferase, cytosolic 2; Belongs to the thiolase-like superfamily. Thiolase family. (415 aa)
ICMTAProtein-S-isoprenylcysteine O-methyltransferase A; Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues, resulting in the modulation of the function of prenylated proteins. Involved in negative regulation of abscisic acid signaling. Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins. Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (197 aa)
DXPS31-D-deoxyxylulose 5-phosphate synthase-like protein. (700 aa)
F1M23.7Geranylgeranyl pyrophosphate synthase 12, chloroplastic; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (360 aa)
MUO10.10Geranylgeranyl pyrophosphate synthase 11, chloroplastic; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (357 aa)
MAL21.19Geranylgeranyl pyrophosphate synthase 10, mitochondrial; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (344 aa)
MOA2.15Putative geranylgeranyl pyrophosphate synthase 8, chloroplastic; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (361 aa)
GGPP3Geranylgeranyl pyrophosphate synthase 3, chloroplastic; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. (360 aa)
GGPPS9Geranylgeranyl pyrophosphate synthase 9, chloroplastic; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (360 aa)
FTAProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. (326 aa)
GGPP4Geranylgeranyl pyrophosphate synthase 4; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. (372 aa)
FLDHNAD(P)-binding Rossmann-fold superfamily protein. (344 aa)
DXR1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic; Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D- erythritol 4-phosphate (MEP). Required for chloroplast development. (477 aa)
F24H14.3Geranylgeranyl pyrophosphate synthase 7, chloroplastic; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (347 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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