STRINGSTRING
SMC33624.1 SMC33624.1 SMC48985.1 SMC48985.1 SMC48704.1 SMC48704.1 SMC48700.1 SMC48700.1 SMC47353.1 SMC47353.1 SMC47342.1 SMC47342.1 SMC47279.1 SMC47279.1 SMC47150.1 SMC47150.1 SMC47129.1 SMC47129.1 SMC47118.1 SMC47118.1 xpt xpt guaB guaB SMC45579.1 SMC45579.1 SMC44520.1 SMC44520.1 SMC44509.1 SMC44509.1 gpsA gpsA SMC44347.1 SMC44347.1 SMC44064.1 SMC44064.1 SMC43963.1 SMC43963.1 rex rex SMC43616.1 SMC43616.1 SMC43584.1 SMC43584.1 SMC43569.1 SMC43569.1 prs prs ldh ldh SMC43044.1 SMC43044.1 tilS tilS SMC43030.1 SMC43030.1 SMC43001.1 SMC43001.1 adk adk SMC42567.1 SMC42567.1 SMC42406.1 SMC42406.1 SMC42138.1 SMC42138.1 arcA arcA SMC41977.1 SMC41977.1 SMC41688.1 SMC41688.1 proC proC SMC40689.1 SMC40689.1 SMC40567.1 SMC40567.1 SMC40333.1 SMC40333.1 SMC40168.1 SMC40168.1 SMC39441.1 SMC39441.1 SMC39088.1 SMC39088.1 SMC39082.1 SMC39082.1 SMC38842.1 SMC38842.1 SMC38672.1 SMC38672.1 purM purM purN purN purH purH SMC38641.1 SMC38641.1 SMC38627.1 SMC38627.1 SMC38622.1 SMC38622.1 SMC38609.1 SMC38609.1 pgi pgi SMC37822.1 SMC37822.1 SMC37671.1 SMC37671.1 SMC37337.1 SMC37337.1 SMC37119.1 SMC37119.1 pfkA pfkA SMC36995.1 SMC36995.1 SMC36668.1 SMC36668.1 SMC36469.1 SMC36469.1 spxA spxA SMC36005.1 SMC36005.1 SMC34816.1 SMC34816.1 SMC34779.1 SMC34779.1 SMC34755.1 SMC34755.1 SMC34580.1 SMC34580.1 SMC34508.1 SMC34508.1 SMC34330.1 SMC34330.1 SMC34329.1 SMC34329.1 SMC34298.1 SMC34298.1 pgk pgk tpiA tpiA gpmI gpmI eno eno prmA prmA SMC33509.1 SMC33509.1 SMC33487.1 SMC33487.1 SMC33465.1 SMC33465.1 SMC33248.1 SMC33248.1 SMC33236.1 SMC33236.1 SMC32911.1 SMC32911.1 SMC32841.1 SMC32841.1 plsY plsY grpE grpE SMC30037.1 SMC30037.1 miaA miaA SMC30047.1 SMC30047.1 SMC30104.1 SMC30104.1 SMC30116.1 SMC30116.1 SMC30161.1 SMC30161.1 SMC30179.1 SMC30179.1 SMC30180.1 SMC30180.1 SMC30183.1 SMC30183.1 fni fni SMC30195.1 SMC30195.1 SMC30248.1 SMC30248.1 SMC30267.1 SMC30267.1 zwf zwf SMC30305.1 SMC30305.1 trmD trmD SMC30402.1 SMC30402.1 acpP acpP plsX plsX SMC30461.1 SMC30461.1 SMC30550.1 SMC30550.1 SMC30551.1 SMC30551.1 SMC30587.1 SMC30587.1 SMC30596.1 SMC30596.1 SMC30597.1 SMC30597.1 SMC30599.1 SMC30599.1 pdhA pdhA SMC30633.1 SMC30633.1 SMC30636.1 SMC30636.1 rpiA rpiA metK metK SMC30687.1 SMC30687.1 SMC30701.1 SMC30701.1 proB proB proA proA SMC30744.1 SMC30744.1 SMC30768.1 SMC30768.1 map map SMC30797.1 SMC30797.1 ispE ispE SMC30875.1 SMC30875.1 SMC30880.1 SMC30880.1 SMC30934.1 SMC30934.1 SMC30949.1 SMC30949.1 SMC30955.1 SMC30955.1 deoD deoD SMC31007.1 SMC31007.1 SMC31506.1 SMC31506.1 SMC31672.1 SMC31672.1 SMC31841.1 SMC31841.1 SMC31882.1 SMC31882.1 tig tig SMC32075.1 SMC32075.1 SMC32171.1 SMC32171.1 SMC32179.1 SMC32179.1 SMC32254.1 SMC32254.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMC33624.1Hypothetical protein. (262 aa)
SMC48985.1Magnesium transporter; Acts as a magnesium transporter. (458 aa)
SMC48704.1Putative transposase. (140 aa)
SMC48700.1Putative transposase. (319 aa)
SMC47353.1Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains. (228 aa)
SMC47342.1Hypothetical protein. (263 aa)
SMC47279.1Lipid kinase, YegS/Rv2252/BmrU family. (300 aa)
SMC47150.1Uncharacterized membrane protein YkvI. (422 aa)
SMC47129.1Uncharacterized membrane protein YkvI. (422 aa)
SMC47118.1Uncharacterized membrane protein YkvI. (409 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
SMC45579.1Catalase; Belongs to the catalase family. (569 aa)
SMC44520.1Phosphoglucomutase. (575 aa)
SMC44509.1UTP--glucose-1-phosphate uridylyltransferase. (291 aa)
gpsAGlycerol 3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (356 aa)
SMC44347.1Mannose-6-phosphate isomerase, cupin superfamily. (140 aa)
SMC44064.1EDD domain protein, DegV family. (281 aa)
SMC43963.1Lactate oxidase. (371 aa)
rexRedox-sensing transcriptional repressor; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (208 aa)
SMC43616.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa)
SMC43584.1Hypothetical protein. (268 aa)
SMC43569.1Alpha amylase, catalytic domain. (446 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (332 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa)
SMC43044.1S1 RNA binding domain protein. (140 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (478 aa)
SMC43030.1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)
SMC43001.1Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (210 aa)
SMC42567.1peptidoglycan-N-acetylmuramate O-acetyltransferase. (623 aa)
SMC42406.1Phenazine biosynthesis protein PhzF family. (278 aa)
SMC42138.1Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (457 aa)
arcAArginine deiminase. (410 aa)
SMC41977.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa)
SMC41688.1Uncharacterized membrane protein YgaE, UPF0421/DUF939 family. (363 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
SMC40689.1Nucleotide-binding universal stress protein, UspA family. (141 aa)
SMC40567.1Acyl-CoA dehydrogenase, N-terminal domain. (166 aa)
SMC40333.1Serine O-acetyltransferase. (178 aa)
SMC40168.116S rRNA m(2)G 1207 methyltransferase. (209 aa)
SMC39441.1GntR family transcriptional regulator, trehalose operon transcriptional repressor. (237 aa)
SMC39088.1tRNA1(Val) A37 N6-methylase TrmN6. (249 aa)
SMC39082.1Putative endonuclease. (113 aa)
SMC38842.1Alcohol dehydrogenase, propanol-preferring. (345 aa)
SMC38672.1Amidophosphoribosyltransferase. (431 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (336 aa)
purNPhosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (193 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (512 aa)
SMC38641.1Phosphoribosylamine--glycine ligase. (412 aa)
SMC38627.1CBS domain-containing protein. (215 aa)
SMC38622.1Putative hemolysin. (444 aa)
SMC38609.1Predicted O-methyltransferase YrrM. (236 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (448 aa)
SMC37822.1General stress protein 13. (129 aa)
SMC37671.1Aspartate aminotransferase. (394 aa)
SMC37337.1Uncharacterized protein YpbB. (337 aa)
SMC37119.1Pyruvate kinase; Belongs to the pyruvate kinase family. (587 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
SMC36995.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (477 aa)
SMC36668.1Methyltransferase domain-containing protein. (248 aa)
SMC36469.1Magnesium transporter; Acts as a magnesium transporter. (470 aa)
spxARegulatory protein spx; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
SMC36005.1UTP--glucose-1-phosphate uridylyltransferase. (291 aa)
SMC34816.1Transcriptional regulator, RpiR family. (247 aa)
SMC34779.1Transcriptional regulator, ArsR family. (104 aa)
SMC34755.1EDD domain protein, DegV family. (296 aa)
SMC34580.1Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (332 aa)
SMC34508.1Glycolate oxidase. (444 aa)
SMC34330.16-phosphogluconolactonase. (342 aa)
SMC34329.1Predicted PurR-regulated permease PerM. (389 aa)
SMC34298.1Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (435 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (323 aa)
SMC33509.1CBS domain-containing protein. (238 aa)
SMC33487.1Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (874 aa)
SMC33465.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (266 aa)
SMC33248.14-alpha-glucanotransferase. (501 aa)
SMC33236.1Starch phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (754 aa)
SMC32911.1Asparaginase. (329 aa)
SMC32841.1Alpha-glycerophosphate oxidase. (612 aa)
plsYAcyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa)
grpEMolecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] (192 aa)
SMC30037.1NADPH:quinone reductase. (320 aa)
miaAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (314 aa)
SMC30047.1Farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (295 aa)
SMC30104.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa)
SMC30116.1Lipid kinase, YegS/Rv2252/BmrU family. (300 aa)
SMC30161.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
SMC30179.1Mevalonate kinase. (316 aa)
SMC30180.1Diphosphomevalonate decarboxylase. (334 aa)
SMC30183.1Phosphomevalonate kinase. (365 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (353 aa)
SMC30195.1Gluconate kinase, FGGY family. (484 aa)
SMC30248.1Glucokinase. (321 aa)
SMC30267.1Glycine cleavage system H protein. (110 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
SMC30305.1ACT domain-containing protein. (87 aa)
trmDtRNA (Guanine37-N(1)-) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (247 aa)
SMC30402.1Hypothetical protein. (269 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa)
plsXPhosphate:acyl-[acyl carrier protein] acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (348 aa)
SMC30461.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa)
SMC30550.1Hypothetical protein. (276 aa)
SMC30551.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (467 aa)
SMC30587.1Myo-inositol-1(or 4)-monophosphatase. (263 aa)
SMC30596.1Dihydrolipoamide dehydrogenase. (470 aa)
SMC30597.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (533 aa)
SMC30599.1Pyruvate dehydrogenase E1 component beta subunit. (323 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (367 aa)
SMC30633.13-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (440 aa)
SMC30636.1hydroxymethylglutaryl-CoA synthase. (388 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
SMC30687.1Transcriptional regulator, GntR family. (238 aa)
SMC30701.1Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (347 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (271 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa)
SMC30744.1EDD domain protein, DegV family. (290 aa)
SMC30768.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (415 aa)
mapMethionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (252 aa)
SMC30797.1Hypothetical protein. (477 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (292 aa)
SMC30875.1Amidohydrolase. (391 aa)
SMC30880.1Putative NADPH-quinone reductase (modulator of drug activity B). (227 aa)
SMC30934.1Arsenate reductase; Belongs to the ArsC family. (116 aa)
SMC30949.1S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
SMC30955.1EDD domain protein, DegV family. (290 aa)
deoDPurine-nucleoside phosphorylase. (237 aa)
SMC31007.1Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
SMC31506.1Nucleotide-binding universal stress protein, UspA family. (150 aa)
SMC31672.1Uncharacterized membrane protein YgaE, UPF0421/DUF939 family. (328 aa)
SMC31841.1Predicted PurR-regulated permease PerM. (383 aa)
SMC31882.1Hypothetical protein. (292 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (426 aa)
SMC32075.11-acyl-sn-glycerol-3-phosphate acyltransferase. (220 aa)
SMC32171.1Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (253 aa)
SMC32179.1Phosphatidate cytidylyltransferase; Belongs to the CDS family. (263 aa)
SMC32254.1Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (318 aa)
Your Current Organism:
Aerococcus suis
NCBI taxonomy Id: 371602
Other names: Aerococcus suis Vela et al. 2007 emend. Tohno et al. 2014, CCUG 52530, CECT 7139, DSM 21500, JCM 18035
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