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| | BRE | BRCA1-A complex subunit BRE. (495 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | SLF1 | Ankyrin repeat domain-containing protein 32. (925 aa) |
| | AV530_008416 | Uncharacterized protein. (102 aa) |
| | NARS | Asparagine--tRNA ligase, cytoplasmic. (1015 aa) |
| | AV530_017375 | Reverse transcriptase domain-containing protein. (274 aa) |
| | RFC1 | Replication factor C subunit 1. (1150 aa) |
| | WHSC1 | Histone-lysine N-methyltransferase NSD2. (1394 aa) |
| | POLN | DNA polymerase nu isoform D. (814 aa) |
| | AV530_000729 | Histone H2B; Belongs to the histone H2B family. (123 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (279 aa) |
| | BLM | Bloom syndrome protein. (1899 aa) |
| | TP53BP1 | Tumor suppressor p53-binding protein 1 isoform A. (1799 aa) |
| | SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (284 aa) |
| | TIMELESS | Timeless-like protein. (1145 aa) |
| | POLQ | DNA polymerase theta isoform B. (2624 aa) |
| | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear protein 1. (277 aa) |
| | AV530_013085 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | AV530_013083 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | AV530_013074 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12. (1993 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (171 aa) |
| | ABL1 | Tyrosine-protein kinase. (1195 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (786 aa) |
| | AV530_017028 | RCC1 and BTB domain-containing protein 2. (591 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2276 aa) |
| | RPS27A | Ubiquitin-40S ribosomal protein S27a. (178 aa) |
| | MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | POLK | DNA polymerase kappa isoform B. (944 aa) |
| | POLE2 | DNA polymerase epsilon subunit 2. (315 aa) |
| | AV530_007135 | DNA_pol_E_B domain-containing protein. (226 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (920 aa) |
| | WRN | Werner syndrome ATP-dependent helicase isoform B. (1720 aa) |
| | AV530_000249 | Short transient receptor potential channel 2-like. (325 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36 isoform B. (261 aa) |
| | CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (309 aa) |
| | EME1 | Crossover junction endonuclease EME1 isoform A. (528 aa) |
| | RAD50 | DNA repair protein RAD50. (1312 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80 isoform C. (807 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2. (139 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4. (1871 aa) |
| | UBE2I | SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1171 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform B. (493 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1016 aa) |
| | SIRT6 | NAD-dependent protein deacetylase sirtuin-6. (357 aa) |
| | AV530_018590 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (603 aa) |
| | KXD1 | KxDL motif-containing protein 1. (190 aa) |
| | BABAM1 | BRISC and BRCA1-A complex member 1. (177 aa) |
| | PIAS4 | E3 SUMO-protein ligase PIAS4. (495 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169. (527 aa) |
| | POLD3 | DNA polymerase delta subunit 3 isoform B. (405 aa) |
| | AV530_007031 | Uncharacterized protein. (93 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RFC5 | Replication factor C subunit 5. (255 aa) |
| | XRCC2 | DNA repair protein XRCC2. (278 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1030 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (755 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (428 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (407 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (144 aa) |
| | SPIDR | DNA repair-scaffolding protein. (947 aa) |
| | AV530_006274 | CtIP_N domain-containing protein. (333 aa) |
| | AV530_008356 | Uncharacterized protein. (99 aa) |
| | RAD51B | DNA repair RAD51-like protein 2 isoform A. (447 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (281 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1 isoform A. (627 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1518 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (690 aa) |
| | RPA3 | Replication protein A subunit. (121 aa) |
| | AV530_009844 | Uncharacterized protein. (98 aa) |
| | XRCC3 | DNA repair protein XRCC3. (330 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3037 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein isoform C. (3432 aa) |
| | CCNA1 | Cyclin-A1; Belongs to the cyclin family. (387 aa) |
| | PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (405 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (180 aa) |
| | RAD52 | DNA repair RAD52-like protein. (454 aa) |
| | RAD51AP1 | RAD51-associated protein 1. (377 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (787 aa) |
| | RFC4 | Replication factor C subunit 4. (362 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2619 aa) |
| | AV530_012178 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (668 aa) |
| | RFC2 | Replication factor C subunit 2. (355 aa) |
| | LIG3 | DNA ligase. (904 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (646 aa) |
| | RAD51D | DNA repair RAD51-like protein 4. (375 aa) |
| | UBC | Polyubiquitin-C isoform A. (365 aa) |
| | RAD51C | DNA repair RAD51-like protein 3. (366 aa) |
| | BRIP1 | Fanconi anemia group J protein. (886 aa) |
| | AV530_000036 | Histone H2B; Belongs to the histone H2B family. (180 aa) |
| | AV530_004707 | CBFD_NFYB_HMF domain-containing protein. (70 aa) |
| | ATRIP | ATR-interacting protein. (715 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (284 aa) |
| | FAM175A | BRCA1-A complex subunit Abraxas. (403 aa) |
| | CCNA2 | Cyclin-A2; Belongs to the cyclin family. (299 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (405 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein. (1749 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | AV530_013466 | Uncharacterized protein. (130 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (357 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (412 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (381 aa) |
| | GEN1 | Flap endonuclease GEN-like protein 1. (901 aa) |
| | EXO1 | Exonuclease 1. (858 aa) |
| | AV530_008472 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (286 aa) |
| | POLH | DNA polymerase eta. (689 aa) |
| | RPA2 | Replication protein A subunit. (271 aa) |
