STRINGSTRING
IRX2 IRX2 IRX4 IRX4 RPS27A RPS27A LDLRAD4 LDLRAD4 AV530_007771 AV530_007771 AV530_007772 AV530_007772 AV530_007773 AV530_007773 FSTL1 FSTL1 RNF111 RNF111 SMAD3 SMAD3 FURIN FURIN SMAD7 SMAD7 SMAD9 SMAD9 SNW1 SNW1 AV530_011467 AV530_011467 ITGB8 ITGB8 TGFBR2 TGFBR2 ZFYVE16 ZFYVE16 MEIS2 MEIS2 LTBP2 LTBP2 TGFB3 TGFB3 PMEPA1 PMEPA1 TGIF1 TGIF1 GDF2 GDF2 AV530_016009 AV530_016009 AV530_016008 AV530_016008 ACVR2B ACVR2B PARD3 PARD3 BAMBI BAMBI MKX MKX F11R F11R AV530_018085 AV530_018085 CHRDL2 CHRDL2 AV530_009446 AV530_009446 AV530_011239 AV530_011239 PRKCZ PRKCZ SKI SKI AV530_014730 AV530_014730 FSTL3 FSTL3 PCSK4 PCSK4 KXD1 KXD1 BMP10 BMP10 FST FST AV530_001042 AV530_001042 STUB1 STUB1 SMURF1 SMURF1 SMAD5 SMAD5 NOG NOG SMURF2 SMURF2 AMH AMH ACVR1B ACVR1B AV530_000487 AV530_000487 CHRDL1 CHRDL1 ATP1B4 ATP1B4 FBN1 FBN1 SMAD6 SMAD6 AV530_012164 AV530_012164 ZCCHC4 ZCCHC4 TGIF2 TGIF2 NEDD4L NEDD4L STRAP STRAP CGN CGN AV530_008391 AV530_008391 PARP1 PARP1 TGFB2 TGFB2 AV530_008392 AV530_008392 LTBP1 LTBP1 GREM2 GREM2 ACVRL1 ACVRL1 PARD3B PARD3B INHBA INHBA AV530_004076 AV530_004076 FKBP1A FKBP1A ITGB3 ITGB3 WWTR1 WWTR1 BMPR1B BMPR1B SMAD1 SMAD1 TGFBR1 TGFBR1 AV530_004028 AV530_004028 BMPR2 BMPR2 ZFYVE9 ZFYVE9 AV530_006895 AV530_006895 AV530_015031 AV530_015031 IRX5 IRX5 IRX3 IRX3 IRX6 IRX6 UBC UBC SKIL SKIL NCOR1 NCOR1 MTMR4 MTMR4 AV530_010153 AV530_010153 SMAD4 SMAD4 ACVR1 ACVR1 AV530_002156 AV530_002156 ACVR2A ACVR2A AV530_002155 AV530_002155 CCNT2 CCNT2 AV530_002275 AV530_002275 INHBB INHBB ITGB6 ITGB6 ITGAV ITGAV MEIS1 MEIS1 CER1 CER1 CDK9 CDK9 CBL CBL IRX1 IRX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRX2Iroquois-class homeodomain protein IRX-2. (261 aa)
IRX4Iroquois-class homeodomain protein IRX-4. (492 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (178 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4 isoform B. (310 aa)
AV530_007771MH2 domain-containing protein. (141 aa)
AV530_007772MH2 domain-containing protein. (174 aa)
AV530_007773MH1 domain-containing protein. (284 aa)
FSTL1Follistatin-related protein 1. (315 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform A. (1051 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
FURINFurin; Belongs to the peptidase S8 family. (789 aa)
SMAD7Mothers against decapentaplegic-like protein 7. (181 aa)
SMAD9Mothers against decapentaplegic homolog. (476 aa)
SNW1SNW domain-containing protein 1. (538 aa)
AV530_011467Uncharacterized protein. (203 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16. (1214 aa)
MEIS2Homeobox protein Meis2 isoform C. (488 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2. (1753 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (319 aa)
PMEPA1Protein TMEPAI. (302 aa)
TGIF1Homeobox protein TGIF1. (269 aa)
GDF2Growth/differentiation factor 2. (428 aa)
AV530_016009Activin_recp domain-containing protein. (147 aa)
AV530_016008Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (324 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
PARD3Partitioning defective 3-like protein isoform A. (1258 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (255 aa)
MKXHomeobox protein Mohawk isoform C. (350 aa)
F11RJunctional adhesion molecule A isoform A. (351 aa)
AV530_018085Iroquois-class homeodomain protein irx-1-like. (229 aa)
CHRDL2Chordin-like protein 2. (228 aa)
AV530_009446Latent-transforming growth factor beta-binding protein 4-like. (110 aa)
AV530_011239Uncharacterized protein. (218 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (587 aa)
SKISki oncogene. (359 aa)
AV530_014730MH1 domain-containing protein. (90 aa)
FSTL3Follistatin-related protein 3. (259 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (523 aa)
KXD1KxDL motif-containing protein 1. (190 aa)
BMP10Bone morphogenetic protein 10. (425 aa)
FSTFollistatin. (485 aa)
AV530_001042Noggin-2-like. (142 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (313 aa)
SMURF1E3 ubiquitin-protein ligase. (819 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
SMURF2E3 ubiquitin-protein ligase. (753 aa)
AMHMuellerian-inhibiting factor. (544 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
AV530_000487Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (150 aa)
CHRDL1Chordin-like protein 1 isoform A. (487 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
FBN1Fibrillin-1. (2872 aa)
SMAD6Mothers against decapentaplegic homolog. (423 aa)
AV530_012164MH1 domain-containing protein. (71 aa)
ZCCHC4Zinc finger CCHC domain-containing protein 4 isoform B. (493 aa)
TGIF2Homeobox protein TGIF2. (262 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like isoform A. (1253 aa)
STRAPSerine-threonine kinase receptor-associated protein. (350 aa)
CGNCingulin. (247 aa)
AV530_008391Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (153 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
AV530_008392Uncharacterized protein. (172 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform B. (1569 aa)
GREM2Gremlin-2. (192 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (313 aa)
PARD3BPartitioning defective 3-like protein B isoform B. (1186 aa)
INHBAInhibin beta A chain. (424 aa)
AV530_004076Uncharacterized protein. (328 aa)
FKBP1APeptidylprolyl isomerase. (126 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (746 aa)
WWTR1WW domain-containing transcription regulator protein 1 isoform A. (270 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
AV530_004028Activin_recp domain-containing protein. (136 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (966 aa)
ZFYVE9Zinc finger FYVE domain-containing protein 9. (1057 aa)
AV530_006895MH1 domain-containing protein. (95 aa)
AV530_015031Partitioning defective 6-like protein beta. (352 aa)
IRX5Iroquois-class homeodomain protein IRX-5. (287 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (351 aa)
IRX6Iroquois-class homeodomain protein IRX-6 isoform B. (327 aa)
UBCPolyubiquitin-C isoform A. (365 aa)
SKILSki-like protein. (658 aa)
NCOR1Nuclear receptor corepressor 1 isoform A. (2558 aa)
MTMR4Myotubularin-related protein 4 isoform A. (994 aa)
AV530_010153Myotubularin phosphatase domain-containing protein. (194 aa)
SMAD4Mothers against decapentaplegic homolog. (362 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
AV530_002156Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (264 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
AV530_002155Uncharacterized protein. (84 aa)
CCNT2Cyclin-T2 isoform B; Belongs to the cyclin family. (687 aa)
AV530_002275TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
INHBBInhibin beta B chain. (392 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (791 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1034 aa)
MEIS1Homeobox protein Meis1 isoform B. (470 aa)
CER1Cerberus. (273 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (339 aa)
CBLE3 ubiquitin-protein ligase CBL. (903 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (394 aa)
Your Current Organism:
Patagioenas fasciata
NCBI taxonomy Id: 372326
Other names: P. fasciata monilis, Patagioenas fasciata monilis
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.