STRINGSTRING
ACACB ACACB PPP1CC PPP1CC PPP1R3B PPP1R3B AV530_000480 AV530_000480 EIF4E EIF4E MAPK10 MAPK10 AV530_019789 AV530_019789 AV530_004154 AV530_004154 AV530_009265 AV530_009265 AV530_008567 AV530_008567 PIK3R3 PIK3R3 MKNK1 MKNK1 PTPRF PTPRF PRKAB2 PRKAB2 PRKACB PRKACB SHC1 SHC1 PRKAR2B PRKAR2B RRAD RRAD AV530_015135 AV530_015135 RPS6KB1 RPS6KB1 CRK CRK PHKG1 PHKG1 FLOT2 FLOT2 SH2B2 SH2B2 RAF1 RAF1 ACACA ACACA PRKCI PRKCI PIK3CA PIK3CA IRS1 IRS1 PIK3CB PIK3CB ALKBH4 ALKBH4 FASN FASN PRKAG3 PRKAG3 G6PC2 G6PC2 INPP5A INPP5A BRAF BRAF SOCS4 SOCS4 AKT1 AKT1 AV530_009991 AV530_009991 PYGB PYGB AV530_001477 AV530_001477 PHKA1 PHKA1 WBSCR22 WBSCR22 AV530_014131 AV530_014131 PRKAA1 PRKAA1 PTPN1 PTPN1 PPP1R3D PPP1R3D SYCP2 SYCP2 PCK1 PCK1 AV530_004561 AV530_004561 GCK GCK IKBKB IKBKB EIF4EBP1 EIF4EBP1 AV530_004636 AV530_004636 MAPK8 MAPK8 SORBS1 SORBS1 AV530_016062 AV530_016062 REM1 REM1 PPP1R3C PPP1R3C RHEB RHEB AV530_011728 AV530_011728 AV530_016061 AV530_016061 RPS6 RPS6 AV530_011727 AV530_011727 PRKCZ PRKCZ AV530_011822 AV530_011822 MTOR MTOR PIK3CD PIK3CD MAP2K2 MAP2K2 SHC2 SHC2 PIK3R2 PIK3R2 AV530_006857 AV530_006857 MYO9B MYO9B INSR INSR AV530_001508 AV530_001508 AV530_001507 AV530_001507 AV530_001509 AV530_001509 PRKAR1B PRKAR1B TSC2 TSC2 SOCS1 SOCS1 HK3 HK3 PDPK1 PDPK1 EIF4E1B EIF4E1B MAPK9 MAPK9 RPTOR RPTOR SOCS3 SOCS3 PRKAR1A PRKAR1A EXOC7 EXOC7 GRB2 GRB2 PTPRS PTPRS CSDE1 CSDE1 NRAS NRAS AV530_003597 AV530_003597 AV530_003857 AV530_003857 AV530_003871 AV530_003871 AV530_007128 AV530_007128 PYGL PYGL AV530_007127 AV530_007127 INPPL1 INPPL1 AV530_004550 AV530_004550 PIK3R1 PIK3R1 TBCA TBCA SOS1 SOS1 CBLB CBLB AV530_016841 AV530_016841 IRS2 IRS2 FOXO1 FOXO1 AV530_000265 AV530_000265 SHC3 SHC3 TSC1 TSC1 RAPGEF1 RAPGEF1 CBL CBL PTPRD PTPRD PPP1R3A PPP1R3A AV530_012839 AV530_012839 BMT2 BMT2 AV530_013046 AV530_013046 AV530_000241 AV530_000241 SREBF2 SREBF2 ELK3 ELK3 AV530_009181 AV530_009181 GSK3B GSK3B PHKA2 PHKA2 MYO9A MYO9A CALML4 CALML4 MAP2K1 MAP2K1 SHC4 SHC4 KRAS KRAS GYS2 GYS2 PPARGC1A PPARGC1A SORBS2 SORBS2 PRKAR2A PRKAR2A RHOQ RHOQ AV530_018824 AV530_018824 PPP1CB PPP1CB AKT3 AKT3 HRAS HRAS INS INS PPP1CA PPP1CA AV530_013471 AV530_013471 PHKB PHKB PDE3B PDE3B G6PC G6PC G6PC3 G6PC3 PRKAB1 PRKAB1 CRKL CRKL CRYBB3 CRYBB3 AV530_018425 AV530_018425
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACACBAcetyl-CoA carboxylase 2 isoform B. (2459 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (595 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (301 aa)
AV530_000480Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (456 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
MAPK10Mitogen-activated protein kinase. (540 aa)
AV530_019789Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (227 aa)
AV530_004154Uncharacterized protein. (282 aa)
AV530_009265Uncharacterized protein. (71 aa)
AV530_008567Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform A. (731 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (412 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform A. (2975 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform B. (273 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (375 aa)
SHC1SHC-transforming protein 1. (323 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (418 aa)
RRADGTP-binding protein RAD. (328 aa)
AV530_015135CBM21 domain-containing protein. (318 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
CRKAdapter molecule crk. (305 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform. (308 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
SH2B2SH2B adapter protein 2. (682 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform A. (698 aa)
ACACAAcetyl-CoA carboxylase 1. (2096 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
IRS1Insulin receptor substrate 1 isoform A. (1123 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1118 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB-like protein 4. (298 aa)
FASNFatty acid synthase. (2513 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (383 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (348 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase. (338 aa)
BRAFSerine/threonine-protein kinase B-raf isoform A. (769 aa)
SOCS4Suppressor of cytokine signaling 4. (436 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AV530_009991Calmodulin; Belongs to the calmodulin family. (195 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
AV530_001477Uncharacterized protein. (75 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1242 aa)
WBSCR22Putative 18S rRNA (Guanine-N(7))-methyltransferase. (282 aa)
AV530_014131Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (621 aa)
PRKAA1Non-specific serine/threonine protein kinase. (796 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (307 aa)
SYCP2Synaptonemal complex protein 2. (1454 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (663 aa)
AV530_004561Protein phosphatase 1 regulatory subunit 3C-B-like. (437 aa)
GCKPhosphotransferase. (465 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (757 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (113 aa)
AV530_004636Uncharacterized protein. (997 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SORBS1Sorbin and SH3 domain-containing protein 1 isoform B. (1373 aa)
AV530_016062Hexokinase-1. (917 aa)
REM1GTP-binding protein REM 1. (292 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (300 aa)
RHEBGTP-binding protein Rheb; Belongs to the beta/gamma-crystallin family. (235 aa)
AV530_0117285'-AMP-activated protein kinase subunit gamma-2-like. (230 aa)
AV530_016061Putative hexokinase HKDC1. (885 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
AV530_0117275'-AMP-activated protein kinase subunit gamma-2. (328 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (587 aa)
AV530_011822Mycocerosic acid synthase-like; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (1533 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2588 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (398 aa)
SHC2SHC-transforming protein 2. (480 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
AV530_006857Protein kinase domain-containing protein. (217 aa)
MYO9BUnconventional myosin-IXb isoform D; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2215 aa)
INSRTyrosine-protein kinase receptor. (1323 aa)
AV530_001508Phosphotransferase. (161 aa)
AV530_001507Phosphotransferase. (361 aa)
AV530_001509Phosphotransferase. (327 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit. (433 aa)
TSC2Tuberin isoform C. (1853 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
HK3Hexokinase-3. (904 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (563 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (234 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RPTORRegulatory-associated protein of mTOR isoform B. (1371 aa)
SOCS3Suppressor of cytokine signaling 3. (209 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (732 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S isoform C. (1958 aa)
CSDE1Cold shock domain-containing protein E1. (1129 aa)
NRASGTPase NRas. (189 aa)
AV530_003597Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2-like. (1195 aa)
AV530_003857Insulin receptor substrate 2-B-like. (958 aa)
AV530_003871Cyclic nucleotide-binding domain-containing protein. (118 aa)
AV530_007128Ras-GEF domain-containing protein. (352 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (892 aa)
AV530_007127DH domain-containing protein. (370 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1139 aa)
AV530_004550Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (194 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (746 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
SOS1Son of sevenless-like protein 1. (1345 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (1023 aa)
AV530_016841PH domain-containing protein. (129 aa)
IRS2Insulin receptor substrate 2. (247 aa)
FOXO1Forkhead box protein O1. (613 aa)
AV530_000265Uncharacterized protein. (319 aa)
SHC3SHC-transforming protein 3 isoform C. (633 aa)
TSC1Hamartin isoform C. (1145 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform B. (1277 aa)
CBLE3 ubiquitin-protein ligase CBL. (903 aa)
PTPRDReceptor-type tyrosine-protein phosphatase delta isoform A. (1618 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (909 aa)
AV530_012839CBM21 domain-containing protein. (277 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (402 aa)
AV530_013046Suppressor of cytokine signaling 1. (187 aa)
AV530_000241Uncharacterized protein. (269 aa)
SREBF2Sterol regulatory element-binding protein 2. (1030 aa)
ELK3ETS domain-containing protein Elk-3. (422 aa)
AV530_009181PID domain-containing protein. (305 aa)
GSK3BGlycogen synthase kinase-3 beta isoform B; Belongs to the protein kinase superfamily. (433 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1246 aa)
MYO9AUnconventional myosin-IXa isoform A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2172 aa)
CALML4Calmodulin-like protein 4. (153 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
SHC4SHC-transforming protein 4. (608 aa)
KRASGTPase KRas isoform A. (192 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (795 aa)
SORBS2Sorbin and SH3 domain-containing protein 2 isoform C. (1076 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (400 aa)
RHOQRho-related GTP-binding protein RhoQ. (280 aa)
AV530_018824Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (418 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HRASGTPase HRas. (184 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (116 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
AV530_013471Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (472 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1037 aa)
PDE3BPhosphodiesterase. (942 aa)
G6PCGlucose-6-phosphatase. (358 aa)
G6PC3Glucose-6-phosphatase 3. (252 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (378 aa)
CRKLCrk-like protein. (303 aa)
CRYBB3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (254 aa)
AV530_018425Tankyrase_bdg_C domain-containing protein. (2072 aa)
Your Current Organism:
Patagioenas fasciata
NCBI taxonomy Id: 372326
Other names: P. fasciata monilis, Patagioenas fasciata monilis
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