STRINGSTRING
RPS6KA1 RPS6KA1 CREB5 CREB5 MAFB MAFB FOSL1 FOSL1 JUNB JUNB DUSP7 DUSP7 ERN1 ERN1 DUSP9 DUSP9 MAPK10 MAPK10 MAPK8 MAPK8 HSF5 HSF5 MAP2K6 MAP2K6 MAFA MAFA CRTC2 CRTC2 PTPN5 PTPN5 CREB3L4 CREB3L4 MAPK13 MAPK13 SIK2 SIK2 CREBBP CREBBP MAPKAPK5 MAPKAPK5 EGR1 EGR1 LOC105712414 LOC105712414 ATF4 ATF4 CREB3L1 CREB3L1 FOSL2 FOSL2 MAP3K2 MAP3K2 RPS6KA5 RPS6KA5 MAPK9 MAPK9 MAPK7 MAPK7 DUSP16 DUSP16 ENSANAP00000013693 ENSANAP00000013693 PPP1R15A PPP1R15A XBP1 XBP1 ENSANAP00000014649 ENSANAP00000014649 CREB3L2 CREB3L2 MAPK1 MAPK1 EP300 EP300 MAP3K3 MAP3K3 CREB1 CREB1 CEBPB CEBPB LOC105715975 LOC105715975 MAPKAPK2 MAPKAPK2 RPS6KA3 RPS6KA3 MAP2K5 MAP2K5 DUSP1 DUSP1 ENSANAP00000019133 ENSANAP00000019133 MAPK15 MAPK15 MAP3K1 MAP3K1 CRTC3 CRTC3 MAPK6 MAPK6 PAK2 PAK2 DUSP10 DUSP10 DDIT3 DDIT3 MAP2K3 MAP2K3 CREB3L3 CREB3L3 CREBRF CREBRF CREB3 CREB3 NAB2 NAB2 FOS FOS EGR2 EGR2 NR4A1 NR4A1 FCRL6 FCRL6 MAPK4 MAPK4 CRTC1 CRTC1 CEBPG CEBPG ATF5 ATF5 SMYD3 SMYD3 PTPRR PTPRR ATF7 ATF7 NR4A3 NR4A3 MAP2K7 MAP2K7 ENSANAP00000030964 ENSANAP00000030964 ATF1 ATF1 NR4A2 NR4A2 PTPN7 PTPN7 ZFP36 ZFP36 PEA15 PEA15 MAPK12 MAPK12 STK33 STK33 MAPK11 MAPK11 FOSB FOSB RPS6KA6 RPS6KA6 MAPK8IP3 MAPK8IP3 MAP2K4 MAP2K4 RPS6KA2 RPS6KA2 ATF6B ATF6B CREM CREM ATF3 ATF3 MAPKAPK3 MAPKAPK3 ATF2 ATF2 MAPK3 MAPK3 DUSP6 DUSP6 EGR3 EGR3 MAPK14 MAPK14 DUSP3 DUSP3 SIK1 SIK1 HSPB1 HSPB1 ENSANAP00000041927 ENSANAP00000041927 RPS6KA4 RPS6KA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (1012 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
MAPK10Mitogen-activated protein kinase. (533 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
HSF5HSF_DOMAIN domain-containing protein. (598 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAFAMAF bZIP transcription factor A. (332 aa)
CRTC2CREB regulated transcription coactivator 2. (702 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (566 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
MAPK13Mitogen-activated protein kinase. (392 aa)
SIK2Salt inducible kinase 2. (922 aa)
CREBBPCREB binding protein. (2445 aa)
MAPKAPK5MAPK activated protein kinase 5. (473 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (546 aa)
LOC105712414SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (175 aa)
ATF4Activating transcription factor 4. (350 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
MAP3K2Uncharacterized protein. (619 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
MAPK9Mitogen-activated protein kinase 9. (442 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
DUSP16Dual specificity phosphatase 16. (662 aa)
ENSANAP00000013693Uncharacterized protein. (110 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (664 aa)
XBP1BZIP domain-containing protein. (379 aa)
ENSANAP00000014649Uncharacterized protein. (218 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (424 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
EP300E1A binding protein p300. (2401 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (705 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CEBPBCCAAT/enhancer-binding protein. (321 aa)
LOC105715975Uncharacterized protein. (596 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (392 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (415 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ENSANAP00000019133BZIP domain-containing protein. (163 aa)
MAPK15Protein kinase domain-containing protein. (246 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
MAPK6Protein kinase domain-containing protein. (721 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
DUSP10Dual specificity phosphatase 10. (494 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (392 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (501 aa)
CREBRFCREB3 regulatory factor. (639 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
NAB2NGFI-A binding protein 2. (525 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EGR2Early growth response 2. (473 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (653 aa)
FCRL6Fc receptor like 6. (435 aa)
MAPK4Mitogen-activated protein kinase 4. (587 aa)
CRTC1CREB regulated transcription coactivator 1. (635 aa)
CEBPGBZIP domain-containing protein. (150 aa)
ATF5BZIP domain-containing protein. (269 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (657 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (436 aa)
ENSANAP00000030964Tyrosine-protein phosphatase domain-containing protein. (117 aa)
ATF1Activating transcription factor 1. (270 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PTPN7Protein tyrosine phosphatase non-receptor type 7. (419 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (149 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
STK33Serine/threonine kinase 33. (514 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (337 aa)
RPS6KA6Ribosomal protein S6 kinase. (783 aa)
MAPK8IP3Mitogen-activated protein kinase 8 interacting protein 3. (1340 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (375 aa)
RPS6KA2Ribosomal protein S6 kinase. (756 aa)
ATF6BActivating transcription factor 6 beta. (700 aa)
CREMcAMP responsive element modulator. (332 aa)
ATF3Activating transcription factor 3. (181 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
ATF2Activating transcription factor 2. (287 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
EGR3Early growth response 3. (387 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
SIK1Uncharacterized protein. (781 aa)
HSPB1SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (205 aa)
ENSANAP00000041927Uncharacterized protein. (334 aa)
RPS6KA4Ribosomal protein S6 kinase. (762 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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