(7 nodes) SREBP signaling pathway network (Aotus nancymaae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCAP	Uncharacterized protein. (1241 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (233 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (280 aa)
	ENSANAP00000018891	Uncharacterized protein. (102 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1143 aa)
	ENSANAP00000037159	WD_REPEATS_REGION domain-containing protein. (508 aa)
	MBTPS1	Membrane bound transcription factor peptidase, site 1. (1052 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSANAP00000018891	ENSANAP00000037159	ENSANAP00000018891	ENSANAP00000037159	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.432
ENSANAP00000018891	INSIG1	ENSANAP00000018891	ENSANAP00000017704	Uncharacterized protein.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.791
ENSANAP00000018891	INSIG2	ENSANAP00000018891	ENSANAP00000006272	Uncharacterized protein.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.791
ENSANAP00000018891	MBTPS1	ENSANAP00000018891	ENSANAP00000040682	Uncharacterized protein.	Membrane bound transcription factor peptidase, site 1.	0.606
ENSANAP00000018891	SREBF2	ENSANAP00000018891	ENSANAP00000019976	Uncharacterized protein.	Sterol regulatory element binding transcription factor 2.	0.896
ENSANAP00000037159	ENSANAP00000018891	ENSANAP00000037159	ENSANAP00000018891	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.432
ENSANAP00000037159	INSIG1	ENSANAP00000037159	ENSANAP00000017704	WD_REPEATS_REGION domain-containing protein.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.888
ENSANAP00000037159	INSIG2	ENSANAP00000037159	ENSANAP00000006272	WD_REPEATS_REGION domain-containing protein.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.844
ENSANAP00000037159	MBTPS1	ENSANAP00000037159	ENSANAP00000040682	WD_REPEATS_REGION domain-containing protein.	Membrane bound transcription factor peptidase, site 1.	0.643
ENSANAP00000037159	SREBF2	ENSANAP00000037159	ENSANAP00000019976	WD_REPEATS_REGION domain-containing protein.	Sterol regulatory element binding transcription factor 2.	0.934
INSIG1	ENSANAP00000018891	ENSANAP00000017704	ENSANAP00000018891	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Uncharacterized protein.	0.791
INSIG1	ENSANAP00000037159	ENSANAP00000017704	ENSANAP00000037159	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	WD_REPEATS_REGION domain-containing protein.	0.888
INSIG1	SCAP	ENSANAP00000017704	ENSANAP00000002592	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Uncharacterized protein.	0.888
INSIG1	SREBF2	ENSANAP00000017704	ENSANAP00000019976	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 2.	0.755
INSIG2	ENSANAP00000018891	ENSANAP00000006272	ENSANAP00000018891	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Uncharacterized protein.	0.791
INSIG2	ENSANAP00000037159	ENSANAP00000006272	ENSANAP00000037159	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	WD_REPEATS_REGION domain-containing protein.	0.844
INSIG2	SCAP	ENSANAP00000006272	ENSANAP00000002592	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Uncharacterized protein.	0.844
INSIG2	SREBF2	ENSANAP00000006272	ENSANAP00000019976	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Sterol regulatory element binding transcription factor 2.	0.623
MBTPS1	ENSANAP00000018891	ENSANAP00000040682	ENSANAP00000018891	Membrane bound transcription factor peptidase, site 1.	Uncharacterized protein.	0.606
MBTPS1	ENSANAP00000037159	ENSANAP00000040682	ENSANAP00000037159	Membrane bound transcription factor peptidase, site 1.	WD_REPEATS_REGION domain-containing protein.	0.643